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Optic neuropathy and increased retinal glial fibrillary acidic protein due to microbead-induced ocular hypertension in the rabbit

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1732-1739页

作者： Jun Zhao Tian-Hui Zhu Wen-Chie Chen Shi-Ming Peng Xiao Sheng Huang Kin-Sang Cho Dong Feng Chen guer-sheung liu School of Ophthalmology & Optometry Affiliated to Shenzhen University Shenzhen 518040 Guangdong Province China Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen Key Laboratory of Ophthalmology Shenzhen 518040 Guangdong Province China Department of Ophthalmology Schepens Eye Research Institute Massachusetts Eye and Ear Harvard Medical School Boston 02114 USA Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital East Melbourne 3002 Australia Ophthalmology Department of Surgery University of Melbourne East Melbourne 3002 Australia

AIM： To characterize whether a glaucoma model with chronic elevation of the intraocular pressure （IOP） was able to be induced by anterior chamber injection of microbeads in ***： In order to screen the optimal dose of microbead injection, IOP was measured every 3d for 4wk using handheld applanation tonometer after a single intracameral injection of 10 μL, 25 μL, 50 μL or 100 μL microbeads （5×10^6 beads/mL; n=6/group） in New Zealand White rabbits. To prolong IOP elevation, two intracameral injections of 50 μL microbeads or phosphate buffer saline （PBS） were made respectively at days 0 and 21 （n=24/group）. The fellow eye was not treated. At 5wk after the second injection of microbeads or PBS, bright-field microscopy and transmission electron microscopy （TEM） were used to assess the changes in the retina. The expression of glial fibrillary acidic protein （GFAP） in the retina was evaluated by immunofluorescence, quantitative real-time polymerase chain reaction and Western blot at 5wk after the second injection of ***： Following a single intracameral injection of 10 μL, 25 μL, 50 μL or 100 μL microbead, IOP levels showed a gradual increase and a later decrease over a 4wk period after a single injection of microbead into the anterior chamber of rabbits. A peak IOP was observed at day 15 after injection. No significant difference in peak value of IOP was found between 10 μL and 25 μL groups （17.13±1.25 mm Hg vs 17.63±0.74 mm Hg; P=0.346）. The peak value of IOP from 50 μL group （23.25±1.16 mm Hg） was significantly higher than 10 μL and 25 μL groups （all P〈0.05）. Administration of 100 μL microbead solution （23.00±0.93 mm Hg） did not lead to a significant increase in IOP compared to the 50 μL group （P=0.64）. A prolonged elevated IOP duration up to 8wk was achieved by administering two injections of 50 μL microbeads （20.48±1.21 mm Hg vs 13.60±0.90 mm Hg in PBS-injected group; P〈0.05）. The bright-field and TEM were used to assess the changes of retinal

关键词： microbead ocular hypertension optic neuropathy glial fibrillary acidic protein rabbit

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Recent advances in RNA-targeting therapy for neurological diseases

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Neural Regeneration Research 2023年第12期18卷 2663-2664页

作者： Satheesh Kumar Guei-sheung liu Center for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVICAustralia Menzies Institute for Medical Research University of TasmaniaHobartTASAustralia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVICAustralia Aier Eye Institute ChangshaHunan ProvinceChina

Advances in sequencing and molecular technology now allow us to understand the genetic underpinnings of complex diseases such as neurological *** variations(or mutations) in the DNA sequence of single genes have been implicated in neurological diseases such as Huntington's disease and spinal muscular *** a result,the development of gene therapies for neurological diseases is now a feasible endeavor.

关键词： diseases neurological Huntington

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Estimating liver weight of adults by body weight and gender

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World Journal of Gastroenterology 2006年第14期12卷 2217-2222页

作者： See Ching Chan Chi Leung liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong sheung Tat Fan Centre for the Study of Liver Disease Department of Surgery The University of Hong Kong Pokfulam Hong Kong China Centre for the Study of Liver Disease Department of Radiology The University of Hong Kong Pokfulam Hong Kong China

AIM： To estimate the standard liver weight for assessing adequacies of graft size in live donor liver transplantation and remnant liver in major hepatectomy for cancer. METHODS： In this study, anthropometric data of body weight and body height were tested for a correlation with liver weight in 159 live liver donors who underwent donor right hepatectomy including the middle hepatic vein. Liver weights were calculated from the right lobe graft weight obtained at the back table, divided by the proportion of the right lobe on the computed tomography. RESULTS： The subjects, all Chinese, had a mean age of 35.8 ± 10.5 years, and a female to male ratio of 118：41. The mean volume of the right lobe was 710.14 ±131.46 mL and occupied 64.55%±4.47% of the whole liver on computed tomography. Right lobe weighed 598.90±117.39 g and the estimated liver weight was 927.54 ± 168.78 g. When body weight and body height were subjected to multiple stepwise linear regression analysis, body height was found to be insignificant. Females of the same body weight had a slightly lower liver weight. A formula based on body weight and gender was derived： Estimated standard liver weight （g）=218＋BW （kg）× 12.3＋gender×51 （R^2 = 0.48）（female=0, male= 1）. Based on the anthropometric data of these 159 subjects, liver weights were calculated using previously published formulae derived from studies on Caucasian, .lapanese, Korean, and Chinese. All formulae overestimated liver weights compared to this formula. The Japanese formula overestimated the estimated standard liver weight （ESLW） for adults less than 60 ***： A formula applicable to Chinese males and females is available. A formula for individual races appears necessary.

