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Journal of Traditional Chinese Medicine 2020年第2期40卷 340-342页

作者： Xu Zhiwei wang Tong Chen Liang Lou ying Sun Xiaoyan Jiang Jinqi Department of Cardiac Surgery Huai'an First People's HospitalThe Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai'an223000China Department of Emergency Shanghai Chest HospitalShanghai Jiaotong UniversityShanghai 200030China Department of Nuclear Medicine Shanghai Chest HospitalShanghai Jiaotong UniversityShanghai 200030China

The management of dilated cardiomyopathy(DCM) is well established. However, a subset of patients does not have recovery from or have recurrences of left ventricular(LV) dysfunction despite receiving optimal medical therapy. Coronary microvascular dysfunction(CMD) can result from structural and functional abnormalities at the intramural and small coronary vessel level affecting coronary blood flow autoregulation and consequently leading to impaired coronary flow reserve. Dilated myocardial phenotype may be responsible for CMD in DCM. Anisodamine can exert a significant effect on relieving microvascular spasm, and improving and dredging the coronary microcirculation. However,whether CMD can be potentially improved with anisodamine to make DCM better remains incompletely understood.

关键词： Anisodamine Coronary microvascular dysfunction Cardiomyopathy,dilated Case reports

Carbamylated Erythropoietin Alleviates Kidney Damage in Diabetic Rats by Suppressing Oxidative Stress

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Current Medical Science 2021年第3期41卷 513-521页

作者： Jian-zhong DANG Ya-fang TU Juan wang ying-jie YANG Department of Geriatrics Rerunin Hospital of Wuhan UniversityWuhan 430060China Department of Nephrology Renmin Hospital of Wuhan UniversityWuhan 430060China

The oxidative stress response plays an important role in the occurrence and development of diabetic kidney disease(DKD).It has become a new treatment target for *** the current study,the effects of carbamylated erythropoietin(CEPO)on renal oxidative stress and damage in diabetic rats were *** Sprague Dawley rats were intraperitoneally administered with 60 mg/kg streptozotocin to establish the diabetes *** diabetic rats were randomly allocated into 4 groups(n=6 each):diabetes model group(DM group),DM+CEPO treatment group(DC group),DM+CEPO+EPO receptor(EPOR)blocking peptide treatment group(DCEB group),and DM+CEPO+CD131 blocking peptide treatment group(DCCB group).Meanwhile,a normal control group(NC group,n=6)was set *** tissues and blood samples were obtained for evaluation of oxidative stress and renal *** results showed that diabetic rats exhibited increased oxidative stress in the kidney and early pathological changes associated with *** with CEPO reduced oxidative stress and attenuated renal ***,diabetic rats treated with the combination of CEPO and EPOR blocking peptide or CD131 blocking peptide showed increased oxidative stress and reduced renal function when compared with CEPO treatment alone *** results suggested that CEPO can protect against kidney damage in DKD by inhibiting oxidative stress injury via EPOR-CD131 heterodimers.

关键词： diabetic kidney disease oxidative stress carbamylated erythropoietin erythropoietin receptor

Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degen- eration in Raw 264.7 cells involving the AMPK/SREBP1 pathway

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Journal of Geriatric Cardiology 2015年第4期12卷 410-416页

作者： Yan-gui wang Tian-Lun YANG Department of Cardiology Xiangya Hospital Central South University No. 8 7 Xiangya Road Changsha Hunan China Deparment of Geriatrics Hunan Provincial People's Hospital No.61 Jiefang West Road Changsha Hunan China

