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Asian Pacific Journal of Tropical Biomedicine 2015年第11期5卷 960-964页

作者： Tarek Benmeddour Hocine Laouer Salah Akkal guido flamini Department of Nature and Life Sciences University of Biskra Laboratory of Natural Biological Resources Valorization Faculty of SciencesUniversity of Setif VARENBIOMOL Department of ChemistryUniversity of Constantine 1 Department of Pharmacy University of Pisa

Objective: To evaluate the essential oil composition and the antibacterial activity of an Algerian endemic plant, Launaea lanifera Pau(L. lanifera), grown in arid steppe ***: L. lanifera essential oil was isolated from aerial parts by steam distillation and its chemical composition was evaluated by gas chromatographyflame ionization detector and gas chromatography with electron impact mass spectrometry. Furthermore, its in vitro antibacterial activity against four bacterial strains was tested following the agar disk diffusion ***: This species had a very low essential oil yield(0.005%). Twenty-four(92.6%)individual components were identified. The main constituents were hexahydrofarnesyl acetone(31.6%),(E)-b-ionone(8.5%),(E)-b-damascenone(7.0%), 2-methyltetradecane(3.8%), n-heptadecane(3.8%), limonene(2.8%) and b-caryophyllene(2.8%). No noteworthy antimicrobial activity was observed on the tested bacteria, neither Gram negative nor Gram ***: This is the first report on the volatile constituents and antibacterial activity of L. lanifera. The studied essential oil does not possess significant activity against the tested microorganisms.

关键词： Launaea lanifera Pau(syn. Launaea acanthoclada Mai

Profiles of the Headspace Volatile Organic and Essential Oil Compounds from the Tunisian Cardaria draba (L.) Desv. and Its Leaf and Stem Epidermal Micromorphology

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 725-744页

作者： Wissal Saadellaoui Samiha Kahlaoui Kheiria Hcini Abir Haddada Noomene Sleimi Roberta Ascrizzi guido flamini Fethia Harzallah-Skhiri Sondes Stambouli-Essassi Laboratory of Biodiversity Biotechnology and Climate Change(LR11-ES09)Faculty of Sciences of TunisUniversity of Tunis El ManarTunis1060Tunisia Laboratory RME-Resources Materials and EcosystemsFaculty of Sciences of BizerteUniversity of CarthageJarzounaBizerte7021Tunisia Dipartimento di Farmacia Universitàdi PisaVia Bonanno 33Pisa56126Italy Laboratory of Bioresources:Integrative Biology and Valorization(LR14-ES06) High Institute of Biotechnology of MonastirUniversity of MonastirMonastir5000Tunisia

In this work, we investigated aroma volatiles emanated by dry roots, stems, leaves, flowers, and fruits of Cardariadraba (L.) Desv. growing wild in Tunisia and its aerial part essential oils (EOs) composition. A total of 37 volatileorganic compounds (96.7%–98.9%) were identified;4 esters, 4 alcohols, 7 hydrocarbons, 12 aldehydes, 5 ketones,1 lactone, 1 organosulfur compound, 2 organonitrogen compounds, and 1 acid. The hydrocarbons form the maingroup, representing 49.5%–84.6% of the total detected volatiles. The main constituent was 2,2,4,6,6-pentamethylheptane(44.5%–76.2%) reaching the highest relative percentages. Forty-two compounds were determined in thetwo fractions of EOs, representing 98.8% and 97.2% of the total oil composition, respectively. The principal componentswere hexadecanoic acid (34.6%), 6-methyl-5-hepten-2-one (18.3%), decanal (15.0%), 6,10,14-trimethyl-2-pentadecanone (13.2%), and n-pentacosane (13%). Micromorphological details of the leaf and stem epidermisusing light microscopy revealed polygonal cells with sinuous walls in the adaxial and abaxial leaf surfaces andnearly rectangular and long ones with linear and thick walls for the stem epidermis. The stomata complexes wereanisocytic in the leaf epidermis and mainly anisocytic and rarely paracytic in the stem epidermis. Non-glandulartrichomes were unbranched and long with an acute apex or short with a convex apex. The glandular ones wereidentified for the first time in this species. They were short-stalked with a large secretory head. The highest stomatalindex (17.02%) was recorded in the abaxial leaf surface. The identification of headspace volatiles and essentialoil compounds can be used to characterize this species, and the various epidermis micromorphologicalfeatures are very useful for biosystematics taxonomic studies within Brassicaceae.

