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Geoscience Frontiers 2022年第1期13卷 498-505页

作者： Kátia Martinello James C.Hower guilherme L.Dotto Claudete G.Ramos Carlos E.Schnorr Diana Pinto Instituto Inanís Rua Felizardo FurtadoPorto AlegreBrazil University of Kentucky Department of Earth&Environmental SciencesLexingtonKY 40506USA University of Kentucky Center for Applied Energy Research2540 Research Park DriveLexingtonKY 40511USA Chemical Engineering Department Federal University of Santa Maria97105-900 Santa MariaBrazil Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia

Because incomplete confirmation is available concerning the influential role of atmosphere contamination on conjunctivitis,myopia,asthma,and allergic rhinitis in Brazil,the focus of the present work is to explore the possible relations among atmosphere contamination and eye *** that a case study on eye diseases,by way of questionnaires supplemented by the investigation of nanoparticles(NPs)on eyeglasses,the study examines the mechanisms in which NPs and ultra-fine particles are deposited on the glasses of children up to 10 years of age in urban and rural *** important connection between atmosphere contaminants and individual protection equipment justifies improving indoor school properties in order could protect children’s eyes,particularly in high-pollution/high-particulate areas.

关键词： Indoor air pollution Nanoparticles Eyes health Allergic reaction Schools

Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process

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Neural Regeneration Research 2021年第1期16卷 58-67页

作者： Mariana Toricelli Arthur Antonio Ruiz Pereira guilherme Souza Abrao Helena Nascimento Malerba Julia Maia Hudson Sousa Buck Tania Araujo Viel Department of Physiological Sciences Santa Casa de Sao Paulo School of Medical SciencesSao PauloBrazil Laboratory of Neurobiology of Aging School of ArtsSciences and HumanitiesUniversidade de São PauloSao PauloBrazil

Aging is a dynamic and progressive process that begins at conception and continues until *** process leads to a decrease in homeostasis and morphological,biochemical and psychological changes,increasing the individual’s vulnerability to various *** growth in the number of aging populations has increased the prevalence of chronic degenerative diseases,impairment of the central nervous system and dementias,such as Alzheimer’s disease,whose main risk factor is age,leading to an increase of the number of individuals who need daily support for life *** theories about aging suggest it is caused by an increase of cellular senescence and reactive oxygen species,which leads to inflammation,oxidation,cell membrane damage and consequently neuronal ***,mitochondrial mutations,which are generated throughout the aging process,can lead to changes in energy production,deficiencies in electron transport and apoptosis induction that can result in decreased ***,increasing cellular senescence and the release of proinflammatory cytokines can cause irreversible damage to neuronal *** reports point to the importance of changing lifestyle by increasing physical exercise,improving nutrition and environmental enrichment to activate neuroprotective defense ***,this review aims to address the latest information about the different mechanisms related to neuroplasticity and neuronal death and to provide strategies that can improve neuroprotection and decrease the neurodegeneration caused by aging and environmental stressors.

关键词： cell senescence cell signaling cholinergic enriched environment long-term potentiation neurodegeneration neurogenesis neuroinflammatory neuronal death neuroprotection neurotophin

An overview of geological originated materials as a trend for adsorption in wastewater treatment

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Geoscience Frontiers 2022年第1期13卷 457-477页

作者： Yasmin Vieira Matias Schadeck Netto Éder C.Lima Ioannis Anastopoulos Marcos L.S.Oliveira guilherme L.Dotto Chemistry Department Federal University of Santa Maria-UFSM1000Roraima Avenue97105-900 Santa MariaRSBrazil Chemical Engineering Department Federal University of Santa Maria-UFSM1000Roraima Avenue97105-900 Santa MariaRSBrazil Institute of Chemistry Federal University of Rio Grande do Sul(UFRGS)P.O.Box 1500391501-970 Porto AlegreRSBrazil Department of Chemistry University of CyprusP.O.Box 20537CY-1678 NicosiaCyprus Universidad de Lima Avenida Javier Prado Este 4600-Santiago de Surco 1503Peru Department of Civil and Environmental Universidad de la CostaCalle 58#55-66080002 BarranquillaAtlánticoColombia

