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Unveiling protein corona composition:predicting with resampling embedding and machine learning

Regenerative Biomaterials 2024年第1期3卷 27-33页

作者： Rong Liao Yan Zhuang Xiangfeng Li Ke Chen Xingming Wang Cong Feng guangfu yin Xiangdong Zhu Jiangli Lin Xingdong Zhang College of Biomedical Engineering National Engineering Research Centre for BiomaterialsSichuan UniversityChengdu610065China

Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue *** nanoparticles(NPs)enter the living system,they quickly interact with proteins in the body fluid,forming the protein corona(PC).The accurate prediction of the PC composition is critical for analyzing the osteoinductivity of biomaterials and guiding the reverse design of ***,achieving accurate predictions remains a significant *** several machine learning(ML)models like Random Forest(RF)have been used for PC prediction,they often fail to consider the extreme values in the abundance region of PC absorption and struggle to improve accuracy due to the imbalanced data *** this study,resampling embedding was introduced to resolve the issue of imbalanced distribution in PC *** ML models were evaluated,and RF model was finally used for prediction,and good correlation coefficient(R^(2))and root-mean-square deviation(RMSE)values were *** ablation experiments demonstrated that the proposed method achieved an R^(2) of 0.68,indicating an improvement of approximately 10%,and an RMSE of 0.90,representing a reduction of approximately 10%.Furthermore,through the verification of label-free quantification of four NPs:hydroxyapatite(HA),titanium dioxide(TiO_(2)),silicon dioxide(SiO_(2))and silver(Ag),and we achieved a prediction performance with an R^(2) value>0.70 using Random ***,the feature analysis revealed that the composition of the PC is most significantly influenced by the incubation plasma concentration,PDI and surface modification.

关键词： nanoparticles protein corona machine learming resampling technique feature analysis

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Fabrication of extracellular matrix-coated conductive polypyrrolepoly(L-lactide)fiber-films and their synergistic effect with(nerve growth factor)/(epidermal growth factor) on neurites growth

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Chinese Chemical Letters 2020年第5期31卷 1141-1146页

作者： Ximing Pu Xingxing Zhou Zhongbing Huang guangfu yin Xianchun Chen College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

Non-nerve cell-derived extracellular matrix(ECM)wa s coated on the aligned porous polypyrrole-poly(Llactide)(PPy-PLLA)fiber-films with the conductivity of^12 mS/m via L929 cells culture and lysing,resulting in^10%increase of PC12 cells attachment and^26μm increase of neurites *** neurite length of^149μm in EGF/NGF group(optimal concentration radio of 12.5/50(ng/mL))on aligned and ECM-conjugated fiber-films was significantly larger than^94μm in only NGF group(50 ng/mL),confirming the synergy of EGF,NGF and aligned ECM-conjuaged PPy-PLLA *** differentiated PC12 cells were exerted electrical stimulation(ES)of 100 mV/cm for 4 h/day in 2 day through ECM-PPyPLLA fiber-films,their neurite length reached to^251μm,significantly larger than^149μm of group without ES,due to the higer expression of related neural proteins in ES group.A simple mechanism was proposed to analyze synergistical effect of ECM,EGF,NGF on axons adhesion and elongation along the aligned ECM-coated fibers under ES condition.

关键词： Extracellular matrix Axonal growth Conducting PPy-PLLA fiber-film Nerve growth factor Epidermal growth factor Electrical stimulation

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Preparation,properties and biomedical applications progress of 1D magnetic nanomaterials with iron

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Biosurface and Biotribology 2023年第4期9卷 101-113页

作者： Zhongbing Huang Juan Wang Ximing Pu guangfu yin College of Biomedical Engineering Sichuan UniversityChengduChina

1D magnetic nanomaterials with iron,with the special physical properties and biological behaviour,have been found to possess the great promising applications in many *** this review,the components,structure,physicochemical properties,biocompatibility and in vitro and in vivo biomedical functions of magnetic nanowires(MNWs),nanorods(MNRs)with iron are summarised,especially their anisotropy shape and magnetism result in their many applications in biodetections and medical treatment *** potential future functions of these 1D magnetic nanomaterials compared to magnetic nanoparticles also is discussed by highlighting the possibility of integration with other metal-compositions or bio-compositions and with existing biotechnology as well as by point-ing out their specific *** limitations in the property improvement and issues related with the outcome of the MNRs in the body are also summarised in order to address the remaining challenge for the extended biomedical functions of MNRs in the clinical application field.

