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Novel biomarkers identifying hypertrophic cardiomyopathy and its obstructive variant based on targeted amino acid metabolomics

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Chinese Medical Journal 2022年第16期135卷 1952-1961页

作者： Lanyan Guo Bo Wang Fuyang Zhang Chao Gao guangyu hu Mengyao Zhou Rutao Wang Hang Zhao Wenjun Yan Ling Zhang Zhiling Ma Weiping Yang Xiong Guo Chong huang Zhe Cui Fangfang Sun Dandan Song Liwen Liu Ling Tao Department of Cardiology Xjing HospitalThe Fourth Military Medical UniversityXi'anShaanxi 710032China Department of Ultrasound Xijing HospitalThe Fourth Military Medical UniversityXi'anShaanxi 710032China.

Background:Hypertrophic cardiomyopathy(HCM)is an underdiagnosed genetic heart disease *** management and prognosis of obstructive HCM(HOCM)and non-obstructive HCM(HNCM)are quite different,but it also remains challenging to discriminate these two *** is characterized by dysmetabolism,and myocardial amino acid(AA)metabolism is robustly *** present study aimed to delineate plasma AA and derivatives profiles,and identify potential biomarkers for ***:Plasma samples from 166 participants,including 57 cases of HOCM,52 cases of HNCM,and 57 normal controls(NCs),who first visited the International Cooperation Center for HCM,Xijing Hospital between December 2019 and September 2020,were collected and analyzed by high-performance liquid chromatography-mass spectrometry based on targeted AA *** separate classification algorithms,including random forest,support vector machine,and logistic regression,were applied for the identification of specific AA and derivatives compositions for HCM and the development of screening models to discriminate HCM from NC as well as HOCM from ***:The univariate analysis showed that the serine,glycine,proline,citrulline,glutamine,cystine,creatinine,cysteine,choline,and aminoadipic acid levels in the HCM group were significantly different from those in the NC *** AAs and derivatives(Panel A;proline,glycine,cysteine,and choline)were screened out by multiple feature selection algorithms for discriminating HCM patients from *** receiver operating characteristic(ROC)analysis in Panel A yielded an area under the ROC curve(AUC)of 0.83(0.75-0.91)in the training set and 0.79(0.65-0.94)in the validation ***,among 10 AAs and derivatives(arginine,phenylalanine,tyrosine,proline,alanine,asparagine,creatine,tryptophan,ornithine,and choline)with statistical significance between HOCM and HNCM,3 AAs(Panel B;arginine,proline,and ornithine)were selected to differentiate the two *** A

关键词： Hypertrophic cardiomyopathy Amino acids Targeted metabolomics Biomarkers Algorithm

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形变诱导铁素体相变技术

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长沙大学学报 2005年第2期19卷 15-18页

作者：夏卿坤胡冠昱长沙大学工程系湖南长沙410003

叙述了形变诱导相变的定义和基本特征,介绍了形变诱导超细晶的机械性能、形变诱导铁素体相变原理,以及该技术在低碳钢板材轧制工艺中的应用前景.

关键词：低碳钢形变相变超细晶

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刑事诉讼繁简分流制度体系构建——以认罪认罚从宽制度为视角

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合肥工业大学学报（社会科学版） 2017年第6期31卷 44-48页

作者：胡光宇张宁安徽师范大学法学院安徽芜湖241000 安徽省芜湖市镜湖区人民检察院安徽芜湖241000

案件的繁简分流已成为现代司法的必然要求,世界各国都在不断探索合理有效的繁简分流制度以解决社会案件的不断增多所带来的司法困境。认罪认罚从宽处罚制度是我国刑事诉讼繁简分流制度建设的一个重要方向。在严格遵循司法所要求的公正... 详细信息

案件的繁简分流已成为现代司法的必然要求,世界各国都在不断探索合理有效的繁简分流制度以解决社会案件的不断增多所带来的司法困境。认罪认罚从宽处罚制度是我国刑事诉讼繁简分流制度建设的一个重要方向。在严格遵循司法所要求的公正的基本价值基础之上,充分地发挥当事人的自愿性,达成控辩双方的认罪协商具结书。这样不仅可以有效保障当事人的诉权,而且可以进一步减轻控辩双方的举证责任,从而达到简化司法审判程序的目的,推动案件的繁简分流。

