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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： guibo qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Temporal-spatial Generation of Astrocytes in the Developing Diencephalon

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Neuroscience Bulletin 2024年第1期40卷 1-16页

作者： Wentong Hong Pifang Gong Xinjie Pan Zhonggan Ren Yitong Liu guibo qi Jun-Liszt Li Wenzhi Sun Woo-Ping Ge Chun-Li Zhang Shumin Duan Song qin Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTexas 75390-9148USA Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaZhejiang University School of MedicineHangzhou 310058China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200032China

tAstrocytes are the largest glial population in the mammalian ***,we have a minimal understanding of astrocyte development,especially fate specification in different regions of the *** lineage tracing of the progenitors of the third ventricle(3V)wall via in-utero electroporation in the embryonic mouse brain,we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V ***,radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types:radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the *** genetic fate mapping analysis,we reveal that the first population of astrocytes appears along the zona incerta in the *** occurs at an early time point in the dorsal region relative to that in the ventral region of the developing *** transcriptomic analysis of the region-specific 3V wall and lateral ventricle(LV)wall,we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal ***,these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon.

关键词： Radial glia Astrocyte specification Lineage tracing Diencephalon Third ventricle

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Specific knockout of Sox2 in astrocytes greatly reduces reactive astrocyte formation and promotes recovery after early postnatal TBI in mouse cortex

Specific knockout of Sox2 in astrocytes greatly reduces reac...

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中国解剖学会2021年年会

作者： Liu Yitong Hong Wentong Gong Pifang Pan Xinjie qi guibo qin Song Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan University

Reactive astrocytes are a double-edged sword for traumatic brain injury (TBI),whether their overall effect on injury is beneficial or harmful depends on the balance between the loss and gain of ***,the mechanism of reactive astrocytes after TBI is poorly *** more and more studies have been conducted to regulate the gene expression of astrocytes as a target to treat the disease.

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Specific knockout of Sox2 in astrocytes greatly reduces reactive astrocyte formation and promotes recovery after early postnatal TBI in mouse cortex

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解剖学杂志 2021年第S1期44卷 110-110页

作者： Liu Yitong Hong Wentong Gong Pifang Pan Xinjie qi guibo qin Song Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032

Reactive astrocytes are a double edged sword for traumatic brain injury(TBD),whether their overall effect on injury is beneficial or harmful depends on the balance between the loss and gain of ***,the mechanism of reactive astrocytes after TBI is poorly *** more and more studies have been conducted to regulate the gene expression of astrocytes as a target to treat the ***,we generated early postnatal TBI in the mouse cortex,indicating typical reactive astrocytes and glial scar were observed around damaged area;We next deleted Sox2 in astrocytes to observe its effects on reactive astrocytes and tissue repair after postnatal injury in the mouse *** a result,specific deletion of Sox2 in astrocytes greatly inhibited the formation of reactive astrocytes and glial scars,and significantly promoted nerve regeneration in the damaged area and post injured ***,our study indicate that Sox2 plays an important role in reactive astrocytes after early postnatal TBI in the mouse ***,Sox2 in astrocytes may be a putative target to develop new therapeutic tools for TBI treatment.

关键词： TBI astrocytes inhibited

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基于经络学说探析卒中后抑郁的发病机制

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世界科学技术-中医药现代化 2020年第3期22卷 863-868页

作者：戚桂波朱贺刘江峰朱媛媛张远衡叶然林法财南京中医药大学第二临床医学院南京210023 南京中医药大学第一临床医学院南京210023 南京中医药大学卫生经济管理学院南京210023 南京中医药大学护理学院江苏南京210023

脑卒中后抑郁(Post-stroke Depression,PSD)是一种情志疾病,本病的发病机制不明确从而制约了其治疗,PSD的发病与经络密切相关,但对其研究较少。本研究创新性地从经络学角度探讨PSD的发病机制,提出PSD的发病与多条经脉相关,尤其是足厥阴... 详细信息

