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A Kind of Lean Approach for Removing Wastes From Non-Manufacturing Process With Various Facilities

IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 307-315页

作者： guangyu Xiong Xiuqin Shang Gang Xiong Timo R.Nyberg IEEE the Silk Road business School Sanya University the Department of Industrial Engineering and Management School of ScienceAalto University the State Key Laboratory for Management and Controlof Complex Systems Institute of AutomationChinese Academy of Sciences(CAS) Qingdao Academy of Intelligent Industries the Cloud Computing Center CAS the beijing Engineering Research Center of Intelligent Systems and Technology Institute of AutomationCAS the School of Science at Aalto University

It is important to identify and remove the wastes not only from manufacturing process, but also from nonmanufacturing process. In the last several decades, significant research achievements and practice benefits have been achieved about removing wastes from manufacturing process. Since the1990 s, some researchers and lean practitioners have paid more attention to removing waste from non-manufacturing *** on the authors' research work and industrial practice, the paper introduces a kind of lean approach for removing waste from non-manufacturing process. In its case study, the order handling process in a value chain is described with respect to a factory and its downstream distribution centers(DCs). The paper proposes a lean approach solution for creating the improved order handling process, and analyze how great improvements in performance can be achieved. As a result, the significant achievement has created a win-win scenario for both the nonmanufacturing process in a factory and non-manufacturing facilities(like DCs) across the value chain. It demonstrates that improvements have been made by removing waste from the non-manufacturing process that takes place within a factory as well as with external participants through the whole value chain. Likewise, the proposed lean approach has helped the case companies to achieve greater levels of efficiency and more benefits. Finally, some conclusions are drawn.

关键词： Lean approach non-manufacturing process optimized order handling process removing wastes value chain win-win scenario

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Seismic stability of earth slopes with tension crack

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Frontiers of Structural and Civil Engineering 2019年第4期13卷 950-964页

作者： Yundong ZHOU Fei ZHANG Jingquan Wang Yufeng GAO guangyu DAI Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210098China Key Laboratory of Concrete and Prestressed Concrete Structure of China Ministry of Education Southeast UniversityNanjing 211189China

Cracks at the crest of slopes frequently occur during earthquakes. Such cracks result from limited tension strength of the soil. A tension cut-off in Mohr-Coulomb shear strength can represent this limited strength. Presented is an extension of variational analysis of slope stability with a tension crack considering seismicity. both translational and rotational failure mechanisms are included in a pseudo-static analysis of slope stability. Developed is a closed-form to assess the seismic stability of slopes with zero tensile strength. The results indicate that the presence of the tension crack has significant effects on the seismic stability of slopes, i.e., leading to small value of the yield acceleration. Considering soil tension strength in seismic slope analysis may lead to overestimation on the stability, as much as 50% for vertical slopes. Imposing tension crack results in transit of the critical failure mode to a straight line from a log-spiral, except for flat slopes with small soil cohesion. Under seismic conditions, large cohesion may increase the depth of crack, moving it closer to the slope.

关键词： slope stability tension crack limit equilibrium seismic effect

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Identifying the sensitive areas in targeted observation for predicting the Kuroshio large meander path in a regional ocean model

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Acta Oceanologica Sinica 2022年第2期41卷 3-14页

作者： Xia Liu Qiang Wang mu mu School of Mathematics Zhengzhou University of AeronauticsZhengzhou 450046China Key Laboratory of Marine Hazards Forecasting of Ministry of Natural Resources Hohai UniversityNanjing 210098China College of Oceanography Hohai UniversityNanjing 210098China Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China

With the Regional Ocean Modeling System(ROMS),this paper investigates the sensitive areas in targeted observation for predicting the Kuroshio large meander(LM)path using the conditional nonlinear optimal perturbation *** identify the sensitive areas,the optimal initial errors(OIEs)featuring the largest nonlinear evolution in the LM prediction are first calculated;the resulting OIEs are localized mainly in the upper 2500 m over the LM upstream region,and their spatial structure has certain similarities with that of the optimal triggering *** on this spatial structure,the sensitive areas are successfully identified,located southeast of Kyushu in the region(29°–32°N,131°–134°E).A series of sensitivity experiments indicate that both the positions and the spatial structure of initial errors have important effects on the LM prediction,verifying the validity of the sensitive ***,the effect of targeted observation in the sensitive areas is evaluated through observing system simulation *** targeted observation is implemented in the identified sensitive areas,the prediction errors are effectively reduced,and the prediction skill of the LM event is improved *** provides scientific guidance for ocean observations related to enhancing the prediction skill of the LM event.