关键词： Cardaria draba aroma profile essential oils epidermis trichomes

Antioxidant activity, volatile and nonvolatile composition of twoPhoenix dactylifera L. by-products

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Journal of Coastal Life Medicine 2017年第6期5卷 254-260页

作者： Amira Thouri Hassiba Chahdoura Amira El Arem guido flamini Aicha Jelled Lotfi Achour Research Laboratory"Bioresources:Biology Integrative and Valorization" Higher Institute of Biotechnology of MonastirAvenue Tahar HaddedBP745000MonastirTunisia Dipartimento di Scienze Farmaceutiche Sede di Chimica Bioorganica e Biofarmaciavia Bonanno3356126PisaItaly Centro Interdipartimentale di Ricerca"Nutraceutica e Alimentazione per la Salute"Nutrafood University of PisaVia del Borghetto8056124PisaItaly Laboratory of Histology and Cytogenetic and Childhood Disease UR12ES10 Faculty of MedicineUniversity of Monastir5019MonastirTunisia

Objective:To examine the nonvolatile components of the date pulp and seeds of two minor Tunisian date palm cultivars Arechti and Korkobbi at besser stage and to investigate their antioxidant activity, their phytochemical compounds and their aromatic volatiles composition. Methods:The physico-chemical properties, the aroma composition, the mineral profile, the phytochemical content and thein vitro antioxidant activity of those two common date palm fruit varieties and those of their seeds were evaluated. All measurements were made at the besser stage, which showed the highest amount of secondary metabolites. Results:New volatiles compounds are detected in both flesh and seeds and the results revealed that those by products are a suitable source of mineral content and have a high potential of natural antioxidants and good antiradical capacities. Conclusions: Thanks to their characteristics, they could potentially be considered as a cheap resource for new functional food ingredient and novel pharmaceutical applications.

关键词： Date palm fruit Seeds Physicochemical composition Aroma composition Total phenolic content In vitro antioxidant activity

In vitro antibacterial activity of the Hertia cheirifolia *** oils

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Journal of Coastal Life Medicine 2016年第11期4卷 865-867页

作者： Kaouther Majouli Malek Besbes Hlila guido flamini Hichem Ben Jannet Abderraouf Kenani Laboratory of Biochemistry:Research Unit 12ES08 Cell Signaling and PathologiesFaculty of MedicineUniversity of MonastirTunisia Laboratory of Transmissible Diseases and Biologically Active Substances MDT01Faculty of PharmacyUniversity of MonastirTunisia Department of Pharmacy University of PisaStreet Bonanno 656126 PisaItaly Laboratory of Heterocyclic Chemistry Natural Products and Reactivity Team:Medicinal Chemistry and Natural Products(LR11ES39)Faculty of SciencesUniversity of MonastirTunisia

Objective:To investigate the antibacterial activity of essential oils from Hertia cheirifolia ***,vegetative part(leaves+stems)and roots against a panel of bacterial ***:The essential oils from Hertia cheirifolia ***,vegetative part(leaves+stems)and roots were analyzed by gas chromatography and gas chromatography-mass *** antibacterial activity of essential oils was evaluated in vitro by the broth dilution ***:The results showed that the essential oil of flowers exhibited a strong antibacterial activity against Staphylococcus aureus with minimal inhibitory concentration of 0.078 mg/***:The essential oils of Hertia cheirifolia can be a good source of antibacterial *** can be used for pharmaceutical treatments.

关键词： Essential oil Chemical composition Antibacterial activity Hertia cheirifolia L.

