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Hepatitis C-associated liver carcinogenesis:Role of PML nuclear bodies

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World Journal of Gastroenterology 2014年第35期20卷 12367-12371页

作者： Kerstin Herzer guido Gerken Thomas G Hofmann Department for Gastroenterology and Hepatology University Hospital Essen Department of General- Visceral- und Transplantation SurgeryUniversity Hospital Essen Cellular Senescence Group DKFZ-ZMBH AllianceDeutsches Krebsforschungszentrum (dkfz.)

Successful escape from immune response characterises chronic hepatitis C virus (HCV) infection, which results in persistence of infection in about 80% of the patients. The deleterious consequences are cirrhosis and hepatocellular carcinoma. HCV accounts the most frequent cause for hepatocellular carcinoma (HCC) and liver transplantation (LT) in the western world. The underlying molecular mechanisms how HCV promotes tumor development are largely unknown. There is some in vitro and in vivo evidence that HCV interferes with the tumor suppressor PML and may thereby importantly contribute to the HCV-associated pathogenesis with respect to the development of HCC. The tumor suppressor protein “promyelocytic leukemia” (PML) has been implicated in the regulation of important cellular processes like differentiation and apoptosis. In cancer biology, PML and its associated nuclear bodies (NBs) have initially attracted intense interest due to its role in the pathogenesis of acute promyelocytic leukemia (APL). More recently, loss of PML has been implicated in human cancers of various histologic origins. Moreover, number and intensity of PML-NBs increase in response to interferons (IFNs) and there is evidence that PML-NBs may represent preferential targets in viral infections. Thus, PML could not only play a role in the mechanisms of the antiviral action of IFNs but may also be involved in a direct oncogenic effect of the HCV on hepatocytes. This review aims to summarise current knowledge about HCV-related liver carcinogenesis and to discuss a potential role of the nuclear body protein PML for this this hard-to-treat cancer.

关键词： Hepatitis C virus Promyelocytic leukemia Nuclear bodies Hepatocellular carcinoma Apoptosis

Comparison of fusion methods based on DST and DBN in human activity recognition

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控制理论与应用（英文版） 2011年第1期9卷 18-27页

作者： Andrei TOLSTIKOV Jit BISWAS Chris NUGENT guido PARENTE Institute for Infocomm Research Networking Protocols Department1 Fusionopolis Way#21-01Singapore 138632 School of Computing and Mathematics University of UlsterShore RoadNewtownabbeyBT37 0QBU.K.

Ambient assistive living environments require sophisticated information fusion and reasoning techniques to accurately identify activities of a person under care. In this paper, we explain, compare and discuss the application of two powerful fusion methods, namely dynamic Bayesian networks (DBN) and Dempster-Shafer theory (DST), for human activity recognition. Both methods are described, the implementation of activity recognition based on these methods is explained, and model acquisition and composition are suggested. We also provide functional comparison of both methods as well as performance comparison based on the publicly available activity dataset. Our findings show that in performance and applicability, both DST and DBN are very similar; however, significant differences exist in the ways the models are obtained. DST being top-down and knowledge-based, differs significantly in qualitative terms, when compared with DBN, which is data-driven. These qualitative differences between DST and DBN should therefore dictate the selection of the appropriate model to use, given a particular activity recognition application.

关键词： Dynamic Bayesian networks Dempster-Shafer theory Healthcare monitoring Ambient assisted living Activity recognition

Rock temperature variability in high-altitude rockfall-prone areas

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Journal of Mountain Science 2022年第3期19卷 798-811页

作者： guido NIGRELLI Marta CHIARLE Andrea MERLONE Graziano COPPA Chiara MUSACCHIO Consiglio Nazionale delle Ricerche(CNR) Istituto di Ricerca per la Protezione Idrogeologica(IRPI)Torino 10135Italy Istituto Nazionale di Ricerca Metrologica(INRiM) Torino 10135Italy

In a context of cryosphere degradation caused by climate warming,rock temperature is one of the main driving factors of rockfalls that occur on high-elevation mountain *** order to improve the knowledge of this critical relationship,it is necessary to increase measurement capability of rock temperature and its variability in different lithological and slope/aspect conditions,and also to increase local scale studies,increasing the quality and the comparability of the *** paper shows an example of metrological characterization of sensors used for rock temperature measurement in mountain regions,by means of the measurement *** such approach,data and results from temperature measurements carried out in the Bessanese high-elevation experimental site(Western European Alps)are *** procedures for the calibration and field characterization of sensors allow to measure temperature in different locations,depths and lithotypes,within 0.10°C of overall *** work has highlighted that metrological traceability is fundamental to asses data quality and establish comparability among different measurements;that there are strong differences between air temperature and near-surface rock temperature;and that there are significant differences of rock temperature acquired in different aspect ***,solar radiation,slope/aspect conditions and lithotype,seem to be the main driving factors of rock temperature.

