检索结果-南通市图书馆

Further Results on Mutually Nearly Orthogonal Latin Squares

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2016年第1期32卷 209-220页

作者： Ke-jun chen Yong ZHANG guang-zhou chen Wen LI Department of Mathematics Taizhou University Department of Mathematics Yancheng Teachers University College of Mathematics and Information Science Hebei Normal University

Nearly orthogonal Latin squares are useful for conducting experiments eliminating heterogeneity in two directions and using different interventions each at each *** this paper,some constructions of mutually nearly orthogonal Latin squares are *** is proved that there exist 3 MNOLS（2m） if and only if m ≥3 nd there exist 4 MNOLS（2m） if and only if m ≥4 with some possible exceptions.

关键词： Latin square orthogonal nearly orthogonal holey

Radioiodine therapy for castration-resistant prostate cancer following prostate-specific membrane antigen promoter-mediated transfer of the human sodium iodide symporter

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第1期16卷 120-123页

作者： Xiao-Feng Gao Tie zhou guang-Hua chen Chuan-Liang Xu Ye-Lei Ding Ying-Hao Sun Department of Urology Changhai Hospital The Second Military Medical University 168 Changhai Road Shanghai 200433 China

Radioiodine therapy, the most effective form of systemic radiotherapy available, is currently useful only for thyroid cancer because of the thyroid-specific expression of the human sodium iodide symporter （hNIS）. Here, we explore the efficacy of a novel form of gene therapy using prostate-specific membrane antigen （PSMA） promoter-mediated hNIS gene transfer followed by radioiodine administration for the treatment of castration-resistant prostate cancer （CRPC）. The androgen-dependent C33 LNCaP cell line and the androgen-independent C81 LNCaP cell line were transfected by adenovirus. PSMA promoter-hNIS （***-hNIS） or ***-hNIS containing the cytomegalovirus promoter （***-hNIS） or a control virus. The iodide uptake was measured in vitro. The in vivo iodide uptake by C81 cell xenografts in nude mice injected with an adenovirus carrying the hNIS gene linked to PSMA and the corresponding tumor volume fluctuation were assessed. Iodide accumulation was shown in different LNCaP cell lines after ***-hNIS and ***-hNIS infection, but not in different LNCaP cell lines after *** （***） infection. At each time point, higher iodide uptake was shown in the C81 cells infected with ***-hNIS than in the C33 cells （P 〈 0.05）. An in vivo animal model showed a significant difference in 1311 radioiodine uptake in the tumors infected with ***-hNIS, ***-hNIS and control virus （P 〈 0.05） and a maximum reduction of tumor volume in mice infected with ***-hNIS. These results show prostate-specific expression of the hNIS gene delivered by the PSMA promoter and effective radioiodine therapy of CRPC by the PSMA promoter-driven hNIS transfection.

关键词： genetic therapy prostate-specific membrane antigen (PSMA) prostatic neoplasms sodium-iodide symporter

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水平井压井立压控制误差分析与井口套压预测

中国石油大学学报（自然科学版） 2008年第1期32卷 51-55,59页

作者：苏堪华管志川周广陈中国石油大学石油工程学院山东东营257061

根据水平井压井的基本原理,考虑环空摩阻、流体流型影响下的计算误差,分析了水平井与直井压井控制立压变化的比较误差。以直井井控理论、多相流理论为基础,建立了水平井井控三相流理论模型,采用有限差分方法对模型进行了数值化求解。算... 详细信息

根据水平井压井的基本原理,考虑环空摩阻、流体流型影响下的计算误差,分析了水平井与直井压井控制立压变化的比较误差。以直井井控理论、多相流理论为基础,建立了水平井井控三相流理论模型,采用有限差分方法对模型进行了数值化求解。算例分析结果表明,在水平井立压控制过程中,如果按直井方式压井,不仅在初始立压点和终了立压点存在误差,而且在造斜点、稳斜点处也存在较大的误差,这将对水平井井控作业产生一定影响。在水平井压井过程中,直到溢流全部移出水平段时水平井的井口套压才开始逐渐增加;岩屑床的存在使水平段和造斜段的环空尺寸减小,对流体流速有一定影响,使井口套压比不考虑其存在的情况时偏高;水平井曲率半径、水平段长、水平段微小倾角、多个造斜率等因素对井口套压影响不大,而井眼尺寸、压井排量、溢流量等因素对井口套压影响较大。

