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Expression and significance of factors related to angiogenesis in choroidal melanoma

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 49-54页

作者： Qiang Xu gui-Qiu zhao Jie zhao Hong Lin Ying-Ying Mou qing Wang and Wei-Rong Sun Department of Ophthalmology Affiliated Hospital of Qingdao University Medical Collage Qingdao 266003 Shandong Province China

AIM: To investigate expression of factors related to angiogenesis: HIF-1 alpha, iNOS, COX-2 and VEGF in choroidal melanoma and its clinical significance. METHODS: Fifty samples of choroidal melanoma and 15 samples of melanocytic nevi of the eyelid identified by pathology were collected. Immunohistochemistry SP method was used to examine the expression of HIF-1 alpha, iNOS, COX-2 and VEGF in these samples. The comparison among groups was done by SPSS 13.0 software. RESULTS: The positive expression rates of HIF-1 alpha, iNOS, COX-2 and VEGF in choroidal melanoma group were significantly higher than those in eyelid nevi group (chi(2)= 6.5542, 7.7224, 8.5828, 15.1749). The positive expression rate of VEGF was associated with the tumor size (chi(2)= 10.9194), but was not associated with pathological type (chi(2)=2.0712) and the situation of scleral invasion (chi(2)= 5.4289). The positive expression rate of HIF-1 alpha was associated with the tumor size (chi(2)=7.1216) and pathological type (chi(2)=9.0889), but was not associated with the situation of scleral invasion (chi(2)=3.3586). The positive expression rate of iNOS was associated with the tumor size (chi(2)=9.5503), but was not associated with pathological type (chi(2)=1.9450) and the situation of scleral invasion (chi(2)=2.3810). The positive expression rate of COX-2 was associated with the tumor size (chi(2)=7.2970), but was not associated with pathological type (chi(2)=1.8421) and the situation of sclera! invasion (chi(2)= 0.4018). The expression of HIF-1 alpha, iNOS and COX-2 were significantly associated with the expression of VEGF (r = 0.9429, 1, 0.9857). The expression of COX-2 was significantly associated with the expression of iNOS (r=0.9857). The expression of HIF-1 alpha was significantly associated with the expression of COX-2 ( r=0.9857). The expression of HIF-1 alpha was significantly associated with the expression of iNOS (r= 0. 9429). CONCLUSION: The expression of HIF-1 alpha, iNOS and COX-2 protein

关键词： choroidal melanoma immunohistoehemistry hypoxia inducible factor-1a inducible nitric oxide synthase cyclooxygenase-2

A new forwarding address for next generation networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第1期13卷 1-10页

作者： A-qun zhao Man-gui LIANG School of Computer and Information Technology Beijing Jiaotong University Beijing 100044 China

The forwarding address plays an important role in constructing a communication network. In this paper, a new forwarding address suitable for next generation networks named the vector address （VA） is proposed which is different from the forwarding address coding methods of current networks. The characteristics of the VA are analyzed. Complex network theory and a theoretical analysis method are introduced to study the average address length of the VA when used to construct a global network Simulation experiments in a practical network topology model are carried out to validate the results. The results show that not only can the VA construct a simpler, more secure, and more scalable network, but it also can accommodate many more users than an Internet Protocol （IP） network with the same address length.

关键词： Next generation networks (NGN) Forwarding address Vector address (VA) Complex network

Nuclear dynamics and particle production near threshold energies in heavy-ion collisions

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Nuclear Science and Techniques 2018年第3期29卷 107-137页

作者： zhao-qing Feng Institute of Modern Physics Chinese Academy of Sciences

Recent progress of the quantum molecular dynamics model for describing the dynamics of heavy-ion collisions is viewed, in particular the nuclear fragmentation, isospin physics, particle production and in-medium effect, hadron-induced nuclear reactions, hypernucleus, *** neck fragmentation in Fermi-energy heavy-ion collisions is investigated for extracting the symmetry energy at subsaturation densities. The isospin effects, in-medium properties, and the behavior of high-density symmetry energy in medium-and high-energy heavy-ion collisions are thoroughly discussed. The hypernuclide dynamics formed in heavy-ion collisions and in hadron-induced reactions is analyzed and addressed in the future experiments at the high-intensity heavy-ion accelerator facility(HIAF).

关键词： LQMD transport model Heavy-ion reactions Hadron-induced nuclear reactions Symmetry energy Strangeness production

A study on the dynamic spectral indices for SEP events on 2000 July 14 and 2005 January 20

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Research in Astronomy and Astrophysics 2020年第3期20卷 129-135页

作者： Ming-Xian zhao gui-Ming Le Key Laboratory of Space Weather National Center for Space WeatherChina Meteorological Administration.Beijing 100081China

We have studied the dynamic proton spectra for the two solar energetic particle(SEP)events on2000 July 14(hereafter GLE59)and 2005 January 20(hereafter GLE69).The source locations of GLE59 and GLE69 are N22 W07 and N12 W58 *** fluxes>30 Me V have been used to compute the dynamic spectral indices of the two SEP *** results show that spectral indices of the two SEP events increased more swiftly at early times,suggesting that the proton fluxes>30 Me V might be accelerated particularly by the concurrent flares at early times for the two SEP *** the GLE69 with source location at N12 W58,both flare site and shock nose are well connected with the Earth at the earliest ***,only the particles accelerated by the shock driven by eastern flank of the CME can propagate along the interplanetary magnetic field line to the Earth after the *** the GLE59 with source location at N22 W07,only the particles accelerated by the shock driven by western flank of the associated CME can reach the Earth after the *** results also show that there was slightly more than one hour during which the proton spectra for GLE69 are softer than that for GLE59 after the flares,suggesting that the shock driven by eastern flank of the CME associated with GLE69 is weaker than the shock driven by the western flank of the CME associated with *** results support that quasi-perpendicular shock has stronger potential in accelerating particles than the quasi-parallel *** results also suggest that only a small part of the shock driven by western flank of the CME associated with the GLE59 is quasi-perpendicular.

