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Engineering 2024年第7期38卷 69-76页

作者： Xi Lu Guoqing Li Jing Pang xinyi yang Colette Cywes-Bentley Xuefu You Gerald B.Pier Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

The b-1-6-linked poly-N-acetylglucosamine(PNAG)polymer is a conserved surface polysaccharide produced by many bacteria,fungi,and protozoan(and even filarial)*** wide-ranging expression makes PNAG an attractive target for vaccine development,as it potentially encompasses a broad range of *** progress has been made in discovering important properties of the biology of PNAG expression in recent *** molecular characterization and regulation of operons for the production of PNAG biosynthetic proteins and enzymes have been studied in many *** addition,the physiological function of PNAG has been further ***-based vaccines and PNAG-targeting antibodies have shown great efficacy in preclinical ***,clinical tests for both vaccines and antibodies have been carried out in humans and economically important animals,and the results are *** it is not destined to be a smooth road,we are optimistic about new vaccines and immunotherapeutics targeting PNAG becoming validated and eventually licensed for clinical use against multiple infectious agents.

关键词： Poly-N-acetylglucosamine Conjugate vaccine Monoclonal antibody

Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis

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World Journal of Gastroenterology 2024年第11期30卷 1588-1608页

作者： xing-Nian Zhou Quan Zhang Hong Peng Yu-Jie Qin Yu-Hong Liu Lu Wang Ming-Liang Cheng xin-Hua Luo Hong Li Department of Infectious Diseases The Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Infectious Diseases Guizhou Provincial People's HospitalGuiyang 550001Guizhou ProvinceChina

BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and *** silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and *** To investigate the association between ferroptosis and pyroptosis and the upstream regulatory *** This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce *** D(GSDMD)^(-/-)mice were used as an experimental *** changes in liver tissue were monitored by hematoxylin and eosin ***,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial ***-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain ***1,p53,and GSDMD were assessed by immunofluorescence *** Serum AST and ALT levels were elevated in patients with ***1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver *** the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was *** mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were *** vitro,knockdown of p53 and overexpression of GPX

关键词： Silent information regulator sirtuin 1 Ferroptosis Pyroptosis p53/glutathione peroxidase 4/gasdermin D Acute liver failure

Sandwich-like Heterochromophore Metallo-Supramolecules Based on Dense Chromophore Arrangements with Energy and Chirality Transfer Properties

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CCS Chemistry 2024年第5期6卷 1264-1277页

作者： Ningxu Han Jianjun Ma Hao Yu Junjuan Shi Qixia Bai xin Jiang Zhe Zhang Pingshan Wang Jing Yu Ming Wang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunJilin 130012 Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhouGuangdong 510006 School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798

Multichromophoric architectures with wellorganized chromophoric arrangements are of vital importance to gain insights into interchromophoric ***,we report a novel heteroleptic self-assembly strategy and construct three achiral and one chiral sandwich-like heterochromophore complexes(Zn_(4)L^(G)L^(A-C)_(2)and Zn_(4)L_(G)L^(D)_(2)).Possible dynamic products,including homoleptic oligomers and isomers,are eliminated,producing achiral complexes with exceptional *** are observed in chiral complexes due to the flexible geometry of *** aligned chromophore arrangements with precise spacing and orientations are evidenced by single-crystal X-ray *** distinct segments in the ligands lead to different interchromophoric ***,energy transfer and tunable emission,including white-light emission,are achieved for Zn_(4)L^(G)L^(A)_(2)and Zn_(4)L^(G)L^(B)_(2).In addition,chirality transfer is observed for Zn_(4)L_(G)L^(D)_(2),due to conformational restriction from chiral LD,leading to chiral rotational conformations of tetraphenylethylene moiety in LG.