关键词： Rock temperature Rockfalls European Alps Climate warming Temperature measurement

The differential benefit of laparoscopic over open minor liver resection for lesions situated in the anterolateral or posterosuperior segments

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 604-615,I0015-I0021页

作者： Jasper P.Sijberden guido Fiorentini Jacopo Lanari Davit Aghayan Daniel Osei-Bordom Nadia Russolillo Arjun Takhar Andrea Benedetti Cacciaguerra Santi Lopez-Ben Mathieu D’Hondt Felice Giuliante David Fuks Fernando Rotellar Andrea Ruzzenente Adnan Alseidi Mikhail Efanov Burak Görgec Giuseppe Zimmitti Enrico Gringeri Federica Cipriani Åsmund Avdem Fretland Ravi Marudanayagam Marco Vivarelli John N.Primrose Alessandro Ferrero Robert P.Sutcliffe Bjørn Edwin Umberto Cillo Marc G.Besselink Mohammad Abu Hilal Luca A.Aldrighetti Department of Surgery Fondazione Poliambulanza Istituto OspedalieroBresciaItaly Amsterdam UMC location University of Amsterdam Department of SurgeryAmsterdamthe Netherlands Cancer Center Amsterdam Amsterdamthe Netherlands Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Surgical Oncological and Gastroenterological SciencesGeneral Surgery 2Hepatobiliary Surgery and Liver TransplantationPadua University HospitalPaduaItaly The Intervention Centre and Department of HPB Surgery Oslo University Hospital and Institute of Clinical MedicineUniversity of OsloOsloNorway Department of Surgery Ringerike HospitalVestre Viken Hospital TrustDrammenNorway Liver Unit Queen Elizabeth HospitalBirminghamUK Department of General and Oncological Surgery Umberto I Mauriziano HospitalLargo TuratiTurinItaly Department of Surgery University Hospital Southampton NHS Foundation TrustSouthamptonUK Hepatobiliary and Abdominal Transplantation Surgery Department of Experimental and Clinical MedicineRiuniti HospitalPolytechnic University of MarcheAnconaItaly Servei de Cirurgia General i Digestiva Hospital Doctor Josep Trueta de GironaGironaCataloniaSpain Department of Digestive and Hepatobiliary/Pancreatic Surgery Groeninge HospitalKortrijkBelgium Chirurgia Epatobiliare UniversitàCattolica del Sacro Cuore-IRCCSRomeItaly Department of Digestive Oncologic and Metabolic SurgeryInstitut Mutualiste MontsourisUniversitéParis DescartesParisFrance HPB and Liver Transplantation Unit Department of SurgeryUniversity ClinicUniversidad de NavarraNavarraSpain Institute of Health Research of Navarra(IdisNA) PamplonaSpain Department of Surgery University of VeronaVeronaItaly Department of Surgery Virginia Mason Medical CenterSeattleWAUSA Department of Surgery University of California San FranciscoSan FranciscoCAUSA Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Research CentreMoscowRussia

Background:It is well known that laparoscopic liver surgery can offer advantages over open liver surgery in selected ***,what type of procedures can benefit most from a laparoscopic approach has been investigated poorly thus *** aim of this study is thus to define the extent of advantages of laparoscopic over open liver surgery for lesions in the anterolateral(AL)and posterosuperior(PS)***:In this international multicentre retrospective cohort study,laparoscopic and open minor liver resections for lesions in the AL and PS segments were compared after propensity score *** differential benefit of laparoscopy over open liver surgery,calculated using bootstrap sampling,was compared between AL and PS resections and expressed as a Delta of the ***:After matching,3,040 AL and 2,336 PS resections were compared,encompassing open and laparoscopic procedures in a 1:1 *** and PS laparoscopic liver resections were more advantageous in comparison to open in terms of blood loss,transfusion rate,complications,and length of ***,AL resections benefitted more from laparoscopy than PS in terms of overall and severe complications(D-difference were 4.8%,P=0.046 and 3%,P=0.046)and blood loss(D-difference was 195 mL,P<0.001).Similar results were observed in the subset for high-volume centres,while in recent years no significant differences were found in the differential benefit between AL and PS ***:The advantage of laparoscopic over open liver surgery is greater in the AL segments than in the PS segments.

关键词： Liver neoplasms hepatectomy laparoscopic liver resection open liver resection

Advancing prognostic precision in hepatocellular carcinoma:a paradigm shift towards machine learning

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 810-812页

作者： Flavio Milana Simone Famularo guido Torzilli Department of Biomedical Sciences Humanitas UniversityMilanItaly Division of Hepatobiliary and General Surgery Department of SurgeryIRCCS Humanitas Research HospitalMilanItaly

Introduction Hepatocellular carcinoma(HCC)stands as a significant contributor to cancer-related mortality,ranking as the fifth leading cause of cancer-related death(1).In 80%of cases,HCC arises from an underlying liver disease(2).Despite screening programs for at-risk patients,the prognosis for HCC remains even dismal because of late *** only curative options currently available are liver resection for selected cases,and liver ***,the high rate of recurrence after surgery makes the prognosis *** fact,following curative intent resection,the 5-year recurrence is approximately 60%(3),with 5-year survival after recurrence of 35%(4).

