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Mapping QTLs Affecting Economic Traits on BTA3 in Chinese Holstein with Microsatellite Markers

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Journal of Integrative Agriculture 2014年第9期13卷 1999-2004页

作者： QIN chun-hua chu Qin chu gui-yan ZHANG Yi ZHANG Qin ZHANG Sheng-li SUN Dong-xiao College of Animal Science and Technology/Key Laboratory of Animal Genetics and Breeding Ministry of Agriculture/National Engineering Laboratory of Animal Genetics China Agricultural University

It had been demonstrated that the strong and highly significant quantitative trait locus（QTL） can affect protein percentage on Bos Taurus Autosome 3（BTA3） at the position 52 cM, near the microsatellite DIK4353, with the 95% confidence interval spanning from 25 to 57 cM in Chinese Holstein population using QTL-express, MQREML, and GRIDQTL softwares. This study herein focused on such region of fine mapping QTLs for milk production and functional traits with 16 microsatellite markers with coverage of 33 cM between the markers BMS2904 and MB099 on BTA3 in a daughter-designed Chinese Holstein population. A total of 1 298 Holstein cows and 7 sires were genotyped for 16 microsatellites with ABI 3700 DNA sequencer. The variance components QTL linkage analysis（LA） and linkage-disequilibrium（LD） analysis（LA/LD） was performed to map QTLs for 7 traits, i.e., 305-d milk yield, fat yield, protein yield, fat percentage, protein percentage, somatic cell score and persistency of milk yield. Four strong and highly significant QTLs were detected for fat yield, fat percentage, protein percentage and somatic cell score at the position 40, 30, 27 and 26 cM, respectively. Two minor QTLs for milk yield and persistency of milk yield were identified at 42 and 46 cM, respectively. These findings provided a general idea for the fine mapping of the causal mutation for milk production and functional traits on BTA3 in the future.

关键词： QTL mapping economic traits microsatellite markers BTA3 Chinese Holstein

Development and Future Trends of Traditional Kampo Medicine in Japan

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Chinese Medicine and Culture 2022年第1期5卷 58-64页

作者： Risa Shibata gui-Xiang chu Xun Lin Jin-Rong Fu Gynaecology Department of TCM Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China International Office Shanghai University of Traditional Chinese MedicineShanghai 201203China

Traditional Kampo medicine is based on traditional Chinese medicine,which spread to Japan via the Korean Peninsula in the 5th *** practice of Kampo developed gradually under the influence of local Japanese culture and prospered until the Meiji *** appeared in schools successively,such as the School of Later Developments,the School of Classic Methods,the School of Textual Research,and the Integrated ***,the practice of Kampo gradually declined after the Meiji ***,through the continuous efforts of knowledgeable Japanese Kampo practitioners,the practice of Kampo has entered a new era as an indispensable aspect of contemporary Japanese medicine.

关键词： Medical history History Japan Kampo Traditional Chinese medicine

Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors

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Chinese Chemical Letters 2006年第3期17卷 325-328页

作者： Chang Bin GUO Zhe Feng CAI Zong Ru GUO Zhi Qiang FENG Feng Ming chu gui-Fang CHENG Feng Ming chu Gui Fang CHENG Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College Beijing 100050

A series of thiazole derivatives of ibuprofen, as cyclooxygenase-2 Inhibitors, were designed, synthesized and in vitro evaluated.

关键词： Cyclooxygenase-2 (COX-2) inhibitor ibuprofen thiazole derivative.

Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期68卷 152-156页

作者： Lihua Zhang Lingjing Chen Huatian Shi Yue Wei gui Chen Tai-chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

关键词： photocatalysis noble metal-free CO2 reduction formate cobalt hydride

Measuring causality by taking the directional symbolic mutual information approach

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Chinese Physics B 2013年第3期22卷 556-560页

作者：陈贵谢磊褚健 Institute of Cyber-System and Control Zhejiang University

We propose a novel measure to assess causality through the comparison of symbolic mutual information between the future of one random quantity and the past of the *** provides a new perspective that is different from the conventional *** on this point of view,a new causality index is derived that uses the definition of directional symbolic mutual *** measure presents properties that are different from the time delayed mutual information since the symbolization captures the dynamic features of the analyzed time *** addition to characterizing the direction and the amplitude of the information flow,it can also detect coupling *** method has the property of robustness,conceptual simplicity,and fast computational speed.

关键词： causality measure Bandt and Pompe method mutual information transfer entropy

基于全局热网络和局部流体动力学建模的全封闭永磁牵引电机热性能优化（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第11期19卷 878-888页

作者： Wei CHEN gui-chu WU You-tong FANG Ji-en MA Key Laboratory of Low-Voltage Apparatus Intellectual Technology of Zhejiang Wenzhou University College of Electrical Engineering Zhejiang University

目的:提出一种适用于全封闭冷却结构的电机热性能优化模型,设计一台600 kW的高速列车用永磁牵引电机。创新点:1.通过耦合局部流体动力学模型的方法求解电机复杂冷却风道内的对流传热系数,并在全局热网络模型的框架内得到快速、准确的电... 详细信息