Baekgound Recent studies have suggested a potential role for liraglutide in the prevention and stabilization ofatherosclerotic vascular disease. However, the molecular mechanisms underlying the effect of liraglutide on atherosclerosis have not been well elucidated. The pur- pose of this study was to examine whether liraglutide protects against oxidative stress and fatty degeneration via modulation of AMP-activated protein kinase （AMPK）/sterol regulatory element binding transcription factor 1 （SREBP1） signaling pathway in foam ceils. Methods Mouse macrophages Raw264.7 cells were exposed to oxidized low density lipoprotein （oxLDL） to induce the formation of foam cells. The cells were incubated with oxLDL （50 μg/mL）, liraglutide （0.1, 0.5, 1 and 2 nmol/L） or exendin-3 （9-39）（1, 10 and 100 nmol/L） alone, or in combination. Oil Red O staining was used to detect intracellular lipid droplets. The levels of TG and cholesterol were measured using the commercial kits. Oxidative stress was determined by measuring intracellular reactive oxygen species （ROS）, malondialdehyde （MDA） and superoxide dismutase 1 （SOD）. Western blot analysis was used to examine the expression of AMPKal, SREBP1, phosphory- lated AMPKal, phosphorylated SREBP1, glucagon-like peptide-1 （GLP-1） and GLP-1 receptor （GLP-1R）. Results Oil Red O staining showed that the cytoplasmic lipid droplet accumulation was visibly decreased in foam cells by treatment with liraglutide. The TG and cholesterol content in the liraglutide-treated foam cells was significantly decreased. In addition, foam ceils manifested an impaired oxidative stress following liraglutide treatment, as evidenced by increased SOD, and decreased ROS and MDA. However, these effects of liraglutide on foam cells were attenuated by the use of GLP-IR antagonist exendin-3 （9-39）. Furthermore, we found that the expression level of AMPKa 1 and phosphorylated AMPKct 1 was significantly increased while the expression level of SREBP 1 and phosphorylated SRE

关键词： AMPK/SREBP1 pathway Fatty degeneration Foam cell Liraglutide Oxidative stress

High-frequency (50 Hz) electroacupuncture ameliorates cognitive impairment in rats with amyloid beta 1–42-induced Alzheimer＇s disease

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Neural Regeneration Research 2018年第10期13卷 1833-1841页

作者： Chao-Chao Yu ying wang Feng Shen Li-Hong Kong Ya-Wen wang Hua Zhou Lei Tang Hubei University of Chinese Medicine WuhanHubei ProvinceChina Department of Acupuncture and Moxibustion College of Acupuncture and OrthopedicsHubei University of Chinese MedicineWuhanHubei ProvinceChina Department of Rehabilitation Wuhan Central Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Acupuncture has been shown to ameliorate cognitive impairment of Alzheimer’s *** and stimulation frequency influence the therapeutic effect of *** models of Alzheimer’s disease were established by injecting amyloid beta 1–42（Aβ_（1–42））into the bilateral lateral *** at 2,30,and 50 Hz was carried out at Baihui（GV20;15°obliquely to a depth of 2mm）and Shenshu（BL23;perpendicularly to 4–6 mm depth）,once a day for 20 minutes（each）,for 15 days,taking a break every 7 *** Morris water maze test was conducted to assess the learning and *** expression levels of glycogen synthase kinase-3β（GSK-3β）,p Ser9-GSK-3β,p Tyr216-GSK-3β,amyloid precursor protein and Aβ_（1–40） in the hippocampus were determined by western blot *** demonstrated that electroacupuncture treatment at different frequencies markedly improved learning and memory ability,increased synaptic curvatures,decreased the width of synaptic clefts,thickened postsynaptic densities,and downregulated the expression of GSK-3β,amyloid precursor protein,and Aβ_（1–40）.pSer9-GSK-3βexpression markedly decreased,while p Tyr216-GSK-3βexpression ***-frequency（50 Hz）electroacupuncture was more effective than low（2 Hz）or medium-frequency（30 Hz）*** conclusion,electroacupuncture treatment exerts a protective effect against Aβ_（1–42）-induced learning and memory deficits and synapse-ultrastructure impairment via inhibition of GSK-3β***,high-frequency electroacupuncture was the most effective therapy.

