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Genetic Polymorphism in the Second Exon of HLA-DRB1 in Cervical Cancer

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Clinical oncology and cancer researeh 2010年第1期7卷 27-32页

作者： yan-yun LI gui-fang yang yan-ju JIA Jun XING yan-ni LI Wei-ming ZHANG Department of Biochemistry and MolecularBiology Basic Medical College Tianjin Medical University Tianjin 300070 China.

OBJECTIVE The aim of this investigation was to assess the association between single nucleotide polymorphisms （SNPs） in HLA-DRB1 and the risk of developing cervical cancer. Our study focused on the second exon of the HLA-DRB1 alleles, which have most of the SNP sites on HLA-DRB1. METHODS We examined 30 cervical cancer patients and 66 control patients using the sequence-based typing polymerase chain reaction technique （PCR-SBT） to type 55 single nucleotide polymorphisms （SNPs） and haplotypes in the second exon of HLA-DRB1. The Chi-square test and the Bonferroni correction method were utilized for the statistical analysis of the data. An association between the alleles and cervical cancer was examined by the linkage disequilibrium test and the odds ratio （OR）. RESULTS Compared with the control group, among the 55 SNPs we studied in the second exon of HLA-DRB1, 4 showed an evident association with cervical cancer. Rs17880292 （P = 0.033, OR = 0.322） and rs1059586 （P = 0.029, OR = 2.657） had positive significance for the risk of developing cervical cancer, while rs17879702 （P = 0.016, OR = 0.222） and rs17882525 （P = 0.025, OR = 0.128） were negative. The difference in frequency of the 5582A-5592A-5667T haplotype between cervical cancer patients and the controls was significant （P = 0.043, OR = 2.735）. CONCLUSION The rs17880292 G/A genotype and the rs1059586 A/A genotype could be linked to an increased risk of cervical cancer. Rs17879702 and rs17882525 might be haplotype-tag SNPs （htSNPs） or belong to some other haplotypes, which might exert a protective effect against cervical cancer in combination. The 582A-5592A-5667T haplotype was shown to be a marker for susceptibility to cervical carcinogenesis.

关键词： HLA-DRB1 susceptibility SNPs. cervical cancer genetic

Expression and Change of B Cell Activation Factor of the TNF Family(BAFF) Gene between Human Normal and Inflamed Fallopian Tubes

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Journal of Reproduction and Contraception 2014年第1期25卷 12-17页

作者： Jian-ying XU gui-yan yang Guo-chao KUANG Jie-li HUANG Zhuhai Maternal and Children's Hospital and Health Institute Department of Obstetrics and Gynecology the Second People Hospital of Zhuhai

Objective To investigate the expression of B cell activation factor of the TNF family （BAFF） gene between human normal and inflamed fallopian tubes. Methods Tissue samples of human normal fallopian tube （n=20） and inflamed fallopian tube （n=20） were collected. The expression of BAFF gene was determined by the real- time reverse transcription polymerase chain reaction （RT-PCR） and immunohistochemistry. Results BAFF immunostaining appeared on the cellular membrane and in the cytoplasm of tubal epithelial cells. Both BAFF protein and mRNA in normal fallopian tubes had lower levels than those in inflamed fallopian tubes （P〈0.01）. Conclusion BAFF protein and mRNA are present in human tubal tissues. BAFF gene in human inflamed fallopian tube would have a high expression.

关键词： tumor necrosis factor (TNF) B cell activation factor of the TNF family (BAFF) fallopian tube inflammation

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体外受精-胚胎移植双胎妊娠的临床分析

中国妇幼保健 2007年第29期22卷 4129-4131页

作者：李异明杨桂艳广东省珠海市妇幼保健院儿科 519000 珠海市妇幼保健院生殖健康中心

目的：了解体外受精-胚胎移植（试管婴儿，IVF—ET）获得的双胎妊娠母儿状况与自然受孕双胎妊娠之异同，探讨体外受精双胎对母儿的影响。方法：将1998年9月～2006年6月在我院出生的52例IVF—ET双胎妊娠（实验组）孕妇孕龄、胎龄及妊娠... 详细信息

目的：了解体外受精-胚胎移植（试管婴儿，IVF—ET）获得的双胎妊娠母儿状况与自然受孕双胎妊娠之异同，探讨体外受精双胎对母儿的影响。方法：将1998年9月～2006年6月在我院出生的52例IVF—ET双胎妊娠（实验组）孕妇孕龄、胎龄及妊娠高血压病、妊娠合并糖尿病、早产、产后出血、胎膜早破、新生儿颅内出血、感染、出生缺陷发病率及新生儿体格发育指标与同一时期41例自然受孕双胎妊娠（对照组）进行回顾性分析，比较各相关资料的差异。结果：实验组妊娠期并发症如妊娠高血压病、子宫出血、妊娠合并糖尿病、早产发病率与对照组无显著性差异，实验组胎膜早破的发病率比对照组低，实验组新生儿窒息、颅内出血、高胆红素血症、小于胎龄儿、出生缺陷的发病率与对照组无显著性差异，而实验组新生儿感染的发病率比对照组低。研究还发现，新生儿体格发育指标实验组平均出生体重、头围及胸围明显大于对照组，均有统计学意义。结论：体外受精一胚胎移植双胎妊娠比自然受孕的双胎妊娠没有更大的风险，反而其胎膜早破及新生儿感染的发病率较自然受孕降低。体格发育指标中，实验组试管婴儿平均出生体重、头围、胸围均显著大于自然受孕儿。

