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Optimization of the intravenous infusion workflow in the isolation ward for patients with coronavirus disease 2019

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International Journal of Nursing Sciences 2020年第2期7卷 148-152页

作者： Yan Song Wenhui Wang Lijun Zhang Li Sha guilan lu Nursing Department The Second Hospital of NanjingNanjing University of Chinese MedicineJiangsuChina Department of Gynaecology and Obsterics The Second Hospital of NanjingNanjing University of Chinese MedicineJiangsuChina Department of Infectious Diseases The Second Hospital of NanjingNanjing University of Chinese MedicineJiangsuChina

Objective:This study aimed to evaluate the effect of optimization of the intravenous infusion workflow in isolation wards for patients with coronavirus disease 2019.Methods:The infusion management group optimized the intravenous infusion workflow based on Hamer's Process Reengineering Theory and applied it to the treatment of patients with coronavirus disease 2019.The work efficiency,patients'satisfaction and economic indicators before and after optimization were compared.Results:After the infusion workflow was optimized,average times for preparation drugs and intravenous admixture,and patients'waiting time decreased from 4.84 min,4.03 min,and 34.33 min to 3.50 min,2.60 min,and 30.87 min,respectively,patients'satisfaction increased from 66.7%to 93.3%,and the cost of personal protective equipment(PPE)decreased from 46.67 sets and 186.6 CNY per day to 36.17 sets and 144.6 CNY,with statistical significance.Conclusion:The optimization of the intravenous infusion workflow can effectively decrease the cost of PPE while improving the efficiency of infusion and patients'satisfaction.

关键词： COVID-19 Drug compounding Intravenous infusions Patient satisfaction Personal protective equipment Workflow

Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone

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Chinese Journal of Cancer Research 2014年第1期26卷 112-118页

作者： Yongxiang Yi Yufeng Zhang Qiang Wei Liang Zhao Jianbo Han Yan Song Ying Ding guilan lu Junmao Liu Huaiying Ding Feng Dai Xiaojun Tang Department of Hepatobiliary Surgery the Second Affiliated Hospital of Southeast University Department of Medical Imaging the Second Affiliated Hospital of Southeast University

Objective：To compare radiofrequency ablation （RFA） or microwave ablation （MWA） and transcatheter arterial chemoembolization （TACE） with RFA or MWA monotherapy in hepatocellular carcinoma （HCC）.Methods：A prospective,randomized,controlled trial was conducted on 94 patients with HCC ≤7 cm at a single tertiary referral center from June 2008 to June 2010 at the Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Southeast University.The patients were randomly assigned into the TACERFA or TACE-MWA （combined treatment group） and the RFA-alone or MWA-alone groups （control group）.The primary end point was overall survival.The secondary end point was recurrence-free survival,and the tertiary end point was adverse effects.Results：Until the time of censor,17 patients in the TACE-RFA or TACE-MWA group had died.The median follow-up time of the patients who were still alive for the TACE-RFA or TACE-MWA group was 47.5±11.3 months （range,29 to 62 months）.The 1-,3-and 5-year overall survival for the TACE-RFA or TACE-MWA group was 93.6％,68.1％ and 61.7％,respectively.Twenty-five patients in the RFA or MWA group had died.The median follow-up time of the patients who were still alive for the RFA or MWA group was 47.0±12.9 months （range,28 to 62 months）.The 1-,3-and 5-year overall survival for the RFA or MWA group was 85.1％,59.6％ and 44.7％,respectively.The patients in the TACE-RFA or TACE-MWA group had better overall survival than the RFA or MWA group [hazard ratio （HR）,0.526; 95％ confidence interval （95％ CO,0.334-0.823; P=0.002],and showed better recurrence-free survival than the RFA or MWA group （HR,0.582; 95％ CI,0.368-0.895; P=0.008）.Conclusions：RFA or MWA combined with TACE in the treatment of HCC ≤7 cm was superior to RFA or MWA alone in improving survival by reducing arterial and portal blood flow due to TACE with iodized oil before RFA.

关键词： Radiofrequency ablation （RFA） transcatheter arterial chemoembolization （TACE） hepatocellular carcinoma （HCC）

Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma

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Science China(Life Sciences) 2010年第10期53卷 1215-1220页

作者： WANG guilan lu JiRong Department of Pediatrics Zhongshan Boai HospitalZhongshan 528403China Department of Pediatrics First HospitalJilin UniversityChangchun 130021China

This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery of IL-4RA to the airways of mice inhibited elevations of airway responsiveness and the development of allergic inflammation in asthmatic mice, and regulated the Th1/Th2 balance in OVA-sensitized and -challenged mouse models. This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms.

