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Molecular regulation of root growth plasticity in Arabidopsis

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Molecular regulation of root growth plasticity in Arabidopsi...

Recognition of a novel functional domain in CMP-N-acetylneuraminic Acid（CMP-NeuAc） synthetase of *** K1

2016年全国植物生物学大会

作者： guangchao liu Shan Gao Zhaojun Ding The Key Laboratory of Plant Cell Engineering and Germplasm Innovation Ministry of EducationCollege of Life SciencesShandong University

Auxin plays an important role to mediates endogenous developmental signals and environmental cues and thus control root growth plasticity. Aluminum stress,which inhibits root growth,is one of the widespread environmental cues in acid(p H<5) soils. Our previous study showed that TAA1 was locally induced in the root-apex transition-zone thus involves in aluminum-induced Arabidopsis root growth inhibition. Here,we report that YUCCA(YUC),which encodes flavin monooxygenase-like proteins,regulates local auxin biosynthesis in the root apex transition zone(TZ) in response to Al stress. Al stress up-regulates the expression of YUCs in the root-apex TZ and YUC-regulated root growth inhibition in an ethylene signalling dependent manner. Ethylene-insensitive3(EIN3) is involved into the direct regulation of YUC9 transcription in this process. Furthermore,we demonstrated that PHYTOCHROME INTERACTING FACTOR4(PIF4) functions as a transcriptional activator for YUC5/8/9. PIF4 promotes Alinhibited primary root growth by regulating the local expression of YUCs and auxin signal in the rootapex TZ. The Al–induced expression of PIF4 in TZ is downstream of ethylene signaling. Taken together,our results highlight a regulatory cascade for YUCs-regulated local auxin biosynthesis in the root-apex TZ mediating root growth inhibition in response to Al stress.

关键词： auxin root growth Al stress YUC EIN3 PIF4

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Recognition of a novel functional domain in CMP-N-acetylneur...

Potential industrial applications of photo/electrocatalysis: Recent progress and future challenges

The Eighth China-Japan-Korea Joint Symposium on Enzyme Engineering

作者： guangchao liu Chunsheng Jin Cheng Jin State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of Sciences

＜正＞It has been determined that *** K1 capsular polysialic acids（PSAs）contribute to the high level of bacteremia,which is required for the development of *** *** biosynthesis of PSAs is involved in Neu5Ac activati...

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Green Energy & Environment 2024年第5期9卷 859-876页

作者： Jinhao Li Jing Ren Shaoquan Li guangchao Li Molly Meng-Jung Li Rengui Li Young Soo Kang Xiaoxin Zou Yong Luo Bin liu Yufei Zhao State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou324000China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong999077China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian National Laboratory for Clean EnergyZhongshan Road 457Dalian116023China Environmental and Climate Technology Track of Korea Institute of Energy Korea Institute of Energy TechnologyNaju-siJeollanam do58217Republic of Korea State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun130012China

Nowadays,the rapid development of the social economy inevitably leads to global energy and environmental *** this reason,more and more scholars focus on the development of photocatalysis and/or electrocatalysis technology for the advantage in the sustainable production of high-value-added products,and the high efﬁciency in pollutants *** there is plenty of outstanding research has been put forward continuously,most of them focuses on catalysis performance and reaction mechanisms in laboratory *** industrial application of photo/electrocatalytic processes is still a challenge that needs to be overcome by social *** this regard,this review comprehensively summarized several explorations in theﬁeld of photo/electrocatalytic reduction towards potential industrial applications in recent *** attention is paid to the successful attempts and the current status of photo/electrocatalytic water splitting,carbon dioxide conversion,resource utilization from waste,etc.,by using advanced *** key problems and challenges of photo/electrocatalysis in future industrial practice are also discussed,and the possible development directions are also pointed out from the industry view.

