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基于NF-κB/MAPK通路探讨五味子甲素对心肌缺血再灌注损伤大鼠的保护作用

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中西医结合心脑血管病杂志 2024年第18期22卷 3299-3305页

作者：赵志成刘贵军黑龙江中医药大学附属第四医院哈尔滨150000

目的:探讨五味子甲素(DSD)对心肌缺血再灌注损伤(MIRI)大鼠的保护作用及其对核因子κB(NF-κB)/丝裂原活化蛋白激酶(MAPK)通路的作用机制。方法:将无特定病原体(SPF)组雄性SD大鼠分为假手术组(仅穿线不结扎,生理盐水灌胃)和造模大鼠(MIR... 详细信息

目的:探讨五味子甲素(DSD)对心肌缺血再灌注损伤(MIRI)大鼠的保护作用及其对核因子κB(NF-κB)/丝裂原活化蛋白激酶(MAPK)通路的作用机制。方法:将无特定病原体(SPF)组雄性SD大鼠分为假手术组(仅穿线不结扎,生理盐水灌胃)和造模大鼠(MIRI模型)。将造模成功大鼠随机分为模型组(生理盐水灌胃)、阳性药物组(复方丹参滴丸8.5 mg/kg灌胃)、DSD低剂量组(DSD 20 mg/kg灌胃)、DSD中剂量组(DSD 40 mg/kg灌胃)、DSD高剂量组(DSD 80 mg/kg灌胃),每组20只。采用酶联免疫吸附法(ELISA)检测血清肌酸激酶同工酶(CK-MB)、肌红蛋白(Mb)和心肌肌钙蛋白I(cTnI);氯化三苯基四氮唑(TTC)测量心肌梗死面积;苏木精-伊红(HE)染色观察心肌组织病理变化;检测心肌组织丙二醛(MDA)和超氧化物歧化酶(SOD)水平;酶联免疫吸附法(ELISA)检测大鼠血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6);蛋白免疫印迹法(Western Blot)检测大鼠心肌组织NF-κB/MAPK通路相关蛋白的表达。结果:与假手术组比较,模型组MIRI大鼠心肌组织肌纤维弯曲,肌细胞减少,肿胀明显,细胞核严重固缩,血清CK-MB、Mb、cTnI水平、心肌梗死面积、心肌细胞凋亡率、MDA、TNF-α、IL-6含量及p-NF-κB p65、磷酸化NF-κB抑制蛋白(p-IκBα)、磷酸化细胞外调节蛋白激酶1/2(p-ERK1/2)、p-p38蛋白水平均升高,SOD活性降低(P<0.05)。与模型组比较,阳性药物组和DSD各剂量组大鼠心肌组织损伤减轻,肌纤维形态完整,肌细胞增加,无明显肿胀,细胞核固缩减轻,血清CK-MB、Mb、cTnI水平、心肌梗死面积、心肌细胞凋亡率、MDA、TNF-α、IL-6含量及p-NF-κB p65、p-IκBα、p-ERK1/2、p-p38蛋白水平均降低,SOD活性升高(P<0.05)。结论:DSD通过抑制NF-κB/MAPK通路,对MIRI大鼠发挥保护作用。

关键词：心肌缺血再灌注五味子甲素核因子κB/丝裂原活化蛋白激酶通路分子机制大鼠实验研究

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蝉花的研究现状与分析

食品与发酵工业 2024年第1期50卷 341-350页

作者：周思静乔宇琛刘桂君陈伟王平宋梅芳王成涛北京市科学技术研究院辐射技术研究所北京100875 北京工商大学北京食品营养与人类健康高精尖创新中心北京100048 北京工商大学北京市食品添加剂工程技术研究中心北京100048

蝉花为我国食药用历史悠久的虫草类真菌之一,具有调节免疫力、抗肿瘤、改善肾功能等多种生理功效。该文综述了蝉花在物质成分、人工发酵培养技术、生物活性作用及组学等方面的研究进展,并对蝉花未来的发展前景进行展望,以期为蝉花的基... 详细信息

蝉花为我国食药用历史悠久的虫草类真菌之一,具有调节免疫力、抗肿瘤、改善肾功能等多种生理功效。该文综述了蝉花在物质成分、人工发酵培养技术、生物活性作用及组学等方面的研究进展,并对蝉花未来的发展前景进行展望,以期为蝉花的基础研究及在食品、药品和化妆品等方面的应用开发提供参考。

关键词：蝉花物质成分生物活性人工培养组学进展

The impact of COVID-19 on China’s regional economies and industries

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Journal of Geographical Sciences 2021年第4期31卷 565-583页

作者： WU Feng liu guijun GUO Naliang LI Zhihui DENG Xiangzheng Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China University of the Chinese Academy of Sciences Beijing 100049China