Adsorption is a unit operation widely used for the tertiary treatment of the most diverse effluents,whose mechanism is based on removing recalcitrant compounds from the organic and inorganic *** this process,choosing a suitable adsorbent is a fundamental *** review article focuses on the adsorbents with natural geological origin:minerals,clays,geopolymers,and even wastes resulted from mining ***,over 450 articles and research papers were *** materials’main sources are described,and their characteristics,composition,and intrinsic properties are related to ***,we discuss the effects of several process parameters,such as p H,temperature,pollutant,and adsorbent ***,equilibrium,kinetics,and thermodynamic aspects are also addressed,and relevant regeneration prospects and final ***,some suggestions and perspectives on applying these adsorbents in wastewater treatment are presented as future trends.

关键词： Adsorption Equilibrium Geological-based adsorbents Process parameters Wastewater treatment

A Proof-of-Concept Assessment of the Safety and Efficacy of Intralesional Diclofenac in the Treatment of Cutaneous Neurofibromas

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International Journal of Clinical Medicine 2015年第12期6卷 975-983页

作者： Mauro Geller Aguinaldo Bonalumi Filho Lisa Oliveira Allan ERubenstein Luiz guilherme Darrigo Jr David Azulay Allan Bernacchi Marcia Goncalves Ribeiro Karin Soares Goncalves cunha Immunology Department Fundacao Educacional Serra dos Orgaos(UNIFESO)TeresopolisBrazil Clinical Immunology Instituto de Pos-Graduacao Medica Carlos Chagas(IPGMCC)Rio de JaneiroBrazil Medical Genetics Service IPPMG-Universidade Federal Rio de JaneiroRio de JaneiroBrazil Hospital Naval Marcilio Dias Rio de JaneiroBrazil Sociedade Evangelica Beneficiente de Curitiba Outpatient Unit CuritibaBrazil NYU Langone Medical Center New YorkNYUSA Bone Marrow Transplant Unit Hospital das Clinicas da Faculdade de Medicina de Ribeirao PretoUniversidade de Sao Paulo(USP)Ribeirao PretoBrazil Pontifica Universidade Catolica do Rio de Janeiro(PUC-RJ) Rio de JaneiroRJBrazil Plastic Surgery Post-Graduation PUC-RJRio de JaneiroBrazil 1 Universidade Federal Fluminense(UFF) Rio de JaneiroBrazil

The objectives of this study were to assess the safety and efficacy of intralesionally administered diclofenac in the treatment of cutaneous neurofibromas in patients with NF1. This was a proof-of-concept, prospective, safety and efficacy study of the effect of intralesionally administered diclofenac 25 mg/ml given once a week to 3 target cutaneous neurofibromas for 4 consecutive weeks. Overall, there was no significant change in neurofibroma size. During the study, some treated lesions developed signs of necrosis and fell off after a few weeks, but none of the control neurofibromas fell off. There were no significant changes in patient’s vital signs. A few adverse events occurred, mostly at the injection sites. During the study, some neurofibromas developed necrosis after the diclofenac injections and eventually detached from the patient. Overall, diclofenac was well tolerated, suggesting minimal systemic exposure, which required confirmation and further studies, including bioavailability analysis.

关键词： Neurofibromatosis Type 1 Cutaneous Neurofibromas Diclofenac Sodium

Al-driven peculiarities of local coordination and magnetic properties in single-phase Al_(x)-CrFeCoNi high-entropy alloys

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Nano Research 2022年第6期15卷 4845-4858页

作者： Alevtina Smekhova Alexei Kuzmin Konrad Siemensmeyer Chen Luo Kai Chen Florin Radu Eugen Weschke Uwe Reinholz Ana guilherme Buzanich Kirill V.Yusenko Helmholtz-Zentrum Berlin für Materialien und Energie(HZB) D-12489Germany Institute of Solid State Physics University of LatviaLV-1063Latvia Bundesanstalt für Materialforschung und-prüfung(BAM) D-12489Germany

