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Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery

World Journal of Gastrointestinal Oncology 2019年第6期11卷 499-508页

作者： Guang-Chuan Mu Yuan huang Zhi-Ming Liu Zhi-Bai chen Xiang-hua Wu Xin-Gan Qin Yan-Jun Zeng Department of Gastrointestinal Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of General Surgery the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Biomechanics and Medical Information Institute Beijing University of TechnologyBeijing 100124China

BACKGROUND Radical D2 lymphadenectomy for advanced gastric cancer as a standard procedure has gained global consensus. Mounting studies have shown that the number of lymph nodes dissection directly affects the prognosis and recurrence of gastric cancer. Our previous study showed that there was no obvious lymph node around the abnormal hepatic artery derived from the superior mesenteric artery. AIM To investigate the relationship between celiac artery variation and the number of lymph nodes dissection in gastric cancer surgery. METHODS The clinicopathological data of 421 patients treated with radical D2 lymphadenectomy were analyzed retrospectively. The difference of the number of lymph nodes dissection between the celiac artery variation group and the normal vessels group and the relationship with prognosis were analyzed. RESULTS Celiac artery variation was found in 110 patients, with a variation rate of 26.13%. Celiac artery variation, tumor staging, and Borrmann typing were factors that affected lymph node clearance in gastric cancer, and the number of lymph nodes dissection in patients with celiac artery variation was significantly less than that of non-variant groups (P 0.05). Univariate and multiple Cox regression analysis showed that celiac artery variation was not a prognostic factor for gastric cancer (P > 0.05). Tumor staging, intraoperative bleeding, and positive lymph node ratio were prognostic factors for gastric cancer patients (all P < 0.05). CONCLUSION The number of lymph nodes dissection in patients with celiac artery variation was reduced, but there was no obvious effect on prognosis. Therefore, lymph nodes around the abnormal hepatic artery may not need to be dissected in radical D2 lymphadenectomy.

关键词： Gastric cancer Celiac artery variation Lymphadenectomy Number of lymph nodes Prognosis

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单箱多室波形钢腹板PC组合梁桥动力特性试验研究

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振动与冲击 2017年第12期36卷 122-127页

作者：陈水生张超桂水荣华东交通大学土木建筑学院南昌330013

为了研究单箱多室波形钢腹板PC组合梁桥动力特性,参照南昌市朝阳大桥非通航孔桥,制作了三跨单箱两室PC连续波形钢腹板试验梁,并对模型桥和实桥进行动力测试。分别利用自互功率谱法和传递率法对动力特性进行分析,识别了试验梁前四阶模态... 详细信息

为了研究单箱多室波形钢腹板PC组合梁桥动力特性,参照南昌市朝阳大桥非通航孔桥,制作了三跨单箱两室PC连续波形钢腹板试验梁,并对模型桥和实桥进行动力测试。分别利用自互功率谱法和传递率法对动力特性进行分析,识别了试验梁前四阶模态参数和实桥前七阶模态参数;同时利用ANSYS程序建立实桥和模型桥的有限元分析模型,并进行动力特性分析;研究结果表明,除因实桥两幅之间横向工字钢连接,导致实桥理论和实测扭转1阶频率相差较大外,实桥各阶理论与实测频率相差较小,振型一致;试验梁低阶频率理论值与实测值能较好吻合。研究设计制作的波形钢腹板缩尺试验梁及测试结果正确,试验梁能较好体现实桥动力特性;传递率法可较好识别该类桥梁结构的模态参数。

关键词：波形钢腹板单箱多室模型实验动力特性模态分析

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论马克思恩格斯的科技异化思想

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科学技术与辩证法 2005年第6期22卷 18-21页

作者：李桂花吉林大学马克思主义学院吉林长春130012

马克思、恩格斯的科技异化思想是马克思主义的一个重要组成部分,具有十分丰富的理论内涵。马克思、恩格斯不仅探讨了科技异化的表现形式,分析了科技异化的根源,还揭示了科技异化的本质,阐明了科技异化的解决途径。深入挖掘和阐述马克思... 详细信息