关键词： nerve regeneration electroacupuncture different frequencies Alzheimer's disease cognitive impairment hippocampus glycogen synthase kinase-3β synaptic curvatures width of synaptic cleft postsynaptic density Baihui(GV20) Shenshu(BL23) neural regeneration

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高原恒压营房强度分析及优化

建材技术与应用 2025年第1期 30-34页

作者：倪剑李杰王晓贵李白业张乐乐新疆地质工程有限公司新疆乌鲁木齐830000

针对人们在高原地区工作时易产生高原反应的问题,设计一种高原恒压营房,并通过有限元仿真分析真实工况下的结构响应,基于响应特征及使用要求对结构进行优化,提出加设斜梁结构或更换管材并调整梁结构跨距两种改进方案,进而分析改进后的... 详细信息

针对人们在高原地区工作时易产生高原反应的问题,设计一种高原恒压营房,并通过有限元仿真分析真实工况下的结构响应,基于响应特征及使用要求对结构进行优化,提出加设斜梁结构或更换管材并调整梁结构跨距两种改进方案,进而分析改进后的结构稳定性。结果表明:加斜梁的钢架结构使得整体最大变形量降低了24.8%,但整体变形量仍较大,无法满足使用要求;更换管材和调整跨距的优化方案使得底板最大变形量降低了79.4%,大大增强了稳定性,同时该方案可以控制结构的最大应力在钢材的许用应力范围内,增加材料的使用寿命,优化后的营房整体质量增加6.67%。

关键词：高原恒压营房有限元仿真优化方案

技术人员流动与团队双元创新:知识互补与替代的影响分析

同方期刊数据库博看期刊评论

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情报学报 2025年第1期44卷 35-47页

作者：王嘉杰王焘孙建军南京大学数据智能与交叉创新实验室南京210023 南京大学信息管理学院南京210023

技术人员流动及其对团队创新绩效的影响受到学界的广泛关注。然而,技术人员的知识如何通过流动与新团队知识网络进行耦合,进而影响新团队的探索式创新和利用式创新水平,学界对此鲜有研究。本文以从欧洲专利局全球专利统计数据库中提取的... 详细信息

技术人员流动及其对团队创新绩效的影响受到学界的广泛关注。然而,技术人员的知识如何通过流动与新团队知识网络进行耦合,进而影响新团队的探索式创新和利用式创新水平,学界对此鲜有研究。本文以从欧洲专利局全球专利统计数据库中提取的108468条技术人员流动数据作为研究样本,从知识耦合角度测度技术人员与新团队之间的知识互补与知识替代水平,利用负二项回归模型实证分析技术人员与新团队的知识互补和知识替代对团队探索式创新与利用式创新水平的影响机制,探究团队知识广度的调节作用。研究结果显示:(1)技术人员与新团队间的知识互补与团队探索式创新呈正相关,而与团队利用式创新呈负相关;(2)知识替代与团队利用式创新呈正相关,与团队探索式创新呈负相关;(3)团队知识广度能够减弱知识替代对团队利用式创新的正向关系,增强其他相关影响。本文在理论上加深了人才流动研究关于知识转移驱动创新机制的理解。在实践层面,本文为人才流动、团队创新协作及相关政策制定提供了新的见解,可为人才中心和创新高地建设提供参考。

关键词：技术人员流动知识耦合知识互补知识替代团队双元创新

Endoscopic classification and pathological features of primary intestinal lymphangiectasia

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World Journal of Gastroenterology 2022年第22期28卷 2482-2493页