Modern design of superior multi-functional alloys composed of several principal components requires in-depth studies of their local structure for developing desired macroscopic ***,peculiarities of atomic arrangements on the local scale and electronic states of constituent elements in the single-phase face-centered cubic(fcc)-and body-centered cubic(bcc)-structured high-entropy Alx-CrFeCoNi alloys(x=0.3 and 3,respectively)are explored by element-specific X-ray absorption spectroscopy in hard and soft X-ray energy *** based on the reverse Monte Carlo approach allow to perform a simultaneous fit of extended X-ray absorption fine structure spectra recorded at K absorption edges of each 3d constituent and to reconstruct the local environment within the first coordination shells of absorbers with high *** revealed unimodal and bimodal distributions of all five elements are in agreement with structure-dependent magnetic properties of studied alloys probed by magnetometry.A degree of surface atoms oxidation uncovered by soft X-rays suggests different kinetics of oxide formation for each type of constituents and has to be taken into account.X-ray magnetic circular dichroism technique employed at L2,3 absorption edges of transition metals demonstrates reduced magnetic moments of 3d metal constituents in the sub-surface region of in situ cleaned fcc-structured Al0.3-CrFeCoNi compared to their bulk *** to nanostructured versions of multicomponent alloys,such studies would bring new insights related to effects of high entropy mixing on low dimensions.

关键词： high-entropy alloys reverse Monte Carlo magnetism element-specific spectroscopy extended X-ray absorption fine structure(EXAFS) X-ray magnetic circular dichroism(XMCD)

Endoscopic balloon dilation of crohn's disease stricturessafety,efficacy and clinical impact

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World Journal of Gastroenterology 2017年第41期23卷 7397-7406页

作者： Susana Lopes Eduardo Rodrigues-Pinto Patrícia Andrade Joana Afonso Todd H Baron Fernando Magro guilherme Macedo Gastroenterology Department Faculty of MedicineHospital de Sao Joao Department of Pharmacology and Therapeutics University of Porto Division of Gastroenterology and Hepatology University of North Carolina

AIM To evaluate the incidence of anastomotic strictures after intestinal resection in Crohn's disease(CD), demonstrate long-term efficacy and safety of endoscopic balloon dilation(EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. METHODS Retrospective single tertiary center study based on prospectively collected data between 2010 and 2015including anastomotic and non-anastomotic strictures. RESULTS29% of 162 CD patients included developed an anastomotic stricture. 43 patients with anastomotic strictures and 37 with non-anastomotic strictures underwent EBD; technical success was 97.7% and 100%, respectively, however, 63% and 41% needed repeat dilation during the 4.4-year follow-up. Longer periods between surgery and index colonoscopy and higher lactoferrin levels were associated with the presence of stricture after surgery. Calprotectin levels > 83.35 μg/g and current or past history of smoking were associated with a shorter time until need for dilation(HR = 3.877, 95%CI: 1.480-10.152 and HR = 3.041, 95%CI: 1.213-7.627). Anastomotic strictures had a greater need for repeat dilation(63% vs 41%, P = 0.047). No differences were found between asymptomatic and symptomatic cohorts. Disease recurrence diagnosis was only possible after EBD in a third of patients. CONCLUSION EBD is an effective and safe alternative to surgery, with a good short and long-term outcome, postponing or even avoiding further surgery. EBD may allow to diagnose disease recurrence in patients with no clinical signs/biomarkers of disease activity.

