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The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu Jing Yang Wen-Jing Zhang Yi-Ling Zhou gui-jun zhao Ya Huang Shu-Yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

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A Multi-Stage Differential-Multifactorial Evolutionary Algorithm for Ingredient Optimization in the Copper Industry

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2135-2153页

作者： Xuerui Zhang Zhongyang Han jun zhao School of Control Science and Engineering Dalian University of TechnologyDalian 116024China IEEE

Ingredient optimization plays a pivotal role in the copper industry,for which it is closely related to the concentrate utilization rate,stability of furnace conditions,and the quality of copper *** acquire a practical ingredient plan,which should exhibit long duration time with sufficient utilization and feeding stability for real applications,an ingredient plan optimization model is proposed in this study to effectively guarantee continuous production and stable furnace *** address the complex challenges posed by this integer programming model,including multiple coupling feeding stages,intricate constraints,and significant non-linearity,a multi-stage differential-multifactorial evolution algorithm is *** the proposed algorithm,the differential evolutionary(DE)algorithm is improved in three aspects to efficiently tackle challenges when optimizing the proposed ***,unlike traditional time-consuming serial approaches,the multifactorial evolutionary algorithm is utilized to optimize multiple complex models contained in the population of evolutionary algorithm caused by the feeding stability in a parallel ***,a repair algorithm is employed to adjust infeasible ingredient lists in a timely *** addition,a local search strategy taking feedback from the current optima and considering the different positions of global optimum is developed to avoiding premature convergence of the differential evolutionary ***,the simulation experiments considering different planning horizons using real data from the copper industry in China are conducted,which demonstrates the superiority of the proposed method on feeding duration and stability compared with other commonly deployed *** is practically helpful for reducing material cost as well as increasing production profit for the copper industry.

关键词： Copper industry differential-multifactorial evolution ingredient optimization multi-stage optimization

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Passivity-Based Stabilization for Switched Stochastic Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1307-1309页

作者： Yaowei Sun jun zhao School of Automation Zhengzhou University of AeronauticsZhengzhou 450046 Henan Key Laboratory of General Aviation Technology Zhengzhou University of AeronauticsZhengzhou 450046China College of Information Science and Engineering Northeastern UniversityShenyang 110819China

Dear Editor,This letter addresses the passivity-based mean square exponential stabilization problem for switched stochastic nonlinear systems.A concept of generalized small-time norm-observability is presented and an appropriate test condition is also *** pre-given passivity rate and average dwell time,a set of feedback controllers is designed by use of the passivity property.

关键词： property letter stabilization

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Comparison of irradiation-induced void formations in tungsten with equiaxed and columnar structures

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Tungsten 2024年第4期6卷 794-805页

作者： Liu Xi Jia-jun zhao Ji-jun zhao Yuan-Yuan Wang Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Ministry of Education) Dalian University of Technology

Tungsten(W) has been received much attention,since it is regarded as one of the most promising plasma facing materials for fusion *** are two typical morphologies of unirradiated polycrystalline W,which have the equiaxed and columnar grains,***,the role of arrangement of grain boundary(GB) in absorbing irradiation-generated point defects is still waiting to be *** current investigation,irradiation-induced void formations in W with equiaxed and columnar microstructures are predicted,respectively,using the developed phase-field *** significant kinetic behavior,such as the generation and annihilation of point defects and the interaction between point defects and GB,is reasonably *** density,size and porosity of void formed in these two microstructures are examined and analyzed according to the effects of GB ratio,temperature and damage *** analytical results show that higher GB ratio can effectively reduce void porosity,and the columnar-grained structure has better irradiation resistance than that of the equiaxed one in the case of small grain *** importantly,the predicted void sizes changed with temperature and damage rate agree well with the experimentally measured *** work has a more beneficial contribution to the microstructural improvement of International Thermonuclear Experimental Reactor-grade W.