作者： Ming-Ming Meng Kui-Liang Liu Xin-ying Xue Kun Hao Jian Dong Chun-Kai Yu Hong Liu Cang-Hai wang Hui Su Wu Lin Guo-Jun Jiang Nan Wei Ren-gui wang Wen-Bin Shen Jing Wu Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Respiratory and Critical Care Medicine Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Departments of Lymphatic Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Departments of Radiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Departments of Pathology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND The appearance of the intestinal mucosa during endoscopy varies among patients with primary intestinal lymphangiectasia(PIL).AIM To classify the endoscopic features of the intestinal mucosa in PIL under endoscopy,combine the patients’imaging and pathological characteristics of the patients,and explain their *** We retrospectively analyzed the endoscopic images of 123 patients with PIL who were treated at the hospital between January 1,2007 and December 31,*** compared and analyzed all endoscopic images,classified them into four types according to the endoscopic features of the intestinal mucosa,and analyzed the post-lymphographic computed tomography(PLCT)and pathological characteristics of each *** According to the endoscopic features of PIL in 123 patients observed during endoscopy,they were classified into four types:nodular-type,granular-type,vesicular-type,and *** showed diffuse thickening of the small intestinal wall,and no contrast agent was seen in the small intestinal wall and mesentery in the patients with nodular and granular *** agent was scattered in the small intestinal wall and mesentery in the patients with vesicular and edematous *** of the small intestinal mucosal pathology revealed that nodular-type and granulartype lymphangiectasia involved the small intestine mucosa in four layers,whereas ectasia of the vesicular-and edematous-type lymphatic vessels largely involved the lamina propria mucosae,submucosae,and muscular *** Endoscopic classification,combined with the patients’clinical manifestations and pathological examination results,is significant and very useful to clinicians when scoping patients with suspected PIL.

关键词： Primary intestinal lymphangiectasia Endoscopic features Post-lymphangiographic computed tomography Pathology

艾草粉对肉鸡生长性能、肉品质、脂质代谢及肠道功能的影响

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中国家禽 2025年第1期47卷 32-40页

作者：王学方王伟宁二娟陈玲归荣李智宁于立芹魏磊景炳年魏攀鹏蒋兵兵王兆贵李晓河南省纳普生物技术有限公司河南郑州450002 河南省科学院河南郑州450002 河南农业大学动物医学院河南郑州450000 河南省高新技术实业有限公司河南郑州450002

试验旨在研究艾草粉对红瑶肉鸡生长性能、肉品质、脂质代谢、血清免疫球蛋白、抗氧化能力及肠道功能的影响。试验选取540只健康状况良好的30日龄红瑶肉公鸡随机分成3组,每组6个重复,每个重复30只鸡。对照组饲喂基础日粮,2%、3%艾草粉组... 详细信息

试验旨在研究艾草粉对红瑶肉鸡生长性能、肉品质、脂质代谢、血清免疫球蛋白、抗氧化能力及肠道功能的影响。试验选取540只健康状况良好的30日龄红瑶肉公鸡随机分成3组,每组6个重复,每个重复30只鸡。对照组饲喂基础日粮,2%、3%艾草粉组分别饲喂添加2%、3%艾草粉的基础日粮,试验期60 d。试验期间,以每个重复为单位统计其生长性能;在第60天,分别从各重复中取3只鸡,取胸肌和腿肌进行肉品质检测;采集血清,用于脂质代谢等生化指标和抗氧化能力的检测;刮取十二指肠、空肠和回肠黏膜,检测闭合小环蛋白1(ZO-1)、闭锁蛋白1(CLDN1)、咬合蛋白(Occludin)含量;取盲肠内容物分析肠道微生物多样性及相对丰度的差异。结果显示:与对照组相比,2%、3%艾草粉组肉鸡料重比显著降低(P<0.05);3%艾草粉组肌肉剪切力显著降低(P<0.05),系水力、多不饱和脂肪酸含量显著升高(P<0.05);2%、3%艾草粉组血清高密度脂蛋白胆固醇含量、过氧化氢酶活性显著升高(P<0.05),低密度脂蛋白胆固醇含量显著降低(P<0.05),3%艾草粉组血清总胆固醇、丙二醛含量显著降低(P<0.05),白蛋白、总蛋白、球蛋白含量显著升高(P<0.05);3%艾草粉组小肠黏膜中闭锁蛋白1含量,十二指肠、空肠黏膜中闭合小环蛋白1、咬合蛋白含量均显著增加(P<0.05);2%、3%艾草粉组肉鸡肠道菌群丰富度指数显著提高(P<0.05),肠道菌群中有益微生物厚壁菌门的相对丰度均显著提高(P<0.05),有害微生物变形菌门相对丰度显著降低(P<0.05)。研究表明,饲粮添加2%~3%艾草粉可显著提高肉鸡生长性能、肉品质,改善脂质代谢,增强试验鸡免疫力和抗氧化能力,提高肠道机械屏障功能以及肠道菌群的丰富度。

