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Cohomology groups of a new class of Kadison-Singer algebras

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Science China Mathematics 2024年第3期67卷 593-606页

作者： guangyu An Xing Cheng Jun Sheng School of Mathematics and Data Science Shaanxi University of Science and TechnologyXi’an 710021China

Let N be a maximal discrete nest on an infinite-dimensional separable Hilbert space H,ξ=∑^(∞)_(n=1)en/2n be a separating vector for the commutant N',E_(ξ)be the projection from H onto the subspace[Cξ]spanned by the vectorξ,and Q be the projection from K=H⊕H⊕H onto the closed subspace{(η,η,η)^(T):η∈H}.Suppose that L is the projection lattice generated by the projections(E_(ξ) 0 0 0 0 0 0 0 0),{(E 0 0 0 0 0 0 0 0):E∈N},(I 0 0 0 I 0 0 0 0) and *** show that L is a Kadison-Singer lattice with the trivial ***,we prove that every n-th bounded cohomology group H~n(AlgL,b(K))with coefficients in b(K)is trivial for n≥1.

关键词： Kadison-Singer algebra Kadison-Singer lattice derivation cohomology group

Theoretical model of azimuthal combustion instability subject to non-trivial boundary conditions

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Chinese Journal of Aeronautics 2024年第9期37卷 113-130页

作者： Lei QIN Xiaoyu WANG guangyu ZHANG Xiaofeng SUN Research Institute of Aero-Engine Beihang UniversityBeijing 100191China School of Energy and Power Engineering Beihang UniversityBeijing 100191China

The problem of evaluating the sensitivity of non-trivial boundary conditions to the onset of azimuthal combustion instability is a longstanding challenge in the development process of mod-ern gas *** difficulty lies in how to describe three-dimensional in-and outlet boundary conditions in an artificial computational *** date,the existing analytical models have still failed to quantitatively explain why the features of the azimuthal combustion instability of a com-bustor in laboratory environment are quite different from that in a real gas turbine,making the sta-bility control devices developed in laboratory generally lose the effectiveness in practical *** overcome this limitation,we provide a novel theoretical framework to directly include the effect of non-trivial boundary conditions on the azimuthal combustion instability.A key step is to take the non-trivial boundary conditions as equivalent distributed sources so as to uniformly describe the physical characteristics of the inner surface in an annular enclosure along with different in-and outlet ***,a dispersion relation equation is established by the application of three-dimensional Green's function approach and generalized impedance *** show that the effects of the generalized modal reflection coefficients on azimuthal unstable modes are extremely prominent,and even prompt the transition from stable to unstable mode,thus reasonably explaining why the thermoacoustic instability phenomena in a real gas tur-bine are difficult to observe in an isolated combustion ***,this work provides an effective tool for analysis of the azimuthal combustion instability including various complicated boundary conditions.

关键词： Combustion instability Aeroacoustics Modeling Optimization techniques Control

Advances in the research and application of neurokinin-1 receptor antagonists

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2024年第2期25卷 91-105页

作者： Xiangyu HONG Junjie MA Shanshan ZHENG guangyu ZHAO Caiyun FU College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou310018China

Recently,the substance P(SP)/neurokinin-1 receptor(NK-1R)system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019(COVID-19).besides,studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK-1R system with the progression of multiple carcinoma types and poor clinical *** findings indicate that the modulation of SP/NK-1R system with NK-1R antagonists can be a potential broad-spectrum antitumor *** review updates the latest potential and applications of NK-1R antagonists in the treatment of human diseases and cancers,as well as the underlying ***,the strategies to improve the bioavailability and efficacy of NK-1R antagonist drugs are summarized,such as solid dispersion systems,nanonization,and *** a radiopharmaceutical therapeutic,the NK-1R antagonist aprepitant was originally developed as radioligand receptor to target NK-1R-overexpressing ***,combining NK-1R antagonists with other drugs can produce a synergistic effect,thereby enhancing the therapeutic effect,alleviating the symptoms,and improving patients’quality of life in several diseases and cancers.