关键词： biocompatibility biointerface biomaterials biosurface

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Adsorption of Lead(II),Copper(II) on tourmaline from Altai mine in China's Sinkiang

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Acta Geologica Sinica(English Edition) 2012年第2期86卷 423-429页

作者： HE Dengliang yin guangfu DONG Faqin ZHANG Wei BIANQingquan SI yunxiang Department of Chemistry Mianyang Normal UniversityMianyang 621000China College of Material Science andEngineering Sichuan UniversityChengdu 610064China Key Laboratory for Advanced Building Materials of Sichuan Province Mianyang 621010China

Tourmaline from Altai mine in China＇s Sinkiang was used to remove lead （II）, copper （II） from aqueous solution. The results demonstrate that tourmaline contains Na（Mg,V）3AI6（BO3）3Si6Ols （OH）4, NaFe3AI6（BO3）3Si6Ols（OH）4. The data show that Tourmaline from Altai mine in China＇s Sinkiang can be used natural adsorbent for lead （II）, copper （II）.It is observed that the adsorption data fitted to the Langmuir isotherm. Furthermore, both Pb （II） and Cu （II） absorbed by tourmaline and tourmaline were characterized by X-ray diffraction, Laser Raman Spectrum, Fourier transform infrared spectroscopy, X-ray energy dispersive spectrometer, Transmission electron microscopy and Zeta potential.

关键词： Tourmaline lead (II) copper (II) adsorption

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Biocompatibility of Surface-Modified Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite in vitro and in vivo

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Journal of Materials Science & Technology 2010年第8期26卷 754-758页

作者： Weizhong Yang guangfu yin Dali Zhou Jianwen Gu Yadong Li Hujun Zhang College of Materials Science and Engineering Sichuan University Chengdu 610064 China Chengdu Military General Hospital Chengdu 610083 China

The biocompatibility of surface-modified biphasic calcium phosphate （mBCP）/poly-L-Lactide （PLLA） biocomposite was investigated through a series of experiments in vitro and in vivo. Acute toxicity and short term systemic toxicity experiments revealed no toxicity of the materials. Hemolysis assay indicated the good blood compatibility of the composite. In cytotoxicity assay, L929 mouse fibroblasts could well differentiate and proliferate. Animal experiments in vivo *** by implanting the materials into rabbits muscle for 8 weeks. The decreasing of inflammatory cells, the building of fibrous tissue layer as well as the growing of blood cells into materials indicated the nontoxicity of the composite. Based on the experiment results, surfacemodified BCP/PLLA biocomposite is proven to have superior biocompatibility, which would be a promising bone repairing material.

关键词： Biocompatibility Biphasic calcium phosphate (BCP) Poly-L-Lactide (PLLA)biocomposite

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Fabrication of Tungsten Carbide Nanoparticles from Refluxing Derived Precursor

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Journal of Wuhan University of Technology(Materials Science) 2015年第2期30卷 231-234页

作者：文季秋 LI Yongdi MENG Xiaopeng yin guangfu 姚亚东 Analytical & Testing Center Sichuan University College of Materials Science and Engineering Sichuan University

Tungsten carbide（WC） nanoparticles were fabricated from a novel refluxing-derived precursor. The precursor was prepared by acid hydrolysis of Na2WO4 with concentrated HCl in water followed by refl uxing with ethanol and n-Dedocane, respectively. Then it was heat-treated to 1 200 ℃ for 2 h in vacuum to obtain WC nanoparticles. X-ray studies reveal the formation of hexagonal tungsten carbide and the grain size of 24.3 nm. SEM image shows WC nanoparticles with particle size of 20-60 nm. Long time refl uxing results in alkane dehydrogenation and coke formation. The coke is the carbon source in the carbothermal reduction reaction. The novel route of two-stage refl uxing is quite general and can be applied in the synthesis of similar carbides.

关键词： ceramics material preparation nanoparticles nanotechnology nanostructured materials

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A novel akermanite/poly (lactic-co-glycolic acid) porous composite scaffold fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process

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Regenerative Biomaterials 2017年第4期4卷 233-242页

作者： Yao Deng Mengjiao Zhang Xianchun Chen Ximing Pu Xiaoming Liao Zhongbing Huang guangfu yin College of Materials Science and Engineering Sichuan UniversityChengdu 610064PR China

Desirable scaffolds for tissue engineering should be biodegradable carriers to supply suitablemicroenvironments mimicked the extracellular matrices for desired cellular interactions and to providesupports for the formation of new tissues. In this work, a kind of slightly soluble bioactiveceramic akermanite (AKT) powders were aboratively selected and introduced in the PLGA matrix,a novel L-lactide modified AKT/poly (lactic-co-glycolic acid) (m-AKT/PLGA) composite scaffold wasfabricated via a solvent casting-particulate leaching method improved by solvent self-proliferatingprocess. The effects of m-AKT contents on properties of composite scaffolds and on MC3T3-E1 cellularbehaviors in vitro have been primarily investigated. The fabricated scaffolds exhibited threedimensionalporous networks, in which homogenously distributed cavities in size of 300–400 lmwere interconnected by some smaller holes in a size of 100–200 lm. Meanwhile, the mechanicalstructure of scaffolds was reinforced by the introduction of m-AKT. Moreover, alkaline ionic productsreleased by m-AKT could neutralize the acidic degradation products of PLGA, and the apatitemineralizationability of scaffolds could be largely improved. More valuably, significant promotionson adhesion, proliferation, and differentiation of MC3T3-E1 have been observed, which implied thecalcium, magnesium and especially silidous ions released sustainably from composite scaffoldscould regulate the behaviors of osteogenesis-related cells.