关键词：体外受精-胚胎移植双胎妊娠新生儿

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金川铜闪速炉喉口部结焦控制研究与实践

有色金属（冶炼部分） 2015年第9期 48-51页

作者：杨述凯杨贵严杨思文金川集团股份有限公司铜冶炼厂甘肃金昌737100

介绍了金川铜闪速炉喉口部结焦的形成机理,重点介绍了结焦抑制剂的使用、富氧油枪烧嘴处理措施及实施后取得的效果,最终实现喉口部零爆破的目标。

关键词：铜闪速炉喉口部结焦结焦抑制剂油枪烧嘴

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao yang Jia Li Xiaojin Han yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Photoelectrocatalysis Z-scheme C–C coupling Ethanol

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong yang Haochen Shen Xiaoming Xiao Zhichao Li Qi Zhou Wei yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

拉曼高光谱成像系统中光在奶粉层的穿透深度研究

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光谱学与光谱分析 2017年第10期37卷 3103-3107页

作者：刘宸王庆艳黄文倩陈立平杨桂燕王晓彬西北农林科技大学机械与电子工程学院陕西杨凌712100 国家农业智能装备工程技术研究中心北京100097 农业部农业信息技术重点实验室北京100097 农业智能装备技术北京市重点实验室北京100097

拉曼高光谱成像技术不仅可以获取样本的空间分布信息,图像上每个像素点还包括了完整的光谱信息,因其信息量丰富的特点已在食品安全检测方面得到了应用。本研究探索拉曼高光谱成像系统中光在奶粉层中的穿透深度,以及采集参数和奶粉类型... 详细信息

拉曼高光谱成像技术不仅可以获取样本的空间分布信息,图像上每个像素点还包括了完整的光谱信息,因其信息量丰富的特点已在食品安全检测方面得到了应用。本研究探索拉曼高光谱成像系统中光在奶粉层中的穿透深度,以及采集参数和奶粉类型对穿透深度的影响。实验选取均匀奶粉层样品放置于厚度为5mm的三聚氰胺样本之上,检测奶粉层厚度为0.8~4.0mm时的三聚氰胺特征峰强度,以此评估光在奶粉层中的穿透性和信号衰减情况。结果显示当奶粉层厚度一定时,随着激光功率变大,拉曼特征峰值随之增加,此外更长的曝光时间也可以使拉曼信号得到增强。在激光功率不小于2 W且曝光时间不小于500ms时,光在全脂奶粉层的穿透深度可达4mm。奶粉层厚度在0.8~4.0mm范围内,穿透奶粉层的拉曼信号随着奶粉层厚度增加呈指数式衰减。在激光功率为8W、曝光时间为1 000ms的条件下,光在全脂、低脂和脱脂奶粉层的穿透深度均达到了4mm。在相同测量厚度下,通过脱脂奶粉层接收的拉曼信号弱于通过全脂和低脂奶粉层接收的拉曼信号强度。研究结果为拉曼高光谱检测中奶粉样品的前处理提供了有益参考。

关键词：拉曼光谱高光谱成像奶粉穿透深度三聚氰胺

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可持续发展伦理观辨正

甘肃理论学刊 2006年第1期 60-63页

作者：杨颖杨贵言陇东学院甘肃西峰745000 甘肃省委党校甘肃兰州730070

可持续发展问题不单是人与自然关系应当如何的问题,归根结底是一个怎样确立人与社会和谐关系的问题。无疑地,应当对可持续发展伦理观作一番仔细辨正。对于发展中的中国来说,在平等与发展之间,孰轻孰重、孰先孰后,应有符合自己国情的选择... 详细信息

可持续发展问题不单是人与自然关系应当如何的问题,归根结底是一个怎样确立人与社会和谐关系的问题。无疑地,应当对可持续发展伦理观作一番仔细辨正。对于发展中的中国来说,在平等与发展之间,孰轻孰重、孰先孰后,应有符合自己国情的选择,不能离开社会现实而抽象地谈论所谓“人与自然的平等”问题。

关键词：可持续发展伦理观平等发展和谐

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外周静脉留置针不同封管液封管效果的研究

中国初级卫生保健 2007年第1期21卷 82-84页

作者：杨桂燕黑龙江省电力医院黑龙江哈尔滨150036

目的比较外周静脉留置针两种封管液的封管效果,以选择更有效的封管液封管,减少临床上由于封管液选用不当而致堵管情况的发生,避免由于堵管而不得不再次穿刺给患者带来的痛苦。方法将68例患者按随机抽样的方法分为对照组和实验组,每组均3... 详细信息

目的比较外周静脉留置针两种封管液的封管效果,以选择更有效的封管液封管,减少临床上由于封管液选用不当而致堵管情况的发生,避免由于堵管而不得不再次穿刺给患者带来的痛苦。方法将68例患者按随机抽样的方法分为对照组和实验组,每组均34例,对照组用0.9%生理盐水5ml封管,实验组用肝素盐水(50u/ml)5ml封管,两组均采用正压封管方法,进行留置效果比较。结果实验组用肝素盐水(50u/ml)5ml封管,有效率为93.10%,对照组用0.9%生理盐水5ml封管,有效率为64.93%。经统计学处理χ2=20.16,P<0.01两组封管方法有显著性差异,肝素盐水封管优于生理盐水。结论对外周静脉留置针而言,主张用肝素盐水封管。

关键词：静脉留置针封管液封管