关键词： Neurokinin-1 receptor(NK-1R)antagonist Pathophysiological disorder Tumor target bioavailability Nanoencapsulation Synergistic therapy

Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase mu

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Genes & Diseases 2024年第2期11卷 528-531页

作者： Jing He Yiran Yu Yilin He Jie He guangyu Ji Haiquan Lu The Second Hospital and Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Department of Nursing The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250014China School of Medicine Xinjiang Medical UniversityUrumqiXinjiang 830054China School of Medicine Binzhou Medical UniversityYantaiShandong 264003China Oncology Department Jinan Zhangqiu District People's HospitalJinanShandong 250200China Key Laboratory for Experimental Teratology of the Ministry of Education Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Center for Reproductive Medicine Shandong UniversityJinanShandong 250012China

Triple-negative breast cancer(TNbC)has aggressive characteristics as exemplified by the high risk of recurrence,metastasis,and patient mortality.1 Cytotoxic chemotherapy may reduce tumor burden initially,but leave behind chemo-resistant breast cancer stem cells(bCSCs)that lead to tumor recurrence and metastasis.2 Chemotherapy induces bCsC enrichment through the activation of glutathione biosynthesis pathways,which increases intracellular glutathione levels and specifies the bCSC phenotype through complicated downstream signaling pathways.3 Glutathione S-transferases(GSTs),a superfamily(which contains seven cytosolic classes:Alpha,Kappa,mu,Omega,Pi,Theta,and Zeta,and one microsomal class MGSTs)of phase Il enzymes that catalyze the conjugation of glutathione with electrophilic compounds,play a critical role in detoxification and chemotherapy resistance of cancer ***,the role of GSTs in the regulation of bCSCs is largely elusive.

关键词： chemotherapy breast metastasis

Rethinking the Encoder-decoder Structure in Medical Image Segmentation from Releasing Decoder Structure

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Journal of bionic Engineering 2024年第3期21卷 1511-1521页

作者： Jiajia Ni Wei mu An Pan Zhengming Chen School of Artificial Intelligence Anhui Polytechnic UniversityWuhu241000China School of Information Science and Engineering HoHai UniversityChangzhou213000China

Medical image segmentation has witnessed rapid advancements with the emergence of encoder-decoder based *** the encoder-decoder structure,the primary goal of the decoding phase is not only to restore feature map resolution,but also to mitigate the loss of feature information incurred during the encoding ***,this approach gives rise to a challenge:multiple up-sampling operations in the decoder segment result in the loss of feature *** address this challenge,we propose a novel network that removes the decoding structure to reduce feature information loss(CbL-Net).In particular,we introduce a Parallel Pooling Module(PPM)to counteract the feature information loss stemming from conventional and pooling operations during the encoding ***,we incorporate a multiplexed Dilation Convolution(MDC)module to expand the network's receptive ***,although we have removed the decoding stage,we still need to recover the feature map ***,we introduced the Global Feature Recovery(GFR)*** uses attention mechanism for the image feature map resolution recovery,which can effectively reduce the loss of feature *** conduct extensive experimental evaluations on three publicly available medical image segmentation datasets:DRIVE,CHASEDb and MoNuSeg *** results show that our proposed network outperforms state-of-the-art methods in medical image *** addition,it achieves higher efficiency than the current network of coding and decoding structures by eliminating the decoding component.

关键词： Medical image segmentation Encoder-decoder architecture Attention mechanisms Releasing decoder architecture Neural network

The role of intestinal flora on tumorigenesis,progression,and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer

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Cancer biology & Medicine 2024年第1期21卷 65-82页

作者： Sen Wang benling Xu Yangyang Zhang guangyu Chen Peng Zhao Quanli Gao Long Yuan Department of Gastrointestinal Surgery Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Immunotherapy Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China

