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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia chen Xin-Ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Relationship Between Leaf C/N Ratio and Insecticidal Protein Expression in Bt Cotton as Affected by High Temperature and N Rate

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Journal of Integrative Agriculture 2014年第1期13卷 82-88页

作者： ZHANG Xiang LU Chun-hua chen Yuan WANG gui-xia chen Yuan chen De-hua Jiangsu Provincial Key Laboratory of Crops Genetics and Physiology Yangzhou University Yangzhou 225009 P.R.China Department of Soil and Crop Sciences Texas A&M University College Station 77843 USA

Expression of insecticidal protein for transgenic Bacillus thuringiensis （Bt） cotton is unstable and related to nitrogen metabolism. The objective of this study was to investigate the relationship between leaf carbon nitrogen ratio （C/N） and insecticidal efficacy of two Bt cotton cultivars. C/N ratio and Bt protein content were both measured at peak square period and peak boll period respectively under 5-7 d high temperature and different nitrogen fertilizer rates on the Yangzhou University Farm and the Ludong Cotton Farm, China. All plants were grown in field. The results showed that the C/N ratio enhanced slightly and the Bt protein content remained stable at peak square period, but significant increases for the C/N ratio and decreases markedly for the leaf Bt protein concentration were detected at the peak boll period. The similar patterns at the two growth periods were found for the leaf C/N ratio and Bt protein content by different N fertilizer treatments. When nitrogen rate was from 0 to 600 kg ha-l, the C/N ratio was reduced by 0.017 and 0.006 for Sikang 1 and Sikang 3 at peak square period, compared to the 1.350 to 1.143 reduction for Sikang 1 and Sikang 3 at peak boll period, respectively. Correspondingly, the leaf Bt protein contents were bolstered by 2.6-11.8 and 26.9-36.9% at the two different growth periods, respectively. The results suggested that enhanced C/N ratio by high temperature and nitrogen application may result in the reduction of inseetiocidal efficacy in Bt cotton, especially in peak boll period.

关键词： Bt cotton C/N ratio Bt protein insecticidal efficacy

肿瘤干细胞表面标志物CD133在肝细胞肝癌组织中的表达及其与肝移植患者预后的关系

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中华肝脏外科手术学电子杂志 2012年第1期1卷 48-52页

作者：曾宪成张彤傅斌生陈伟陈冠中李华张琪杨扬陈规划中山大学器官移植研究所中山大学附属第三医院肝移植中心广州511300 广东省增城市人民医院(中山大学附属博济医院)普通外科浙江大学医学院附属第二医院普通外科

目的探讨肿瘤干细胞表面标志物分化群抗原（CD）133在肝细胞肝癌（肝癌）组织中的表达及其与肝移植患者预后的关系。方法本回顾性研究的109例肝癌组织标本来源于2004年1月至2007年12月在中山大学附属第三医院肝移植中心施行同种异体原... 详细信息

目的探讨肿瘤干细胞表面标志物分化群抗原（CD）133在肝细胞肝癌（肝癌）组织中的表达及其与肝移植患者预后的关系。方法本回顾性研究的109例肝癌组织标本来源于2004年1月至2007年12月在中山大学附属第三医院肝移植中心施行同种异体原位肝移植，组织病理学检查证实为肝癌的手术切除标本，另取41例肝穿刺正常肝组织作为正常对照。收集109例肝癌患者的临床病理学资料，并对其进行术后随访，收集患者存活时间，肿瘤复发、转移及死亡情况的随访资料。所有患者均签署知情同意书，符合医学伦理学规定。应用免疫组织化学方法检测109例肝癌组织和41例正常肝组织中CD133的表达水平，分析CD133阳性表达与患者年龄、性别、甲胎蛋白（AFP）、外周血中性粒细胞与淋巴细胞比值（NLR）、肿瘤直径、肿瘤数量、分化程度、血管侵犯等肝癌临床病理学参数的关系。应用Kaplan—Meier法计算患者移植后存活率，应用Log—rank检验比较各参数对存活率的影响。结果全组肝癌患者均接受随访，随访时间6～77个月。随访期间肿瘤复发37例，复发部位分别为肝内24例、肺部6例、腹腔3例、全身多发性转移或骨转移4例。随访期间死亡40例，分别死于肿瘤复发35例、胆道并发症3例、肺部感染和急性粒细胞白血病各1例。肝癌组织中CD133阳性表达44例，阳性率为40．4％，正常肝组织无CD133表达，比较差异有学意义（P〈0．01）。CD133阳性表达与肿瘤直径、肿瘤分化程度有关（均为P〈0．05）。CD133阳性组患者肝移植的1、3、5年存活率明显低于CD133阴性组患者（χ2=8．008，P〈0．05）。结论肝癌组织存在CD133表达，CD133阳性表达的肝癌肝移植患者预后较差。

