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血清S-CD105、periostin、TK1水平与非小细胞肺癌根治术后复发的关系研究

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首都食品与医药 2024年第6期31卷 36-39页

作者：黄光俊吕增波张朝青贵州省盘州市人民医院贵州盘州553000 云南省曲靖市第一人民医院云南曲靖655000

目的探讨血清可溶性CD105(S-CD105)、骨膜素(periostin)、胸苷激酶(TK1)水平与非小细胞肺癌(NSCLC)根治术后复发的关系,为NSCLC根治术后复发诊治提供参考依据.方法选择2019年1月-2021年6月盘州市人民医院收治的127例NSCLC患者,根据术后... 详细信息

目的探讨血清可溶性CD105(S-CD105)、骨膜素(periostin)、胸苷激酶(TK1)水平与非小细胞肺癌(NSCLC)根治术后复发的关系,为NSCLC根治术后复发诊治提供参考依据.方法选择2019年1月-2021年6月盘州市人民医院收治的127例NSCLC患者,根据术后是否发生复发将患者分为复发组(53例)和无复发组(74例).检测血清S-CD105、periostin、TK1以及癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)水平,采用多因素Logistic回归分析影响NSCLC术后复发的危险因素.绘制受试者工作特征曲线(ROC),分析S-CD105、periostin、TK1以及联合检测预测NSCLC术后复发的价值.结果复发组血清S-CD105、periostin、TK1、CEA、NSE水平高于无复发组(P<0.05).多因素Logistic回归分析显示,纵隔淋巴结转移、高水平S-CD105、高水平periostin、高水平TK1是NSCLC术后复发的危险因素(P<0.05).S-CD105、periostin、TK1预测NSCLC术后复发的曲线下面积分别为0.700、0.717、0.718,periostin、TK1曲线下面积高于CEA(Z=2.141、2.086,P<0.05),S-CD105、periostin、TK1曲线下面积均高于NSE(Z=2.766、3.139、2.905,P<0.05).联合S-CD105、periostin、TK1预测NSCLC术后复发的曲线下面积为0.892,高于单独S-CD105、periostin、TK1(Z=4.358、3.848、3.611,P<0.05).结论NSCLC根治术后复发患者血清S-CD105、periostin、TK1水平均增高,且与术后复发密切相关,可作为复发预测的生物学指标.

关键词： S-CD105 periostin TK1 非小细胞肺癌根治术复发预测价值

Progress on Bionic Textured Cutting Tools:A Review and Prospects

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Journal of Bionic Engineering 2024年第1期21卷 19-55页

作者： Hong Wei guangjun Chen Zhuang Chen Zhiwei Yu Jiashuai huang Tianjin Key Laboratory of High Speed Cutting and Precision Processing Tianjin 300222China School of Mechanical Engineering Tianjin University of Technology and EducationTianjin 300222China

Cutting tools are known as the“productivity”of the manufacturing industry,which affects the production efficiency and quality of the workpiece,and has become the focus of research and attention in academia and ***,traditional cutting tools often suffer from adhesion or wear during the cutting process,which considerably reduces the cutting efficiency and service life of the tools,and makes it difficult to meet current production *** solve the above problems,scholars have introduced bionics into the tool’s design,applying the microscopic structure of the biological surface to the tool surface to alleviate the tool’s *** paper mainly summarizes the research progress of bionic textured cutting ***,categorize whether the bionic texture design is inspired by a single organism or multiple ***,it is discussed that the non-smooth surface of the biological surface has five characteristics:hydrophilic lubricity,wear resistance,drag reduction and hydrophobicity,anti-adhesion,and arrangement,and the non-smooth structure of these different characteristics are applied to the surface of the tool is designed with bionic ***,the cutting performance of bionic textured cutting tools is *** anti-friction and wear-resisting mechanism of bionic textured cutting tools is ***,some pending problems and perspectives have been proposed to provide new inspirations for the design of bionic textured cutting tools.