关键词： Kuroshio large meander targeted observation sensitive areas ROMS

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人工智能辅助的蛋白质稳定性优化

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上海医药 2024年第7期45卷 10-15,75页

作者：李瑞赵阳张晗杨广宇上海交通大学生命科学技术学院微生物代谢国家重点实验室上海200240 上海市实验医学研究院关键原材料研究所上海200240

蛋白质药物具有作用机制清晰、作用特异性强、不良反应少等优势,临床应用前景巨大。蛋白质的稳定性是蛋白质药物的一项非常重要的指标,对于其成药性、安全性和有效性都至关重要。近年来,人工智能辅助的蛋白质改造工程逐渐发展成为一种... 详细信息

蛋白质药物具有作用机制清晰、作用特异性强、不良反应少等优势,临床应用前景巨大。蛋白质的稳定性是蛋白质药物的一项非常重要的指标,对于其成药性、安全性和有效性都至关重要。近年来,人工智能辅助的蛋白质改造工程逐渐发展成为一种高效的蛋白质分子设计新策略,并被广泛应用于蛋白质稳定性预测、药物设计和抗体优化等方面。本文介绍主要的人工智能辅助的蛋白质稳定性优化方法,讨论不同种类优化方法的优劣及其在蛋白质药物设计和优化中的应用,探讨人工智能在蛋白质稳定性设计中的挑战和前景,以期为研究者们开发更稳定、更高效的蛋白质药物提供新的思路。

关键词：人工智能蛋白质稳定性蛋白质药物

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Recent Progress in Applications of the Conditional Nonlinear Optimal Perturbation Approach to Atmosphere-Ocean Sciences

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Chinese Annals of Mathematics,Series b 2022年第6期43卷 1033-1048页

作者： mu mu Kun ZHANG Qiang WANG Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Shanghai 200438China CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China Key Laboratory of Marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210098China College of Oceanography Hohai UniversityNanjing 210098China

The conditional nonlinear optimal perturbation(CNOP for short) approach is a powerful tool for predictability and targeted observation studies in atmosphere-ocean sciences. by fully considering nonlinearity under appropriate physical constraints, the CNOP approach can reveal the optimal perturbations of initial conditions, boundary conditions, model parameters, and model tendencies that cause the largest simulation or prediction uncertainties. This paper reviews the progress of applying the CNOP approach to atmosphere-ocean sciences during the past five years. Following an introduction of the CNOP approach, the algorithm developments for solving the CNOP are ***, recent CNOP applications, including predictability studies of some high-impact ocean-atmospheric environmental events, ensemble forecast, parameter sensitivity analysis, uncertainty estimation caused by errors of model tendency or boundary condition, are reviewed. Finally, a summary and discussion on future applications and challenges of the CNOP approach are presented.

关键词： Conditional nonlinear optimal perturbation Atmosphere Ocean Targeted observation Predictability

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含蜡水合物浆液的生成特性及其黏度预测

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石油化工 2024年第9期53卷 1324-1330页

作者：张洁王瑞康李光哲王世豪汪瑞孙广宇中国石油大学(华东)储运与建筑工程学院山东青岛266580

为了防治深海油气输送过程中因浆液流动性恶化导致的堵管事故,采用旋转流变仪开展了含蜡量、含水率以及剪切条件对含蜡水合物浆液生成过程和流变特性的影响研究,并从热力学角度分析了对水合物生成和乳状液稳定性的影响。实验结果表明,... 详细信息