关键词：水平井压井循环立压误差分析井口套压

霉酚酸酯对血管内皮细胞与淋巴细胞粘附及其表达CD40L的影响

在线全文

学校读者我要写书评

暂无评论

中国免疫学杂志 2008年第9期24卷 818-820,824页

作者：周广臣顾晓扬州大学附属苏北人民医院泌尿外科扬州225001

目的:观察霉酚酸酯(MMF)对细胞因子刺激下人脐静脉内皮细胞(HUVEC)CD40L的影响。方法:正常分娩人脐带经胶原酶消化后,分离出内皮细胞,培养至3～5代,用于细胞粘附和CD40L表达试验。以TNF-α和/或霉酚酸(MPA)处理HUVEC20小时后,用虎红法... 详细信息

目的:观察霉酚酸酯(MMF)对细胞因子刺激下人脐静脉内皮细胞(HUVEC)CD40L的影响。方法:正常分娩人脐带经胶原酶消化后,分离出内皮细胞,培养至3～5代,用于细胞粘附和CD40L表达试验。以TNF-α和/或霉酚酸(MPA)处理HUVEC20小时后,用虎红法研究对淋巴细胞与内皮细胞粘附作用。以TNF-α、rIFN-γ、LPS分别和MPA同时作用HUVEC24小时。加不同浓度的MPA与LPS诱导HUVEC24小时,用Cell-ELISA检测CD40L的表达。结果:(1)MMF能抑制静息及TNF-α激活的内皮细胞与淋巴细胞间的粘附作用。(2)三种细胞因子均可明显诱导内皮细胞表达CD40L分子。(3)MMF不能抑制静息状态下内皮细胞CD40L的表达,但抑制TNF-α、rIFN-γ和LPS诱导CD40L的表达作用,且MMF抑制LPS诱导的内皮细胞CD40L表达呈剂量依赖效应。结论:MMF通过抑制内皮细胞表达CD40L而影响淋巴细胞与内皮细胞的相互作用,这可能是MMF抗排斥反应机制之一。

关键词：霉酚酸酯内皮细胞细胞因子 CIMOL

在线全文

学校读者我要写书评

暂无评论

同种异体原位肾移植的临床分析

肾脏病与透析肾移植杂志 2011年第5期20卷 422-424页

作者：周广臣何小舟巢志复扬州大学临床医学院泌尿外科扬州225001 苏州大学第三附属医院泌尿外科

目的:探讨原位肾移植的手术适应证、手术技巧及临床效果。方法:对5例临床同种异体原位肾移植受者进行回顾性分析,其中男3例,女2例,年龄28～55岁,平均45岁,多囊肾1例,三次肾移植2例,二次肾移植髂血管粥样硬化2例,均先行左肾切除,再行原... 详细信息

目的:探讨原位肾移植的手术适应证、手术技巧及临床效果。方法:对5例临床同种异体原位肾移植受者进行回顾性分析,其中男3例,女2例,年龄28～55岁,平均45岁,多囊肾1例,三次肾移植2例,二次肾移植髂血管粥样硬化2例,均先行左肾切除,再行原位肾移植,尿路重建采用肾盂-肾盂端端吻合,术后常规三联免疫抑制治疗。结果:手术经过均顺利,术后2例再次移植受者发生移植肾功能延迟恢复(DGF)。术后1月平均血清肌酐(SCr)124μmol/L。术后随访6月～7年均带肾存活,4例受者移植肾肾功能正常,1例受者术后7年出现慢性移植肾肾病,SCr波动于340～462μmol/L。结论:原位肾移植对于第二、三次肾移植,双侧髂血管条件不好的受者,原位肾移植能达到良好的治疗效果。

关键词：原位肾移植再次移植动脉粥样硬化

工程化同种胰岛移植治疗1型糖尿病小鼠的实验研究

在线全文

学校读者我要写书评

暂无评论

复旦学报（医学版） 2011年第1期38卷 42-46页

作者：顾晓杨进赵鸿周广臣扬州大学第一临床医学院泌尿外科扬州225001 美国路易维尔大学细胞治疗研究所路易维尔40202

目的将外源蛋白FasL修饰的供者胰岛移植于糖尿病小鼠肾包膜下,观察其治疗1型糖尿病的效果。方法采用ProtExTM技术将嵌合蛋白SA-FasL修饰于供者小鼠胰岛,流式细胞检测蛋白的表达;以近交系小鼠BALB/c和C57BL/6分别为胰岛移植的供受者,进... 详细信息

