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High-Tech Acupuncture for Prevention of Lifestyle Diseases--A Sino-Austrian Cooperation Research Protocol on Heart Rate Variability

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Chinese Journal of Integrative Medicine 2018年第6期24卷 423-428页

作者： LIANG Feng-xia chen Ze-bin WU Song LIU Jian-min WANG Jing-zhi LU Ji-dong WANG Lu-shan chen Li SHU Qing Daniela Litscher WANG Lu WANG hua Gerhard Litscher College of Acupuncture and Orthopaedics Hubei University of Chinese Medicine Wuhan 430061 China Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture & Moxibustion Wuhan 430061 China Traditional Chinese Medicine Research Center Graz Research Unit for Complementary and Integrative Laser Medicine Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine Medical University of Graz Graz 8036 Austria

Background： Acupuncture can not only be used for well-known diseases, but also for so-called modern lifestyle-related diseases. Using innovative methods like e.g. new analyses of heart rate variability （HRV）, it is also possible to investigate diseases like burnout syndrome, ie., qi deficiency in Chinese medicine （CM）. Objective： The main object of this research protocol is to perform research on the relationship of burnout syndrome and heart rate （HR） and HRV. Methods： A total of 175 patients with burnout syndrome （qi deficiency syndrome） in five groups and 35 healthy volunteers will be investigated. Based on random numbers generated by computer and concealed in opaque envelops, the patients will be assigned to four acupuncture groups using Zusanli （ST 36） acupuncture stimulation, Guanyuan （CV4） acupuncture stimulation, both points, and both points with Streitberger device respectively, and a moxibustion group using both points mentioned above, with 35 cases in each group. Altogether four different experiments are planned. Experiment 1 includes 70 subjects and is a comparison between a burnout group and a control group （healthy volunteers）. The evaluation parameters are different scores and indices of HR and HRV. Experiment 2 includes 140 subjects and compares the efficacy of different acupuncture points. In experiment 3 （105 subjects）, acupuncture and moxibustion should be compared to healthy volunteers. Experiment 4 （70 subjects） investigates the long-term therapeutic effects of acupuncture and moxibustion on the scores of qi deficiency and HR/HRV in qi deficiency patients. In both the acupuncture and moxibustion groups, a total of 10 treatments will be performed. Conclusions： The joint research aims at the scientific evaluation of CM, mainly in the field of HRV. This parameter could be a very good indicator of the state of health and can be influenced by different acupuncture methods, as shown in the past.

关键词： heart rate variability burnout syndrome qi deficiency acupuncture moxibustion

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Inhibition of chemokine-like factor 1 improves bloodbrain barrier dysfunction in rats following focal cerebral ischemia

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中国药理学与毒理学杂志 2016年第10期30卷 1024-1025页

作者： KONG Ling-lei HU Jin-feng YUAN Yu-he chen Nai-hong DU Guan-hua State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

OBJECTIVE To investigate the role of chemokine-like factor 1(CKLF1),a novel C-C chemokine,on brain-blood barrier(BBB)integrity in rat focal cerebral ischemia and reperfusion *** Antibodies against CKLF1 was applied to the rightcerebral ventricle immediately after transient middle cerebral artery *** water content,Evans blue leakage and the expression of aquaporin-4(AQP-4),matrix metalloproteinase-9(MMP-9),zonula occludens-1(ZO-1)and occludin were *** After treatment with antiCKLF1 antibody,brain water content and Evans blue leakage in ipsilateral hemisphere were decreased in a dose-dependent manner at 24 h after reperfusion,but not changed in contralateral ***-CKLF1 antibody reduced the expression of AQP-4 and MMP-9,and upregulated the expression of ZO-1 and *** results suggest that CKLF1 is involved in BBB disruption after *** Inhibition of CKLF1 protects against cerebral ischemia by maintaining BBB integrity,possibly via inhibiting the expression of AQP-4 and MMP-9,and increasing the expression of tight junction protein.

