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Clinicopathological Description of a Chronic Lymphocytic Leukemia in a Dog

Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： Maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic Luíz guilherme Dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro Fernanda Barthelson Carvalho de moura Priscylla Tatiana Chalfun Guimarães Okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha Department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

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Clinical outcomes after intrastromal corneal ring segments reoperation in keratoconus patients

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 796-800页

作者： Lconardo Torquetti guilherme Ferrara Franklin Almeida Leandro cunha Paulo Ferrara Jesus Merayo-Lloves Ferrara Eye Clinic Fernandez-Vega Eye Institute Hilton Rocha Foundation

AIM:To evaluate the clinical outcomes after Ferrara intrastromal corneal ring segments(ICRS)reoperation in patients with ***:A total of 37 keratoconus eyes implanted with intrastromal corneal ring segments,which had an ICRS exchange,addition,reposition or removal were *** visual acuity(UCVA),best corrected visual acuity(BCVA),keratometry(K),asphericity(Q)and pachymetry at the thinnest point(PTP)of the cornea were evaluated using a corneal tomography(Oculus Pentacam,USA)RESULTS:The mean follow-up time after the reoperation was 30.5±9.7 *** mean UCVA improved from 20/300 to 20/80(P=0.005);the mean BCVA improved from 20/160 to 20/50(P=0.0002),the mean keratometry reduced from 49.33±4.19D to 46.16±3.90D(P=0.0001),the mean pachymetry at the thinnest point increased from 450±42.9μm to 469±40.8μm(P=0.0001).The asphericity increased from-0.84±0.74 to-0.35±0.81(P=0.15)and the spherical equivalent reduced from-4.64±4.87D to-3.04±3.45D(P=0.137).The changes in the asphericity and spherical equivalent were not statistically ***:Ferrara ICRS implantation showed to be a reversible and readjustable surgical procedure for keratoconus *** outcomes can be obtained even after removal,addition,reposition or exchange of ICRS.

关键词： keratoconus intrastromal corneal ring segments reoperation

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís guilherme de Oliveira Silva Mariana Santos Calmon Cláudio Lima Souza Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

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Journal of Pharmaceutical Analysis 2022年第3期12卷 424-435页

作者： Ihatanderson A.Silva Ana Luiza Lima Tais Gratieri guilherme M.Gelfuso Livia L.Sa-Barreto Marcilio cunha-Filho Laboratory of Food Drugand Cosmetics(LTMAC)School of Health SciencesUniversity of Brasilia70910-900BrasíliaDFBrazil Faculty of Ceilandia University of Brasilia(UnB)72220-900BrasíliaDFBrazil

One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high *** work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,tested regarding their morphology and thermal,crystallographic,and spectroscopic ***,despite the strong drug-polymer interactions observed,the chemical stability of the model drugs was preserved under such *** fact,in the metoprolol and Soluplus®composition,the drug's solubilization in the polymer produced a delay in the drug decomposition,suggesting a protective effect of the *** and polyvinyl alcohol mixture,in turn,showed unmistakable signs of thermal instability and chemical decomposition,in addition to physical *** the presented context,establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.

关键词： Three-dimensional printing Preformulation Hot-melt extrusion Thermal analysis Drug-polymer compatibility

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Immune pathway through endometriosis to ovarian cancer

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World Journal of Clinical Oncology 2024年第4期15卷 496-522页

作者： Mariana Santos Calmon Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Luis guilherme de Oliveira Silva Gabriel Lima Correa Santos Gabriel Reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Endometriosis is an estrogen-dependent inflammatory disease,defined by the presence of functional endometrial tissue outside of the uterine *** disease is one of the main gynecological diseases,affecting around 10%-15%women and girls of reproductive age,being a common gynecologic *** endometriosis is a benign disease,it shares several characteristics with invasive *** support that it has been linked with an increased chance of developing endometrial ovarian cancer,representing an earlier stage of neoplastic *** is particularly true for women with clear cell carcinoma,low-grade serous carcinoma and ***,the carcinogenic pathways between both pathologies remain poorly *** studies suggest a connection between endometriosis and endometriosis-associated ovarian cancers(EAOCs)via pathways associated with oxidative stress,inflammation,and *** article aims to review current data on the molecular events linked to the development of EAOCs from endometriosis,specifically focusing on the complex relationship between the immune response to endometriosis and cancer,including the molecular mechanisms and their *** recent developments in immunotherapy and their potential to boost the effectiveness of future treatments.