马克思、恩格斯的科技异化思想是马克思主义的一个重要组成部分,具有十分丰富的理论内涵。马克思、恩格斯不仅探讨了科技异化的表现形式,分析了科技异化的根源,还揭示了科技异化的本质,阐明了科技异化的解决途径。深入挖掘和阐述马克思、恩格斯的科技异化思想,对于今天社会的发展与进步将具有特别重大的理论意义与现实意义。

关键词：马克思恩格斯科技异化思想

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An O(rL)Infeasible Interior-point Algorithm for Symmetric Cone LCP via CHKS Function

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Acta Mathematicae Applicatae Sinica 2009年第4期25卷 593-606页

作者： Zi-yan Luo Nai-hua Xiu Department of Mathematics School of Science Beijing Jiaotong University Beijing 100044 China Department of Mathematics School of Science Beijing Jiaotong University Key Laboratory of Communication and Information System (Beijing Jiaotong University) Beijing Municipal Commission of Education Beijing 100044 China

In this paper, we propose a theoretical framework of an infeasible interior-point algorithm for solving monotone linear cornplementarity problems over symmetric cones （SCLCP）. The new algorithm gets Newton-like directions from the chen-Harker-Kanzow-Smale （CHKS） smoothing equation of the SCLCP. It possesses the following features： The starting point is easily chosen; one approximate Newton step is computed and accepted at each iteration; the iterative point with unit stepsize automatically remains in the neighborhood of central path; the iterative sequence is bounded and possesses （9（rL） polynomial-time complexity under the monotonicity and solvability of the SCLCP.

关键词： Infeasible interior-point algorithm symmetric cone linear complementarity problem monotonicity polynomial complexity

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双重控制导弹微分对策制导方法

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系统工程与电子技术 2011年第3期33卷 627-632页

作者：花文华陈兴林哈尔滨工业大学航天学院黑龙江哈尔滨150001

针对单一鸭舵控制或尾舵控制的不足,基于双边优化微分对策理论给出了一种双重控制微分对策制导律,实现了二者的有效融合。对该制导律微分对策空间进行了分析,分别研究了理想拦截情形和非理想拦截情形下鞍点解存在的条件。考虑量测噪声因... 详细信息

针对单一鸭舵控制或尾舵控制的不足,基于双边优化微分对策理论给出了一种双重控制微分对策制导律,实现了二者的有效融合。对该制导律微分对策空间进行了分析,分别研究了理想拦截情形和非理想拦截情形下鞍点解存在的条件。考虑量测噪声因素,进行了估计器和目标拦截性能指标的设计,并基于蒙特卡罗法进行了仿真。结果表明相比于单一的鸭舵或尾舵控制,该双重控制制导律具有较好的目标拦截性能和较高的单发命中概率。

关键词：末制导律微分对策双重控制鸭舵控制目标拦截

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CMOS APS图像传感器的像质分析

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光电工程 2006年第5期33卷 104-107,140页

作者：范红陈桂林东华大学信息科学与技术学院上海200051 上海技术物理研究所上海200083

使用标准CMOS制作工艺生产的有源像素传感器(APS)引起了广泛关注。为了确定CMOSAPS成像系统设计的主要参数选择的正确性,以及能否满足要求或指标,需要对相机系统的像质进行分析。考虑到CMOSAPS图像传感器与CCD的不同,在分析时计算了CMOS... 详细信息

使用标准CMOS制作工艺生产的有源像素传感器(APS)引起了广泛关注。为了确定CMOSAPS成像系统设计的主要参数选择的正确性,以及能否满足要求或指标,需要对相机系统的像质进行分析。考虑到CMOSAPS图像传感器与CCD的不同,在分析时计算了CMOSAPS成像系统中的镜头、滤光片和焦平面的调制传递函数(MTF),系统MTF曲线为各个部分MTF值之积。在系统截止频率范围内,利用MTF曲线所围面积的大小来评价系统的成像质量。在系统制造之前,用调制传递函数作为像质的评价方法,看其是否符合使用要求,是十分有价值的工作。