关键词： heterochromophore complexes fluorescence single crystal dissymmetrical ligands chirality

Effect of alumina occurrence form on metallurgical properties of hematite and magnetite pellets

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Journal of Iron and Steel Research(International) 2024年第4期31卷 797-809页

作者： Jian Pan Chen-mei Tang Cong-cong yang De-qing Zhu Zheng-qi Guo Wei-qun Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Exploration and Development of Geology and Mineral Resources Co. Ltd.Nanchang 330030JiangxiChina

The effect of alumina occurrence form on the metallurgical properties of both hematite and magnetite pellets was investigated at the same Al_(2)O level of 2 wt.%,including reduction index(RI),low-temperature reduction disintegration index(RDI),reduction swelling index(RSI),and high-temperature softening-dripping *** mineralogy of fired pellets was also studied to reveal the influence of alumina occurrence form on the phase composition and *** the results,the alumina occurrence form presents tremendous impacts on the metallurgical perfor-mance of both magnetite and hematite *** of all alumina occurrence forms contributes to inferior reducibility of pellets,especially in the case of gibbsite for magnetite pellets with a RI of 58.4%and kaolinite for hematite pellets with a RI of 56.8%.However,addition of all alumina occurrence forms improves the RDI of magnetite pellets,while there is no significant difference among various alumina occurrence *** contrast,alumina occurrence forms have little influence on the RDI of hematite *** presence of free alumina,gibbsite,and kaolinite tends to improve the RSI of hematite and magnetite pellets,whereas hercynite gives the opposite trend with a RSI of 25.6%.For softening-dripping performance of magnetite pellets,all alumina occurrence forms contribute to narrower softening-melting ***,alumina,gibbsite,and kaolinite give narrower softening-dripping interval,at 229,217,and 88℃,respectively,whereas addition of hercynite results in the largest melting range at 276℃ due to its high melting *** hematite pellets,free alumina,gibbsite,and hercynite tend to enlarge melting range,whereas kaolinite contributes to lower dripping temperature of 1148℃ and narrow softening-dripping interval of 88℃ due to the formation of a greater amount of slag phase at high temperatures.

关键词： Oxidized pellet Magnetite Hematite Alumina occurrence form Metallurgical performance Blast furnace

Estrogen receptor beta suppresses the androgen receptor oncogenic effects in triple-negative breast cancer

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Chinese Medical Journal 2024年第3期137卷 338-349页

作者： Feng Xu Kun Xu Lingling Fan xintong Li Yiqiu Liu Fang yang Chengjun Zhu Xiaoxiang Guan Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Institute of Cancer ResearchNanjingJiangsu 210009China The Comprehensive Cancer Center of Nanjing Drum Tower Hospital Affiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu 210008China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Background:Triple-negative breast cancer(TNBC)is an aggressive type of breast cancer associated with poor prognosis and limited treatment *** androgen receptor(AR)has emerged as a potential therapeutic target for luminal androgen receptor(LAR)***,multiple studies have claimed that anti-androgen therapy for AR-positive TNBC only has limited clinical *** study aimed to investigate the role of AR in TNBC and its detailed ***:Immunohistochemistry and TNBC tissue sections were applied to investigate AR and nectin cell adhesion molecule 4(NECTIN4)expression in TNBC ***,in vitro and in vivo assays were used to explore the function of AR and estrogen receptor beta(ERβ)in *** immunoprecipitation sequencing(ChIP-seq),co-immunoprecipitation(co-IP),molecular docking method,and luciferase reporter assay were performed to identify key molecules that affect the function of ***:Based on the TNBC tissue array analysis,we revealed that ERβand AR were positive in 21.92%(32/146)and 24.66%(36/146)of 146 TNBC samples,respectively,and about 13.70%(20/146)of TNBC patients were ERβpositive and AR *** further demonstrated the pro-tumoral effects of AR on TNBC cells,however,the oncogenic biology was significantly suppressed when ERβtransfection in LAR TNBC cell lines but not in AR-negative ***,we identified that NECTIN4 promoter–42 bp to–28 bp was an AR response element,and that ERβinteracted with AR thus impeding the AR-mediated NECTIN4 transcription which promoted epithelial–mesenchymal transition in tumor ***:This study suggests that ERβfunctions as a suppressor mediating the effect of AR in TNBC prognosis and cell ***,our current research facilitates a better understanding of the role and mechanisms of AR in TNBC carcinogenesis.