为了防治深海油气输送过程中因浆液流动性恶化导致的堵管事故,采用旋转流变仪开展了含蜡量、含水率以及剪切条件对含蜡水合物浆液生成过程和流变特性的影响研究,并从热力学角度分析了对水合物生成和乳状液稳定性的影响。实验结果表明,水合物浆液表现出典型的剪切稀释性和触变性;含水率在5%~30%(w)范围内,含水率越高越容易在停输再启动的过程中发生堵管事故;含蜡量在3%~10%(w)范围内,含蜡量越高越容易维持水合物解离后乳状液的稳定性。最后,基于流变测试数据,将任意形状颗粒的修正悬浮液黏度模型的适用范围拓展至含蜡水合物浆液体系,提高了水合物体积分数高于0.15时的拟合准确度。

关键词：水合物蜡流变性黏度模型乳状液流动保障

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密度泛函理论研究富勒烯C_(70)对偏二甲肼与NO_(2)的抽氢反应机制

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火炸药学报 2024年第3期47卷 237-244,I0004页

作者：赵子航慕晓刚王生辉马海霞西北大学化工学院/西安市特种能源材料重点实验室陕西西安710069 火箭军工程大学陕西西安710025

为了探讨富勒烯(C_(70))作为催化剂用于偏二甲肼(UDMH)推进剂分解的可行性,采用密度泛函理论(DFT)研究了UDMH分子与C_(70)团簇分子的相互作用,分析了UDMH在C_(70)表面的吸附行为及分解路径,计算获得了UDMH在C_(70)存在时发生抽氢反应的... 详细信息

为了探讨富勒烯(C_(70))作为催化剂用于偏二甲肼(UDMH)推进剂分解的可行性,采用密度泛函理论(DFT)研究了UDMH分子与C_(70)团簇分子的相互作用,分析了UDMH在C_(70)表面的吸附行为及分解路径,计算获得了UDMH在C_(70)存在时发生抽氢反应的活化能和反应热。结果表明,UDMH分子在C_(70)表面表现为两种吸附构型,主要发生物理吸附且吸附能较小,C_(70)分子的加入并未改变UDMH分解的初始和次级反应位点,在与NO_(2)抽氢反应时表现为在NH _(2)基团上依次发生。与纯UDMH分解相比,A、b两种吸附构型中UDMH分解初始基元反应的反应活化能分别下降了19.4 kJ/mol、21.1 kJ/mol,反应热分别降低了24.2 kJ/mol和27 kJ/mol。因此,C_(70)对于UDMH分解的前两步反应具有催化能力,能够促进UDMH的分解。

关键词：量子化学富勒烯C_(70) 偏二甲肼 UDMH 密度泛函理论 DFT

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整合素α6靶向自组装促凋亡纳米多肽对中枢神经系统急性淋巴细胞白血病的靶向治疗

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Engineering 2024年第4期35卷 226-240页

作者： Jia-Cong Ye Wan-Qiong Li Mei-Ling Chen Qian-Kun Shi Hua Wang Xin-Ling Li Ying-He Li Jie Yang Qiao-Li Wang Fang Hu Yan-Feng Gao Shu-Wen Liu mu-Sheng Zeng Guo-Kai Feng Guangdong Provincial Key Laboratory of New Drug Screening&NMPA Key Laboratory of Drug Metabolism Research and Evaluation School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Oncology in South China&Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Biomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of NephrologySouthern Medical UniversityGuangzhou 510515China

There is currently no effective targeted therapeutic strategy for the treatment of central nervous system acute lymphoblastic leukemia(CNS-ALL).Integrinα6 is considered a potential target for CNS-ALL diagnosis and therapy because of its role in promoting CNS-ALL disease *** targeted peptide D(RWYD)(abbreviated RD),with nanomolar affinity to integrinα6 was identified by peptide scanning techniques such as alanine scanning,truncation,and ***,we developed a therapeutic nanoparticle based on the integrinα6-targeted peptide for treating *** self-assembled proapoptotic nanopeptide_(D)(RWYD)-_(D)(KLAKLAK)_(2)-G_(D)(FFY)(abbreviated RD-KLA-Gffy)contains the integrinα6-targeted peptide RD,the well-known proapoptotic peptide_(D)(KLAKLAK)_(2)(abbreviated KLA),and the self-assembling tetrapeptide GD(FFY)(abbreviated Gffy).The functional mechanism of RD-KLA-Gffy is clarified using different *** results demonstrate that RD-KLA-Gffy is highly enriched in CNS-ALL lesions and induces tumor cell apoptosis,thus reducing CNS-ALL disease burden and prolonging the survival of CNS-ALL mice without obvious ***,the combined use of RD-KLA-Gffy and methotrexate(MTX)shows a potent antitumor effect in treating CNS-ALL,indicating that RD-KLA-Gffy plays an important role in suppressing CNS-ALL progression either as a single agent or in combination with MTX,which shows promise for application in CNS-ALL therapy.