Essential Oil of Phyllanthus reticulatus Poiret from Nigeria

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American Journal of Plant Sciences 2015年第1期6卷 6-13页

作者： Akintayo L. Ogundajo Afusat M. Aruna Ayo O. Owolabi Isiaka A. Ogunwande guido flamini Natural Products Research Unit Department of Chemistry Faculty of Science Lagos State University PMB 0001 LASU Post Office Ojo Lagos Nigeria Dipartimento di Scienze Farmaceutiche sede Chimica Bioorganica e Biofarmacia Universita di Pisa Via Bonanno 33 Pisa Italy

The chemical composition of the essential oil obtained by hydrodistillation from the leaves of Phyllanthus reticulatus Poiret (Euphorbiaceae) growing in Nigeria has been studied. The constituents of the oil were analyzed by means of gas chromatography (GC-FID) and gas chromatography coupled with mass spectrometry (GC-MS). Monoterpenes (64.9%) were the dominant class of compounds, followed by sesquiterpenes (23.0%). The major constituents were α-pinene (6.0%), sabinene (7.6%), β-pinene (18.1%), linalool (6.9%) and camphor (7.7%), among the monoterpenes, and β-caryophyllene (11.9%) and germacrene D (8.6%) among the sesquiterpenes. This is the first report on the volatile constituents of Phyllanthus reticulatus.

关键词： Phyllanthus reticulatus Essential Oil Composition Monoterpenes Sesquiterpenes

Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio Celestino Santos-Buelga Ana M.Gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.Costa Lima Salette Reis Angela Fernandes Isabel C.F.R.Ferreira Virginia Fernandez-Ruiz Patricia Morales guido flamini Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly Center for Marine Sciences(CCMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of Chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSC were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

A comparison study of the nutritional, mineral and volatile compositions of three dry forms of ginger rhizomes, and antioxidant properties of their ethanolic and aqueous extracts

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Journal of Coastal Life Medicine 2017年第2期5卷 70-76页

作者： Aicha Jelled Hassiba Chahdoura guido flamini Amira Thouri Amira El Arem Khawla Adouni Zohra Haouas Isabel C.F.R.Ferreira Lotfi Achour Hassen Ben Cheikh Laboratory of Histology and Cytogenetics(UR12ES10) Faculty of MedicineUniversity of MonastirMonastirTunisia Laboratory of Bioressources Integrative Biology and Valorisation(LR14ES06)High Institute of BiotechnologyUniversity of MonastirMonastirTunisia Mountain Research Centre Higher Agricultural SchoolPolytechnic Institute of BragancaCampus of Santa Apolonia11725301-855 BragancaPortugal Interdepartmental Research Centre"Nutraceutical and Food for Health" University of PisaPisaItaly

Objective:To compare the most accessible dry forms of ginger rhizomes (Zingiber officinale) used as a spice and as a remedy in order to choose the best ginger for medicinal purpose. Methods:Freshly air dried ginger, commercially dry rhizomes and ginger available in powder form are investigated in terms of nutritional values (proximate and mineral compositions) and volatiles profile. Ethanolic and aqueous extracts (decoctions and infusions) were prepared for total phenolic, flavonoid and tannin contents determination. Also, three standard tests were established in order to estimate the best extract with the better antioxidant potential. Results:The results showed unlike proximate composition revealing different nutritional values. In fact, freshly dried ginger contained much ash, while already dry samples contained much protein. In addition, mineral contents of studied samples indicated their dissimilar richness especially in Ca, Mg, Na, K, Cu, Fe, and Mn. Solid phase micro-extraction gave volatile profiles with many interesting compounds, only 26 from the 51 identified components were common to studied samples with bioactive compounds predominance in freshly dried sample. Also, the antioxidant potential established by three different tests was higher in already dry samples and was positively correlated with their higher contents in the determined phytochemicals. The ethanolic extracts showed higher antioxidant activities than aqueous extracts. Decoctions and infusions were almost similar proving that long cooking time did not affect ginger antioxidant potential. Conclusions:This work highlighted the benefits of traditional preparations of ginger as sources of bioactive compounds, namely antioxidants, and proved that the available commercial samples are not identical and encouraged analyzing samples before uses depending on needs.