关键词：艾草粉肉鸡生长性能肉品质脂质代谢抗氧化能力肠道功能

Acute extensive portal and mesenteric venous thrombosis after splenectomy:Treated by interventional thrombolysis with transjugular approach

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World Journal of Gastroenterology 2009年第24期15卷 3038-3045页

作者： Mao-Qiang wang Han-ying Lin Li-Ping Guo Feng-Yong Liu Feng Duan Zhi-Jun wang Department of Interventional Radiology Chinese PLA General Hospital Beijing 100853 China

AIM:To present a series of cases with symptomatic acute extensive portal vein(PV)and superior mesenteric vein(SMV)thrombosis after splenectomy treated by transjugular intrahepatic approach catheter-directed thrombolysis. METHODS:A total of 6 patients with acute extensive PV-SMV thrombosis after splenectomy were treated by transjugular approach catheter-directed thrombolysis. The mean age of the patients was 41.2 *** access to the portal system via the transjugular approach,pigtail catheter fragmentation of clots, local urokinase injection,and manual aspiration thrombectomy were used for the initial treatment of PV-SMV thrombosis,followed by continuous thrombolytic therapy via an indwelling infusion catheter in the SMV,which was performed for three to six days. Adequate anticoagulation was given during treatment, throughout hospitalization,and after discharge. RESULTS:Technical success was achieved in all 6 *** improvement was seen in these patients within 12-24 h of the *** complications were *** 6 patients were discharged 6-14 d(8±2.5 d)after *** mean duration of follow-up after hospital discharge was 40±16.5 *** and contrast-enhanced computed tomography confirmed patency of the PV and SMV,and no recurrent episodes of PV-SMV thrombosis developed during the follow-up period. CONCLUSION:Catheter-directed thrombolysis via transjugular intrahepatic access is a safe and effective therapy for the management of patients with symptomatic acute extensive PV-SMV thrombosis.

关键词： Mechanical thrombectomy Portal vein Splenectomy Superior mesenteric vein Thrombolysis Thrombosis

Achievement of complete response to nivolumab in a patient with advanced sarcomatoid hepatocellular carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1209-1215页

作者： Shu-Guang Zhu Hai-Bo Li Ze-Nan Yuan Wei Liu Qing Yang ying Cheng Wen-Jing wang Guo-ying wang Hua Li Department of Hepatic Surgery and Liver Transplantation The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina Liver Transplant Branch of Organ Transplant Center Organ Transplantation Institute of Sun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Medicine OrigiMed Inc.Shanghai 201100China

BACKGROUND Sarcomatoid hepatocellular carcinoma(SHC)is a rare subtype of hepatocellular carcinoma(HCC),with a high recurrence rate after *** addition to limited effective treatment for the advanced stage of SHC,the prognosis of patients with this malignancy is worse than that of patients with conventional *** SUMMARY We present the case of a 54-year-old man with SHC who underwent radical segmental hepatectomy,which relapsed 4 mo after surgery due to lymphatic metastasis in the porta *** a second surgery was performed,new metastasis developed in the mediastinal lymph ***,sorafenib and lenvatinib were sequentially administered as first-and second-line systemic therapies,***,progressive disease was confirmed based on a recurrent hepatic lesion and new metastatic lesion in the abdominal *** transhepatic cholangial drainage was performed to alleviate the biliary *** the tumor was strongly positive for programmed death-ligand 1,the patient was started on *** studies revealed that after two cycles of immunotherapy,the metastatic lesions decreased to undetectable *** The patient experienced continuous complete remission for 8 *** checkpoint inhibitors are useful for the treatment of advanced SHC.

关键词： Sarcomatoid hepatocellular carcinoma Hepatocellular carcinoma Programmed death-ligand 1 Immunotherapy Nivolumab Case report