Intestinal flora affects the maturation of the host immune system,serves as a biomarker and efficacy predictor in the immunotherapy of several cancers,and has an important role in the development of colorectal cancer(CRC).Anti-PD-1/PD-L1 antibodies have shown satisfactory results in MSI-H/d MMR CRC but performed poorly in patients with MSS/p MMR *** recent years an increasing number of studies have shown that intestinal flora has an important impact on anti-PD-1/PD-L1 antibody efficacy in CRC *** and clinical evidence have suggested that anti-PD-1/PD-L1 antibody efficacy can be improved by altering the composition of the intestinal flora in ***,we summarize the studies related to the influence of intestinal flora on anti-PD-1/PD-L1 antibody efficacy in CRC and discuss the potential underlying mechanism(s).We have focused on the impact of the intestinal flora on the efficacy and safety of anti-PD-1/PD-L1 antibodies in CRC and how to better utilize the intestinal flora as an adjuvant to improve the efficacy of anti-PD-1/PD-L1 *** addition,we have provided a basis for the potential of the intestinal flora as a new treatment modality and indicator for determining patient prognosis.

关键词： Intestinal flora anti-PD-1/PD-L1 therapy colorectal cancer immune checkpoint inhibitor CD8~+T cell

Research On The Universities Second Classroom Teaching Mode Resources System

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Research On The Universities Second Classroom Teaching Mode ...

Navigating Epstein–barr virus autoimmunity:role of NK cells and T cells in multiple sclerosis

2012 4th International Conference on Education Technology and Computer(ICETC 2012)

作者： Desheng wu a guangyu mu b Yuanhui Guan a a School of Information Communication Engineering Changchun University of Technology Changchun 130012 China b School of Management Science and Information Engineering Jilin University of Finance and Economics Changchun 130117 China

A new kind of teaching model called the second classroom for college teaching system platform is presented, it can arouse students’ interest in learning and avoid wasting time. The platform contains the system of the teacher, the teacher plays the core part of the system through the module, including the student management information, the examination paper information, news information, chapter information and the message information management. The student personal information is designed for students to the use learning, which should reflect student-centered theory. Through it, students can download videos and self- study materials, do on-line tests, communicate with teachers and other students and so on. by the system the students can learn more out of *** platform have already been put into use, the effect is very good.

关键词： MANAGNMEN THE SECOND CLASSROOM ONLIN TEACHER SYSTEM INSTRUCTIONAL TESOURES

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Signal Transduction and Targeted Therapy 2024年第3期9卷 833-835页

作者： Chu Xie Cong Sun mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouP.R.China

In a recent study published in Cell,Vietzen and colleagues discovered the novel role of natural killer(NK)cells and EbVspecific CD8+T cell response in controlling EbV-inducing autoimmune response and collectively def... 详细信息

关键词： Epstein sclerosis killer

Existence of Positive Solutions to a Fractional-Kirchhoff System

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 225-240页

作者： Peng-fei Li Jun-hui Xie Dan mu School of Mathematics and Statistics Hubei Minzu UniversityEnshi445000China

LetΩbe a bounded smooth domain in RN(N≥3).Assuming that 00 are constants,we consider the existence results for positive solutions of a class of fractional elliptic system below,{(a+b[u]^(2)_(s))(-Δ)^(s)u=vp+h_(1)(x... 详细信息

LetΩbe a bounded smooth domain in RN(N≥3).Assuming that 0b>0 are constants,we consider the existence results for positive solutions of a class of fractional elliptic system below,{(a+b[u]^(2)_(s))(-Δ)^(s)u=vp+h_(1)(x,u,v,▽u,▽v),x∈Ω,(-Δ)^(s)v=u^(q)+h_(2)(x,u,▽,▽u,▽v),x∈Q,u,v>0,x∈Ω,u=v=0,x∈RN\Ω.Under some assumptions of hi(x,u,v,▽u,▽v)(i=1,2),we get a priori bounds of the positive solutions to the problem(1.1)by the blow-up methods and rescaling *** on these estimates and degree theory,we establish the existence of positive solutions to problem(1.1).

关键词： fractional-Kirchhoff system a priori bounds degree theory positive solution