目的:提出一种适用于全封闭冷却结构的电机热性能优化模型,设计一台600 kW的高速列车用永磁牵引电机。创新点:1.通过耦合局部流体动力学模型的方法求解电机复杂冷却风道内的对流传热系数,并在全局热网络模型的框架内得到快速、准确的电机温升结果以用于结构优化;2.在冷却风道中引入栅格结构,采用热性能分析模型优化冷却结构,提升电机热性能;3.通过三维流体动力学模型计算电机局部温升最大值,并提山一种预测特定结构下电机铁损工作阈值的工程方法。方法:1.采用热网络法建立全局热网络模型(图3),并通过耦合局部流体动力学模型计算风道内的热网络参数(图4和6); 2.应用田口设计法对电机风道结构进行优化,并研制样机进行验证(计算与试验结果见表5); 3.假设铁损的谐波附加值与磁密值成正比,通过三维流体动力学模型计算给山端部绕组、永磁体温升值与铁损的预测曲线,并用样机试验进行验证。结论:1.采用全局热网络和局部流体动力学建模的方法可以快速、正确地计算复杂冷却结构下的电机温升分布,且优化后的冷却结构至少可以提升文中电机15%的热性能;2.本文提出的优化模型适用于全封闭风冷或者水冷等冷却结构相对独立且尚无经验公式可参考的电机热性能优化设计;3.铁损工作阈值的预测方法可以为电磁和控制系统设计提供参考。

关键词：热网络模型流体动力学永磁电机全封闭强制风冷

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关于侧滑检测暨修改标准问题的探讨

公路交通科技 2000年第2期17卷 64-66页

作者：褚桂阳江苏省镇江市公安局车辆管理所江苏镇江212001

针对GB72 5 8 97标准中有关侧滑检测的条款以及执行中出现的问题 ,粗略分析关于侧滑量限值选取和检测局限性问题 ,指出修改标准的必要性 ,提出修改与执行标准的方法。同时根据文章分析 ,引出侧滑仪的改良思路 ,以及为全面贯彻GB72 5 8 9... 详细信息

针对GB72 5 8 97标准中有关侧滑检测的条款以及执行中出现的问题 ,粗略分析关于侧滑量限值选取和检测局限性问题 ,指出修改标准的必要性 ,提出修改与执行标准的方法。同时根据文章分析 ,引出侧滑仪的改良思路 ,以及为全面贯彻GB72 5 8 97标准 ,应当实行分级管理的思路。

关键词：侧滑检测标准汽车分级管理

缺氧缺血新生大鼠脑组织caspase-1和白细胞介素18mRNA表达及其关系探讨

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中华儿科杂志 2005年第8期43卷 568-571页

作者：辛玥初桂兰天津医科大学总医院儿科 300052

目的研究caspase1及其底物之一白细胞介素(IL)18mRNA的表达在缺氧缺血性脑损伤(HIBD)中的作用及其意义。方法112只7日龄新生Wistar大鼠按照完全随机化方法分为对照组、HIBD3、8、24h、3、6和14d组,每组16只。其中8只采用RTPCR方法检测ca... 详细信息

目的研究caspase1及其底物之一白细胞介素(IL)18mRNA的表达在缺氧缺血性脑损伤(HIBD)中的作用及其意义。方法112只7日龄新生Wistar大鼠按照完全随机化方法分为对照组、HIBD3、8、24h、3、6和14d组,每组16只。其中8只采用RTPCR方法检测caspase1和IL18mRNA在HIBD后脑皮层中的表达及其相关性,另外8只光镜下观察脑组织病理学改变。结果对照组有caspase1mRNA少量表达(0.2918±0.0809),HIBD24h组其水平开始增加(0.5222±0.0941,与对照组比较P<0.01),6d达高峰(0.7886±0.0480,与其余各组相比P<0.01),此后下降,但HIBD14d(0.5314±0.1272)仍可检测出。对照组IL18mRNA水平为0.3218±0.0466,HIBD24h至6d其表达逐渐增加(24h:0.5823±0.0740;3d:0.6976±0.1073;6d:0.9110±0.0647,与对照组比较均为P<0.01),并达高峰(HIBD6d组与其余各组相比P<0.01)。HIBD后IL18mRNA的表达在时间上与caspase1具有紧密相关性(r=0.871,P<0.01)。组织学检查发现神经元变性、坏死在HIBD1～6天逐渐加重。结论HIBD后caspase1和IL18mRNA的表达逐渐增加,其变化规律与光镜观察到的脑损伤进展的时间框架吻合,提示它们均参与了新生鼠HIBD的病理形成过程。

关键词：缺氧缺血,脑半胱氨酸天冬氨酸蛋白酶1 白细胞介素18 大鼠,Wistar caspase-1 缺氧缺血性脑损伤白细胞介素大鼠脑组织新生鼠表达及

Function of GATA transcription factors in hydroxyurea-induced HEL cells

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Cell Research 2001年第4期11卷 301-310页

作者： ZHANG SHU BING, QI YE HE, HUI ZHAO, CHANG YUN gui, chu JIANG, RUO LAN QIAN Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

HEL cells, a human erythroleukemia cell line, mainly express the fetal (r)globin gene and trace amount of the embryonic (E)globin gene, but not adult (B) globin gene. Here we show that hydroxyurea (HU) can induce HEL cells to express adult (B) globin gene and lead these cells to terminal differentiation. Results showed in Gel mobility shift assays that GATA factors could specifically bind to the regulatory elements of human B- globin gene, including the proximal regulatory element (the B- promoter) and the distal regulatory elements (the DNase I hypersensitive sites in the LCR, HS2-HS4 core sequences). However, the DNA binding patterns of GATA factors were quite different between HU-induced and uninduced HEL cells. Western-blot analysis of nuclear extracts from both the uninduced and HU- induced HEL cells revealed that the level of GATA-2 transcription factor decreased, whereas the level of GATA-1 transcription factor increased following the time of hydroxyurea induction. Furthermore, using RT-PCR analysis the expression of human B-globin gene in HU-induced HEL cells could be blocked again when HEL cells were incubated in the presence of antisense oligonucleotides for hGATA-1, suggesting that the upregulation of hGATA-1 transcription factor might be critical for the expression of human β- globin gene in HU-induced HEL cells.

关键词： GATA transcription factors human β-gobin gene HEL cells hydroxyurea.