关键词： Zingiber officinale Dry forms Minerals Aroma volatiles Antioxidant properties

A New Paradigm in Quantum Fields: The Quantum Oscillator with Semi-Quanta (IQuO) (Part Two)

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Journal of High Energy Physics, Gravitation and Cosmology 2025年第1期11卷 138-164页

作者： Giovanni guido Department of Physics and Mathematics High Scholl C. Cavalleri Parabiago Milano Italy

In this second part of a study about quantum field oscillators with sub-oscillators and semi-quanta (IQuO), it is possible to show that in the initial phase of an interaction between two particles a no-dynamic process of reduction from a non-local to a local state takes place which cannot be described by Hamiltonian. We then describe the coupling of two IQuO of different particle-fields either at one point in space or at two distant points via an intermediary chain of coupled IQuO. The first aspect provides an understanding of the basic processes of creating and annihilating a pair. The second aspect describes the behaviour of two electrically charged particles through a process of phase shifts between the respective IQuO chains (CF1, CF2) implemented in a quantum entanglement via an intermediary chain (CB) of IQuO that originates changes in the direction of the two (CF1, CF2) distance-correlated ones. Thus, the semi-quanta structure of an IQuO and quantum entanglement identify the origin of the empirical law of attraction and repulsion between two electric charges.

关键词： IQuO Quantum Entanglement Phase Fermion Boson Electric Charge

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The Qixiangzhan Lava Flow at the Tianchi Volcano:Eruptive Dynamics,Emplacement Mechanism and Implications for the Formation of Long-lived Magmatic Systems Prior to Caldera-forming Eruptions

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 114-125页

作者： LI Jiahui SHAN Xuanlong YI Jian WU Chengzhi Ventura guido LIU Pengcheng GUO Jiannan WANG Wei College of Earth Science Jilin UniversityChangchun 130061China International Center of Future Science Changchun 130061China Changbaishan Tianchi Volcano Observatory AntuJilin 133613China Istituto Nazionale di Geofisica e Vulcanologia Roma 00143Italy Istituto per lo Studio degli impatti Antropici e Sostenibilitàin ambiente marino(IAS) Capo Granitola(TP)91021Italy Tianjin Branch of the China National Offshore Oil Company Ltd. Tianjin 300452China

The 7 ka old Qixiangzhan lava flow(QXZ,Tianchi volcano)represents the last eruptive event before the 946 CE,caldera-forming‘Millennium’eruption(ME).Petrographic,whole rock,mineral composition,Sr-Nd isotopic data on QXZ show that:(a)the lava consists of two components,constituted by comenditic obsidian fragments immersed in a continuous,aphanitic component;(b)both components have the same geochemical and isotopic variations of the ME *** QXZ and ME comendites result from fractional crystallization and crustal assimilation *** temperature of the QXZ magma was about 790℃ and the depth of the magma reservoir around 7 km,the same values as estimated for *** had a viscosity of 10^(5.5)-10^(9) Pa s and a velocity of 3-10 km/*** emplacement time was 0.5-1.6yr and the flow rate 0.48-1.50 m^(3)/*** values lie within the range estimated for other rhyolitic flows *** QXZ lava originated through a mixed explosive-effusive activity with the obsidian resulting from the ascent of undercooling,degassing and the fragmentation of magma along the conduit walls,whereas the aphanitic component testifies to the less undercooled and segregated flow at the center of the *** QXZ lava demonstrates the extensive history of the ME magma chamber.

关键词： lava flow rhyolitic volcanism eruptive mechanism long-lived magmatic systems Tianchi volcano Qixiangzhan Formation

Lectures on Wonderful Varieties

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Acta Mathematica Sinica,English Series 2018年第3期34卷 417-438页

作者： guido PEZZINI Dipartimento di Matematica "guido Castelnuovo" "Sapienza" Università di Roma

These notes are an introduction to wonderful varieties. We discuss some general results on their geometry, their role in the theory of spherical varieties, several aspects of the combinatorics arising from these varie... 详细信息

关键词： Wonderful varieties spherical varieties reductive groups