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Biomedical and Environmental Sciences 2024年第9期37卷 1067-1079页

作者： Jingzhi Yang Hao Shen Sicheng wang Long Bai Zhen Geng Yingying Jing Ke Xu Yuhe Liu Wenqian Wu Hao Zhang Yuanwei Zhang Zuhao Li Chuandong wang guangchao wang Xiao Chen Jiacan Su Institute of Translational Medicine Shanghai UniversityShanghai 200444China Orthopedic Department of Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200092China Department of Orthopedics Trauma Shanghai Zhongye HospitalShanghai 200941China Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Objective The aim of this study was to investigate the prospective association between physical activity(PA),independently or in conjunction with other contributing factors,and osteoporosis(OP)*** The Physical Activity in Osteoporosis Outcomes(PAOPO)study was a community-based cohort investigation.A structured questionnaire was used to gather the participants’sociodemographic *** mineral density(BMD)measurements were performed to assess OP outcomes,and the relationship between BMD and OP was evaluated within this *** From 2013 to 2014,8,471 participants aged 18 years and older were recruited from Tangshan,China’s Jidong *** on their PA level,participants were categorized as inactive,moderately active,or very *** showed higher physical exercise levels than women across the activity *** was significantly higher in the very active group than in the moderately active and inactive *** aged>50 years are at a higher risk of developing OP and *** The PAOPO study offers promising insights into the relationship between PA and OP outcomes,encouraging the implementation of PA in preventing and managing OP.

关键词： Osteoporosis Physical activity Risk factors Cohort study

αExtractor: a system for automatic extraction of chemical information from biomedical literature

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Science China(Life Sciences) 2024年第3期67卷 618-621页

作者： Jiacheng Xiong Xiaohong Liu Zhaojun Li Hongzhong Xiao guangchao wang Zhenjiang Niu Chaoyuan Fei Feisheng Zhong Gang wang Wei Zhang Zunyun Fu Zhiguo Liu Kaixian Chen Hualiang Jiang Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215125China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China

Dear Editor,Great progress has been made using artificial intelligence(AI) techniques in learning knowledge from biomedical databases in recent years, revolutionizing the study of many fields, such as protein structure prediction and protein design(Madani et al., 2023). However, there is massive biomedical knowledge not curated in the form of structured data but hidden in primary scientific literature.

关键词： has such knowledge

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车货供需匹配模型与算法研究综述

交通运输工程与信息学报 2024年第1期22卷 191-205页

作者：徐新昊张小强杨云王光超西南交通大学交通运输与物流学院成都611756 综合交通大数据应用技术国家工程实验室成都611756 综合交通运输智能化国家地方联合工程实验室成都611756 华中师范大学信息管理学院武汉430079

随着货车保有量及货运需求的迅速增长,车货供需匹配问题成为了货运电子商务平台的核心和热点。本文主要针对车货供需匹配问题从模型和算法两个方面对现有文献进行梳理和总结。在车货供需匹配模型方面,考虑的优化目标主要包括满意度、公... 详细信息

随着货车保有量及货运需求的迅速增长,车货供需匹配问题成为了货运电子商务平台的核心和热点。本文主要针对车货供需匹配问题从模型和算法两个方面对现有文献进行梳理和总结。在车货供需匹配模型方面,考虑的优化目标主要包括满意度、公平性和稳定性三个方面的评价指标,根据应用场景,将车货供需匹配模型分为一对一、一对多和多对多三类,其中一对一车货供需匹配模型针对整车运输,其他两种则对应零担运输。随着三种应用场景的模型复杂程度越来越高,相应求解难度、求解时间也呈现递增趋势。在车货供需匹配算法方面,根据货运需求数据的结构与特点可以划分为最优化算法、人工智能算法、推荐算法以及其他算法四类:对于小规模、时效性要求不高的货运需求,可以根据模型的特点与特性设计最优化求解算法;对于大数据、交互性数据或实时性要求高的货运需求,人工智能算法和推荐算法则是车货供需匹配问题的有效途径,其中人工智能算法通过预测车主行为或匹配结果实现匹配任务,而推荐算法可以针对车货需求大数据实现有效的召回并推荐。最后,本文总结了现有研究的不足之处,并从中归纳出三个值得进一步研究的方向:一是结合实际业务场景和车货信息大数据背景,提高车货供需匹配方法的实际可行性;二是进一步挖掘更多的评价指标,如车主偏好以及订单目的地接单概率等指标;三是关注车货供需匹配的实时决策问题,重点考虑货运需求的动态随机性以及平台和车主的长期收益目标。

关键词：公路运输货运电子商务平台车货供需匹配模型车货供需匹配算法

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脑机接口赋能运动损伤康复

中华创伤杂志 2024年第9期40卷 781-786页

作者：何崇儒陈晓王光超苏佳灿上海交通大学医学院附属新华医院骨科上海200092 上海大学转化医学研究院上海200444

运动损伤源于运动时遭遇的外伤,可导致不同程度的疼痛、活动障碍,严重者可致残。但当前的传统康复训练疗效有限,个性化治疗不足。脑机接口(BCI)技术通过在大脑与外部设备之间建立直接通信与控制通道,为运动损伤患者的康复提供了新的解... 详细信息