关键词：肝细胞肝癌肝移植分化群抗原133 干细胞表面标志物预后肿瘤复发

Void Closure Behavior in Large Diameter Steel Rod during H-V Rolling Process

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Journal of Iron and Steel Research International 2014年第3期21卷 287-294页

作者： hua-gui huaNG Yong LIU Feng-shan DU Lei chen National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University

In order to reveal the mechanism and condition of void closure in large diameter steel rod during horizontal- vertical （H-V） groove rolling process, a three-dimensional thermomechanicaily coupled finite element model was es- tablished for 9-stand H-V groove rolling process aiming at a 4150 mm steel rod production line. A spherical hole with diameter from 2 to 10 mm was preset into the center of continuous casting billet with a rectangle cross section of 300 mmX 360 mm in this model to simulate the void defect, and then finite element analyses were carried out to observe and quantify the void shape evolution in each pass on the three orthogonal coordinate plane sections. The re- suits showed that the void was formed roughly in the reduction and extension directions, and crushed gradually from spherical shape to an approximate ellipsoid, micro-crack and finally to be closed. A quantitative analysis was carried out by using elliptic radii and closure ratio to describe this evolution process; it indicated that the longest axis of the ellipsoid coincided with the rolling line, and the second and third axes were alternatively ihorizontal and vertical on the exit cross section according to change of the reduction direction in H-V groove. The void closure behavior during H- V rolling was more complicated than that of common horizontal rolling, and the influence of groove type and the ex- tension coefficient on the void closure ratio was presented. Finally, a pilot rolling experiment was performed on a 5- stand H-V experimental mill to verify the numerical simulation results, and the experimental results are in good agree- ment with the numerical simulation results.

关键词： large diameter steel rod continuous casting billet H-V groove rolling~ void closure FEM

紫杉醇在大鼠原位肝移植中的作用及其对细胞毒性T淋巴细胞实验的影响

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中华普通外科学文献（电子版） 2010年第4期4卷 19-21页

作者：郭卫平卫洪波李玺陈图峰汪根树陈规划中山大学附属第三医院普通外科广州510630

目的观察紫杉醇在大鼠原位肝移植中的作用及其对细胞毒性T淋巴细胞(CTL)的影响。方法建立Wistar→SD大鼠肝移植的急性排斥模型。将大鼠分为对照组(阻断全肝血流)、急排组(Wistar→SD肝移植)、紫杉醇组(Wistar→SD肝移植,紫杉醇腹腔注射0... 详细信息

目的观察紫杉醇在大鼠原位肝移植中的作用及其对细胞毒性T淋巴细胞(CTL)的影响。方法建立Wistar→SD大鼠肝移植的急性排斥模型。将大鼠分为对照组(阻断全肝血流)、急排组(Wistar→SD肝移植)、紫杉醇组(Wistar→SD肝移植,紫杉醇腹腔注射0.75mg·kg-1·d-1,观察生存时间、病理改变、生化指标及CTL、T淋巴细胞凋亡情况。结果紫杉醇组大鼠的术后存活时间高于急排组,[(18.2±1.5)dvs(8.8±1.9)d,P<0.01)。急排组的HE评分(Banff)高于紫杉醇组(7.80±0.83vs4.80±0.82,P<0.01)。紫杉醇组的白蛋白水平高于急排组(P=0.003);紫杉醇组的谷丙转氨酶水平低于急排组(t=25.23,P<0.01)。CTL检测中,急排组的特异性杀伤靶细胞的百分率均高于紫杉醇组(P<0.01)。急排组的T淋巴细胞的凋亡率低于紫杉醇组[(7.16±1.56)%vs(16.47±2.51)%,P<0.01]。结论紫杉醇在大鼠肝移植中具有免疫抑制作用,可能通过诱导T淋巴细胞凋亡来抑制T淋巴细胞的活化发挥作用。

关键词：紫杉醇大鼠肝移植毒性细胞T淋巴细胞试验

Preserving global features of fluid animation from a single image using video examples

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第7期13卷 510-519页

作者： Yan gui Li-zhuang MA Chao YIN Zhi-hua chen School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Computer Science and Engineering East China University of Science and TechnologyShanghai 200237China

We synthesize animations from a single image by transferring fluid motion of a video example *** a target image of a fluid scene,an alpha matte is required to extract the fluid *** method needs to adjust a user-specified video example for producing the fluid motion suitable for the extracted fluid *** the fluid video database,the flow field of the target image is obtained by warping the optical flow of a video frame that has a visually similar scene to the target image according to their scene correspondences,which assigns fluid orientation and speed *** show that our method is successful in preserving large fluid features in the synthesized *** comparison to existing approaches,it is both possible and useful to utilize our method to create flow animations with higher quality.