关键词： Bionic textured cutting tools Biological microstructure characteristics Cutting performance Anti-friction and wear-resisting mechanism

Recovering rare earths,lithium and fluorine from rare earth molten salt electrolytic slag using sub-molten salt method

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Journal of Rare Earths 2024年第9期42卷 1774-1781,I0005页

作者： Delong Yang Mingming Yu Yusufujiang Mubula Weiquan Yuan Zheyu huang Bo Lin guangjun Mei Tingsheng Qiu School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou341000China Jiangxi Key Laboratory of Mining Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan430070China Gannan Institute of Science and Technology Ganzhou341000China

Viewing the problem of high ene rgy consumption in the process of recovering rare earths from rare earth molten salt electrolysis slag,an environmentally friendly and low carbon process by sub-molten salt decomposition was *** thermodynamic analysis of sub-molten salt reaction indicates that the recovery of rare earths from the slag using sub-molten salt medium is thermodynamically *** this process,the rare earth fluoride and lithium in the slag are almost transformed into rare earth hydroxide,sodium fluoride and lithium hydroxide,fluorine and lithium are transferred into the washing solution,and the rare earths in the residues can be leached into solution by acid *** the optimum reaction conditions of reaction temperature 200℃,reaction time 3 h,NaOH initial concentration 80%,NaOH-Slag mass ratio 3:1,the leaching efficiency of rare earths,fluorine and lithium can reach to 99.05%,98.23% and 99.22%.After evaporation,the fluorine and lithium in the washing solution can be obtained in the forms of sodium fluoride and lithium fluoride,the recovery efficiency reach 95.5%and 92.8%,*** RE oxides(99.53%) can be obtained from the leaching solution after precipitation and roasting.

关键词： Rare earth electrolysis slag Sub-molten salt Green extraction Fluorine Lithium Recovery

Clinical characteristics and outcomes of hospitalized kidney transplant recipients with COVID-19 infection in China during the Omicron wave:a single-center cohort study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 529-540页

作者： Duo LV Xishao XIE Qinyun YANG Zhimin CHEN guangjun LIU Wenhan PENG Rending WANG Hongfeng huang Jianghua CHEN Jianyong WU Department of Clinical Pharmacy the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research Hangzhou 310003China Kidney Disease Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Kidney Disease Prevention and Control Technology Zhejiang ProvinceHangzhou 310003China Institute of Nephrology Zhejiang UniversityHangzhou 310003China Zhejiang Clinical Research Center of Kidney and Urinary System Disease Hangzhou 310003China The Third Grade Laboratory under the National State Administration of Traditional Chinese MedicineHangzhou 310003China Information Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Following the short-term outbreak of coronavirus disease 2019(COVID-19)in December 2022 in China,clinical data on kidney transplant recipients(KTRs)with COVID-19 are ***:We conducted a single-center retrospective study to describe the clinical features,complications,and mortality rates of hospitalized KTRs infected with COVID-19 between Dec.16,2022 and Jan.31,*** patients were followed up until Mar.31,***:A total of 324 KTRs with COVID-19 were *** median age was 49 *** median time between the onset of symptoms and admission was 13 ***,azvudine,and nirmatrelvir/ritonavir were administered to 67(20.7%),11(3.4%),and 148(45.7%)patients,***-nine(9.0%)patients were treated with more than one antiviral ***-eight(14.8%)patients were treated with tocilizumab and 53(16.4%)patients received baricitinib *** acute kidney injury(AKI)occurred in 81(25.0%)patients and 39(12.0%)patients were admitted to intensive care *** infections were observed in 55(17.0%)***(15.4%)patients lost their *** 28-d mortality rate of patients was 9.0%and 42(13.0%)patients died by the end of *** Cox regression analysis identified that cerebrovascular disease,AKI incidence,interleukin(IL)-6 level of>6.8 pg/mL,daily dose of corticosteroids of>50 mg,and fungal infection were all associated with an increased risk of death for hospitalized ***:Our findings demonstrate that hospitalized KTRs with COVID-19 are at high risk of *** administration of immunomodulators or the late application of antiviral drugs does not improve patient survival,while higher doses of corticosteroids may increase the death risk.