关键词： Central nervous system acute lymphoblastic leukemia Integrinα6 Targeted peptide Proapoptotic Nanopeptide

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RNA-based NGS检测EML4-ALK融合V1亚型肺腺癌1例

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中国肺癌杂志 2024年第6期27卷 480-484页

作者：徐悦穆宁刘梅吴盛楠马春华天津市人民医院肿瘤诊疗中心天津300121

肺癌是全球发病率和死亡率最高的恶性肿瘤。对于肺腺癌而言,识别特定的基因突变并给予相应靶向药物可大大提高患者的生存时间。其中,间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)融合发生在3%-7%的非小细胞肺癌(non-small cell lu... 详细信息

肺癌是全球发病率和死亡率最高的恶性肿瘤。对于肺腺癌而言,识别特定的基因突变并给予相应靶向药物可大大提高患者的生存时间。其中,间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)融合发生在3%-7%的非小细胞肺癌(non-small cell lung cancer,NSCLC)中。在临床中,多种检测方法可应用于判断ALK融合状态,但存在检测结果假阴性可能。本文回顾性分析1例肺腺癌患者的诊治经过,经多种检测方式判断ALK融合状态,其中,免疫组化(immunohistochemistry,IHC)(Ventana D5F3)、基于RNA的下一代测序(RNA-based next-generation sequencing,RNA-based NGS)检测证实棘皮类微管关联蛋白样4(echinoderm microtubule associated protein like 4,EML4)-ALK融合阳性,而基于DNA的NGS(DNA-based NGS)检测为阴性。本文比较分析判断ALK融合的检测方法,以明确在不同临床案例中选择何种检测方式最准确、最简便,以便于指导后续治疗。

关键词：肺肿瘤间变性淋巴瘤激酶基因融合下一代测序免疫组化靶向治疗

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轴扭耦合冲击器结构设计与室内试验

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石油钻探技术 2024年第1期52卷 78-83页

作者：陈东方全兵肖新启张光宇陈志华中石化江钻石油机械有限公司湖北武汉430223

为提高PDC钻头切削齿在硬地层中的吃入深度、消除扭转振动带来的危害,在自激换向式扭冲总成结构的基础上,增设水力脉冲式轴冲总成,利用扭冲总成拨叉带动轴冲总成动盘阀同步旋转,使过流面积发生周期性变化,产生水力脉冲轴冲载荷,与扭冲... 详细信息

为提高PDC钻头切削齿在硬地层中的吃入深度、消除扭转振动带来的危害,在自激换向式扭冲总成结构的基础上,增设水力脉冲式轴冲总成,利用扭冲总成拨叉带动轴冲总成动盘阀同步旋转,使过流面积发生周期性变化,产生水力脉冲轴冲载荷,与扭冲载荷一起形成轴扭耦合冲击,设计出一种结构简单、冲击频率相同的新型轴扭耦合冲击器。同时,基于能量转换与守恒定律,建立了冲击器性能参数数学模型,并开展了轴扭耦合冲击器性能参数室内试验。试验结果表明,该轴扭耦合冲击器的压降、轴冲载荷与流量平方呈正比,扭冲载荷、冲击频率与流量呈线性增大关系,最大相对误差仅7.91%,验证了该数学模型的准确性。研究结果可为同类冲击钻井工具的开发提供理论指导。

关键词：轴扭耦合冲击器结构设计实验室试验性能参数数学模型

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