关键词： Hepatocellular carcinoma(HCC) machine learning liver resection early recurrence

Unravel hepatic artery infusion chemotherapy in patients with resected colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 257-260页

作者： Matteo Donadon Lorenza Rimassa guido Torzilli Department of Biomedical Sciences Humanitas UniversityPieve EmanueleMilanItaly Department of Hepatobiliary and General Surgery IRCCS Humanitas Research HospitalRozzanoMilanItaly Humanitas Cancer Center IRCCS Humanitas Research HospitalRozzanoMilanItaly

Over the past years,important progresses have been made in the treatment of patients with colorectal liver metastases(CLM).Now,5-year overall survival rate may exceed 50%by using the combination of multimodality therapies among which modern systemic chemotherapy,with or without monoclonal antibodies,and hepatic resection are the cornerstones(1,2).In such multimodality,hepatic artery infusion(HAI)has been proposed since many years with the rationale of increasing the concentration of chemotherapy agents in the liver(3).However,HAI still remains infrequently used,in particular in the adjuvant setting mainly because of the requirement of a multidisciplinary team to manage therapy,and the more widespread use of systemic chemotherapy-in particular following the perioperative“sandwich”schema(4).

关键词： infusion chemotherapy hepatic

Role of ileostomy in restorative proctocolectomy

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World Journal of Gastroenterology 2012年第15期18卷 1703-1707页

作者： Gianluca Pellino guido Sciaudone Silvestro Canonico Francesco Selvaggi Division of General Surgery Second University of Naples42-80122 NaplesItaly

Restorative proctocolectomy(RP) is the treatment of choice in patients affected with refractory ulcerative colitis or familial adenomatous *** in elective settings is often performed in 2 stages,fashioning an ileostomy which is closed 2-3-mo *** is still debated whether omitting ileostomy could offer advantages in the management of patients undergoing RP.

关键词： Restorative proctocolectomy Ileostomy Ulcerative colitis Familial adenomatous polyposis Ileopouch-anal anastomosis

CEREBRAL BLOOD FLOW AND METABOLISM EVALUATION IN COMATOSE PATIENTS BY DYNAMIC SPECT

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Nuclear Science and Techniques 1993年第1期4卷 33-38页

作者： AlessandroGiordano MariaLuciaCalcagni FrancescoDellaCorte MarianoAlbertoPennisi guido Galli 王凤琴赵惠杨 Institute of Nuclear Medicine Institute of Anaesthesiology and Intensive Care of the Catholic University of the Sacred Heart Roma Italy Zhongshan Hospital Shanghai Medical University Shanghai 200032 China

Thirty patients in coma state underwent dynamic SPECT with 133Xe, a validated technique for the quantitation of CBF by SPECT, using a new brain dedicated tomograph: CERTO-96. CMRO2 was computed by multiplying the mean CBF by AVDO2 according to the Fick’s principle. The mean values of CBF, AVDO2 and CMRO2 in patients with good outcome were significantly different from those with worse outcome. On the basis of the best "discriminant threshold", CBF and AVDO2 demonstrated an intermediate accuracy in separating the two groups, while CMRO2 showed a satisfactory accuracy.

关键词： Dynamic SPECT Cerebral blood flow Cerebral metabolic rate of oxygen Comatose patients

Bio-feedback treatment of fecal incontinence: Where are we, and where are we going?

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World Journal of Gastroenterology 2005年第31期11卷 4771-4775页

作者： Giuseppe Chiarioni Barbara Ferri Antonio Morelli guido Iantorno Gabrio Bassotti Gastroenterological Rehabilitation Division of the University of Verona Gastroenterology and Digestive Endoscopy Institute Gastroenterology and Hepatology Section Digestive Motility Unit

Fecal incontinence is a disabling disease, often observed in young subjects, that may have devastating psycho-social consequences. In the last years, numerous evidences have been reported on the efficacy of bio-feedback techniques for the treatment of this disorder. Overall, the literature data claim a success rate in more than 70% of cases in the short term. However, recent controlled trials have not confirmed this optimistic view, thus emphasizing the role of standard care. Nonetheless, many authors believe that this should be the first therapeutic approach for fecal incontinence due to the efficacy, lack of side-effects,and scarce invasiveness. Well-designed randomized,controlled trial are eagerly awaited to solve this therapeutic dilemma.

关键词： Biofeedback Fecal incontinence