关键词： Androgen receptor Estrogen receptor beta Triple-negative breast cancer NECTIN4 Oncogenic effects Tumor progression

Side-Chain-Type Polyimide-Cu Complexes with Suppressed Activation Energy of Relaxation for Advanced High-Temperature Capacitor

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Chinese Journal of Polymer Science 2024年第8期42卷 1038-1048页

作者： Bai-yang Zhou Ze-Tong Ma Shi-Long Zhong Zhen-Jie Huang Qi Guo Deng-Chong Feng Zhong-Ke Yuan Shao-Lin Lu Yu-Zhao yang Cheng Wang Ding-Shan Yu Xu-Dong Chen Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Guangdong Engineering Technology Research Centre for High Performance Organic and Polymer Photoelectric Functional FilmsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Industry Jieyang Centre Jieyang 515200China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515031China

The burgeoning growth of the new energy vehicles and aviation industry has escalated the need for energy storage capacitors capable of stable operation in harsh *** advent of metal-polyimide complexes has illuminated a novel approach for preparing tem perature-resistant ***,the general application of these metal-polyimide com plexes is impeded by the high dielectric loss and low breakdown strength,consequences of main-chain coordination and excessive metal ions ***,our study proposes a novel polyimideCu complex material(POP-Cu)predicated on side-chain-type pyridine-Cu coordination,utilizing the structural backbone PMDA-ODA of mature commercial PI(Kapton)with reliable *** to the high degree of freedom afforded by the side chain with suppressed relaxation activation energy and the long-range electron delocalization formed by d-πcoordination,the dielectric constant of this material containing merely 2.7 mol%Cu increases from 3.25(POPI)to 5.58,while maintaining a remarkably low dielectric loss of ***,this material exhibits a substantial DC breakdown strength of 436.2 MV·m^(-1)and a high energy density of 5.42 J·cm^(-3),coupled with superior mechanical and thermal *** at 150℃,it retains over 90%of its room-temperature energy density,demon strating notable dielectric stability under high *** attributes underscore its promising application for capacitors operating in harsh environments.

关键词： Dielectric performance Polyimide complexes Side-Chain-Type High-temperature capacitor

Hydrodynamic characteristics and particle tracking of 90° lateral intakes at an inclined river slope

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Water Science and Engineering 2024年第2期17卷 197-208页

作者： Wei He Si-yuan Feng Jian Zhang Hong-wu Tang yang Xiao Sheng Chen Chun-sheng Liu College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Collaborative Innovation Center on Water Safety and Water Science Hohai UniversityNanjing 210098China

Lateral intakes are common in *** pump effciency and sediment deposition are determined by the local hydrodynamic characteristics and mainstream division *** hydraulic characteristics of lateral withdrawal from inclined river slopes at different intake elevations should be ***,the division width exhibits significant vertical non-uniformity at an inclined river slope,which should be ***,a three-dimensional(3-D)hydrodynamic and particle-tracking model was developed with the Open Source Field Operation and Manipulation(Open FOAM),and the model was validated with physical model tests for 90°lateral withdrawal from an inclined side *** flow fields,withdrawal sources,and division widths were investigated with different intake bottom elevations,withdrawal discharges,and main channel *** study showed that under inclined side bank conditions,water entered the intake at an oblique angle,causing significant 3-D spiral flows in the intake rather than two-dimensional closed recirculation.A lower withdrawal discharge,a lower bottom elevation of the intake,or a higher main channel velocity could further strengthen this *** average division width and turbulent kinetic energy were smaller under inclined side bank conditions than under vertical bank *** a low intake bottom elevation,a low withdrawal discharge,or a high main channel velocity,the sources of lateral withdrawal were in similar ranges near the local inclined bank in the vertical *** inclined slope conditions,sediment deposition near the intake entrance could be reduced,compared to that under vertical slope *** results provide hydrodynamic and sediment references for engineering designs for natural rivers with inclined terrains.