关键词：宽严相济繁简分流权利保障

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健康期望寿命指标分类及评价比较

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中国社会医学杂志 2012年第3期29卷 149-151页

作者：胡广宇谢学勤首都医科大学卫生管理与教育学院北京100069 北京市公共卫生信息中心北京100050

健康期望寿命是人群健康综合测量的代表性指标,在国际上已得到广泛研究和应用。重点介绍了健康期望寿命指标的分类,对健康状态期望(health state expectancy,HSE)和健康调整期望寿命(health-adjusted life ex-pectancy,HALE)两类指标群... 详细信息

健康期望寿命是人群健康综合测量的代表性指标,在国际上已得到广泛研究和应用。重点介绍了健康期望寿命指标的分类,对健康状态期望(health state expectancy,HSE)和健康调整期望寿命(health-adjusted life ex-pectancy,HALE)两类指标群进行了评价与比较,提出适宜研究资料的缺乏与计算方法的分歧是当前国内健康期望寿命研究应着力解决的两大重要问题。

关键词：健康期望寿命指标分类评价比较

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思南历史价值与文化特色的发掘研究

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城市发展研究 2024年第1期31卷 26-29页

作者：常光宇胡燕曹昌智山西工程科技职业大学建筑设计学院中国城市科学研究会历史文化名城委员会

保护传承历史文化，只有发掘研究它的价值特色,把握本质内涵，才能获得清晰认知，坚持价值导向，激发保护传承的内在动力。通过对思南县历史文脉耙梳，研读史料文献，揭示厚重的历史文化，彰显重要历史价值和地域民族文化，以期唤起保... 详细信息

保护传承历史文化，只有发掘研究它的价值特色,把握本质内涵，才能获得清晰认知，坚持价值导向，激发保护传承的内在动力。通过对思南县历史文脉耙梳，研读史料文献，揭示厚重的历史文化，彰显重要历史价值和地域民族文化，以期唤起保护传承历史文化的社会意识与热情。

关键词：思南价值特色乌江盐运改土归流多民族文化

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斜置槽道在翼型失速控制中的应用

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北京航空航天大学学报 2024年第8期50卷 2601-2618页

作者：杨光宇张扬胡澜翔付一帆西安交通大学机械结构强度与振动国家重点实验室西安710049

翼型失速问题是风力机设计过程中需要重点考虑的气动现象,而引起失速的主要原因是附面层内流动能量不足,无法提供足够的附着力。利用翼型内部开槽,将大迎角状态时翼型下方的高动量气流引射进上部分离区可以有效解决这一问题。为了设计... 详细信息

翼型失速问题是风力机设计过程中需要重点考虑的气动现象,而引起失速的主要原因是附面层内流动能量不足,无法提供足够的附着力。利用翼型内部开槽,将大迎角状态时翼型下方的高动量气流引射进上部分离区可以有效解决这一问题。为了设计出具有更好气动特性的开槽翼型,研究了在不同宽度下2种不同形状的开槽对翼型气动特性的影响,通过观察不同开槽翼型的流场图和分析不同开槽翼型槽内、槽出口的气流流速,优化出具有更好气动特性的开槽翼型。经过优化设计的开槽翼型在深失速环境下,失速迎角增大了8°,相较于初始翼型,有了较大的气动性能的提升,并证明了开槽在较大迎角时有改善翼型气动特性的特征。

关键词：风力机翼型翼型失速斜置槽道边界层分离流速

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羟磷灰石涂层钛合金植入材料的实验研究

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上海医学 2002年第10期25卷 628-631页

作者：胡光宇李华东上海第二医科大学附属仁济医院骨科 200001 轻工业部玻璃塘瓷工业科学研究所

目的　通过测定一种新的羟磷灰石 (HAP)涂层钛合金植入材料的理化参数、与宿主骨的生物相容性观察及骨 HAP界面最大剪切强度的测定 ,评估该材料作为人工骨或人工关节材料的临床应用价值。方法　①测定材料的最佳烧结温度和机械强度 ,... 详细信息