关键词： Photocatalysis Electrocatalysis Industrial applications H2 economy

2002—2021年中国农村与城市居民呼吸道结核死亡趋势及年龄-时期-队列分析

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中国预防医学杂志 2024年第4期25卷 466-472页

作者：梁智超刘广超胥婉婷张燕王俊安文保峰王森路曹明芹新疆医科大学流行病与卫生统计学教研室新疆维吾尔自治区乌鲁木齐830011 新疆维吾尔自治区疾病与预防控制中心结麻中心

目的分析2002—2021年中国呼吸道结核死亡趋势,探讨年龄、时期、队列效应对呼吸道结核死亡风险的影响。方法收集2003—2022年《中国卫生健康统计年鉴》中5~85岁中国居民呼吸道结核年龄别死亡率数据,采用Joinpoint回归模型分析2002—202... 详细信息

目的分析2002—2021年中国呼吸道结核死亡趋势,探讨年龄、时期、队列效应对呼吸道结核死亡风险的影响。方法收集2003—2022年《中国卫生健康统计年鉴》中5~85岁中国居民呼吸道结核年龄别死亡率数据,采用Joinpoint回归模型分析2002—2021年中国城市、农村居民呼吸道结核死亡率的变化趋势,采用年龄-时期-队列模型分析年龄、时期和队列效应对中国城市、农村居民呼吸道结核死亡风险的影响。结果2002—2021年,城市居民、农村居民,男性、女性的呼吸道结核标化死亡率均呈下降趋势,城市居民、农村居民、城市男性、城市女性、农村男性和农村女性平均年度变化百分比分别为-8.42%(t=-6.29,P<0.01)、-8.39%(t=-6.11,P<0.01)、-7.69%(t=-6.19,P<0.01)、-6.69%(t=-5.19,P<0.05)、-7.69%(t=-5.01,P<0.05)、-7.72%(t=-3.49,P<0.01),差异有统计学意义。年龄-时期-队列分析结果显示,农村居民死亡风险快速上升年龄段和最高峰普遍早于城市居民,男性死亡风险快速上升年龄段和最高峰普遍早于女性(年龄效应);时期效应显示城市居民呈下降趋势;队列效应显示,城市居民和农村居民出生越晚的人发病风险越小。结论我国居民呼吸道结核死亡风险整体逐年降低,年龄、时期和出生队列效应对不同性别和区域(城市与农村)居民死亡风险均有一定程度影响。

关键词：呼吸道结核死亡率变化趋势 Join-point回归模型年龄-时期-队列模型

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"林草兴"之于"生态兴"的基础性作用

福建师范大学学报（哲学社会科学版） 2023年第1期 39-47页

作者：刘广超北京林业大学马克思主义学院北京100086

当前关于森林和草原对推动生态文明作用重要性的学术研究多为定性论述,而基于科学数据和生态学原理的学理性研究鲜有涉及。森林和草原作为自然生态系统的主体,是保持生态平衡、维护生态安全的基础,是绿色循环经济体的主要载体,是实现"双... 详细信息

当前关于森林和草原对推动生态文明作用重要性的学术研究多为定性论述,而基于科学数据和生态学原理的学理性研究鲜有涉及。森林和草原作为自然生态系统的主体,是保持生态平衡、维护生态安全的基础,是绿色循环经济体的主要载体,是实现"双碳"目标的重要保障,同时也是生态文明教育的天然课堂。"林草兴"对提升生态系统的整体功能,实现天蓝、地绿、水清等良好生态环境,推进绿色循环低碳发展,培养公众生态文明理念,加强生态文明建设等方面具有基础性作用。新时代"林草兴"推动"生态兴",需科学开展大规模国土绿化行动,坚持山水林田湖草沙一体化保护,建立生态价值转化和生态保护补偿机制,大力提升公众的生态文明意识,共同打造人与自然和谐共生的美丽家园。

关键词：林草兴生态兴国土绿化生态文明生态文明建设

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大断裂构造井上下联合注浆加固技术

煤矿安全 2018年第10期49卷 163-167页

作者：刘广超河南工业和信息化职业学院河南焦作454003

针对九里山马坊泉大断层上下盘岩层极为破碎、裂隙极为发育,二水平3条暗斜井在开拓中存在极大突水风险的现状,结合矿井实际情况,通过井下探测钻孔确定断层准确位置,并在此基础上,先在井下使用高水双液速凝堵水材料加固断层破碎带、切断... 详细信息