关键词： Single image Video example Fluid feature Fluid motion Flow animation

略论新时代高校网络意识形态安全的风险挑战与应对策略

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湖北科技学院学报 2025年第1期45卷 73-79页

作者：田贵华沈思雨武汉大学马克思主义学院湖北武汉430072

高校意识形态安全作为国家安全的重要方面,对培养社会主义事业合格建设者和可靠接班人,确保高校坚持社会主义办学方向尤为重要。新时代高校网络意识形态安全面临着西方敌对势力渗透、错误社会思潮干扰、信息传播圈层化阻隔等诸多挑战。... 详细信息

高校意识形态安全作为国家安全的重要方面,对培养社会主义事业合格建设者和可靠接班人,确保高校坚持社会主义办学方向尤为重要。新时代高校网络意识形态安全面临着西方敌对势力渗透、错误社会思潮干扰、信息传播圈层化阻隔等诸多挑战。为有效应对这些风险挑战,高校亟需强化价值引领,提高抵御风险能力;建强工作队伍,构建协同育人格局;加强网络管理,营造清朗网络环境;创新方式方法,提升青年网络安全素养。

关键词：新时代高校网络意识形态安全挑战对策

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Analysis of longitude profiled rolling process of Cu/Al cladded sheet and evaluation of outlet warpage

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Journal of Iron and Steel Research International 2022年第6期29卷 973-982页

作者： Jing-na Sun Chi chen Shuo Wang Guan-nan Liu hua-gui huang National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina Xinxiang Aviation Industry(Group)Co. Ltd.Xinxiang 453000HenanChina Harbin Dongan Engine Co. Ltd.Harbin 150060HeilongjiangChina

Longitude profiled cladded sheet is obtained by rolling bimetal cladded sheet with variable gauge rolling *** longitude profiled rolling process of Cu/Al cladded sheets was studied by finite element method and *** rolling force rises with the increase in reduction,and a sudden change appears at the end of the thickness variation *** thickness ratio of copper layer is enlarged after rolling owing to its relatively large deformation resistance and continues to rise with the increase in reduction *** elongation of copper side leads to the warpage of exit metal to copper side,which further hinders the deformation of *** influence of asymmetric rolling parameters indicates that increasing the work roll diameter ratio,speed radio,and friction coefficient on Al side can reduce the warpage when the reduction rate is below a certain value depending on the thickness ratio and other rolling *** of experiments and simulation results showed good agreement and verified the finite element model.

关键词： Longitude profiled rolling Cladded sheet Rolling force Layer thickness ratio Outlet warpage Asymmetric rolling

Effect of hot rolling and cooling process on microstructure and properties of 2205/Q235 clad plate

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Journal of Iron and Steel Research International 2018年第11期25卷 1113-1122页

作者： Meng Yan Jing-na Sun hua-gui huang Lei chen Ke Dong Zhen-ye chen National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University Qinhuangdao 066004HebeiChina China National Heavy Machinery Research Institute Co. Ltd.Xi'an 710032ShaanxiChina HBIS GROUP Central Iron and Steel Research Institute Shijiazhuang 050023HebeiChina

The 2205/Q235 clad plate was fabricated by vacuum hot rolling with symmetrical assembling pattern of Q235/2205/2205/ *** flow stress behavior and processing map of 2205 duplex stainless steel (DSS)were investigated by hot compressive tests on a Gleeble-3800 ***,thermal-mechanical coupled nonlinear finite element models of vacuum hot rolling and subsequent cooling process were *** the simulation results,the influence of rolling reduction and rolling speed on hot deformation state of 2205 DSS in the assembled slab was disclosed and the optimal rolling parameters were ***,the cooling rate of 2205 DSS under different cooling conditions and thicknesses of the clad plate was *** to the numerical simulation results,pilot experiments were successfully carried out on a laboratory *** material universal testing machine,optical microscope,scanning electron microscope and energy-dispersive spectrometer were used to evaluate the mechanical properties and microstructure of bonding interface and 2205 DSS matrix for different rolling reduction and cooling *** results showed that with symmetrical assembling pattern,the approximate thermodynamic conditions can be established for 2205 DSS to avoid cracks in hot rolling *** the rolling reduction increased from 10 to 40%,the shear strength of the bonding interface is increased from 120 to 530 MPa,and the uniform two-phase microstructure of 2205 DSS and satisfactory' mechanical properties can be obtained with cooling rate higher than 10℃/s between 1050 and 500℃ after rolling.

关键词： 2205/Q235 clad plate 2205 duplex stainless steel Vacuum hot rolling Finite element method Bonding interface Dual-phase scale