关键词： Crohn’s disease Endoscopic recurrence Anastomotic strictures Non-anastomotic strictures Endoscopic balloon dilation

Not all liver tumors are alike—an accidentally discovered primary hepatic leiomyosarcoma:A case report

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World Journal of Hepatology 2022年第4期14卷 860-865页

作者： Isabel Garrido Patrícia Andrade João Pacheco Elisabete Rios guilherme Macedo Gastroenterology and Hepatology Department Centro Hospitalar Universitário de São JoãoPorto 4200-319Portugal World Gastroenterology Organization Porto Training Center Porto 4200-319Portugal Pathology Department Centro Hospitalar Universitário de São JoãoPorto 4200-319Portugal

BACKGROUND Primary hepatic leiomyosarcoma is a very rare entity that originates from smooth *** diagnosis requires a high degree of suspicion due to atypical clinical presentation and non-specific imaging *** SUMMARY We report the case of a 42-year-old man,with no relevant past medical history,accidentally diagnosed with a nodular liver lesion on a routine abdominal *** function tests and hematology parameters as well as tumor markers were normal.A contrast-enhanced abdominal computed tomography scan revealed a heterogenous hepatic lesion measuring 40 mm 30 mm,adjacent to the left branch of the portal vein and the round *** to the unclear diagnosis,the patient underwent surgical *** and immunohistochemical examinations confirmed complete(R0)resection of a hepatic *** patient remains without any signs of tumor recurrence for more than 2 *** We report a rare case of accidentally diagnosed primary hepatic leiomyosarcoma originating from the portal vein or the round *** this tumor has aggressive metastatic potential,a tumor-free resection margin is essential to improve survival.

关键词： Primary hepatic leiomyosarcoma Portal vein Round ligament Surgical resection Case report

Endoscopic ultrasound artificial intelligence-assisted for prediction of gastrointestinal stromal tumors diagnosis:A systematic review and meta-analysis

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World Journal of Gastrointestinal Endoscopy 2023年第8期15卷 528-539页

作者： Rômulo Sérgio Araújo Gomes guilherme Henrique Peixoto de Oliveira Diogo Turiani Hourneaux de moura Ana Paula Samy Tanaka Kotinda Carolina Ogawa Matsubayashi Bruno Salomão Hirsch Matheus de Oliveira Veras João guilherme Ribeiro Jordão Sasso Roberto Paolo Trasolini Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de moura Department of Gastroenterology Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Division of Hepatology and Endoscopy Department of GastroenterologyHarvard Medical SchoolBrigham and Women’s HospitalBostonMA 02115United States

BACKGROUND Subepithelial lesions(SELs)are gastrointestinal tumors with heterogeneous malignant *** ultrasonography(EUS)is the leading method for evaluation,but without histopathological analysis,precise differentiation of SEL risk is *** intelligence(AI)is a promising aid for the diagnosis of gastrointestinal lesions in the absence of *** To determine the diagnostic accuracy of AI-assisted EUS in diagnosing SELs,especially lesions originating from the muscularis propria *** Electronic databases including PubMed,EMBASE,and Cochrane Library were *** of any sex and>18 years,with SELs assessed by EUS AIassisted,with previous histopathological diagnosis,and presented sufficient data values which were extracted to construct a 2×2 *** reference standard was *** primary outcome was the accuracy of AI for gastrointestinal stromal tumor(GIST).Secondary outcomes were AI-assisted EUS diagnosis for GIST vs gastrointestinal leiomyoma(GIL),the diagnostic performance of experienced endoscopists for GIST,and GIST vs *** sensitivity,specificity,positive,and negative predictive values were *** corresponding summary receiver operating characteristic curve and post-test probability were also *** Eight retrospective studies with a total of 2355 patients and 44154 images were included in this *** AI-assisted EUS for GIST diagnosis showed a sensitivity of 92%[95%confidence interval(CI):0.89-0.95;P<0.01),specificity of 80%(95%CI:0.75-0.85;P<0.01),and area under the curve(AUC)of *** diagnosis of GIST vs GIL by AI-assisted EUS,specificity was 90%(95%CI:0.88-0.95;P=0.02)and AUC of *** experienced endoscopists’values were sensitivity of 72%(95%CI:0.67-0.76;P<0.01),specificity of 70%(95%CI:0.64-0.76;P<0.01),and AUC of 0.777 for *** GIST vs GIL,the experts achieved a sensitivity of 73%(95%CI:0.65-0.80;P<0.01)and an AUC of ***

