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Bone physiological microenvironment and healing mechanism:Basis for future bone-tissue engineering scaffolds

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Bioactive Materials 2021年第11期6卷 4110-4140页

作者： guanyin zhu Tianxu Zhang Miao Chen Ke Yao Xinqi Huang Bo Zhang Yazhen Li Jun Liu Yunbing Wang Zhihe Zhao State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041PR China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610041PR China

Bone-tissue defects affect millions of people *** being common treatment approaches,autologous and allogeneic bone grafting have not achieved the ideal therapeutic *** has prompted researchers to explore novel bone-regeneration *** recent decades,the development of bone tissue engineering(BTE)scaffolds has been leading the forefront of this *** researchers have provided deep insights into bone physiology and the bone-healing mechanism,various biomimicking and bioinspired BTE scaffolds have been *** it is necessary to review the progress of natural bone physiology and bone healing mechanism,which will provide more valuable enlightenments for researchers in this *** work details the physiological microenvironment of the natural bone tissue,bone-healing process,and various biomolecules involved ***,according to the bone physiological microenvironment and the delivery of bioactive factors based on the bone-healing mechanism,it elaborates the biomimetic design of a scaffold,highlighting the designing of BTE scaffolds according to bone biology and providing the rationale for designing next-generation BTE scaffolds that conform to natural bone healing and regeneration.

关键词： Bone tissue engineering Scaffold Bone biology Cytokine Bone regeneration

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刘景源教授治疗外感初期发热临床经验

吉林中医药 2020年第6期40卷 748-750页

作者：李奕菊王莹王琦朱官印航空总医院中医科北京100012 北京市西城区首都医科大学附属复兴医院月坛社区卫生服务中心北京100045 山东省博兴县中医院山东256500 北京按摩医院北京100035

刘景源教授治疗外感发热,常分为寒邪束表证、风热袭表证、表寒里热证、外感咳嗽风寒蕴热证4种类型。其中,寒邪束表证、风热袭表证是临床常见的外感表证。由于近年来人们的饮食起居多不规律,饮食肥甘较多,又贪食生冷,伤脾生痰,痰阻气机,... 详细信息

刘景源教授治疗外感发热,常分为寒邪束表证、风热袭表证、表寒里热证、外感咳嗽风寒蕴热证4种类型。其中,寒邪束表证、风热袭表证是临床常见的外感表证。由于近年来人们的饮食起居多不规律,饮食肥甘较多,又贪食生冷,伤脾生痰,痰阻气机,气郁化热,故体内往往多有蕴热,一旦外感风寒,多易形成表寒里热之证。本文的重点探讨了刘景源教授用自拟清解汤辨治外感发热表寒里热证、用自拟止咳平喘八味饮治疗外感咳嗽风寒蕴热证等独到的临床经验。

关键词：寒邪束表证风热袭表证表寒里热证外感咳嗽风寒蕴热证

久病入络学说在针刺治疗老年膝关节骨关节炎中的应用

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光明中医 2022年第3期37卷 392-395页

作者：朱官印刘宁王琦王莹李奕菊北京按摩医院针灸科北京100035 北京中医药大学东直门医院针灸科北京100700 博兴县中医院中医科山东滨州256500 北京市西城区首都医科大学附属复兴医院月坛社区卫生服务中心中医科北京100045 航空总医院中医科北京100012

"久病入络"学说是温病大家叶天士运用中医药治疗内科疾病时提出的理论学说。后世医家广泛应用于临床多种病证,包括各种痹证的治疗。针刺作为治疗疼痛类疾病的重要方法,其临床疗效得到了各科医师的一致认可。从经脉理论来看,络脉的分布... 详细信息

"久病入络"学说是温病大家叶天士运用中医药治疗内科疾病时提出的理论学说。后世医家广泛应用于临床多种病证,包括各种痹证的治疗。针刺作为治疗疼痛类疾病的重要方法,其临床疗效得到了各科医师的一致认可。从经脉理论来看,络脉的分布比经脉更广阔、更深入,老年膝关节骨关节炎属中医的"痹证"范畴,其疼痛病理表现与"久病入络"学说十分贴切,在此将"久病入络"学说与针刺治疗老年膝关节骨关节炎相结合,从理论到临床进行了相关阐述。