关键词： Coronavirus disease 2019(COVID-19) Kidney transplant Hospitalization Mortality

Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer

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Nano Research 2024年第10期17卷 9044-9051页

作者： Mengdie Chen Anying Zhu Furong Zhu Ziwen Lei Tao huang Shengnan Du Dongdong Wang Xiaoyu Zhang Huan Min Yingqiu Qi guangjun Nie Department of Pharmacology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450008China Department of General Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Breast Disease The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450003China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China

Breast cancer remains a leading cause of morbidity and mortality among women worldwide,emphasizing the urgent need for enhanced diagnostic and therapeutic ***-rich-alpha-2-glycoprotein 1(LRG1)has emerged as a notable target due to its markedly elevated expression in breast tumors,suggesting the viability of LRG1 as a theranostic *** our study,we employed phage display technology to identify a peptide,termed ET,that binds to LRG1 with a dissociation constant of 48.4μ*** modified with fluorescent cyanine dye,the ET peptide showcased effective tumor-targeting imaging across three different primary breast tumor models and a metastatic breast tumor *** also undertook a comprehensive safety evaluation,which verified the good biosafety credentials of ET *** summary,the ET peptide identified in this study shows effective LRG1-targeting ability both in vitro and in vivo,thus exhibiting immense potential for clinical translation.

关键词： breast cancer leucine-rich-alpha-2-glycoprotein 1(LRG1) phage display peptide tumor targeting

One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China

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Portal Hypertension & Cirrhosis 2024年第2期3卷 116-123页

作者： Jitao Wang Ting Cui Linpeng Zhang Zhiping Yan Lei Li Jinjun Chen Junhui Sun Hua Xiang He Zhu Hao Wu Jiancuo Gengzang Feng Zhang Wei Wu Guohong Cao Wuhua Guo Haibin Shi Hui Xue guangjun huang Qiang Yu Meng Niu Huiling Xiang Derun Kong Wei Gou Xuefeng Luo Fuliang He Min Yuan Wei Liu Yong Wang Hongjie Hu Xiaoli Zhu Tao Yu Qinxue Sun Wei Qu Ting Lu Deqiang Ma Li Zhang Jun Ma Jun Yang Ketao Mu Xiaoliang Zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng huang Fang Wang Zexin Wang Yong huang Jianan Li Hongfeng Yi Birun huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun Zhu Fan Wu Xiaogang Hu Wenfeng Zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu Zhuang Weidong Wang Qingliang Zhu Kunpeng Zhang Chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao Weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei He Chengda Zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian Zhang Xiaolong Qi Hebei Provincial Key Laboratory of Cirrhosis&Portal Hypertension Xingtai People's HospitalXingtaiHebeiChina Center of Portal Hypertension Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuChina Department of Interventional Therapy Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Department of Intervention Taiyuan Third People's HospitalTaiyuanShanxiChina Department of Intervention Zhongshan Hospital Affiliated to Fudan UniversityShanghaiChina Department of Interventional Medicine The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Infectious Diseases Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdongChina Hepatobiliary and Pancreatic Intervention Center The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina Interventional Vascular Surgery Hunan Provincial People's HospitalChangshaHunanChina Department of Intervention Sixth People's Hospital of ShenyangShenyangLiaoningChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Intervention The Fourth People's Hospital of Qinghai ProvinceXiningQinghaiChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Radiology Shulan(Hangzhou)HospitalHangzhouZhejiangChina Department of Intervention Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouFujianChina Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Department of Interventional Radiology Fifth Medical Center

Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in *** article aimed to investigate the status of hepatic venous pressure gradient measurement in China in ***:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online *** counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in ***:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured *** average cost of HVPG measurement was 5646.8±2327.9 *** the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy ***:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this *** is still necessary to continue promoting and popularizing this technology in the future.