关键词： Subepithelial lesions Ultrasound endoscopy Artificial intelligence

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漂浮的建筑与公共空间的创造

时代建筑 2024年第1期 91-101页

作者： [巴西]吉列尔梅·维斯尼克于云龙(译) [巴西]潘思如(校) 圣保罗大学建筑与城市规划学院同济大学建筑与城市规划学院

由于巴西的殖民历史和20世纪对高速公路建设的侧重,巴西城市在公共空间建设方面表现较为薄弱。与此同时,早期受柯布西耶影响,巴西发展出了享誉世界的现代建筑风格。柯布西耶推崇底层架空支柱,建筑仿佛悬空在地面之上;而在巴西的建筑实践... 详细信息

由于巴西的殖民历史和20世纪对高速公路建设的侧重,巴西城市在公共空间建设方面表现较为薄弱。与此同时,早期受柯布西耶影响,巴西发展出了享誉世界的现代建筑风格。柯布西耶推崇底层架空支柱,建筑仿佛悬空在地面之上;而在巴西的建筑实践中,许多建筑的底层因此变成了广场。这些空间虽位于私有土地上,却被作为公共空间供市民共享。这种建筑与城市的紧密联系促进了巴西一种特殊的形式美学的发展。这种美学倾向于创造开阔无垠、几乎不设柱的大型空间,并寻求在大跨度中实现空间的自由延展,是一种以建造公共空间为基底,追求轻盈与变化的建筑美学。

关键词：跨度架空支柱广场轻盈感

Effects of Soluble Silicate and Nanosilica Application on Rice Nutrition in an Oxisol

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Pedosphere 2018年第4期28卷 597-606页

作者： Rita de Cassia FELIX ALVAREZ Renato de Mello PRADO guilherme FELISBERTO Angelica Cristina FERNANDES DEUS Raimundo Leonardo LIMA DE OLIVEIRA Federal University of Mato Grosso do Sul Chapadao do Sul 79560-000 (Brazil) University of the State of Sao Paulo UNESP School of Agronomic Sciences Department of Soils and Fertilizers Jaboticabal 14884-900 (Brazil)

Silicon （Si） has been supplied to plants via application of calcium silicate to soil; however, high doses of calcium silicate are required because of its low solubility. Nanoparticles can reduce Si doses and be applied to seeding furrows. This study investigated the effects of liquid Si sources, i.e., highly soluble silicate （115.2 g L^-1 Si and 60.5 g L^-1 Na20） and nanosilica （〈 200 nm）, on Si uptake by rice plants, plant lignification, plant C：N：P stoichiometry, plant physiology, and grain yield using an Oxisol under greanhouse condistions. The treatments included the application of nanosilica and soluble silicate to seeding furrows at Si doses of 0, 605, 1210, and 2 420 g ha^-1. Plant uptake and treatment effects were evaluated by measuring C and lignin contents, Si, N, and P accumulation, physiological characteristics, and grain yield of rice. The deposition of silica bodies and amorphous silica in the flag leaves was analyzed using scanning electron microscopy. Application of liquid Si increased Si accumulation in rice by 47.3% in relation to the control （0 g ha^-1 Si）, regardless of the Si sources used. Nanosilica application increased leaf lignin content by 112.7% when compared to that in the control. Silicon moderately affected the net C assimilation （increased by 1.83%） and transpiration rates （increased by 48.3%）; however, Si influenced neither plant growth nor grain yield of rice. These results are explained by the lack of biotic or abiotic stress in rice plants during the experiment. To the best of our knowledge, in Brazilian agriculture, this is the first report on the use of nanosilica as a Si fertilizer and its effect on plant nutrition. This study provides evidence that rice plants absorb and accumulate nanoparticles; however, further studies are required to investigate the use of nanoparticles in other plant species.

关键词： C:N:P stoichiometry grain yield leaf lignin net C assimilation plant physiology silicon source