运动损伤源于运动时遭遇的外伤,可导致不同程度的疼痛、活动障碍,严重者可致残。但当前的传统康复训练疗效有限,个性化治疗不足。脑机接口(BCI)技术通过在大脑与外部设备之间建立直接通信与控制通道,为运动损伤患者的康复提供了新的解决方案。BCI技术可通过运动意图解码、神经反馈、人工感觉反馈等方式,在运动功能重建、感觉缺陷改善和神经性疼痛调控等方面发挥独特优势。BCI系统包括脑电信号采集、分析与处理和外部设备控制三个关键环节,其中与人工智能(AI)结合为脑电信号分析处理提供了新思路。为进一步推动新型康复技术的发展、降低治疗成本、促进患者全面康复,笔者就BCI技术特点、运动损伤康复存在的问题和BCI在运动损伤康复中的应用等方面进行阐述,为相关领域的科研和临床工作者提供参考和启发,加速BCI技术的创新突破和转化应用,造福更多运动损伤患者。

关键词：运动损伤,康复人工智能脑机接口

A^(2)former模型在时间序列预测中的应用研究

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人工智能科学与工程 2024年第1期 41-50页

作者：胡倩伟王秀青安阳张诺飞王广超河北师范大学计算机与网络空间安全学院石家庄050024 河北师范大学河北省网络与信息安全重点实验室石家庄050024 河北师范大学河北省供应链大数据分析与数据安全工程研究中心石家庄050024

时间序列预测在金融、医疗、交通和气象等领域发挥着重要作用。在长时间序列预测中,迫切需要提高预测的精度,解决内存不足等问题。近年来,Transformer模型在自然语言处理领域得以成功应用的同时,在预测研究领域也引起了学者们的广泛关注... 详细信息

时间序列预测在金融、医疗、交通和气象等领域发挥着重要作用。在长时间序列预测中,迫切需要提高预测的精度,解决内存不足等问题。近年来,Transformer模型在自然语言处理领域得以成功应用的同时,在预测研究领域也引起了学者们的广泛关注,Transformer变体Informer模型的研究在时间序列预测中取得了较大进展。本研究以Informer框架为基础,与加性注意力机制相结合,提出了A^(2)former模型。利用A^(2)former模型在ETT,WTH,ECL和PM2.5数据集上进行了长时间序列预测的实验,实验结果表明所提模型在长时间序列预测中表现出比基线方法(如Informer模型和LSTMa模型)更好的性能。A^(2)former模型不仅将计算时间复杂度降低到线性,而且可以实现更有效的序列建模。本研究的工作为时间序列预测提供了有益参考。

关键词：时间序列预测加性注意力机制 Transformer模型 Informer模型深度学习

Joint Content Caching and Fetching Scheme with Cooperative Transmission in Hierarchical Networks

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China Communications 2023年第3期20卷 146-160页

作者： Jizhe Zhou guangchao wang Kaifeng Han Ying Du Zhiqin wang Wenbo wang China Academy of Information and Communications Technology Beijing 100191China Beijing University of Posts and Telecommunications Beijing 100876China

Concerned with the surge of contentcentric applications,it is challenging to balance network traffic and cater to low-delay *** caching architecture of both edge network(EN)and core network(CN)emerges and leverages caching resources to reduce the delivery delay of *** previous work takes an impractical assumption to treat the CN as a content provider,which neglects the collaboration by intermediate CN *** importantly,it is still necessary to thoroughly study the tradeoff between CN delay and edge delay for files delivery so as to minimize the overall delivery delay across the *** this paper,we consider a hierarchical caching network with distributed CN nodes and edge nodes,where cooperative transmission is enabled for edge nodes to transmit multi-files *** poses a joint optimization problem of hierarchical file caching and fetching to minimize the overall delivery delay of *** the problem is NP-hard,we decompose the original problem and design an iterative algorithm to address *** results validate that the proposed scheme can find a balanced solution between lowering edge delay by utilizing coordinated CN caching and lowering CN delay by solely relying on edge caching.

关键词： hierarchical caching content distribution

Radio Resource Allocation for Bidirectional Offloading in Space-Air-Ground Integrated Vehicular Network

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Journal of Communications and Information Networks 2019年第4期4卷 24-31页

作者： guangchao wang Sheng Zhou Zhisheng Niu Beijing National Research Center for Information Science and Technology Department of Electronic EngineeringTsinghua UniversityBeijing 100084China

Aerial platforms and edge servers have been recognized as two promising building blocks to improve the quality of service(QoS)in space-air-ground integrated vehicular networks(SAGIN).Communication intensive tasks can be offloaded to aerial platforms via broadcasting,while computation intensive tasks can be offloaded to ground edge ***,the key issues including how to allocate radio resources and how to determine the task offloading strategy for the two types of tasks,are yet to be *** this paper,the joint optimization of radio resource allocation and bidirectional offloading configuration is *** deal with the non-convex nature of the original problem,we decouple it into a two-step optimization *** the first step,we optimize the bidirectional offloading configuration in the case of the radio resource allocation known in advance,which is proved to be a convex optimization *** the second step,we optimize the radio resource allocation through a brute-force search *** use queuing theories to analyze the average delay of the two tasks with respect to the broadcasting capacity and task arrival *** offloading strategies with closed-form expressions of communication intensive tasks are *** then propose a heuristic algorithm which is shown to perform better than interior point algorithm in *** numerical results also demonstrate that the aerial platforms and edge servers can significantly reduce the average delay of the tasks under different network conditions.