关键词： Grain morphology Irradiation-induced void Phase-field Tungsten

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Asynchronous Learning-Based Output Feedback Sliding Mode Control for Semi-Markov Jump Systems: A Descriptor Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1358-1369页

作者： Zheng Wu Yiyun zhao Fanbiao Li Tao Yang Yang Shi Weihua gui School of Automation Central South UniversityChangsha 410083China Power Electronics Machines and Control GroupThe University of NottinghamNottingham NG72RDUK Department of Mechanical Engineering University of VictoriaVictoria BC V8W 3P6Canada IEEE

This paper presents an asynchronous output-feed-back control strategy of semi-Markovian systems via sliding mode-based learning *** with most literature results that require exact prior knowledge of system state and mode information,an asynchronous output-feedback sliding sur-face is adopted in the case of incompletely available state and non-synchronization *** holonomic dynamics of the sliding mode are characterized by a descriptor system in which the switching surface is regarded as the fast subsystem and the system dynamics are viewed as the slow *** upon the co-occurrence of two subsystems,the sufficient stochastic admissibility criterion of the holonomic dynamics is derived by utilizing the characteristics of cumulative distribution ***,a recursive learning controller is formulated to guarantee the reachability of the sliding manifold and realize the chattering reduction of the asynchronous switching and sliding ***,the proposed theoretical method is substantia-ted through two numerical simulations with the practical contin-uous stirred tank reactor and F-404 aircraft engine model,respectively.

关键词： Asynchronous switching learning-based control output feedback semi-Markovian jump systems sliding mode con-trol(SMC).

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Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： Rong zhao jun-e Feng Dawei Zhang the School of Mathematics Shandong UniversityShandong UniversityJinan 250100China

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

关键词： Boolean control networks(BCNs) output regulation self-triggered control semi-tensor product of matrices set stabilization synchronization

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Effect of Wave Nonlinearity on the Instantaneous Seabed Liquefaction

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China Ocean Engineering 2024年第1期38卷 93-103页

作者： WANG zhao-jun SUI Ti-ti ZHANG Chi PAN jun-ning Key Laboratory of Port Waterway and Sedimentation Engineering of the Ministry of TransportNanjing Hydraulic Research InstituteNanjing 210024China Key Laboratory of Coastal Disaster and Protection(Hohai University) Ministry of EducationNanjing 210098China The National Key Laboratory of Water Disaster Prevention Nanjing 210098China

The nonlinear variation of wave is commonly seen in nearshore area,and the resulting seabed response and liquefaction are of high concern to coastal *** this study,an analytical formula considering the nonlinear wave skewness and asymmetry is adopted to provide wave pressure on the seabed *** liquefaction depth attenuation coefficient and width growth coefficient are defined to quantitatively characterize the nonlinear effect of wave on seabed *** on the 2D full dynamic model of wave-induced seabed response,a detailed parametric study is carried out in order to evaluate the influence of the nonlinear variation of wave loadings on seabed ***,new empirical prediction formulas are proposed to fast predict the maximum liquefaction under nonlinear *** indicate that(1)Due to the influence of wave nonlinearity,the vertical transmission of negative pore water pressure in the seabed is hindered,and therefore,the amplitude decreases significantly.(2)In general,with the increase of wave nonlinearity,the liquefaction depth of seabed decreases *** under asymmetric and skewed wave loading,the attenuation of maximum seabed liquefaction depth is the most significant among all the nonlinear wave ***,highly skewed wave can cause the liquefaction depth of seabed greater than that under linear wave.(3)The asymmetry of wave pressure leads to the increase of liquefaction width,whereas the influence of skewedness is not significant.(4)Compared with the nonlinear waveform,seabed liquefaction is more sensitive to the variation of nonlinear degree of wave loading.