关键词： akermanite PLGA composite scaffolds solvent self-proliferating process

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Fabrication of carboxylic graphene oxide-composited polypyrrole film for neurite growth under electrical stimulation

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Frontiers of Materials Science 2019年第3期13卷 258-269页

作者： Chaoyuan LIU Zhongbing HUANG Ximing PU Lei SHANG guangfu yin Xianchun CHEN Shuang CHENG College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

An aligned composite film was fabricated via the deposition of carboxylic graphe ne oxide(C-GO)and polypyrrole(PPy)nano particles on alig ned poly(L-lactic acid)(PLLA)fiber-films(named as C-GO/PPy/PLLA),which has the core(PLLA)-sheath(C-GO/PPy)structure,and the composition of C-GO(~4.8 wt.%of PPy sheath)significantly enhanced the tensile strength and the conductivity of the PPy/PLLA film?Especially,after 4 weeks of immersion in the PBS solution,the conductivity and the tensile strength of CGO/PPy/PLLA films still remained-6.10 S/cm and 28.9 MPa,respectively,which could meet the need of the sustained electrical stimulation(ES)therapy for nerve ***,the neurite length and the neurite alignment were significantly in creased through exerting ES on C-GO/PPy/PLLA films due to their sustained conductivity in the fluid of cell *** results indicated that C-GO/PPy/PLLA with sustained conductivity and mechanical property possessed great potential of nerve repair by exerting lasting-ES.

关键词： sustained conductivity electrical stimulation carboxylic graphene oxide polypyrrole

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Degradation of Residual Formaldehyde in Fabric by Photo-catalysis

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Journal of Wuhan University of Technology(Materials Science) 2008年第2期23卷 147-150页

作者： YAO Yadong GUO Xiangli KANG Yunqing LI Xieji CHEN Aizheng YANG Weizhong yin guangfu College of Materials Science ＆ Engineering Sichuan University Chengdu 610064 China

The residual formaldehyde （HCHO） in fabric was degraded using photo-catalysis assisted by the compound catalyst of nano-TiO2 and nano-ZnO. The effects of several factors on the degradation, such as the composing of catalyst, irradiation time, pH value and the H2CHO concentration of the immersed solution were investigated. Results showed that H2CHO of the immersed solution had degraded 93% after 5 h irradiation, and the degradation ratio of formaldehyde could be improved and the aging of the fabric can be avoided with the addition of ZnO nanoparticles and pH value of the immersed-fibric solution. The fabric with residual formaldehyde about 1 800 μg/g can be efficiently treated to satisfy the China National Standard （GB/2912.1-1998） with the photo-catalytic degradation.

关键词： photo-catalytic degradation fabric formaldehyde

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Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor

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Chinese Chemical Letters 2020年第1期31卷 285-291页

作者： Weina Zhang Zhongbing Huang Ximing Pua Xianchun Chen guangfu yin Lei Wang Fei Zhang Fabao Gao College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Molecular Imaging Center Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610093China

It is urgent to find a technology accurately to better diagnose and treat to brain ***-doped Gd2 O3 nanorods(Eu-Gd2 O3 NRs)with paramagnetic and fluorescent properties were conjugated with doxorubicin(Dox)and chlorotoxin(CTX)via PEGylation,hydrazone bond and sulfur bond(named as CTXNRs-Dox),and these NRs could release more Dox in lower pH *** results of cell experiments indicated that CTX-NRs-Dox had obvious targeting and toxic effects on U251 cells,as well as good fluorescence imaging *** orthotopic glioma-transplanted mice models were constructed via the intracranial injection of glioma cells(U87 MG).The result of experiments after the tail-vein injection of the prepared NRs suggested that CTX-NRs-Dox could target to brain tumors via the long-time blood circulation,leading to their obvious contrast enhancement of MR imaging of the intracranial tumor and their significant inhibitory effect on the growth and metastasis of brain tumors.A mechanism of synergistic effect of CTX-NRs-Dox on targeting and inhabiting the brain tumor was *** research suggested that CTX-NRs-Dox had potential application prospect in the detection and treatment of glioma.

关键词： Brain tumor Dual-model imaging Doxorubicin Chlorotoxin Eu-Gd2O3 nanorods Targeted therapy

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