关键词： chemokine-like factor 1 cerebral ischemia brain-blood barrier

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New Geiger-Nuttall law for two-proton radioactivity

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Chinese Physics C 2021年第2期45卷 487-492页

作者： Hong-Ming Liu You-Tian Zou Xiao Pan Jiu-Long chen Biao He Xiao-hua Li School of Nuclear Science and Technology University of South ChinaHengyang 421001China College of Physics and Electronics Central South UniversityChangsha 410083China Cooperative Innovation Center for Nuclear Fuel Cycle Technology&Equipment University of South ChinaHengyang 421001China Key Laboratory of Low Dimensional Quantum Structures and Quantum Control Hunan Normal UniversityChangsha 410081China

In the present work,a two-parameter empirical formula is proposed,based on the Geiger-Nuttall law,to study two-proton( 2p )*** this formula,the calculated 2p radioactivity half-lives are in good agreement with the experimental data as well as with calculated results obtained by Goncalves et al.[***.B 774,14(2017)]using the effective liquid drop model(ELDM),Sreeja et al.[***.J.A 55,33(2019)]using a four-parameter empirical formula,and Cui et al.[***.C 101:014301(2020)]using a generalized liquid drop model(GLDM).In addition,this two-parameter empirical formula is extended to predict the half-lives of 22 possible 2p radioactivity candidates with 2p radioactivity released energy Q_(2p)>0 ,obtained from the latest evaluated atomic mass table *** predicted results are highly consistent with those obtained using other theoretical models such as the ELDM,GLDM and four-parameter empirical formula.

关键词： two-proton radioactivity Geiger-Nuttall law empirical formula

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汶川地震小鱼洞地区的地表破裂和同震位移及其机制讨论

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地震地质 2013年第2期35卷 247-260页

作者：谭锡斌袁仁茂徐锡伟陈桂华张中白中国地震局地质研究所活动构造与火山重点实验室北京100029 中央大学空间遥感研究中心桃园32001

2008年5月12日在四川西部发生的汶川地震是一次以逆冲运动为主,兼有右旋走滑运动的斜滑型地震,形成了有史以来最长、最复杂的地表破裂之一。其中,很多复杂现象到目前为止还没有得到很好的解释或一致的认识,如小鱼洞地区出现的NW走向的... 详细信息

2008年5月12日在四川西部发生的汶川地震是一次以逆冲运动为主,兼有右旋走滑运动的斜滑型地震,形成了有史以来最长、最复杂的地表破裂之一。其中,很多复杂现象到目前为止还没有得到很好的解释或一致的认识,如小鱼洞地区出现的NW走向的小鱼洞断裂,在小鱼洞以北出现的2条相距11km的平行断裂同时破裂的现象等。通过在小鱼洞地区的详细野外调查,获得了详细的地表破裂分布及同震位移分布,在此基础上对小鱼洞地区地表破裂的机制进行了分析。结果表明,造成上述复杂地表破裂的根本原因是汶川地震的主断层北川-映秀断裂的产状变化,即北川-映秀断裂在小鱼洞以北向NW偏移约3.5km。其破裂机制是:1)北川-映秀断裂的右旋走滑运动在小鱼洞西侧的左阶挤压阶区引起的挤压隆升形成前冲断层,即小鱼洞断裂;2)由于北川-映秀断裂在小鱼洞以北向NW偏移3.5km,导致其断层面倾角变大,逆冲运动引起的断层上盘对下盘的挤压方向变化,结合右旋走滑引起的上盘对下盘的侧向推挤,两者共同作用突破了彭灌断裂,从而形成了2条相距11km的平行断裂同时错动的现象。另外,文中建议应该重视北川-映秀断裂右旋走滑运动分量、断层产状变化以及断层上、下盘的岩性差异对汶川地震地表破裂过程及地表破裂分布的影响。

关键词：汶川地震同震地表破裂挤压阶区小鱼洞断裂龙门山

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Correction of distorted X-ray absorption spectra collected with capillary sample cell

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Nuclear Science and Techniques 2023年第7期34卷 179-188页

作者： Hao Wang Yue-cheng Lai Jia-Jun Zhong Yun-Peng Liu Lei Yao Li-Xiong Qian Xue-Qing Xing Zhong-Jun chen Guang Mo Zhong-hua Wu Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China

In certain exceptional cases,capillary samples must be used to measure X-ray absorption spectra(XAS).However,the inho-mogeneous thickness of capillary samples causes XAS *** study discusses the distortion and correction of the XAS curve caused by the inhomogeneous thickness of capillary *** relationship between the distorted XAS curveμ′d_(eq)(measured values)and the real absorption coefficientμ_(s)d_(eq)(true values)of the sample was *** distortion was slight and negligible when the vertical size(2h)of the X-ray beam spot was smaller than 60%of the capillary tube’s inner diameter(2R_(in)).When h/R_(in)>1,X-ray leakage is inevitable and should be avoided during *** X-ray leakage caused by an X-ray beam spot size larger than the inner diameter of the capillary tube leads to serious compressed distortion of the XAS *** h/R_(in)<1,the distorted XAS data were well *** errors and their influence on the corrected XAS are also *** and corrections for distortions verify the feasibility and effectiveness of the corrected method.