关键词： application status hepatic vein pressure gradient questionnaire survey

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一种基于阈值的嵌入式实时系统调度算法

计算机工程 2006年第3期32卷 68-69,84页

作者：黄广君胡正国河南科技大学计算机系洛阳471003 西北工业大学计算机系西安710072

基于阈值的双优先级调度算法结合了抢占式与非抢占式调度算法的优点,可以提高任务集的调度成功率,并减少由于任务切换引起的系统开销。对阈值的分配是调度算法的核心。在基本优先级已知的条件下,基于回溯技术的阈值分配算法利用低端任... 详细信息

基于阈值的双优先级调度算法结合了抢占式与非抢占式调度算法的优点,可以提高任务集的调度成功率,并减少由于任务切换引起的系统开销。对阈值的分配是调度算法的核心。在基本优先级已知的条件下,基于回溯技术的阈值分配算法利用低端任务阈值单向影响高端任务最大响应时间的特性,可以在有限的时间内为任务集找出一组具有极大值特征的阈值。该组阈值可以将任务切换次数降至最低。

关键词：阈值双优先级回溯技术任务切换

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结合概念语义空间的语义扩展技术研究

计算机工程与应用 2012年第35期48卷 106-109,193页

作者：王磊黄广君河南科技大学电子信息工程学院河南洛阳471003

查询扩展是在原查询词的基础上加入相关的词或者词组,以克服自然语言的"二义性"问题,改进查询意愿的描述。在概念语义空间中进行查询词扩展,可以充分挖掘出查询词之间的关联程度,在整体上把握查询意愿。利用WordNet语义词典中的上下文... 详细信息

查询扩展是在原查询词的基础上加入相关的词或者词组,以克服自然语言的"二义性"问题,改进查询意愿的描述。在概念语义空间中进行查询词扩展,可以充分挖掘出查询词之间的关联程度,在整体上把握查询意愿。利用WordNet语义词典中的上下文关系和相似度关系为各个原始查询词构建语义树,并将这些语义树向上溯源建立完整的概念语义空间,以共现信息为特征参数对扩展源中的词进行筛选,以避免过度扩展引起查询语义漂移。还引入动态观察窗口加权模型,以强化共现信息对单词之间关联度的表示。实验结果表明,该扩展算法比传统伪相关反馈算法的扩展质量有明显提高。

关键词：查询扩展伪相关反馈语义空间观察窗口加权平均倒数排名

融合改进LBP和SVM的偏光片外观缺陷检测与分类

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计算机工程与应用 2020年第22期56卷 251-255页

作者：黄广俊邓元龙深圳大学机电与控制工程学院广东深圳518060

偏光片的外观缺陷是影响TFT-LCD面板质量的重要因素之一。为提高偏光片外观缺陷图像识别的准确性,提出一种改进局部二值模式(Local Binary Pattern,LBP)描述符和支持向量机(Support Vector Machine,SVM)的识别方法。缺陷图像通过暗场成... 详细信息

偏光片的外观缺陷是影响TFT-LCD面板质量的重要因素之一。为提高偏光片外观缺陷图像识别的准确性,提出一种改进局部二值模式(Local Binary Pattern,LBP)描述符和支持向量机(Support Vector Machine,SVM)的识别方法。缺陷图像通过暗场成像原理获得,将缺陷图像划分为不同的区,对每一个区域提取LBP特征并组成高维复合特征。将不同分区的像素均值特征与LBP复合特征进行集成,利用主成分分析(Principal Component Analysis,PCA)消除特征间的相关性和噪声,使用线性判别分析(Linear Discriminant Analysis,LDA)进一步投影变换至低维特征,使用支持向量机对上述特征进行分类。结合改进LBP描述符、PCA、LDA和SVM四种算法的优点,在总数250的数据库中进行仿真实验,结果表明,该方法识别准确率达到99.2%,单张图像识别时间为0.92 s,完全满足工业生产线的实际应用要求。

关键词：偏光片缺陷检测 LBP描述符支持向量机(SVM) 主成分分析(PCA) 线性判别分析(LDA)