关键词： Lateral withdrawal Hydrodynamic characteristics Particle tracking Inclined river slope Bottom elevation of intake OpenFOAM

背景·实景·前景:高校辅导员“两双”政策的演化逻辑

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高校辅导员学刊 2024年第2期16卷 7-11,95页

作者：杨长亮王鑫同济大学马克思主义学院上海200092 上海中医药大学党的建设研究中心上海201203

经过70余年的发展,高校辅导员已在制度上建立教师和管理人员的双重身份,形成专技职称和管理职级的双线发展路径。然而,“两双”政策要求辅导员既要完成教学科研,又要做好思政和管理工作,巨大的压力和繁杂的事务性工作削弱了辅导员专技... 详细信息

经过70余年的发展,高校辅导员已在制度上建立教师和管理人员的双重身份,形成专技职称和管理职级的双线发展路径。然而,“两双”政策要求辅导员既要完成教学科研,又要做好思政和管理工作,巨大的压力和繁杂的事务性工作削弱了辅导员专技职称发展的竞争力;现有辅导员管理职级的发展体系则缺乏“规划性”和“可预见性”,辅导员管理晋升具有虚化的态势。“两双”政策的“空转”更多归因于政策本身。高校可探索变革人事管理制度,打破现有的岗位划分类别,设立高校综合育人岗,变身份管理为岗位管理,让辅导员根据专业领域自主选择发展路径,增强辅导员职业发展的学科依托,实现辅导员职业化和专业化的进一步分化,提升辅导员职业效能感。

关键词：高校辅导员 “两双”政策演化

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社交媒体使用对公众疫苗接种行为的影响:社会规范的中介效应研究

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新闻大学 2024年第1期213卷 104-118,123页

作者：张明新袁向玲杨天姿华中科技大学新闻与信息传播学院湖北武汉430074 中国审计报社北京100020

接种疫苗是抵御新冠病毒感染,构筑免疫屏障的重要手段之一。本研究基于对接种过新冠疫苗的公众的问卷调查,分析社交媒体使用对新冠疫苗接种行为的影响,重点考察“我群”和“他群”层面社会规范的中介效应。研究发现,社交媒体使用越多的... 详细信息

接种疫苗是抵御新冠病毒感染,构筑免疫屏障的重要手段之一。本研究基于对接种过新冠疫苗的公众的问卷调查,分析社交媒体使用对新冠疫苗接种行为的影响,重点考察“我群”和“他群”层面社会规范的中介效应。研究发现,社交媒体使用越多的公众,越可能积极接种新冠疫苗,并通过“我群”层面的指令性规范、“他群”层面的描述性规范与指令性规范产生间接影响。通过深入探究社交媒体使用对新冠疫苗接种行为的影响机制,本研究丰富了学界对流行病预防行为的规律性认识。研究还基于中国社会交往的现实结构,通过引入“我群”和“他群”的概念,拓展了对社会规范与公众健康防护行为关系的理解。

关键词：新冠疫苗接种社交媒体使用社会规范 “我群” “他群”

MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment

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Bone Research 2024年第1期12卷 153-164页

作者： Jiakang yang Jing Shuai Lixuen Siow Jingyi Lu Miao Sun Wenyue An Mengfei Yu Baixiang Wang Qianming Chen Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310000China

Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge,as chronic local inflammation can largely impair bone ***,we used magnesium silicate nanospheres(MSNs)to load microRNA-146a-5p(miR-146a)to fabricate a nanobiomaterial,MSN+miR-146a,which showed synergistic promoting effects on the osteogenic differentiation of human dental pulp stem cells(hDPSCs).In addition,miR-146a exhibited an anti-inflammatory effect on mouse bone marrow-derived macrophages(BMMs)under lipopolysaccharide(LPS)stimulation by inhibiting the NF-κB pathway via targeting tumor necrosis factor receptor-associated factor 6(TRAF6),and MSNs could simultaneously promote M2 polarization of ***-146a was also found to inhibit osteoclast ***,the dual osteogenic-promoting and immunoregulatory effects of MSN+miR-146a were further validated in a stimulated infected mouse mandibular bone defect model via delivery by a photocuring ***,the MSN+miR-146a complex revealed good potential in treating inflammatory irregular oralmaxillofacial bone defects.

关键词： inflammatory healing stimulation