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Lymph node involvement in pancreatic neuroendocrine tumors: significance as a predictor of survival

Journal of Bio-X Research 2019年第1期2卷 25-33页

作者： Li Yu Rongjie zhao Xufeng Han Jiawei Shou Liangkun You Hanliang Jiang Xiaoyun Zhou zhen Liu Hongming Pan Weidong Han Department of Medical Oncology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou Department of Internal Medicine Yuyao Hospital of Traditional Chinese MedicineYuyao Department of Respiratory Medicine Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

Whether regional lymph node involvement exerts significant effect on the prognosis still remains obscure for pancreatic neuroendocrine *** clarify this association and identify predictors for lymph node involvement,we studied the data of patients aged>18 years with regional lymph node involvement histologically confirmed pancreatic neuroendocrine tumors from 2004 to 2014 in the Surveillance,Epidemiology,and End Results database(http://***/about).We evaluated Lymph node involvement as a prognostic factor by Cox *** reduced 9 variables of demographic and tumor characteristics to 5 potential predictors using least absolute shrinkage and selection operator(LASSO)regression *** further constructed a lymph node involvement model by logistic *** model was verified by the verification set,and the visual expression of the model was realized by a nomogram.A total of 1545 cases of pancreatic neuroendocrine tumors were included in our *** node positivity was significantly associated with disease-specific survival(P<0.001).Younger patients(P<0.05),patients with tumors in the pancreatic head(P<0.05),patients at high American Joint Committee on Cancer T stage(P<0.001),and patients of an undifferentiated status(P<0.05)showed a significantly higher possibility of developing lymph node *** reliability of this model was verified by cross-validation between the training and testing set,and we obtained good discrimination and calibration *** model also showed great performance in C-index and area under receiver operating characteristic *** node positivity was an important negative prognostic predictor for pancreatic neuroendocrine *** developed a lymph node involvement model based on the predictors including age,marital status,primary site,T status,and tumor grade.

关键词： Surveillance Epidemiology and End Results database logistic regression lymph node involvement nomogram pancreatic neuroendocrine tumors

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Risk factors and drug resistance in early-onset neonatal group B streptococcal disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第12期19卷 973-978页

作者： Ying-wei WANG Yao-qiang DU Xiao-lin MIAO guang-yong YE Yi-yun WANG Ai-bo XU Yun-zhong JING Yu TONG Kai XU Mei-qin zhenG Dong CHEN zhen WANG Department of Laboratory Medicine Tiantai People's Hospital Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical College Department of Infectious Diseases Eye Hospital of Wenzhou Medical University Department of Laboratory Medicine Women's Hospital Zhejiang University School of Medicine Department of Laboratory Medicine Wenzhou People's Hospital Department of Laboratory Medicine The Sixth People Hospital of Wenzhou

In recent years,group B streptococcus (GBS) has become an important pathogen that causes infections in many neonatal organs,including the brain, hmg,and eye (Ballard et al.,2016).A series of studies performed on GBS infections in western countries have revealed that GBS is one of the primary patho-gens implicated in perinatal infection,and GBS infections are a major cause of neonatal morbidity and mortality in the United States (Decheva et al.,2013).

关键词：新生儿无乳链球菌风险因素耐药性

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Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D

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Chinese Journal of Natural Medicines 2015年第9期13卷 673-679页

作者： LU Jin-Jian LU De-zhao CHEN Yu-Fei DONG Ya-Ting ZHANG Jun-Ren LI Ting TANG zheng-Hai YANG zhen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macao College of Life Sciences Zhejiang Chinese Medical University

Platycodin D(PD), a triterpenoid saponin isolated from Platycodonis Radix, is a famous Chinese herbal medicine that has been shown to have anti-proliferative effects in several cancer cell lines. The aim of this study was to determine the changes in cellular proteins after the treatment of hepatocellular carcinoma HepG2 cells with PD using proteomics approaches. The cell viability was determined using the MTT assay. The proteome was analyzed by two-dimensional difference gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Western blot analysis was used to confirm the expression of changed proteins. Our results showed that PD inhibited the proliferation of HepG2 cells in concentration- and time-dependent manners. Sixteen proteins were identified to be up-regulated in PD-treated HepG2 cells, including ATP5 H, OXCT1, KRT9, CCDC40, ERP29, RCN1, ZNF175, HNRNPH1, HSP27, PA2G4, PHB, BANF1, TPM3, ECH1, LGALS1, and MYL6. Three proteins(i.e., RPS12, EMG1, and KRT1) decreased in HepG2 cells after treatment with PD. The changes in HSP27 and PHB were further confirmed by Western blotting. In conclusion, our results shed new lights on the mechanisms of action for the anti-cancer activity of PD.