关键词：久病入络膝关节骨关节炎针刺疗法浅刺

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刘景源论伤寒与温热病初期辨治之别

吉林中医药 2022年第8期42卷 908-912页

作者：朱官印王莹王琦刘宁李奕菊北京按摩医院针灸科北京100035 北京市西城区首都医科大学附属复兴医院月坛社区卫生服务中心中医科北京100045 山东省博兴县中医院山东滨州256500 北京中医药大学东直门医院北京100700 航空总医院中医科北京100012

在临床中,辨外感寒邪导致的伤寒病与外感温热邪气导致的温病的区别,关键在于其初期恶寒与发热的轻重。外感寒邪,因寒主收引,闭塞腠理,故恶寒重、发热轻;外感温热邪气,腠理并不闭塞,但表邪欲入里而导致表郁,故发热重、恶寒轻。二者以此... 详细信息

在临床中,辨外感寒邪导致的伤寒病与外感温热邪气导致的温病的区别,关键在于其初期恶寒与发热的轻重。外感寒邪,因寒主收引,闭塞腠理,故恶寒重、发热轻;外感温热邪气,腠理并不闭塞,但表邪欲入里而导致表郁,故发热重、恶寒轻。二者以此为鉴别要点。辛温解表法,是针对外感寒邪初期的治法,它通过发汗散寒以解表;辛凉轻解法,是针对外感温热邪气初期的治法,它通过疏风清热以解表。在“八法”中二者一属汗法,一属清法,作用截然不同,临床不可混淆。

关键词：辛温解表辛凉解表辛平表散

浅析“调督升阳”针刺治疗耳石症复位后残余头晕

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中国中医药信息杂志 2019年第2期26卷 114-116页

作者：李虹李翠贤郭晶晶朱官印北京按摩医院北京100035

近年来,耳石症复位后残余头晕的出现逐渐得到关注,虽然机理尚不明确,但治疗方面已陆续有相关文献报道。笔者临证从"调督升阳"思路出发,选取百会、神庭、印堂、风府为主穴,辨证配伍,治疗耳石症复位后残余头晕取得良好的效果。

关键词：耳石症残余头晕调督升阳针刺

Enzootic epidemiology of Brucella in livestock in central Gansu Province after the National Brucellosis Prevention and Control Plan

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Animal Diseases 2023年第2期3卷 128-142页

作者： Yupeng Fang Jianjun Wang guanyin Zhang Fengdong zhu Chaoyue Guo Jiandong Zhang Kaixuan Guo Yun Deng Jinxue Zhang Huanchun Chen Zhengfei Liu National Key Laboratory of Agricultural Microbiology Hongshan Laboratoryand Key Laboratory of Preventive Veterinary Medicine in Hubei ProvinceCollege of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China Wuwei Institute of Animal Husbandry and Veterinary Wuwei 733000GansuChina

Brucellosis remains one of the most common zoonoses spread worldwide,inducing enormous economic losses to the livestock industry and posing serious health threats to *** re-emerged in China in the mid-1990s and reached a historically high level in *** National Brucellosis Prevention and Control Plan(NBPCP)was initiated from 2016 to ***,the present epidemiological status in livestock has not been elucidated,and whether Brucella variation occurred remains *** study performed an extensive serological investigation in ruminant livestock from 2019 to 2021 in central Gansu Province,*** total,11,296 samples from 337 farms were collected to detect the specific antibodies of *** yearly average serological prevalence of Brucella at the flock level and individual level declined from 11.32%to 8.26%and 1.17%to 0.57%,*** apparent individuallevel seroprevalence of small and large ruminants was 0.89%and 0.52%,*** brucellosis distribution has shifted from pastoral areas to agro-pastoral *** size and gender may be major risks of Brucella ***,the *** TZ strain was isolated from female Tibetan sheep blood cell *** characterization demonstrated that it belongs to *** 3,and multilocus sequencing typing results indicated that it belongs to *** whole genome and subsequent phylogenetic analysis demonstrated that the *** TZ strain is genetically more closely related to the *** QH61 *** *** TZ strain has similar growth characteristics to the *** 16 M ***,our study suggests that after strengthening control and prevention measures based on the NBPCP,there is a very low prevalence or absence of *** in the central Gansu Province of China,and the genotype of an epidemic strain of Brucella in Northwest China is relatively stable.

