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Experimental Investigation of the Anisotropic Thermal Conductivity of C/SiC Composite Thin Slab

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Chinese Physics Letters 2024年第3期41卷 48-60页

作者：毋克凡张虎唐桂华 State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China MOE Key Laboratory of Thermo-Fluid Science and Engineering School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049China

Fiber-reinforced composites possess anisotropic mechanical and heat transfer properties due to their anisotropic fibers and structure *** C/Si C composites,the out-of-plane thermal conductivity has mainly been studied... 详细信息

关键词： composites C/Si anisotropic

Euphorstranoids A and B,two highly rearranged ingenane diterpenoids from Euphorbia stracheyi:structural elucidation,chemical transformation,and lipid-lowering activity

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Organic Chemistry Frontiers 2022年第3期9卷 775-780页

作者： Fang-Yu Yuan Yue-hua Pan Ai-Ping Yin Wei Li Dong huang Xue-Long Yan Shu-Qi Wu gui-hua tang Rong Pu Sheng Yin School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510006People’s Republic of China Department of Clinical Laboratory the Third People’s Hospital of DongguanDongguan 523326People’s Republic of China

Euphorstranoids A(1)and B(2),two highly rearranged ingenane diterpenoids with an unusual 5/6/7/3 carbon ring system,were isolated from Euphorbia *** structures were determined by a combination of spectral,chemical,and X-ray diffraction *** plausible biosynthetic pathway of 1 and 2 was proposed and chemically *** 1 and 2 significantly inhibited the triglyceride(TG)level in 3T3-L1 adipocytes via retarding cell adipogenesis at the early stage.

关键词： methods chemical elucidation

Mulberry Diels-Alder-type adducts:isolation,structure,bioactivity,and synthesis

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Natural Products and Bioprospecting 2022年第1期12卷 442-504页

作者： Si-Yuan Luo Jun-Yu Zhu Ming-Feng Zou Sheng Yin gui-hua tang School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510006People’s Republic of China

Mulberry Diels-Alder-type adducts(MDAAs)are unique phenolic natural products biosynthetically derived from the intermolecular[4+2]-cycloaddition of dienophiles(mainly chalcones)and dehydroprenylphenol dienes,which are exclusively distributed in moraceous plants.A total of 166 MDAAs with diverse skeletons have been isolated and identified since ***,the classic MDAAs characterized by the chalcone-skeleton dienophiles can be divided into eight groups(Types A−H),while others with non-chalcone dienophiles or some variations of classic MDAAs are non-classic MDAAs(Type I).These compounds have attracted significant attention of natural products and synthetic chemists due to their complex architectures,remarkable biological activities,and synthetic *** present review provides a comprehensive summary of the structural properties,bioactivities,and syntheses of *** references were collected between 1980 and 2021 from the SciFinder,Web of Science,and China National Knowledge Internet(CNKI).

关键词： Mulberry Diels-Alder-type adducts MDAAs Natural products Bioactivity Synthesis

Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

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Natural Products and Bioprospecting 2012年第1期2卷 29-34页

作者： Wen-Xing LIU gui-hua tang Hong-Ping HE Yu ZHANG Shun-Lin LI Xiao-Jiang HAO State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Graduate University of Chinese Academy of Sciences Beijing 100049China

Four new limonoids,dysohainanins A-D(1-4),and two new triterpenoids,dysohainanins E and F(5 and 6),together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense *** structures of the new compounds were determined by a variety of spectroscopic *** cytotoxic activities of these compounds were evaluated,and the known compound ent-19-nor-4,16,18-trihydroxy-8(14)-pomaren-15-one(13)showed in vitro cytotoxicity against HL-60,A-549,MCF-7,and SW480 cells,with IC50 values of 24.3,28.1,30.7,and 22.5mM,*** 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive.

关键词： Dysoxylum hainanense Meliaceae limonoids triterpenoids cytotoxicity

Five new limonoids isolated from Walsura robusta

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Natural Products and Bioprospecting 2023年第1期13卷 657-664页

作者： Li Hou Cui-Xuan Mei Chun-Mao Yuan gui-hua tang Duo-Zhi Chen Qing Zhao Hong-Ping He Ming-Ming Cao Xiao-Jiang Hao State Key Laboratory of Photochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal ChemistryKunming Institute of BotanyChinese Academy of SciencesKunming 650201China School of Ethnic Medicine and School of Chinese Materia MedicalYunnan University of Chinese MedicineKunming 650500China University of Chinese Academy of Sciences Beijing 100049China Bureau of Commerce and Market Supervision of Management Committee of Hunan Xiangjiang New Area Changsha 410205China The Key Laboratory of Chemistry for Natural Products of guizhou Province and Chinese Academy of Sciences Guiyang 550014China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China Yunnan Characteristic Plant Extraction Laboratory Kunming 650106China

Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D(1-4),and one new furan ring degraded limonoid walsurobustone E(5)together with one known compound toonapubesic acid B(6)were isolated from the leaves of Walsura *** structures were elucidated by NMR and MS ***,the absolute configuration of toonapubesic acid B(6)was confirmed by X-ray diffraction *** 1-6 exhibited good cytotoxicity against the cancer cell lines HL-60,SMMC-7721,A-549,MCF-7,and SW480.