关键词： asthma model retrovirus vector IL-4RA gene transfer

A triple-enhanced chemodynamic approach based on glucosepowered hybrid nanoreactors for effective bacteria killing

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Nano Research 2023年第2期16卷 2682-2694页

作者： Jintao Fu Yixian Zhou Ting Liu Wenhao Wang Yiting Zhao Ying Sun Yiming Zhang Wenxuan Qin Zhongwei Chen Chao lu guilan Quan Chuanbin Wu Xin Pan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 511443China

Rapid evolution of multidrug resistance in bacterial pathogens is outpacing the development of new antibiotics,and chemodynamic therapy(CDT)provides an excellent alternative.However,achieving highly efficient CDT is still a great challenge,since the pH in the infection site is close to neutral and the supply of H_(2)O_(2)is inadequate.We herein constructed the antibacterial nanoreactors.Indocyanine green(ICG)and glucose oxidase(GOx)were incorporated into homologous zeolitic imidazolate framework-8(ZIF-8)nanoparticles coating with metal polyphenol network(MPN)composed by Fe^(3+)and tannic acid(TA).The well-designed nanoreactors could simultaneously break the pH and H_(2)O_(2)limitations,and generate hyperthermia under irradiation,thus realizing a triple-enhanced CDT for high-efficiency sterilization.Furthermore,the nanoreactors could combine CDT with photothermal therapy(PTT)and photodynamic therapy(PDT),which not only improved the bactericidal efficiency and broadened the antibacterial spectrum,but also alleviated the antibiotics resistance issues.Remarkably,the proposed nanoreactors achieved a robust in vitro bacterial killing against Gram-positive methicillin-resistant Staphylococcus aureus(MRSA)and Gram-negative Pseudomonas aeruginosa.The nanoreactors achieved an 99.7%MRSA reduction in an MRSA-induced murine abscess model accompanied with negligible toxicity.Overall,this study provides a promising strategy for multiple-enhanced CDT and multimodal combined therapy for pathogenic infections.

关键词： metal-organic frameworks glucose oxidase photothermal therapy photodynamic therapy localized bacterial infection

外源褪黑素对干旱胁迫下不同抗旱型玉米幼苗生理特性的影响

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北京农学院学报 2024年第3期39卷 39-46页

作者：洪越周贵兰刘瑞路振宗袁雪王晔李润枝农业应用新技术北京市重点实验室植物生产国家级实验教学示范中心北京农学院北京102206 四川省壤塘县石里乡农业服务中心四川阿坝624399

【目的】为研究外源褪黑素对玉米幼苗抗旱性的影响。【方法】以‘东单507’、‘京科665’、‘郑单958’等9份不同抗旱型玉米为试验材料,进行干旱胁迫试验。测定玉米幼苗表型指标、抗氧化酶活性和渗透调节物质含量等指标,从形态和生理水... 详细信息

【目的】为研究外源褪黑素对玉米幼苗抗旱性的影响。【方法】以‘东单507’、‘京科665’、‘郑单958’等9份不同抗旱型玉米为试验材料,进行干旱胁迫试验。测定玉米幼苗表型指标、抗氧化酶活性和渗透调节物质含量等指标,从形态和生理水平阐明干旱胁迫下不同抗旱型玉米对外源褪黑素的响应。【结果】对干旱胁迫下不同抗旱型玉米施加外源褪黑素后,玉米幼苗的株高、叶面积、地上部生物量、叶绿素含量以及叶片相对含水量显著增加;丙二醛含量显著降低;脯氨酸含量、可溶性糖含量、可溶性蛋白含量、超氧化物歧化酶活性、过氧化物酶活性、抗坏血酸过氧化物酶活性均显著升高。【结论】外源褪黑素通过提高玉米的抗氧化能力,增强干旱胁迫下不同抗旱型玉米的干旱适应性,使玉米抗旱性提高。相比于干旱敏感型玉米,对抗旱型玉米效果更显著。

关键词：玉米褪黑素干旱胁迫抗氧化系统

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低温对小麦种子萌发不同阶段生理特性的影响

北京农学院学报 2024年第3期39卷 32-38页

作者：刘瑞周贵兰洪越路振宗袁雪王晔李润枝农业应用新技术北京市重点实验室植物生产国家级实验教学示范中心北京农学院北京102206 四川省壤塘县石里乡农业服务中心四川阿坝624399

【目的】为今后给小麦种子低温萌发及高产栽培提供理论依据。【方法】以‘航麦247’和‘济麦22’为试验材料,通过标准发芽试验划分吸胀、萌动和发芽阶段,分别在3个阶段均进行6 h、12 h和24 h的4℃低温胁迫,测定其萌发指标、形态指标和... 详细信息