关键词： CMOS 有源像素传感器调制传递函数像质分析图像传感器

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快速成型制备Al-Si/粉煤灰基高温相变蓄热球的尺寸效应

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材料热处理学报 2021年第11期42卷 20-27页

作者：陈丰朱桂花吕硕杨俊杰北方民族大学化学与化学工程学院宁夏银川750021 北方民族大学国家民委化工技术基础重点实验室宁夏银川750021 北方民族大学机电学院宁夏银川750021

以Al-Si共晶合金粉为相变介质、粉煤灰为基体材料,采用干法快速成型及混合烧结法制备了不同直径的(10、15和20 mm)陶瓷基高温相变蓄热球。结果表明:不同直径蓄热球的成型压力及性能存在显著差异。素坯成型时,压力分解为使其致密的向心... 详细信息

以Al-Si共晶合金粉为相变介质、粉煤灰为基体材料,采用干法快速成型及混合烧结法制备了不同直径的(10、15和20 mm)陶瓷基高温相变蓄热球。结果表明:不同直径蓄热球的成型压力及性能存在显著差异。素坯成型时,压力分解为使其致密的向心力以及耗散掉的切向力,直径大则向心力大,但压力传递深度有限,素坯尺寸越大越难完全致密,易产生硬化层,导致蓄热球中合金粉颗粒破裂加剧、相变潜热降低。不同直径蓄热球的成型压力范围分别为:ϕ10 mm,1~6 MPa;ϕ15 mm,2~6 MPa;ϕ20 mm,4~10 MPa。ϕ10 mm蓄热球在压力为1 MPa时相变潜热较高(92.47 J·g^(-1)),但密度较低(1.57 g·cm^(-3))。ϕ15 mm蓄热球在2~4 MPa时综合性能良好,相变潜热为105.54~90.68 J·g^(-1)、密度为1.64~1.89 g·cm^(-3)。ϕ20 mm蓄热球均存在硬化层,相变潜热偏低,小于40 J·g^(-1)。

关键词： Al-Si合金蓄热球快速成型尺寸效应硬化层

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Relationship between LRP6 polymorphisms and sudden cardiac death in patients with chronic heart failure in Chinese han population

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中国病理生理杂志 2016年第8期32卷 1527-1528页

作者： GUO Qi CHU Jian-min REN Lan chen Xu-hua PU Jie-lin ZHANG Shu State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical College

AIM: Chronic heart failure( CHF),caused by ischemic cardiomyopathy( ICM) and nonischemic cardiomyopathy( NICM),is among the leading causes of mortality and morbidity worldwide. Low-density lipoprotein receptor-related protein 6( LRP6) plays a critical role in regulating Wnt signaling. Dysregulated Wnt signaling contributes to high incidence of arrhythmias. Thus,there might be an association between genetic variations of LRP6 and sudden cardiac death( SCD). The objective of the study was to examine the association between common variants of LRP6 and prognosis of CHF patients. METHODS: From July 2005 to December 2009,patients with CHF referred from 10 hospitals and participants without structural heart disease in China were undergone a prospective study. The single-nucleotide polymorphism rs2302684 was selected to evaluate the effect of LRP6 polymorphisms on the survival of the patients. RESULTS: A total of 1 887 patients(1 437 with CHF and 450 in the control group) were finally enrolled for the analysis. During a median follow-up of 61 months,a total of 546(38. 00%) patients died,including 201(36. 81%) cases with SCD and 345(63. 19%) cases with NSCD. No end point event occurred in the control group. Patients carrying A allele of rs2302684 had increased risks of allcause death( P A in LRP6 is associated with an increased risk of all-cause death and SCD in patients with CHF in Chinese Han p

关键词： LRP CHF Relationship between LRP6 polymorphisms and sudden cardiac death in patients with chronic heart failure in Chinese han population

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Novel mutations in the BEST1 gene cause distinct retinopathies in two Chinese families

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 205-212页

作者： Zhi-Hong Zhu Xin Jin Yi-Xin Zhang Rui Wang Tong Wu Wei Liu Ze-hua chen Hai-Nan Xie Lan-Lan chen Zi-Hao Liu Hou-Bin huang Department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanya 572013Hainan ProvinceChina Department of Ophthalmology Chinese PLA General HospitalBeijing 100853China Department of Ophthalmology the PLA Rocket Force Characteristic Medical CenterBeijing 100088China Department of Ophthalmology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