关键词： radio resource allocation bidirectional offloading space-air-ground integrated networks

Connections between metabolism and epigenetic modifications in cancer

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Medical Review 2021年第2期1卷 199-221页

作者： guangchao wang Jingdong J.Han Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology(CQB)Peking University5 Yiheyuan RdHaidian DistrictBeijing 100871China

How cells sense and respond to environmental changes is still a key *** has been identified that cellular metabolism is an important modifier of various epigenetic modifications,such as DNA methylation,histone methylation and acetylation and RNA N6-methyladenosine(m6A)*** closely links the environmental nutrient availability to the maintenance of chromatin structure and gene expression,and is crucial to regulate cellular homeostasis,cell growth and *** metabolic reprogramming and epigenetic alterations are widely observed,and facilitate cancer development and *** cancer cells,oncogenic signaling-driven metabolic reprogramming modifies the epigenetic landscape via changes in the keymetabolite *** this review,we briefly summarized the current evidence that the abundance of key metabolites,such as S-adenosyl methionine(SAM),acetyl-CoA,α-ketoglutarate(α-KG),2-hydroxyglutarate(2-HG),uridine diphospho-N-acetylglucosamine(UDP-GlcNAc)and lactate,affected by metabolic reprogramming plays an important role in dynamically regulating epigenetic modifications in *** improved understanding of the roles of metabolic reprogramming in epigenetic regulation can contribute to uncover the underlying mechanisms of metabolic reprogramming in cancer development and identify the potential targets for cancer therapies.

关键词： cancer metabolic reprogramming DNA methylation epigenetic modifications histone acetylation histone methylation RNA m6A.

ZNF292 suppresses proliferation of ESCC cells through ZNF292/SKP2/P27 signaling axis

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Chinese Journal of Cancer Research 2021年第6期33卷 637-648页

作者： Wei Gong Jiancheng Xu guangchao wang Dan Li Qimin Zhan State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:Increasing evidence has demonstrated that ZNF292 plays a suppressive role in cancer,however,little is known about its function and exact mechanism in esophageal squamous cell carcinoma(ESCC).Methods:Bioinformatic analysis and immunohistochemistry(IHC)were performed to analyze the role of ZNF292 in affecting the prognosis of *** proliferation and colony formation ability assays were performed to analyze cell growth after inferring the expression of *** cytometry was used to analyze changes in the cell cycle upon the depletion of *** real-time polymerase chain reaction(q RT-PCR)and western blot analysis were used to determine the alteration of cell cycle related RNAs and proteins after knocking down ***-132,cycloheximide(CHX)treatment experiments were performed to analyze the change and half-life time of P27 after knockdown of *** immunoprecipitation(Ch IP)and luciferase reporter assays were used to analyze the transcriptional regulation of SKP2 by ***:We report that low expression of ZNF292 is associated with poor prognosis,and ZNF292 emerges to be highly expressed in adjacent and normal tissues rather than tumor tissues in *** of ZNF292 significantly boosts cell growth and S phase entry in ESCC ***292 depletion will decrease the expression and half-life time of P27,while knockdown of SKP2 will result in elevated expression of ***292 can bind to the promoter region of SKP2,and knockdown of ZNF292 will boost the expression of ***:Knockdown of ZNF292 mediates G1/S cell cycle procession by activating SKP2/P27 signaling in ESCC ***292 knockdown promotes SKP2 expression at the transcriptional level,thereby boosting P27 ubiquitin-degradation,and eventually facilitating the S phase entrance.

关键词： ZNF292 cell cycle SKP2 ESCC

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6G通信计算融合关键技术研究

邮电设计技术 2024年第7期 9-12页

作者：周吉喆杜滢汪广超张晶中国信息通信研究院北京100191

面向6G业务性能极致化与能力融合化需求,通信与计算融合成为6G网络的演进趋势。当前,移动通信网算力调度模式单一,且网络与算力状态动态变化,存在通算资源供给与业务需求难以匹配的问题。针对上述挑战,分析通算融合的国内外研究进展,阐... 详细信息

面向6G业务性能极致化与能力融合化需求,通信与计算融合成为6G网络的演进趋势。当前,移动通信网算力调度模式单一,且网络与算力状态动态变化,存在通算资源供给与业务需求难以匹配的问题。针对上述挑战,分析通算融合的国内外研究进展,阐明通算融合的发展特征,并提出通算融合在评价体系、控制与调度、服务与开放等方面的关键技术,从而满足6G多样化的业务需求,提升未来网络的运行效率。

关键词： 6G 通算融合资源管理