关键词： Limonoids Tetranortriterpenoids Walsura robusta Cytotoxicity

Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4934-4944页

作者： Jia-Luo huang Xue-Long Yan Dong huang Lu Gan huahua Gao Run-Zhu Fan Shen Li Fang-Yu Yuan Xinying Zhu gui-hua tang Hong-Wu Chen Junjian Wang Sheng Yin School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Guizhou Medical UniversityGuian New DistrictGuizhou 550025China School of Medicine University of California DavisSacramentoCA 95817USA

Nuclear transporter importin-β1 is emerging as an attractive target by virtue of its prevalence in many ***,the lack of druggable inhibitors restricts its therapeutic proof of *** the present work,we optimized a natural importin-β1 inhibitor DD1 to afford an improved analog DD1-Br with better tolerability(>25 folds)and oral ***1-Br inhibited the survival of castration-resistant prostate cancer(CRPC)cells with sub-nanomolar potency and completely prevented tumor growth in resistant CRPC models both in monotherapy(0.5 mg/kg)and in enzalutamidecombination *** study revealed that by targeting importin-β1,DD1-Br markedly inhibited the nuclear accumulation of multiple CRPC drivers,particularly AR-V7,a main contributor to enzalutamide resistance,leading to the integral suppression of downstream oncogenic *** study provides a promising lead for CRPC and demonstrates the potential of overcoming drug resistance in advanced CRPC via targeting importin-β1.

关键词： Importin-β1 CRPC Drug discovery Enzalutamide-resistance Natural product Cancer Daphnane diterpenoid Nuclear transporter

Two new tirucallane triterpenoids from Aphanamixis grandifolia

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Natural Products and Bioprospecting 2012年第5期2卷 222-226页

作者： Xiao-Ying WANG gui-hua tang Chun-Mao YUAN Yu ZHANG Li HOU Qing ZHAO Xiao-Jiang HAO Hong-Ping HE State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Faculty of Pharmacy Yunnan University of TCMKunming 650500China

Two new tirucallane triterpenoids,2a-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid(1)and(23E)-2a-hydroxytirucalla-7,23,25-triene-3-one(2),along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,23-dione(3),were isolated from the leaves and twigs of Aphanamixis *** structures were elucidated by extensive NMR and MS data,and compound 3 was further confirmed by X-ray crystal diffraction *** activities and insecticidal activities of these three compounds were also *** 1 showed good antimicrobial activity against Staphylococcus aureus with the MIC value of 1.56μg/mL,while compounds 1 and 2 showed insecticidal activity at 100 ppm,with the corrected mortality 79.1%and 60.6%,respectively.

关键词： Aphanamixis grandifolia Meliaceae 2 3-seco-tirucallane triterpenoid bioassays

波形蛋白在子痫前期蜕膜组织中的表达及其意义

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生殖与避孕 2008年第8期28卷 477-481,490页

作者：冯亚玲周昌菊唐华贵中南大学湘雅医学院第三附属医院妇产科长沙410013 深圳市宝安区福永医院深圳518103

目的:探讨波形蛋白在子痫前期蜕膜组织中的表达及意义。方法:采用荧光实时定量PCR(SYBR GREEN I assay)、Western blotting和免疫组织化学技术分别对晚发型重度子痫前期(A组)及早发型重度子痫前期(B组)和正常足月妊娠妇女(对照组,C组)... 详细信息

目的:探讨波形蛋白在子痫前期蜕膜组织中的表达及意义。方法:采用荧光实时定量PCR(SYBR GREEN I assay)、Western blotting和免疫组织化学技术分别对晚发型重度子痫前期(A组)及早发型重度子痫前期(B组)和正常足月妊娠妇女(对照组,C组)各10例的波形蛋白mRNA及蛋白进行测定。结果:波形蛋白主要表达于蜕膜细胞的胞膜、胞浆及间质。荧光实时定量PCR,Western blotting和免疫组化表达等各方法验证结果显示:波形蛋白mRNA及蛋白在C组蜕膜组织中表达最高;B组中次之;A组中最低,各组间差异有统计学意义(P<0.05)。结论:波形蛋白表达下调可能参与子痫前期的病理过程,并且波形蛋白下调的程度同子痫前期发病的早晚有关。

关键词：子痫前期波形蛋白免疫组化荧光实时定量PCR 免疫印迹

Chloraserrtone A,a Sesquiterpenoid Dimer from Chloranthus serratus

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Chloraserrtone A,a Sesquiterpenoid Dimer from Chloranthus se...