AIM:To describe the clinical heterogeneity of patients with novel mutations in ***:All the members in the two Chinese families underwent detailed clinical evaluations including best-corrected visual acuity,slit-lamp examination,applanation tonometry,and dilated fundus *** autofluorescence,fundus fluorescein angiography,spectral-domain optical coherence tomography,electrooculography,and electroretinogram were also *** DNA was extracted from venous blood for all the *** targeted next-generation sequencing of inherited retinal disease-associated genes was conducted to identify the causative ***:A novel BEST1 missense mutation c.41T>C(***14Ser) was identified in Family *** was co-segregated with the phenotype of best vitelliform macular dystrophy(BVMD) and bioinformatics analysis confirmed it was *** novel BEST1 frameshift mutation c.345_(3)46insGGCAAGGACG(***119Glyfs*116) and a novel USH2A missense mutation c.12560G>A,***4187 His were identified in family 2 with retinitis pigmentosa(RP),which might interact and lead to the phenotype of ***:Two novel mutations in the BEST1 gene in two unrelated families with distinct phenotypes and BEST1 mutation accompanied with USH2A mutation would result in RP,which could be enormously helpful in understanding the pathogenesis of the inherited retinal disease caused by a BEST1 mutation.

关键词： BEST1 gene best vitelliform macular dystrophy retinitis pigmentosa gene mutation

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Characterization of inflammatory factor-induced changes in mesenchymal stem cell exosomes and sequencing analysis of exosomal microRNAs

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World Journal of Stem Cells 2019年第10期11卷 859-890页

作者： chen huang Wen-Feng Luo Yu-Feng Ye Li Lin Zhe Wang Ming-hua Luo Qi-De Song Xue-Ping He Han-Wei chen Yi Kong Yu-Kuan Tang Department of Minimally Invasive Interventional Radiology Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Jinan University Guangzhou 510632Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou 511400Guangdong ProvinceChina Jinan University Biomedical Translational Research Institute Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Pharmacy the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Radiology Shiyan People’s HospitalShenzhen 518108Guangdong ProvinceChina

BACKGROUND Treatments utilizing stems cells often require stem cells to be exposed to inflammatory environments,but the effects of such environments are *** To examine the effects of inflammatory cytokines on the morphology and quantity of mesenchymal stem cell exosomes(MSCs-exo)as well as the differential expression of microRNAs(miRNAs)in the *** MSCs were isolated from human umbilical tissue by enzymatic *** were then collected after a 48-h incubation period in a serum-free medium with one of the following the inflammatory cytokines:None(control),vascular cell adhesion molecule-1(VCAM-1),tumor necrosis factor(TNF)α,and interleukin(IL)*** morphology and quantity of each group of MSC exosomes were observed and *** miRNAs in MSCs-exo were *** compared the sequenced data with the miRBase and other non-coding databases in order to detect differentially expressed miRNAs and explore their target genes and regulatory *** vitro tube formation assays and Western blot were performed in endothelial cells which were used to assess the angiogenic potential of MSCs-exo after inflammatory cytokine *** MSCs-exo were numerous,small,and regularly shaped in the VCAM-1 ***αstimulated MSCs to secrete larger and irregular ***6 led to a reduced quantity of *** to the control group,the TNFαand IL6 groups had more downregulated differentially expressed miRNAs,particularly angiogenesis-related *** angiogenic potential of MSCs-exo declined after IL6 *** TNFαand IL6 may influence the expression of miRNAs that down-regulate the PI3K-AKT,MAPK,and VEGF signaling pathways;particularly,IL6 significantly down-regulates the PI3K-AKT signaling ***,inflammatory cytokines may lead to changes in exosomal miRNAs that abnormally impact cellular components,molecular function,and biological processes.

关键词： Mesenchymal stem cells Exosomes MiRNA Inflammatory cytokines Angiogenesis

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