关键词： Platycodin D HepG2 Proteome 2-D DIGE

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外资银行进入模式选择:基于网点的信贷竞争

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管理工程学报 2017年第2期31卷 64-73页

作者：徐振业曾勇邓光军赵武电子科技大学经济与管理学院四川成都611731

网点是银行的主要渠道资源,对竞争有重要影响。在网点规模方面,中资大小银行间存在巨大差异,这将影响外资银行入股模式下的选择;中资银行的网点规模远超过外资银行,这将影响外资银行独立发展模式下的竞争力。基于此,本文扩展经典Salop模... 详细信息

网点是银行的主要渠道资源,对竞争有重要影响。在网点规模方面,中资大小银行间存在巨大差异,这将影响外资银行入股模式下的选择;中资银行的网点规模远超过外资银行,这将影响外资银行独立发展模式下的竞争力。基于此,本文扩展经典Salop模型,建立了银行间基于网点的信贷竞争模型,其中,银行通过网点吸收信贷资金,并通过网点竞争借款者,银行间进行有资金约束的竞争。本文分析了银行网点规模的格局对外资银行进入模式选择的影响。

关键词：网点进入模式 Salop模型信贷竞争资金约束

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东濮凹陷濮城地区沙一段盐湖相原油地球化学特征

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中国石油大学学报（自然科学版） 2007年第3期31卷 22-27页

作者：常振恒陈中红王兴武赵广珍王志萍中国石油大学地球资源与信息学院山东东营257061 中原油田分公司勘探开发科学研究院河南濮阳457001

应用地球化学研究手段,对东濮凹陷濮城地区沙一段盐湖相烃源岩岩样、原油样和油砂样进行了族组分、饱和烃色谱-质谱实验分析。结果表明,濮城地区沙一段原油与含油砂岩抽提物的饱和烃含量在47.39%～65.33%,族组分碳同位素分布在-28.06‰... 详细信息

应用地球化学研究手段,对东濮凹陷濮城地区沙一段盐湖相烃源岩岩样、原油样和油砂样进行了族组分、饱和烃色谱-质谱实验分析。结果表明,濮城地区沙一段原油与含油砂岩抽提物的饱和烃含量在47.39%～65.33%,族组分碳同位素分布在-28.06‰～-26.29‰,芳烃、非烃和沥青质组分之间的同位素分馏效应较小;w(Pr)/w(Ph)小于0.5,具有明显的植烷优势;甾烷w(C2920R)/w(20(R+S))为0.23～0.27,w(C29ββ)/w(αα+ββ)为0.19～0.40,甾烷系列中C27含量略占优势,重排甾烷含量极低;γ-蜡烷含量较高,w(γ-蜡烷)/w(C30藿烷)在0.60左右,w(γ-蜡烷)/w(HC3122S)大于2.0,三升藿烷～五升藿烷呈“翘尾”状升序分布,反映了高盐度水体沉积环境下形成的未熟-低熟油特征。油源对比分析认为其烃源灶为沙一段泥岩和部分沙三段泥岩。

关键词：东濮凹陷沙一段盐湖相低熟油生物标志物地球化学特征

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Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival

Ligand-dependent EphB1 signaling suppresses glioma invasion ...

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第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： Lei Teng Da-Yong Han Yun-Bo zhen Yao-Hua Liu Li-Gang Wang guang Yang Huai-Lei Liu Jia-Ning Wu Shi-guang zhao Affiliated First Hospital of Harbin Medical University

＜正＞Extensive evidence implicates the Eph receptor family of tyrosine kinases and its liga nd,ephrin in glioma invasion,but it remains incompletely understood how these recept ors affect chemotactic behavior of ***,...

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一例比格犬肺炎克雷伯氏菌病的诊断及防控

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青岛农业大学学报（自然科学版） 2024年第1期41卷 32-38页

作者：满成徐士杰王馨锐甄建瑜赵天祎李聪曲雪婷尹燕博张灿青岛农业大学动物医学院山东青岛266000 青岛博隆实验动物有限公司山东青岛266000

为了诊断青岛博隆实验动物养殖基地比格犬病死原因并制定有效防控措施,试验通过临床观察和病理解剖对病犬进行初步诊断;无菌采集病死幼犬肺组织,采用特异性聚合酶链式反应(polymerase chain reaction,PCR)诊断三种常见犬呼吸道病毒,通... 详细信息

为了诊断青岛博隆实验动物养殖基地比格犬病死原因并制定有效防控措施,试验通过临床观察和病理解剖对病犬进行初步诊断;无菌采集病死幼犬肺组织,采用特异性聚合酶链式反应(polymerase chain reaction,PCR)诊断三种常见犬呼吸道病毒,通过细菌形态学观察、生化试验、基因测序鉴定分离病原菌,并通过小鼠致病性试验和药敏试验分析其致病性和优化用药方案。结果表明:犬发病时主要表现为咳嗽、流鼻涕、食欲不振和轻度腹泻等症状。剖检可见胸腔积液,肺叶淤血和坏死。PCR鉴定犬腺病毒2型(canineadenovirus type 2,CAV 2)、H3N2亚型犬流感病毒(H3N2 subtype canine influenza virus,CIV)和犬副流感病毒(canine parainfluenza virus,CPIV)均为阴性。细菌分离培养显示为该菌革兰氏阴性的粗短杆菌;生化试验和16S rDNA测序鉴定该菌为肺炎克雷伯菌。回归试验结果表明该菌可引起小鼠肺炎症状,具有较强致病力。药敏试验结果显示分离菌株对阿奇霉素、环丙沙星、恩诺沙星敏感,对氨苄西林、头孢他啶、庆大霉素、头孢噻肟、头孢替安、头孢曲松耐药。经犬舍消毒和药物治疗后,该犬养殖场的病情得到有效控制。