关键词： nonlinear wave seabed response seabed liquefaction numerical simulation liquefaction prediction

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A novel small-signal equivalent circuit model for GaN HEMTs incorporating a dual-field-plate

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Journal of Semiconductors 2024年第5期45卷 61-68页

作者： Jinye Wang jun Liu Zhenxin zhao School of Integrated Circuit Science and Engineering Hangzhou Dianzi UniversityHangzhou 310018China

An accurate and novel small-signal equivalent circuit model for GaN high-electron-mobility transistors(HEMTs)is proposed,which considers a dual-field-plate(FP)made up of a gate-FP and a *** equivalent circuit of the overall model is composed of parasitic elements,intrinsic transistors,gate-FP,and source-FP *** equivalent circuit of the gate-FP is identical to that of the intrinsic *** order to simplify the complexity of the model,a series combination of a resistor and a capacitor is employed to represent the *** analytical extraction procedure of the model parameters is presented based on the proposed equivalent *** verification is carried out on a 4×250μm GaN HEMT device with a gate-FP and a source-FP in a 0.45μm *** with the classic model,the proposed novel small-signal model shows closer agreement with measured S-parameters in the range of 1.0 to 18.0 GHz.

关键词： small-signal model dual field-plate(FP) GaN high-electron-mobility transistors(HEMT) parameter extraction

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Application of CFD and FEA Coupling to Predict Structural Dynamic Responses of A Trimaran in Uni-and Bi-Directional Waves

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China Ocean Engineering 2024年第1期38卷 81-92页

作者： LIAO Xi-yu XIA Jin-song CHEN Zhan-yang TANG Qin zhao Nan zhao Wei-dong gui Hong-bin Marine Design&Research Institute of China Shanghai 200011China Ship Structure Division China Ship Scientific Research CenterWuxi 214082China College of Ocean Engineering Harbin Institute of TechnologyWeihaiWeihai 264209China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China School of Foreign Studies Jiangnan UniversityWuxi 214122China

To predict the wave loads of a flexible trimaran in different wave fields,a one-way interaction numerical simulation method is proposed by integrating the fluid solver(Star-CCM+)and structural solver(Abaqus).Differing from the existing coupled CFD-FEA method for monohull ships in head waves,the presented method equates the mass and stiffness of the whole ship to the hull shell so that any transverse and longitudinal section stress of the hull in oblique waves can be ***,verification study and sensitivity analysis are carried out by comparing the trimaran motions using different mesh sizes and time step *** on the wave elevation of uni-and bi-directional waves is also carried *** a comprehensive analysis on the structural responses of the trimaran in different uni-directional regular wave and bi-directional cross sea conditions is carried out,***,the differences in structural response characteristics of trimaran in different wave fields are *** results show that the present method can reduce the computational burden of the two-way fluid-structure interaction simulations.

关键词： CFD-FEA fluid-structure coupling structural responses trimaran bi-directional cross sea

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Effects of Rattling Behavior of K and Cd Atoms along Different Directions in Anisotropic KCdAs on Lattice Thermal Transport and Thermoelectric Properties

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Energy & Environmental Materials 2024年第6期7卷 388-398页

作者： Yue Wang Yinchang zhao jun Ni Zhenhong Dai Department of Physics Yantai UniversityYantai 264005China State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China

We employ advanced first principles methodology,merging self-consistent phonon theory and the Boltzmann transport equation,to comprehensively explore the thermal transport and thermoelectric properties of ***,the study accounts for the impact of quartic anharmonicity on phonon group velocities in the pursuit of lattice thermal conductivity and investigates 3ph and 4ph scattering processes on phonon *** various methodologies,including examining atomic vibrational modes and analyzing 3ph and 4ph scattering processes,the article unveils microphysical mechanisms contributing to the lowκL within *** features include significant anisotropy in Cd atoms,pronounced anharmonicity in K atoms,and relative vibrations in non-equivalent As atomic *** atoms,situated between As layers,exhibit rattling modes and strong lattice anharmonicity,contributing to the observed lowκ*** flat bands near the valence band maximum translate into high PF,aligning with ultralowκL for exceptional thermoelectric *** optimal temperature and carrier concentration doping,outstanding ZT values are achieved:4.25(a(b)-axis,p-type,3×10^(19)cm^(−3),500 K),0.90(c-axis,p-type,5×10^(20)cm^(−3),700 K),1.61(a(b)-axis,n-type,2×10^(18)cm^(−3),700 K),and 3.06(c-axis,n-type,9×10^(17)cm^(−3),700 K).

关键词： anharmonic lattice dynamics electron transport characteristics first principles calculation lattice thermal transport octahedron thermoelectric properties

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