关键词： Ovarian neoplasms Endometriosis Endometriosis-associated ovarian cancers Immune response Immunotherapy

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Evidence-Based Complementary and Alternative Medicine Effects of Capybara Oil on Cardiac Remodeling of C57bl/6 Mice

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Journal of Biosciences and Medicines 2024年第5期12卷 213-232页

作者： Rafael M. Almeida Wagner D. Giannetti guilherme R. Silveira Carolina R. Castilho Renata V. Lisboa Bianca T. Ciambarella Rodrigo N. Ferreira Jorge José de Carvalho Laboratory of Ultrastructure and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education Center of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main cause of morbidity and mortality in the world, and obesity and the metabolic syndrome are risk factors for its development. One of the therapies to reduce cardiovascular risk is the use of polyunsaturated fatty acids. In Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and cardiac remodeling. We assessed the effects of capybara oil treatment on body mass, lipid and carbohydrate metabolism, systolic blood pressure, adipose tissue and cardiac remodeling, and performed an ultrastructural evaluation of the myocardium in C57Bl/6 mice treated with high-fat diet. Treatment with capybara oil reduced total cholesterol and triglyceride levels, systolic blood pressure, visceral and subcutaneous adipose tissue, and adipocyte diameter. In addition, cardiac remodeling was attenuated, preserving cardiomyocytes, increasing vascularization, reducing cardiomyocyte hypertrophy and the extracellular matrix, and preserving the morphological integrity of mitochondria. Capybara oil has several beneficial effects on the cardiovascular and metabolic system, and further studies are needed to better understand its role in the prevention or treatment of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodeling Polyunsaturated Fatty Acids Obesity Metabolic Syndrome

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The influence of porosity on tablet subdivision

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Particuology 2020年第6期18卷 192-196页

作者： Maira T.Teixeira Livia L.Sa-Barreto Izabel C.Silva Tais Gratieri guilherme M.Gelfuso Ricardo N.Marreto Mariana Landin Marcilio cunha-Filho Laboratory of Food Drugs and Cosmetics(LTMAC)University of Brasilia(UnB)70910-900 BrasiliaDFBrazil Laboratory of Nanosystems and Drug Delivery Devices(NanoSYS) Federal University of GoiasGoianiaGO.Brazil Departamento de Farmacologia Farmacia y Tecnologia Farmaceutica1+D Farma Group(Gl-1645)Universidade de Santiago de CompostelaSpain

A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical ***,tablet subdivisions were studied as a functi on of tablet *** tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose ***,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of *** assays were corre lated to the subdivision performs *** increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the *** all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision *** in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision *** trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

关键词： Tablet subdivision Porosity Mass variation Mass loss Friability Hardness

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Human occupation explains species invasion better than biotic stability:evaluating Artocarpus heterophyllus Lam.(Moraceae;jackfruit)invasion in the Neotropics

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Journal of Plant Ecology 2018年第3期11卷 465-474页

作者： guilherme de Oliveira Laboratório de Biogeografia da Conservação Universidade Federal do Recôncavo da Bahia(UFRB)Centro de Ciências AgráriasAmbientais e Biológicas(CCAAB)Setor de Ciências BiológicasRua Rui Barbosa 710Centro 44380-000Cruz das AlmasBahiaBrasil