针对九里山马坊泉大断层上下盘岩层极为破碎、裂隙极为发育,二水平3条暗斜井在开拓中存在极大突水风险的现状,结合矿井实际情况,通过井下探测钻孔确定断层准确位置,并在此基础上,先在井下使用高水双液速凝堵水材料加固断层破碎带、切断断层导水通道、封堵突水点,然后在地面使用水泥黏土材料大范围注浆,截断冲积层含水层涌水通道及深部L2、O_2灰岩含水层向上的补给通道。结果表明:巷道涌水量降低至0.7 m^3/min,有效的降低了巷道涌水量;含水层水压由2.8 MPa降至1.2 MPa以下,水位下降40 m左右。实现了九里山矿井巷工程穿过大断裂构造过程中"零突水、零淹面、零影响"的水害治理目标。

关键词：大断裂构造破碎围岩双液注浆材料联合注浆注浆加固矿井防治水

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开关簧片冲压工艺分析及模具设计

制造技术与机床 2014年第10期 150-152,163页

作者：袁泉刘光超四川理工学院机械工程学院四川自贡643000

介绍了一副用于制造开关簧片的模具。在对冲压工艺、工艺方案以及排样分析的基础上,设计了分区冲压的多工位级进模结构,并对模具设计中的要点进行了总结。模具结构可靠,精度和生产效率高,为同类制件的加工提供了参考。

关键词：弹簧片冲压工艺模具设计级进模

De novo design of highly efficient type-Ⅰphotosensitizer based onπ-conjugated oligomer for photodynamic eradication of multidrug-resistant bacterial infections

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Chinese Chemical Letters 2024年第3期35卷 389-393页

作者： Qi Zhao guangchao Qing Jie Yu Ying liu Jianliang Shen Yang Luo Xingjie Zan Shengliang Li State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou InstituteUniversity of Chinese Academy of SciencesOujiang Laboratory(Zhejiang Lab for Regenerative MedicineVision and Brain Health)Wenzhou 325001China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Center of Smart Laboratory and Molecular Medicine School of MedicineChongqing UniversityChongqing 400044China College of Life Science and Laboratory Medicine Kunming Medical UniversityKunming 650050China

Traditional photosensitizers show limited singlet oxygen generation in hypoxic infection lesions,which greatly suppress their performance in antibacterial ***,there still is lack of feasible design strategy for developing hypoxia-overcoming photosensitizers ***,radical generation ofπ-conjugated small molecules is efficiently manipulated by an individual selenium(Se)*** this strategy,the first proof-of-concept study of a Se-anchored oligo(thienyl ethynylene)(OT-Se)with high-performance superoxide radical(O_(2)^(·-))and hydroxyl radical(·OH)generation capability is present,and achieves efficient antibacterial activities towards the clinically extracted multidrug-resistant bacteria methicillin-resistant ***(MRSA)and carbapenem-resistant ***(CREC)at sub-micromolar concentration under a low white light irradiation(30 mW/cm^(2)).The water-dispersible OT-Se shows a good bacteria-anchoring capability,biocompatibility,and complete elimination of multidrug-resistant bacteria wound infection in *** work offers a strategy to boost type-I photodynamic therapy(PDT)performance for efficient antibacterial treatments,advancing the development of antibacterial agents.

关键词： Photodynamic therapy Antibacterial Type-Ⅰphotosensitizers Multidrug-resistant bacteria Conjugated oligomers

αExtractor: a system for automatic extraction of chemical information from biomedical literature

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Science China(Life Sciences) 2024年第3期67卷 618-621页

作者： Jiacheng Xiong Xiaohong liu Zhaojun Li Hongzhong Xiao guangchao Wang Zhenjiang Niu Chaoyuan Fei Feisheng Zhong Gang Wang Wei Zhang Zunyun Fu Zhiguo liu Kaixian Chen Hualiang Jiang Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215125China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China

Dear Editor,Great progress has been made using artificial intelligence(AI) techniques in learning knowledge from biomedical databases in recent years, revolutionizing the study of many fields, such as protein structure prediction and protein design(Madani et al., 2023). However, there is massive biomedical knowledge not curated in the form of structured data but hidden in primary scientific literature.

关键词： has such knowledge