Scientifically assessing the economic impact of major public health emergencies,containing their negative effects,and enhancing the resilience of an economy are important national strategic *** new coronavirus disease(COVID-19)has,to date,been effectively contained in China,but the threat of imported cases and local risks still *** systematic identification of the virus’s path of influence and intensity is significant for economic *** study is based on a refined multi-regional general equilibrium analysis model,which measures the economic and industrial impacts at different epidemic risk levels in China and simulates development trends and the degree of damage to industries and the economy under changes to supplies of production materials and product *** results show that,at the macroeconomic level,China’s GDP will decline about 0.4%to 0.8%compared to normal in 2020,with an average drop of about 2%in short-term consumption,an average drop in employment of about 0.7%,and an average increase in prices of about 0.9%.At the industry level,the epidemic will have the greatest short-term impact on consumer and laborintensive *** example,the output value of the service industry will fall 6.3%compared to *** at the impact of the epidemic on the industrial system,the province most affected by the epidemic is Hubei,which is the only province in China in the level-1 risk *** the disease spread outward from Hubei,there were clear differences in the main industries that were impacted in different *** addition,simulation results of recovery intensity of regional economies under the two epidemic response scenarios of resumption of work and production and active fiscal stimulus policies show that an increase in fiscal stimulus policies produces a 0.3%higher rate of gross regional product growth but it causes commodity prices to rise by about 1.8%.Measures to resume work and production offer a wider scope for industria

关键词： COVID-19 economic system impact industrial impact zoning classification multi-region general equilibrium system resilience recovery strategy

Ferroptosis:a potential therapeutic target for stroke

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Neural Regeneration Research 2024年第5期19卷 988-997页

作者： Chengli liu guijun Wang Wenrui Han Qi Tian Mingchang Li Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Ferroptosis is a form of regulated cell death characterized by massive iron accumulation and iron-dependent lipid peroxidation,differing from apoptosis,necroptosis,and autophagy in several *** is regarded as a critical mechanism of a series of pathophysiological reactions after stroke because of iron overload caused by hemoglobin degradation and iron metabolism *** this review,we discuss ferroptosis-related metabolisms,important molecules directly or indirectly targeting iron metabolism and lipid peroxidation,and transcriptional regulation of ferroptosis,revealing the role of ferroptosis in the progression of *** present updated progress in the intervention of ferroptosis as therapeutic strategies for stroke in vivo and in vitro and summarize the effects of ferroptosis inhibitors on *** review facilitates further understanding of ferroptosis pathogenesis in stroke,proposes new targets for the treatment of stroke,and suggests that more efforts should be made to investigate the mechanism of ferroptosis in stroke.

关键词： cell death ferroptosis oxidative stress stroke treatment

A fluorescent film sensor for high-performance detection of Listeria monocytogenes via vapor sampling

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聚集体(英文)

聚集体(英文) 2023年第1期4卷 165-172页

作者： Rongrong Huang Meiqi Li Dehui Lin Yangtao Shao Congdi Shang Qianqian liu guijun liu Nan Li Rong Miao Haonan Peng Yanli Tang Yu Fang Key Laboratory of Applied Surface and Colloid Chemistry(Ministry of Education) School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’anChina Shaanxi Engineering Laboratory for Food Green Processing and Safety Control College of Food Engineering and Nutritional ScienceShaanxi Normal UniversityXi’anChina Department of Food Safety College of Food Science and EngineeringNorthwest A&F UniversityShaanxiChina

Foodborne Listeria monocytogenes poses serious threats to public *** and sensitive detection of the pathogen at the point of contamination is thus crucial to halt the spread of bacteria-related ***,we report for the first time a fluorescent film sensor to detect the biomarker of ***,*** sensor demonstrated unprecedented sensing performance for the analyte with a detection limit lower than 0.05 mg/m^(3),response time less than 1 s,full reversibility,and excellent *** study showed that the sensor can be used to monitor the growth of *** with much-improved *** superior performance of the sensor is ascribed to the specific binding,efficient charge transfer emission,and porous adlayer structure of the specially designed sensing fluorophore-based *** work paves the way to develop a portable detector to meet the needs for on-site and real-time detection of foodborne pathogens.

关键词： 3-hydroxy-2-butanone biomarkers fluorescent film sensors Listeria monocytogenes

NH_(4)Cl-assisted synthesis of TaON nanoparticle applied to photocatalytic hydrogen and oxygen evolution from water

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Journal of Energy Chemistry 2024年第7期94卷 541-550页

作者： Yao Xu Kaiwei liu Jifang Zhang Boyang Zhang Jiaming Zhang Ke Shi Haifeng Wang guijun Ma School of Physical Science and Technology Shanghaitech UniversityShanghai 201210China