关键词： Sun:flares-Sun coronal mass ejections(CMEs)-Sun particle emission-Sun solarterrestrial relations

A breakthrough in direct conversion of methane tooxygenates under mild conditions

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Science China Materials 2018年第7期61卷 1012-1014页

作者： Yan-Xia zhao Sheng-gui He State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100190China Beijing National Laboratory for Molecular Sciences CAS Research/Education Center of Excellence in Molecular Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Methane is an attractive C1 resource for production ofvalue-added chemicals. The current industrial utilizationof methane involves indirect route via preliminary oxi-dation to syngas （a mixture of CO and H2） that can beconverted to desired products [1]. Such two-stage processis energy-intensive. Considerable efforts have been de-voted to developing catalytic processes that can efficientlyand directly transform methane through oxidative ornon-oxidative pathways [2,3].

关键词：材料科学研究

农业新质生产力赋能农业强国建设的逻辑理路及其推进机制

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广西师范大学学报（哲学社会科学版） 2025年第1期61卷 46-57页

作者：陈桂生吴合庆安徽大学管理学院安徽合肥230601 天津师范大学政治与行政学院天津300387

农业新质生产力赋能农业强国建设已成为中国式农业农村现代化的时代命题。数字农业生产的技术嵌入、农业新质生产力的动能转换、农业强国建设的目标跃升,是解说新质生产力赋能农业强国建设的新框架。农业新质生产力赋能农业强国的内在... 详细信息

农业新质生产力赋能农业强国建设已成为中国式农业农村现代化的时代命题。数字农业生产的技术嵌入、农业新质生产力的动能转换、农业强国建设的目标跃升,是解说新质生产力赋能农业强国建设的新框架。农业新质生产力赋能农业强国的内在逻辑包括以“强”“富”“美”为意涵的价值逻辑,以动力、组织、调适为内容的驱动逻辑,以现实需要和创新任务为目标的现实逻辑。就其推进机制而言,从迭代新技术增动能、重组新要素增形态与拓展新空间增场景等三方面着手,是持续释放农业新质生产力赋能农业强国建设韧性的有效解。

关键词：农业新质生产力赋能农业强国农业农村现代化乡村振兴

Plant–soil microbe feedbacks drive seedling establishment during secondary forest succession:the‘successional stage hypothesis’

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Journal of Plant Ecology 2023年第6期16卷 259-270页

作者： qing Liu Wenqiang zhao CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China

INTRODUCTION Forests are increasingly under threat due to logging,fire,severe drought and other natural disturbances,which may compromise their ability to conserve biodiversity and regulate climate systems(Powers and Marin-spiotta 2017).Extensive deforestation and forest degradation will leave behind a complex landscape consisting of a matrix of forest patches under different levels of succession(Quesada et al.2009).

关键词： forest seedling soil

Progress on pollen-stigma compatibility in Corylus (hazelnuts): a review

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Journal of Forestry Research 2013年第3期24卷 397-402页

作者： MA qing-hua WANG gui-xi LIANG Wei-jian CHEN Xin LIANG Li-song zhao Tian-tian Research Institute of Forestry Chinese Academy of Forestry / State Key Laboratory of Tree Genetics and Breeding Liaoning Institute of Economic Forestry

The genus Corylus is an important member in the Betulaceae family of the order Fagales. Self-incompatibility is one of the choke points in breeding and hazelnut production. This reviewe describes, the progress on pollen-stigma compatibility in Corylus, including basic re- productive characteristics, S-alleles testing and their applications, in- ter-specific hybridization, self-compatibility in wild species, and recent molecular research on the genetic mechanism of compatibility. Com- pared with other species, progress on pollen-stigma compatibility （sporophytic self-incompatibility, SSI） in Corylus is slow, especially those in the Brassicaceae family. De novo approaches should be used to target the unique reproductive characteristics of hazelnuts. The continu- ous improvement of technological platforms based on molecular biology should broaden the pathways in investigating compatibility in Corylus. In addition, research should be conducted on overcoming self- and cross- incompatibility, and approaches based on biological, chemical, and physical principles should be introduced. Both theoretical and practical study of compatibility in Corylus should be devoted to change the self-incompatibility trait into a benefit in the species evolvement and nut quality establishment.

关键词： SSI S-locus basic mechanism breeding pollination

Modeling stochastic mortality with O-U type processes

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Applied Mathematics(A Journal of Chinese Universities) 2018年第1期33卷 48-58页

作者： ZHENG Jing TONG Chang-qing ZHANG gui-jun College of Economics Hangzhou Dianzi University

Modeling log-mortality rates on O-U type processes and forecasting life expectancies are explored using U.S. data. In the classic Lee-Carter model of mortality, the time trend and the age-specific pattern of mortality over age group are linear, this is not the feature of mortality model. To avoid this disadvantage, O-U type processes will be used to model the log-mortality in this paper. In fact, this model is an AR(1) process, but with a nonlinear time drift *** on the mortality data of America from Human Mortality database(HMD), mortality projection consistently indicates a preference for mortality with O-U type processes over those with the classical Lee-Carter model. By means of this model, the low bounds of mortality rates at every age are given. Therefore, lengthening of maximum life expectancies span is estimated in this paper.

关键词： mortality stochastic forecasting O-U type process