Aims Biological invasions are recognized to put native species in risk of *** this study,I tested whether the invasion of Artocarpus heterophyllus Lam.(Moraceae;jackfruit)in the Neotropics was explained by its biotic stability,an intrinsic force,or by human occupation,an extrinsic *** I used an ensemble framework combining 12 ecological niche models(ENMs)and 4 atmosphere-ocean general circulation *** were constructed for the pre-industrial time period in the Indo-Malaya biogeographic region,the native habitat of ***,and were then projected to past(last glacial maximum,21000 years ago and mid-Holocene,6000 years ago)and future(end of century,2080)*** ENMs were used to establish the biotic stability of ***-phyllus in areas where it was predicted to be present concomitantly within these four time *** biotic stability was projected onto the Neotropics,and then I used a null model and logistic regression to test what the main driver of *** *** Findings In general,the presence of *** in the Neotropics was not explained by biotic stability,tested by the null ***,human occupation explained much of its presence in the invaded habitat,once all standardized coefficients related to this driver was significant positive in the logistic *** on these results,humans sustained the presence of ***-erophyllus in the Neotropics,probably because of the additive influences of propagule pressure and habitat ***,the recommendation is that the cultivation of *** in the Neotropics must be regulated and supervised,primarily near reserve areas.

关键词： ecological niche models(ENMs) ensemble forecasting climate change habitat disturbance propagule pressure

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Necrotizing Pneumonia and Conservative Treatment: A Case Report and Review of the Literature

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Open Journal of Respiratory Diseases 2024年第3期14卷 69-76页

作者： Pedro Rogerio Magalhães Braga Eduarda Kipper Beck Carolina de Mello Viera Cecília Gatti Wolff Laura Gazal Passos guilherme Bastos de Mello Luis Felipe Pilar Gomes Giacomo Farias Tramontin Taíse Rosa de Carvalho Department of Internal Medicine Hospital So Lucas da PUCRS Porto Alegre Brazil School of Medicine Pontifcia Universidade Catlica do Rio Grande do Sul Porto Alegre Brazil Department of Radiology Hospital So Lucas da PUCRS Porto Alegre Brazil

We present a case of necrotizing pneumonia in an 87-year-old man without severe respiratory instability. Clinical suspicion arose due to the need for supplementary oxygen and persistent fever during treatment for community-acquired pneumonia. The diagnosis was confirmed by chest computed tomography. Although necrotizing pneumonia typically requires major surgical intervention upon diagnosis, we chose conservative management with antimicrobials and chest drainage alone. The patient experienced significant improvement and resolution of pneumonia with conservative management.

关键词： Respiratory Tract Infections Lung Disease Bacterial Pneumonia

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Surgical treatment of familial adenomatous polyposis: Dilemmas and current recommendations

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World Journal of Gastroenterology 2014年第44期20卷 16620-16629页

作者： Fábio guilherme Campos Department of Gastroenterology Colorectal Surgery Division Hospital das Clínicas University of So Paulo Medical School

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited syndrome characterized by multiple adenomatous polyps (predisposing to colorectal cancer development) and numerous extracolonic manifestations. The underlying genetic burden generates variable clinical features that may influence operative management. As a precancerous hereditary condition, the rationale of performing a prophylactic surgery is a mainstay of FAP management. The purpose of the present paper is to bring up many controversial aspects regarding surgical treatment for FAP, and to discuss the results and perspectives of the operative choices and approaches. Preferably, the decision-making process should not be limited to the conventional confrontation of pros and cons of ileorectal anastomosis or restorative proctocolectomy. A wide discussion with the patient may evaluate issues such as age, genotype, family history, sphincter function, the presence or risk of desmoid disease, potential complications of each procedure and chances of postoperative surveillance. Therefore, the definition of the best moment and the choice of appropriate procedure constitute an individual decision that must take into consideration patient’s preferences and full information about the complex nature of the disease. All these facts reinforce the idea that FAP patients should be managed by experienced surgeons working in specialized centers to achieve the best immediate and long-term results.

关键词： Familial adenomatous polyposis Surgical treatment Restorative proctocolectomy Ileal pouch-anal anastomosis Ileorectal anastomosis Adenocarcinomas

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