【目的】为今后给小麦种子低温萌发及高产栽培提供理论依据。【方法】以‘航麦247’和‘济麦22’为试验材料,通过标准发芽试验划分吸胀、萌动和发芽阶段,分别在3个阶段均进行6 h、12 h和24 h的4℃低温胁迫,测定其萌发指标、形态指标和生理指标。【结果】‘济麦22’和‘航麦247’种子萌发的3阶段分别为0~6 h、6~21 h、21 h和0~6 h、6~18 h、18 h;小麦种子在低温胁迫时,萌发不同阶段的发芽率、发芽势、萌发指数和活力指数均下降,苗长、主根长和鲜重降低,可溶性糖含量、相对电解质外渗率和丙二醛含量升高;吸胀阶段的低温胁迫对小麦种子萌发的影响最大;‘航麦247’萌发期耐低温胁迫的能力高于‘济麦22’。【结论】低温胁迫对小麦种子萌发过程中不同阶段的生理特性均有影响,在吸胀阶段的影响最大。

关键词：小麦低温胁迫萌发生理特性

An Improved Graphics Processing Unit Acceleration Approach for Three-Dimensional Structural Topology Optimization Using the Element-Free Galerkin Method

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Computer Modeling in Engineering & Sciences 2021年第9期128卷 1151-1178页

作者： Haishan lu Shuguang Gong Jianping Zhang guilan Xie Shuohui Yin School of Mechanical Engineering Xiangtan UniversityXiangtan411105China

We proposed an improved graphics processing unit(GPU)acceleration approach for three-dimensional structural topology optimization using the element-free Galerkin(EFG)method.This method can effectively eliminate the race condition under parallelization.We established a structural topology optimization model by combining the EFG method and the solid isotropic microstructures with penalization model.We explored the GPU parallel algorithm of assembling stiffness matrix,solving discrete equation,analyzing sensitivity,and updating design variables in detail.We also proposed a node pair-wise method for assembling the stiffnessmatrix and a node-wise method for sensitivity analysis to eliminate race conditions during the parallelization.Furthermore,we investigated the effects of the thread block size,the number of degrees of freedom,and the convergence error of preconditioned conjugate gradient(PCG)on GPU computing performance.Finally,the results of the three numerical examples demonstrated the validity of the proposed approach and showed the significant acceleration of structural topology optimization.To save the cost of optimization calculation,we proposed the appropriate thread block size and the convergence error of the PCG method.

关键词： Topology optimization EFG method GPU acceleration race condition preconditioned conjugate gradient

Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2326-2343页

作者： Ting Liu Minglong Chen Jintao Fu Ying Sun Chao lu guilan Quan Xin Pan Chuanbin Wu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 510632China

Proteins and peptides have become a significant therapeutic modality for various diseases because of their high potency and specificity.However,the inherent properties of these drugs,such as large molecular weight,poor stability,and conformational flexibility,make them difficult to be formulated and delivered.Injection is the primary route for clinical administration of protein and peptide drugs,which usually leads to poor patient’s compliance.As a portable,minimally invasive device,microneedles(MNs)can overcome the skin barrier and generate reversible microchannels for effective macromolecule permeation.In this review,we highlighted the recent advances in MNs-mediated transdermal delivery of protein and peptide drugs.Emphasis was given to the latest development in representative MNs design and fabrication.We also summarize the current application status of MNs-mediated transdermal protein and peptide delivery,especially in the field of infectious disease,diabetes,cancer,and other disease therapy.Finally,the current status of clinical translation and a perspective on future development are also provided.

关键词： Microneedles Transdermal drug delivery Proteins Peptides Infectious diseases Diabetes Cancer Clinic

Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk–Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery

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Nano-Micro Letters 2018年第1期10卷 63-73页

作者： guilan Li Yidan Chen Lingyu Zhang Manjie Zhang Shengnan Li lu Li Tingting Wang Chungang Wang Faculty of Chemistry Northeast Normal University School of Chemistry and Environmental Engineering Changchun University of Science and Technology

A facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate(Au NR@-PAA/Ca P) yolk–shell nanoparticles(NPs) composed with a PAA/Ca P shell and an Au NR yolk is reported. The asobtained Au NR@PAA/Ca P yolk–shell NPs possess ultrahigh doxorubicin(DOX) loading capability(1 mg DOX/mg NPs), superior photothermal conversion property(26%)and p H/near-infrared(NIR) dual-responsive drug delivery performance. The released DOX continuously increased due to the damage of the Ca P shell at low p H values. When the DOX-loaded Au NR@PAA/Ca P yolk–shell NPs wereexposed to NIR irradiation, a burst-like drug release occurs owing to the heat produced by the Au NRs. Furthermore,Au NR@PAA/Ca P yolk–shell NPs are successfully employed for synergic dual-mode X-ray computed tomography/photoacoustic imaging and chemo-photothermal cancer therapy. Therefore, this work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.

关键词： Yolk–shell structure Calcium phosphate Dual-mode imaging Photothermal therapy Drug delivery