关键词： Brucella NBPCP Epidemiology Ruminant Isolation Genotype

元代北方多民族佛教信仰的互动与融合——以麦积山石窟第48窟四臂观音为中心

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五台山研究 2024年第1期 9-14页

作者：朱淑娥郑炳林兰州大学敦煌学研究所甘肃兰州731000

麦积山第48窟东龛内四臂观音造像属于藏传佛教体系,四臂观音造像样式独特,发式为三重螺髻,仰覆莲花宝座基座为十字折角须弥座,此尊四臂观音造像样式反映出藏传佛教在北方地区的盛行以及元代北方多民族佛教信仰的互动与融合。

关键词：麦积山四臂观音多民族佛教互动与融合

Automatic determination of optimal spectral peaks for classification of Chinese tea varieties using laser-induced breakdown spectroscopy

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International Journal of Agricultural and Biological Engineering 2018年第3期11卷 154-158页

作者： Hongyang Zhang Qibing zhu Min Huang Ya Guo Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Jiangnan UniversityWuxi 214122JiangsuChina

The accurate identification of tea varieties is of great significance to ensure the interests of tea producers and *** a non-destructive or micro damage detection method,laser-induced breakdown spectroscopy(LIBS)has been widely used in the quality detection or classification of agricultural products and *** objective of this research was to automatically select optimal spectral peaks from the full LIBS spectra,and develop effective classification model for identifying tea *** LIBS spectra covering the region 200-500 nm were measured for 600 Chinese tea leaves including six varieties(*** green tea,Jinhao black tea,Tie guanyin,Huang Jinya,White peony tea,and Anhua dark tea).A total of 50 optimal spectral peaks were automatically selected from full LIBS spectra(6102)by using the uninformative variable elimination(UVE)and partial least squares projection analysis,and the selected spectral peaks mainly represent the elemental difference in C,Fe,Mg,Mn,Al and *** Least Squares Discriminant Analysis(PLS-DA)was used for developing classification model using selected optimal spectral peaks,and yielded the 99.77%classification accuracy for 300 test samples was *** results indicate that the proposed method can be used to identify leaf varieties in various tea products.

关键词： LIBS tea varieties classification feature selection PLS projection algorithm UVE PLSDA

颗粒植骨,钛网植骨和髂骨植骨在后入路单节段腰椎结核病灶清除术中的疗效研究

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中国临床解剖学杂志 2022年第2期40卷 204-210页

作者：蒋官印欧云生朱勇罗伟杜兴张威秦万元重庆医科大学附属第一医院骨科重庆400016

目的比较颗粒植骨,钛网植骨和自体髂骨植骨在后入路单节段腰椎结核病灶清除术中的临床疗效。方法回顾性分析本科2015年7月至2020年9月接受后入路单节段腰椎结核病灶清除+植骨融合内固定术的98例患者,其中32例自体髂骨植骨,32例钛网植骨... 详细信息

目的比较颗粒植骨,钛网植骨和自体髂骨植骨在后入路单节段腰椎结核病灶清除术中的临床疗效。方法回顾性分析本科2015年7月至2020年9月接受后入路单节段腰椎结核病灶清除+植骨融合内固定术的98例患者,其中32例自体髂骨植骨,32例钛网植骨,34例颗粒植骨。主要的观察指标包括:手术时间,术中出血量,术后住院时间,VAS评分(visual analogue scale,VAS),血细胞沉降率,C反应蛋白和美国脊髓损伤协会分级;次要参考指标:矫正和丢失Cobb角,植骨融合时间。记录所有参考数据并进行统计学分析。结果术后平均随访时间为28月(14~53月)。颗粒组手术时间(192.6±42.2)min,植骨融合时间(5.2±1.1)月,均优于髂骨块组(229.2±61.6)min,(8.0±2.9)月和钛网组(233.1±51.1)min,(8.6±5.6)月,P0.05)。余指标3组间无统计学差异。结论与髂骨块植骨和钛网植骨相比,颗粒骨植骨简单易行,手术时间短,术中出血量少,术后植骨融合快,应用于后入路单节段腰椎结核术中,是一种安全,有效的植骨方式。

关键词：腰椎结核后入路内固定植骨融合方式