目的将外源蛋白FasL修饰的供者胰岛移植于糖尿病小鼠肾包膜下,观察其治疗1型糖尿病的效果。方法采用ProtExTM技术将嵌合蛋白SA-FasL修饰于供者小鼠胰岛,流式细胞检测蛋白的表达;以近交系小鼠BALB/c和C57BL/6分别为胰岛移植的供受者,进行同种小鼠胰岛移植,部分受者联合免疫抑制剂雷帕霉素(rapamycin,RPM)治疗,从手术当日开始应用RPM(0.2 mg/kg),连续治疗10天。根据移植胰岛的不同及有无联合RPM治疗将受者分为5组:(1)SA-FasL修饰组(FasL组,n=33);(2)SA-FasL修饰+RPM治疗组(FasL-RPM组,n=31);(3)SA修饰组(SA组,n=27);(4)SA修饰+RPM治疗组(SA-RPM组,n=30);(5)未修饰胰岛组(Islet组,n=20)。术后连续3天测定血糖,其后每周测定尿糖3次。若受者尿糖阳性并连续2天血糖≥250 mg/dL为移植排斥反应,尿糖阴性超过100天为移植胰岛长期存活。结果激光共聚焦显微镜观察生物素呈绿色,FasL蛋白呈红色表达于胰岛表面,胰岛细胞的平均生物素化效率为(90.8±0.9)%,FasL蛋白平均表达率为(82.6±2.2)%。FasL组中28%受者的移植胰岛获得长期存活,联合应用RPM之后(FasL-RPM组)长期存活率提高到92%,两组间差异有显著统计学意义(P<0.05);SA组于术后25天全部受者均发生排斥反应,移植胰岛平均存活时间(mean survival time,MST)为(16±1.5)天,联合应用RPM之后(SA-RPM组)21%受者的移植胰岛获得长期存活,但显著低于FasL-RPM组的存活率(P<0.05)。Islet组于术后22天全部受者均发生排斥反应,移植胰岛MST为(14±1.7)天。结论表达FasL嵌合蛋白的工程化胰岛移植于糖尿病小鼠并联合短程免疫抑制剂治疗,有可能诱导移植胰岛长期存活,对1型糖尿病的治疗具有潜在的临床意义。

关键词：蛋白 FasL 胰岛移植免疫糖尿病小鼠

Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu zhou Pang-Chi Hsu Lin chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

A Novel Self-Supervised Learning Network for Binocular Disparity Estimation

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 209-229页

作者： Jiawei Tian Yu zhou Xiaobing chen Salman A.AlQahtani Hongrong chen Bo Yang Siyu Lu Wenfeng Zheng Department of Computer Science and Engineering Major in Bio Artificial IntelligenceHanyang UniversityAnsan-si15577Republic of Korea School of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11574Saudi Arabia School of Automation University of Electronic Science and Technology of ChinaChengdu610054China

Two-dimensional endoscopic images are susceptible to interferences such as specular reflections and monotonous texture illumination,hindering accurate three-dimensional lesion reconstruction by surgical *** study proposes a novel end-to-end disparity estimation model to address these *** approach combines a Pseudo-Siamese neural network architecture with pyramid dilated convolutions,integrating multi-scale image information to enhance robustness against lighting *** study introduces a Pseudo-Siamese structure-based disparity regression model that simplifies left-right image comparison,improving accuracy and *** model was evaluated using a dataset of stereo endoscopic videos captured by the Da Vinci surgical robot,comprising simulated silicone heart sequences and real heart video *** results demonstrate significant improvement in the network’s resistance to lighting interference without substantially increasing ***,the model exhibited faster convergence during training,contributing to overall performance *** study advances endoscopic image processing accuracy and has potential implications for surgical robot applications in complex environments.

关键词： Parallax estimation parallax regression model self-supervised learning Pseudo-Siamese neural network pyramid dilated convolution binocular disparity estimation