关键词：犬肺炎克雷伯氏菌诊断药敏试验防控

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Research on etiology and pathogenesis of cancer based on data mining under theguidance of Neijing theory

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TMR Theory and Hypothesis 2018年第2期1卷 26-33页

作者： Hui-Ting Wang guang-Xiao Zhu Xin-Sheng Cai zhao-guang Yan guang-Chun Wang Lin Yu Rui-HuaSun Shandong traditional Chinese medicine university Cancer center of weifang hospital affiliated to shandong university of traditional Chinese medicine

Etiology and pathogenesis are the causes and mechanisms of disease development and change. The unification and innovation of cancer pathogenesis is the key to the breakthrough of Chinese medicine. According to the related theory in Neijing, cancer in different parts of the body could be classified based on the five elements. Chinese mainland is divided into five parts： east, south, west, north and central section. Based on the annual data of China Cancer Center, we analyzed the data of 72 cancer registries covering 32 provinces and autonomous regions for consecutive 5 years. The results showed that the total incidence of the five regions in the mainland of China was statistically significant （F = 8.561, P 〈 0.01）; the east was the highest, the west was the lowest, and the south, middle and north were in the middle level. The incidence of tumors in different parts of the human body was statistically significant （F = 523.382, P 〈 0.01）. The incidence rate from high to low was lung, spleen, kidney, liver and heart. The heat is too much in China＇s eastern and the southern, and Qi is not too enough in the northwest. Five-Qi was imbalance. The pathogenesis of cancer is due to the two aspects, deficiency of five Zang-organs and abnormal seasonal climates. The viscera weakness for a long period and abnormal seasonal climates causes the body Yin and Yang disharmony, resulting in five zang organs dysfunction.

关键词： Huangdi neijing Cancer Big data Etiology and pathogenesis

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内蒙古额济纳旗三个井矿区铅金矿地质特征及成因分析

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世界有色金属 2024年第5期 91-93页

作者：赵合兵甘肃智广地质工程勘察设计有限公司甘肃兰州730000

三个井矿区位于额济纳旗-大兴安岭一带铜、铅、锌、金、银、铬、铌成矿区和额济纳-雅干华力西期铁、金、铜、钼、镍成矿带上;也是在北山成矿远景区黄砬子-三个井金多金属成矿带上。地质条件较好,构造复杂,岩浆岩活动频繁,本文重点分析... 详细信息

三个井矿区位于额济纳旗-大兴安岭一带铜、铅、锌、金、银、铬、铌成矿区和额济纳-雅干华力西期铁、金、铜、钼、镍成矿带上;也是在北山成矿远景区黄砬子-三个井金多金属成矿带上。地质条件较好,构造复杂,岩浆岩活动频繁,本文重点分析三个井铅金矿地质特征,初步圈定8条铅金矿体,总结了矿床成因类型及找矿标志。

关键词：地质特征矿床成因远景评价

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Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2392-2407页

作者： Sihui Cai Chenqiu Zhang zhen Zhuang Shengnan Zhang Ling Ma Shuai Yang Tao Zhou Zheyu Wang Weihong Xie Shouheng Jin Jincun zhao Xiangdong Guan Jianfeng Wu Jun Cui Yaoxing Wu guangdong Province Key Laboratory of Pharmaceutical Functional Genes The First Affiliated Hospital of Sun Yat-sen UniversitySchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdongChina MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Critical Care Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Currently,the incidence and fatality rate of SARS-CoV-2 remain continually high ***-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon(IFN-I)signal,along with limited activation of antiviral immune responses as well as enhanced viral *** progresses have been made in revealing the multiple strategies employed by SARS-CoV-2 in impairing canonical RNA sensing ***,it remains to be determined about the SARS-CoV-2 antagonism of cGAS-mediated activation of IFN responses during *** the current study,we figure out that SARS-CoV-2 infection leads to the accumulation of released mitochondria DNA(mtDNA),which in turn triggers cGAS to activate IFN-I *** countermeasures,SARS-CoV-2 nucleocapsid(N)protein restricts the DNA recognition capacity of cGAS to impair cGAS-induced IFN-I ***,N protein disrupts the assembly of cGAS with its co-factor G3BP1 by undergoing DNA-induced liquid-liquid phase separation(LLPS),subsequently impairs the double-strand DNA(dsDNA)detection ability of *** together,our findings unravel a novel antagonistic strategy by which SARS-CoV-2 reduces DNA-triggered IFN-I pathway through interfering with cGAS-DNA phase separation.

关键词： interferon separated cGAS

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