Oxynitride semiconductors are promising photocatalyst materials for visible light-driven water splitting,while the synthesis of well crystalized oxynitride still remains *** present work,narrow-bandgap TaON nanoparticles are synthesized via heating a vacuum-sealed mixture of KTaO_(3),Ta and NH_(4)*** method possesses multiple advantages in terms of lower calcination parameter,higher N conversion efficiency and superior photocatalytic activity in comparison with the traditional thermal ammonolysis using NH_(3) gas as a nitrogen *** the analysis of intermediates produced upon the elevation of heating temperature,a gas-solid-phase reaction between TaCl_(5) and Ta_(2)O_(5) is demonstrated as the final step,which is conducive to decreasing thermal energy barrier and accelerating nitridation *** control of preparation conditions,including calcination temperature and duration,allows for the regulation of surface O/N ratio of TaON particles to unity,resulting in optimized photocat-alytic *** assessment and intensity modulated photocurrent spectroscopy provide convincing evidence for improved charge transfer effciency of photoexcited holes at TaON surface.A Z-scheme overall water splitting is accomplished by employing the TaON as an effective oxygen evolution photocatalyst,SrTiO_(3):Rh as a hydrogen evolution photocatalyst,and reduced graphene oxide(rGO)as a solid-state electron *** work presents a promising strategy for the synthesis of high-quality oxynitride materials in application to photocatalytic water splitting.

关键词： TaON Oxynitride synthesis Photocatalyst Water splitting,Hydrogen Z-scheme

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基于分子钳化合物的手性识别研究进展

有机化学 2016年第11期36卷 2583-2601页

作者：刘贵君石浩浙江工业大学药学院杭州310014

手性是自然界中广泛存在的现象,设计合成新型人工受体模拟生物体内的分子识别已经成为生物有机化学和超分子化学等领域富于挑战性的课题之一.分子钳类人工受体结构易于修饰,在手性识别和检测中具有广泛的应用前景,本文对近年来合成的分... 详细信息

手性是自然界中广泛存在的现象,设计合成新型人工受体模拟生物体内的分子识别已经成为生物有机化学和超分子化学等领域富于挑战性的课题之一.分子钳类人工受体结构易于修饰,在手性识别和检测中具有广泛的应用前景,本文对近年来合成的分子钳人工受体以及应用光谱、色谱和质谱等检测手段对其手性识别性能的研究进行了总结,并对分子钳人工受体的发展前景作出了展望.

关键词：分子钳人工受体手性识别光谱色谱质谱

Weak minimum aberration and maximum number of clear two-factor interactions in 2_(IV)^(m-p)designs

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Science China Mathematics 2005年第11期48卷 1479-1487页

作者： YANG guijun,liu Minqian & ZHANG Runchu Department of Statistics, Tianjin University of Finance and Economics, Tianjin 300222, China Department of Statistics, School of Mathematical Sciences and LPMC, Nankai University, Tianjin 300071, China Department of Statistics Tianjin University of Finance and Economics Tianjin China Department of Statistics School of Mathematical Sciences and LPMC Nankai University Tianjin China

Both the clear effects and minimum aberration criteria are the important rules for the design selection. In this paper, it is proved that some 2IVm-p designs have weak minimum aberration, by considering the number of clear two-factor interactions in the designs. And some conditions are provided, under which a 2IVm-p design can have the maximum number of clear two-factor interactions and weak minimum aberration at the same time. Some weak minimum aberration 2IVm-p designs are provided for illustrations and two non-isomorphic weak minimum aberration 2IV13-6 designs are constructed at the end of this paper.

关键词： clear weak minimum aberration resolution wordlength pattern.

HVDC Multi-infeed Analysis of the Brazilian Transmission System and Possible Mitigation Methods

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CSEE Journal of Power and Energy Systems 2018年第4期4卷 487-494页

作者： Felipe R.V.de A.Pedroso Marcos T.Bassini Marco A.B.Horita Jose A.Jardini John F.Graham guijun liu ITAEE(Technical Institute of Automation and Electrical Studies) Sao PauloSP05502-020 State Grid Brazilian Holding Rio de JaneiroRJ20071-004

The Brazilian transmission system is facing challenging problems with the distance between its generation areas and consumer centers that will be partly solved by the use of HVDC point-to-point *** the near future,the southeast subsystem will have a large amount of power injected through HVDC Systems in multiple points with relatively close electrical ***,the effects of a multi-infeed system are expected to influence the performance and operation of the *** studies and simulations will play an important role in determining the extension of the interactions among HVDC converters and determine if such interactions cause multiple commutation failures,thus disturbing the dynamic stability of the *** use of CCC(Capacitor Commutated Converter)HVDC systems will also be assessed and is expected to diminish the need for a strong AC network(high short circuit level)and,therefore,mitigate multi-infeed *** southeast subsystem of the Brazilian Power System currently has four LCC inverters,two of them belong to the Madeira power plant and the other two are from the Itaipu power *** the year 2024,four other HVDC systems will be arriving in the same *** paper discusses the HVDC multi-infeed phenomena regarding the relevance of using synchronous machine models to represent important power plants and the application of mitigation methods regarding the 2020 network model,where six HVDC links will be present.

关键词： CCC system commutation failure HVDC converters multi-infeed power system dynamic stability