关键词： XAS Capillary Compression distortion Correction Python

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Synthesis and Crystal Structure of a New Mononuclear Cadmium(Ⅱ) Cryptate Derived from the Condensation of Tri(2-aminoethyl)amine with Glyoxal

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1276-1280页

作者： chen hua XU Xing-You GAO Jian YANG Xu-Jie LU Lu-De WANG Xin Materials Chemistry Laboratory Nanjing Universityof Science and Technology Nanjing 210094 China Department of Chemical Engineering Huahai Institute of Technology Lianyungang 222005 China

A new mononuclear cadmium（Ⅱ） cryptate has been synthesized by [2＋3] Schiff base condensation of tri（2-aminoethyl）amine with glyoxal in the presence of Cd（ClO4）2·6H2O. The crystal structure, spectral characterization and molar conductivity show that cadmium（Ⅱ） is sixcoordinated （N6） into a distorted octahedral geometry.

关键词： mononuclear cadmium cryptate synthesis crystal structure

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锐钛型二氧化钛/水悬浮体的流变性研究

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无机材料学报 2000年第3期15卷 431-436页

作者：杨化桂高丕英古宏晨方图南华东理工大学技术化学物理研究所上海200237

本文用流变学的方法在Brabender流变仪上研究了不同因素对二氧化钛悬浮体流变性的影响．在同一体积分率下，与粒度分布宽的颗粒形成的悬浮体相比，粒度分布窄的颗粒形成的悬浮体其屈服应力和稳态剪切粘度较大；在二氧化钛体积分率很小... 详细信息

本文用流变学的方法在Brabender流变仪上研究了不同因素对二氧化钛悬浮体流变性的影响．在同一体积分率下，与粒度分布宽的颗粒形成的悬浮体相比，粒度分布窄的颗粒形成的悬浮体其屈服应力和稳态剪切粘度较大；在二氧化钛体积分率很小时，悬浮体呈牛顿性；当体积分率大于一定值时，悬浮体具有零剪切粘度和剪切稀化特征；当其大于一临界值时，存在屈服应力并有强烈的剪切稀化行为．悬浮体粘度服从广义Quemada流变方程．在温度＜40℃时，温度升高使粘度和屈服应力降低；在温度＞40℃时，温度升高，屈服应力升高，而粘度在不同的剪切速率范围内有复杂的行为，这可用分散介质中颗粒的碰撞理论来解释．

关键词：二氧化钛剪切粘度粒度悬浮体流变性锐钛型

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Preclinical evaluation of ZL006-05,a new antistroke drug with fast-onset antidepressant and anxiolytic effects

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Stroke & Vascular Neurology 2023年第6期8卷 463-474页

作者： Haiyin Wu Zhenquan huang Xuan Wang Mingyu chen Wei chen Yao hua Jian Ren Luyao Shen Yixuan Song Ying Zhou Chunxia Luo Yuhui Lin Yilong Wang Lei Chang Fei Li Dongya Zhu Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjingJiangsuChina Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjingChina NeuroDawn Pharmaceutical Co. LtdNanjingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background Poststroke depression and anxiety,independent predictor of poor functional outcomes,are common in the acute phase of *** to now,there is no fast-onset antidepressive and anxiolytic agents suitable for the management of acute ***006-05,a dual-target analgesic we developed,dissociates nitric oxide synthase from postsynaptic density-95 while potentiatesα2-containingγ-aminobutyric acid type A *** study aims to determine whether ZL006-05 can be used as an antistroke agent with fast-onset antidepressant and anxiolytic *** Photothrombotic stroke and transient middle cerebral artery occlusion were induced in rats and *** size was measured by TTC(2,3,5-Triphenyltetrazolium chloride)staining or Nissl *** defects were assessed by four-point scale neurological score or modified Neurological Severity ***-walking,cylinder and modified adhesive removal tasks were conducted to assess sensorimotor *** learning was assessed using Morris water maze *** and anxiety were induced by unpredictable chronic mild *** behaviours were assessed by tail suspension,forced swim and sucrose preference *** behaviours were assessed by novelty-suppressed feeding and elevated plus maze ***,toxicokinetics and long-term toxicity studies were performed in *** Administration of ZL006-05 in the acute phase of stroke attenuated transient and permanent ischaemic injury and ameliorated long-term functional impairments significantly,with a treatment window of 12 hours after ischemia,and reduced plasminogen activato-induced haemorrhagic ***006-05 produced fast-onset antidepressant and anxiolytic effects with onset latency of 1 hour in the normal and CMS mice,had antidepressant and anxiolytic effects in stroke ***006-05 crossed the blood-brain barrier and distributed into the brain rapidly,and had a high safety profile in toxicokinetics and