脑卒中后抑郁(Post-stroke Depression,PSD)是一种情志疾病,本病的发病机制不明确从而制约了其治疗,PSD的发病与经络密切相关,但对其研究较少。本研究创新性地从经络学角度探讨PSD的发病机制,提出PSD的发病与多条经脉相关,尤其是足厥阴肝经,为PSD机制的揭示奠定了经络学基础,为本病的防治提供了新的思路和方法。

关键词：卒中后抑郁中风抑郁经络学说发病机制

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基于身心同治的新型无痛分娩模式的探讨

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中国现代医生 2019年第32期57卷 165-168页

作者：凌至远林法财宋汉焘戚桂波南京中医药大学第二临床医学院

针灸镇痛、经皮神经电刺激(transcutaneous electrical nerve stimulation,TENS)是目前研究较多且效果较好的两种无创式镇痛方法。随着大众健康观念的改变,二者有着巨大的发展潜力。目前国内分娩镇痛仍较多地使用椎管内麻醉的方法来进行... 详细信息

针灸镇痛、经皮神经电刺激(transcutaneous electrical nerve stimulation,TENS)是目前研究较多且效果较好的两种无创式镇痛方法。随着大众健康观念的改变,二者有着巨大的发展潜力。目前国内分娩镇痛仍较多地使用椎管内麻醉的方法来进行,然而由于麻醉师缺失、医患沟通不足、大众疼痛教育水平不足等原因,此模式常常达不到理想的效果,分娩的疼痛管理、分娩焦虑与抑郁得不到很好的控制。本文提出一个针灸、TENS联合镇痛,施以导乐陪伴与五行音乐疗法进行辅助的新型无痛分娩模式,以期在临床中取得更好的效果。

关键词：无痛分娩针灸镇痛经皮神经电刺激五行音乐导乐陪伴分娩痛

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脊髓损伤特有康复评定量表的应用现状及思考

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中国民康医学 2019年第16期31卷 4-7页

作者：戚桂波凌至远熊曦雨彭娟娟南京中医药大学第二临床医学院

脊髓损伤(SCI)严重影响患者的自理能力和生命质量,给家庭和社会带来沉重经济负担。SCI修复时间长、治疗费用高、康复难度大,临床康复治疗的关键是运用特定量表进行准确康复评估,为个性化和最优化训练方案的制定打下坚实基础。本文总结SC... 详细信息

脊髓损伤(SCI)严重影响患者的自理能力和生命质量,给家庭和社会带来沉重经济负担。SCI修复时间长、治疗费用高、康复难度大,临床康复治疗的关键是运用特定量表进行准确康复评估,为个性化和最优化训练方案的制定打下坚实基础。本文总结SCI特有康复评定量表的应用现状和不足,并从SCI最低功能恢复节段、轻触觉联合检查、中国元素和心理专项评定、加重因素和危险因素、职业评估五个方面对量表的完善方向进行展望。

关键词：脊髓损伤康复评定量表综述

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In-situ growth of CNTs encapsulating P-doped NiSe_(2) nanoparticles on carbon framework as efficient bifunctional electrocatalyst for overall water splitting

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Journal of Energy Chemistry 2021年第9期30卷 111-120页

作者： Jing Yu Wei-Jian Li guibo Kao Cheng-Yan Xu Rongrong Chen qi Liu Jingyuan Liu Hongsen Zhang Jun Wang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China College of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005China