关键词： Estimated standard liver weight Liver tranplantation

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Rapid onset Chilaiditi's sign on top of fulminant hepatic failure

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 476-477页

作者： See-Ching Chan Chi-Leung liu Chung-Mau Lo sheung-Tat Fan Centre for the Study of Liver Disease and Departmentof Surgery the University of Hong Kong Pokfulam Hong Kong China

ABSTRACT: Fulminant hepatic failure is a medical emer-gency. When this condition declared itself irreversible, atimely liver transplantation is the only effective treatment.A 34-year-old Chinese with fulminant hepatic failure wasevaluated as a potential liver transplantation candidate. Onthe erect chest radiograph, Chilaiditi' s sign has developedover a very short period of a week due to rapid shrinkage ofthe liver. Awareness of Chilaiditi' s sign facilitated distin-guishing the condition of free gas under the diaphragm dueto bowel perforation and subphrenic abscess by gas formingmicro-organisms. Rapidity of onset of this sign parallels thedeterioration of liver function and reflects the urgency ofcondition.

关键词： Chilaiditi's sign fulminant hepatic failure

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Long-term survival after intraluminal brachytherapy for inoperable hilar cholangiocarcinoma: A case report

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World Journal of Gastroenterology 2005年第20期11卷 3161-3164页

作者： Siu-Yin Chan Ronnie T. Poon Kelvin K. Ng Chi-Leung liu Raymond T. Chan sheung-Tat Fan Centre for the Study of Liver Disease and Department of Surgery The University of Hong Kong PokfulamHong Kong China Department of Clinical Oncology The University of Hong Kong Pokfulam Hong Kong China

Surgical resection with a tumor-free margin is the onlycurative treatment for hilar cholangiocarcinoma (Klatskin tumor). However, over half of the patients present late with unresectable tumors. Radiotherapy using external beamirradiation or intraluminal brachytherapy (ILBT) has been used to treat unresectable hilar cholangiocarcinoma with satisfactory outcome. We reported a patient with unresectable hilar cholangiocarcinoma surviving more than 6 years after combined external beam irradiation and ILBT.

关键词： Brachytherapy Hilar cholangiocarcinoma

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Versatility and viability of hepatic venoplasty in live donor liver transplantation using the right lobe with the middle hepatic vein

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Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 618-621页

作者： See-Ching Chan Chung-Mau Lo Chi-Leung liu Yik Wong sheung-Tat Fan Centre for the Study of Liver Disease and Departments of Surgery The University of Hong KongPokfulamHong KongChina Radiology The University of Hong Kong PokfulamHong KongPokfulamHong KongChina

Including the middle hepatic vein in the right lobe liver graft has the advantage of providing direct venous drainage of the right anterior segment. To allow unimpeded passage of blood flow, we previously designed venoplasty of the middle and right hepatic veins. We found that venoplasty is also feasible when the inferior right hepatic vein is near to the right hepatic vein, or when multiple segment 8 hepatic vein orifices are exposed adjacent to the middle hepatic vein at the graft transection surface. By joining the hepatic vein orifices into a single opening, the anastomosis into the inferior vena cava is much facilitated. The technique is simple, yet versatile , and able to cope with variation of the configurations of the hepatic vein.

关键词： venoplasty live donor liver transplantation

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Experience of donor right lobe hepatectomy in adult-to-adult live donor liver transplantation: clinical analysis of 89 cases

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Hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 166-171页

作者： sheung-Tat Fan Chung-Mau Lo Chi-Leung liu From the Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China Ctr. Stud. of Liver Dis./Dept. Surg. University of Hong Kong Medical Ctr. Queen Mary Hospital Hong Kong China

Objective: To review the experience of donor selec- tion and right lobe hepatectomy in adult-to-adult live donor liver transplantation. Methods: From May 1996 to December 2001, 89 live donor liver transplants using right lobe grafts were performed at Queen Mary Hospital, Hong Kong. All donors had received psychological counseling before donor operations. They were screened by laboratory tests including complete blood cell count, liver and renal biochemistry, and viral serology studies. Com- puted tomography (CT), CT volumetry and hepatic arteriography were routinely performed. All donors underwent the operations using the method designed by us. Results: The median duration of the operations was 8.8 hours. The median blood loss recorded 466 ml. The median intensive care unit and hospital stays were 2 and 10 days, respectively. There was no do- nor mortality. Complications of donor operations in- cluded wound infection, urinary tract infection, bili- ary stricture, cholestasis, subphrenic collection, bowel obstruction and incision hernia, etc. All do- nors have recovered and returned to their previous occupations. Conclusions: Live donation of right lobe grafts for a- dult-to-adult liver transplantation is safe, provided that donor selection is strict and utmost care is exer- cised during the operation.