关键词： elevated transient kinetics

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Susceptible time window and endurable duration of cotton fiber development to high temperature stress

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Journal of Integrative Agriculture 2017年第9期16卷 1936-1945页

作者： XU Bo ZHOU Zhi-guo GUO Lin-tao XU Wen-zheng ZHAO Wen-qin chen Bing-lin MENG Ya-li WANG You-hua College of Agronomy Nanjing Agricultural UniversityNanjing 210095P.R.China Modern Crop Production Collaborative Innovation Center of Jiangsu Province Nanjing 210095P.R.China

The development of the cotton fiber is very sensitive to temperature variation, and high temperature stress often causes reduced fiber yield and fiber quality. Short-term high temperature stress often occurs during cotton production, but little is known about the specific timing and duration of stress that affects fiber development. To make this clear, pot experiments were carried in 2014 and 2015 in a climate chamber using cotton cultivars HY370WR（less sensitive variety） and Sumian 15（heat sensitive variety）, which present different temperature sensitivities. Changes of the most important fiber quality indices（i.e., fiber length, fiber strength and marcironaire） and three very important fiber development components（i.e., cellulose, sucrose and callose） were analyzed to define the time window and critical duration to the high temperature stress at 34°C（max38°C/min30°C）. When developing bolls were subjected to 5 days of high temperature stress at different days post-anthesis（DPA）, the changes（Δ%） of fiber length, strength and micronire, as a function of imposed time followed square polynomial eq. as y=a＋bx＋cx^2, and the time around 15 DPA was the most sensitive period for fiber quality development in response to heat stress. When 15 DPA bolls were heat-stressed for different durations（2, 3, 4, 5, 6, 7 days）, the changes（Δ%） of fiber length, strength and micronire, as a function of stress duration followed logistic equations y=A_1-A_2/1＋（x/x_0）~p＋A_2. Referred to that 5, 10 and 15% are usually used as criteria to decide whether techniques are effective or changes are significant in crop culture practice and reguard to the fiber quality indices change range, we suggested that 5% changes of the major fiber quality indices（fiber length, fiber strength and micronaire） and 10% changes of fiber development components（cellulose, sucrose and callose） could be taken as criteria to judge whether fiber development and fiber quality have been significantly affected by high temper

关键词： cotton(Gossypium hirsutum L.) fiber quality high temperature stress susceptible time window stress endurable duration

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关于我国2010年人口普查事后质量检查样本量测算的建议

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数理统计与管理 2008年第6期27卷 992-996页

作者：胡桂华广西财经学院数学与统计系广西南宁530003

同以往历次进行的人口普查一样,我国在2010年第六次人口普查后也将进行事后质量检查。样本量估计是抽取事后质量检查样本之前必须要做的一项工作。本人建议,用2000年人口普查事后质量检查样本资料估计其抽样方案的设计效应,然后用这个... 详细信息

同以往历次进行的人口普查一样,我国在2010年第六次人口普查后也将进行事后质量检查。样本量估计是抽取事后质量检查样本之前必须要做的一项工作。本人建议,用2000年人口普查事后质量检查样本资料估计其抽样方案的设计效应,然后用这个设计效应估计2010年在既定精度要求下所需要的样本量。

关键词：人口普查事后质量检查抽样调查设计效应样本量估计

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