目的　通过测定一种新的羟磷灰石 (HAP)涂层钛合金植入材料的理化参数、与宿主骨的生物相容性观察及骨 HAP界面最大剪切强度的测定 ,评估该材料作为人工骨或人工关节材料的临床应用价值。方法　①测定材料的最佳烧结温度和机械强度 ,观察材料表面的多孔结构。②取 2 4只新西兰种家兔 ,在两侧股骨外髁上共植入 4 8个HAP表面涂层及非涂层钛合金材料 ,分别于术后 1、2、3、6及 12周处死家兔取材。测定骨 HAP界面最大剪切强度并作组织学观察。结果　①材料的最佳烧结温度为 80 0°C ,抗剪强度为 18.5MPa ,抗压强度为 170MPa ,孔隙率为 10 %～ 15 % ,孔径为 30～ 70 μm。②HAP涂层钛合金组能与宿主骨紧贴 ,新骨能迅速长入材料的裂隙和被降解的封闭小孔内 ,而非涂层材料则使新生骨组织死亡并为结缔组织取代。③术后任一时间段涂层材料骨 HAP界面最大剪切强度均明显高于非涂层组。

关键词：钛合金实验研究羟基磷灰石涂层植入物生物相容性人工关节

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Associations between parental adherence to a healthy lifestyle and cognitive performance in offspring: A prospective cohort study in China

Associations between parental adherence to a healthy lifesty...

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中国营养学会第十五届全国营养科学大会

作者： Rongxia Lv Yuhui huang Siyi huang Shiyi Wu Siwen Wang guangyu hu Yanan Ma Peige Song Jorge E Chavarro S V Subramanian Chunling Lu Zhihui Li Changzheng Yuan School of Public Health the Children's Hospital and National Clinical Research Center for Child Health Zhejiang University School of Medicine Department of Nutrition Harvard T.H.Chan School of Public Health Institute of Medical Information/Center for Health Policy and Management Chinese Academy of Medical Sciences and Peking Union Medical College Department of Biostatistics and Epidemiology School of Public Health China Medical University Department of Social and Behavioral Sciences Harvard T.H.Chan School of Public Health Division of Global Health Equity Brigham and Women's Hospital Harvard Medical School Department of Global Health and Social Medicine Harvard Medical School Vanke School of Public Health Tsinghua University Department of Global Health and Population Harvard T.H.Chan School of Public Health

Adolescence is a critical period development of higher-order cognition and the corresponding refinements of the structure and function of the brain regions supporting it. The development of higher-order cognition is determined by neurobiological and genetic mechanisms as well as household, community, and environmental factors. Lifestyle, as an important factor of the family environment, plays a critical role in affecting offspring s cognition and behaviors. However, previous studies on parental lifestyle and offspring cognitive performance have mainly focused on individual lifestyle factors or lifestyle profiles of one of the parents, and were limited to the observation in offspring’s early childhood. Little is known about the potential role of parental adherence to an overall healthy lifestyle in the cognitive performance of offspring during adolescence and early adulthood. Therefore, our study aimed to investigate the prospective association between overall parental lifestyle and cognitive performance in offspring during adolescence and young adulthood, using a nationally representative sample from China. Methods We included 2531 adolescents aged 10-15 years at the study baseline in 2010 from the China Family Panel Studies(CFPS). Five healthy lifestyle factors were defined as(1) modified dietary diversity score greater than or equal to 5 points(about the top 35%),(2) never smoking,(3) non-habitual drinking(no more than three times per week in the last month),(4) exercise weekly,(5) taking a short afternoon nap(<30 min/day). Parents received 1 point if they met any criteria for healthy lifestyle behaviors. The combination of these five lifestyle factors constructed the healthy lifestyle score ranging from 0 to 5, with a higher score indicating a healthier lifestyle. Two sets of cognitive measures were used to assess offspring crystallized intelligence(summed by z-transformed vocabulary and mathematics test scores) and fluid intelligence(summed by z-transformed imme

关键词： Parental healthy lifestyle offspring cognitive performance cohort study

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