Nickel diselenide(NiSe_(2)) is a promising low-cost catalyst for both hydrogen evolution reaction(HER) and oxygen evolution reaction(OER),due to its suitable d-electron configuration and high electrical *** representative elements,e.g.,Co,Fe and P,have been utilized as cation or anion to promote the electrocatalytic activity of NiSe_(2) by modulating the interaction with Se element,whilst the catalyst stability is less *** this work,the catalytic Ni nanoparticles were in-situ encapsulated in carbon nanotubes grown on three-dimensional conducting carbon *** phosphorization and selenization yield dispersed P-doped NiSe_(2) nanoparticles protected by carbon shell with highly exposed yet stable active sides,resulting in significantly promoted HER and OER activities as well as accelerated *** detail,the P-NiSe_(2)@N-CNTs/NC hybrid catalyst deliver low overpotentials of 95 and 306 mV at10 mA cm^(-2) for HER and OER in alkaline media,*** calculations reveal that P doping reduces the electron density surrounding Ni atoms while accumulates the charges to Se, respectively,which in turn reduces the energy barriers for both water dissociation and intermediates adsorption for both HER and *** a concept of proof,a cell assembled by P-NiSe_(2)@N-CNTs/NC hybrid catalystbased anode and cathode performs a low applied voltage of 1.609 V to reach 10 mA cm^(-2),and outstanding long-term stability.

关键词： Electrocatalyst NiSe_(2) Doping Water splitting DFT calculations

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高钛焊丝钢ER70S-G冶炼工艺优化实践

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金属制品 2024年第1期50卷 39-43页

作者：张行利亓奉友苏永泽唐庆崔贵博中信泰富特钢研究院青钢分院山东青岛266000

高钛焊丝钢ER70S-G研发时经常出现水口结瘤、结晶器“结鱼”、铸坯夹渣等问题,尤其是铸坯夹渣导致轧制后盘条表面出现连续性锯齿状结疤缺陷,严重影响盘条表面质量。引起水口结瘤、结晶器“结鱼”的主要原因是存在TiO_(x)、TiN等高熔点... 详细信息

高钛焊丝钢ER70S-G研发时经常出现水口结瘤、结晶器“结鱼”、铸坯夹渣等问题,尤其是铸坯夹渣导致轧制后盘条表面出现连续性锯齿状结疤缺陷,严重影响盘条表面质量。引起水口结瘤、结晶器“结鱼”的主要原因是存在TiO_(x)、TiN等高熔点非金属夹杂物。通过控制钢水中氧氮含量、使用纯净合金、降低渣中SiO_(2)活度、调整钛合金化时机及温度等手段,解决了水口结瘤、结晶器“结鱼”、铸坯夹渣等问题,将高钛焊丝钢ER70S-G连浇炉数提高至10炉,盘条成材率提高至97%,优化效果显著。

关键词：高钛焊丝钢 ER70S-G 非金属夹杂物水口结瘤结晶器铸坯夹渣

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高级别管线用焊丝EF3超低磷冶炼工艺实践

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特殊钢 2024年第6期45卷 57-61页

作者：张行利亓奉友苏永泽崔贵博唐庆侯建伟中信泰富特钢研究院青钢分院青岛266000

为实现高级别管线用超低P焊丝EF3的批量稳定生产,对脱P的热力学条件和动力学条件研究,明确脱P的条件。通过铁水脱P、100 t转炉脱P、钢包脱P配合扒渣、二次LF精炼防回P工艺,配合低P合金,实现了超低P焊丝EF3的稳定生产。控制铁水w[Si]≤0.... 详细信息

为实现高级别管线用超低P焊丝EF3的批量稳定生产,对脱P的热力学条件和动力学条件研究,明确脱P的条件。通过铁水脱P、100 t转炉脱P、钢包脱P配合扒渣、二次LF精炼防回P工艺,配合低P合金,实现了超低P焊丝EF3的稳定生产。控制铁水w[Si]≤0.15%,造高碱度(R=6)的炉渣,可同时脱P、脱S,实现铁水w[P]≤0.020%、铁水w[S]≤0.005%;转炉终点温度在1595~1610℃,终渣碱度4.0左右,终渣中w[FeO]在23.0%~26.0%,可实现转炉出钢w[P]≤0.008%;采用钢包脱P,可实现钢水w[P]≤0.004%;钢包脱磷后配合扒渣工艺,扒渣前后基本不回P,采用二次LF精炼防增P,配合低P合金,增P量极少;从而可实现中间包钢水w[P]≤0.005%。

关键词：超低P焊丝EF3 转炉脱P 扒渣 P含量

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