关键词： right lobe graft liver transplantation hepstectomy

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生物硅的生成与溶解速率的研究-以胶州湾为例

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中国海洋大学学报（自然科学版） 2008年第5期38卷 781-785页

作者：刘素美 Pall Treguer Charlotte Beucher Rudolph Corvaisier 张经中国海洋大学化学化工学院海洋化学理论与工程技术教育部重点实验室山东青岛266100 Institut Universitaire Europeen de la Mer UMR 6539 Universite de Bretagne Occidentale Technopole Brest-Iroise Place Nicolas Copernic 29280 Plouzane France

营养盐的含量与元素间的比值直接控制着生态系统的生产力和浮游植物的种类组成。近岸海区硅藻可占初级生产的75%,但其生长速率受Si(OH)4含量的限制。胶州湾浮游植物的物种组成以硅藻为主。用29Si同位素示踪培养方法,采用四极杆质谱同位... 详细信息

营养盐的含量与元素间的比值直接控制着生态系统的生产力和浮游植物的种类组成。近岸海区硅藻可占初级生产的75%,但其生长速率受Si(OH)4含量的限制。胶州湾浮游植物的物种组成以硅藻为主。用29Si同位素示踪培养方法,采用四极杆质谱同位素稀释技术同时测定了胶州湾硅的生成速率与溶解速率。胶州湾生物硅(BSi)的含量为0.90～1.14μmol/L,岩成硅(LSi)的含量为46.3～52.3μmol/L。岩成硅是生物硅的约50倍。胶州湾BSi的含量处于世界近岸海区的低值范围,LSi的含量与LSi/BSi的比值均处于高值区。BSi的绝对生成速率为4～6 nmol/L.d,比生成速率为6～17/d。BSi的绝对溶解速率为<9 nmol/d,比溶解速率为<23/d。进一步开展胶州湾不同季节水体中BSi的生成速率与溶解速率的研究,是深入认识海湾浮游植物生长限制及其资源可持续利用的基础。

关键词：生物硅溶解速率生成速率胶州湾

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长足大竹象幼虫消化酶活性的初步研究

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四川动物 2011年第1期30卷 61-63页

作者：刘超万东海乐山师范学院峨眉山生物多样性保护与利用研究所四川乐山614004

应用酶学分析法研究了长足大竹象Cyrtotrachelus buqueti guer幼虫消化酶的主要种类和活性。结果表明，长足大竹象幼虫主要有7种消化酶。长足大竹象幼虫的消化酶活性大小排列顺序为：半纤维素酶〉果胶酶〉纤维素酶〉淀粉酶〉蔗糖酶〉脂... 详细信息

应用酶学分析法研究了长足大竹象Cyrtotrachelus buqueti guer幼虫消化酶的主要种类和活性。结果表明，长足大竹象幼虫主要有7种消化酶。长足大竹象幼虫的消化酶活性大小排列顺序为：半纤维素酶〉果胶酶〉纤维素酶〉淀粉酶〉蔗糖酶〉脂肪酶〉蛋白酶；在40～55℃、pH值7．4～8．5时，半纤维素酶和果胶酶活性最高。

关键词：长足大竹象幼虫消化酶活性

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中国东部地区气溶胶光学特性和类型特性分析

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激光与光电子学进展 2023年第15期60卷 113-119页

作者：韩亚芳马骕刘焱春来庆广青岛地质工程勘察院(青岛地质勘查开发局) 山东青岛266101 自然资源部滨海城市地下空间地质安全重点实验室山东青岛266101 青岛市勘察测绘研究院山东青岛266033

本文基于我国东部沿海岸线分布的Beijing-RADI、Beijing-CAMS、Xuzhou-CUMT、Taihu、Hong_Kong_PolyU、Hong_Kong_sheung六个AERONET长期观测站点的光学厚度(AOD)、Angstrom指数(AE)、单次散射反照率(SSA)、细粒子百分比(FMF)四种气溶胶的物理光学特性观测产品,结合Terra/Aqua MODIS Level2 C6 AOD产品,研究了我国东部地区气溶胶时空变化特性及类型特性。研究表明:1)北京、徐州、太湖、香港地区四个地区地基的AOD年均值徐州>太湖>北京>香港地区,依次为0.805±0.129、0.775±0.069、0.664±0.197、0.519±0.125;2)在AERONET站点处,MODIS AOD年均值检测值太湖>徐州>香港地区>北京,依次为0.902±0.227、0.772±0.082、0.547±0.064、0.517±0.234,与地基检测值依次相差22.2%、4.1%、5.5%、16.3%;3)AE年均值香港地区>太湖>徐州>北京,依次为1.314±0.054、1.213±0.084、1.198±0.104、1.118±0.078,表明中国东部地区污染物的粒径从北往南逐渐减小;4)北京、徐州、太湖、香港地区四个地区均以弱吸收型细粒子所占比重最大,依次为38.29%、44.99%、44.30%、48.14%,中度吸收型细粒子和强散射细粒子次之,其他类型的粒子均较少。

关键词：大气光学与海洋光学气溶胶气溶胶光学厚度 Angstrom指数单次散射反照率细粒子百分比

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