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Large deflection deformation behavior of a Zr-based bulk metallic glass for compliant spinal fixation application

Journal of Materials Science & Technology 2024年第6期173卷 86-99页

作者： Diao-Feng Li Chun-guang Bai Zhi-Qiang Zhang Hui-Bo Zhang Nan Li Jian zhao Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

A novel compliant spinal fixation designed based on the concept of compliant mechanisms can reduce the stress-shielding effect and adjacent segment degeneration(ASD)effectively,but propose higher requirements for the properties of the used *** metallic glasses(BMGs),as a kind of young biomaterials,exhibiting excellent comprehensive properties,which are attractive for compliant spinal ***,according to the practical service condition of the basic elements in compliant spinal fixation,large deflection deformation behaviors of Zr_(61)Ti_(2)Cu_(25)Al_(12)(at.%,ZT1)BMG beam,including elastic,yielding and plastic were investigated *** was shown that the theoretical nonlinear analytical solution curve as the benchmark not only with the capacity to predict the nonlinear load-deflection relation within the elastic deformation regime,but also assists to capture the yielding event roughly,which can be used as a powerful design tool for *** capture the beginning of the yielding event exactly,bending proof strength(σ_(p),0.05%)accompanied with tiny permanent strain of 0.05% was proposed and determined for BMGs in biomedical implant applications,which is of significance for setting the allowable operating limits of the basic flexible *** approach of interrupted loading-unloading cycles,plastic deformation driven by the bending moment can be classified into two typical stages:the initial stage which mainly characterized by the nucleation and intense interaction of abundant shear bands when the plastic strain below the critical value,and the second stage which dominated by the progressive propagation of shear bands and coupled with the emergence of shear offsets on tensile *** plasticity of BMG beam structures depends on the BMG's inherent plastic zone size(rp).When the half beam thickness less than that of the rp,the plastic deformation of BMGs will behave in a stable manner,which can be acted as the margin of safety effectiv

关键词： Metallic glasses Biomaterials Compliant spinal fixation Large deflection deformation Plastic deformation

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Current Immunotherapy Strategies for Rheumatoid Arthritis:The Immunoengineering and Delivery Systems

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Research 2024年第3期2023卷 169-189页

作者： Chenyu Zhang Peixiang Ma An qin Liao Wang Kerong Dai Yuanyuan Liu Jie zhao Zuyan Lu School of Medicine Shanghai UniversityShanghaiChina Clinical and Translational Research Center for 3D Printing Technology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System ShanghaiChina.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease accompanied by persistent multiarticular synovitis and cartilage degradation. The present clinical treatments are limited to disease-modifying anti-rheumatic drugs (DMARDs) and aims to relieve pain and control the inflammation of RA. Despite considerable advances in the research of RA, the employment of current clinical procedure is enormous, hindered by systemic side effect, frequent administration, tolerance from long-lasting administration, and high costs. Emerging immunoengineering-based strategies, such as multiple immune-active nanotechnologies via mechanism-based immunology approaches, have been developed to improve specific targeting and to reduce adverse reactions for RA treatments. Here, we review recent studies in immunoengineering for the treatment of RA. The prospect of future immunoengineering treatment for RA has also been discussed.

关键词： drugs Rheumatoid treatment

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Advances in ice avalanches on the Tibetan Plateau

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Journal of Mountain Science 2024年第6期21卷 1814-1829页

作者： TANG Minggao LI guang zhao Huanle XU Qiang WU guangjian YANG Wei GUO Daojing State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Environment and Civil Engineering Chengdu University of TechnologyChengdu 610059China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China

As some of the greatest natural disasters in the cryosphere,ice avalanches(IAs)seriously threaten lives and cause catastrophic damage to the resource environment,but a comprehensive overview of the state of knowledge on IAs remains *** summarized 63 IAs on the Tibetan Plateau(TP)since the 20th century,of which,over 20 IAs occurred after the 21st *** distributions of IAs are mainly concentrated in the southeastern and northwestern TP,and the occurrence time of IAs is mostly concentrated from July to *** highlight recent advances in mechanical properties and genetic mechanisms of IAs and emphasize that temperature,rainfall,and seismicity are the inducing *** failure modes of IAs are summarized into 6 categories by examples:slip pulling type,slip toppling type,slip breaking type,water level collapse type,cave roof collapse type,and wedge failure ***,we deliver recommendations concerning the risk assessment and prediction of *** results provide important scientific value for addressing climate change and resisting glacier-related hazards.

关键词： Ice avalanche Global warming Genetic mechanism Risk assessment Tibetan Plateau

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A novel lightweight computerized ECG interpretation approach based on clinical 12-lead data

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Science China(Technological Sciences) 2024年第2期67卷 449-463页

作者： LIU Yunqing qin ChengJin LIU JinLei JIN YanRui LI ZhiYuan zhao LiQun LIU ChengLiang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Key Labof Artificial Intelligence(Ministryof Education) AI InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Cardiology Shanghai First Peoples Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200080China

Although 12-lead electrocardiograms(ECGs)provide a wide range of spatiotemporal characteristics,interpreting them for arrhythmia detection is difficult due to a lack of reliable large-scale clinical ***,we proposed an innovative lightweight computerized ECG interpretation approach based on 12-lead *** model was trained,validated,and tested on 53845 standard 12-lead ECG records collected at Shanghai First People’s Hospital in affiliation with Shanghai Jiao Tong *** experiments revealed that our approach had a classification accuracy of 94.41%in the classification task of seven types of rhythms,which was markedly superior to related single-lead and 12-lead ECG classification ***,the average receiver operating characteristic area under the curve reached a value of 0.940,and the precision values for sinus tachycardia and sinus bradycardia were 0.945 and 0.91,respectively,with specificity values of 0.996 and *** employing our boosting method,we were able to improve the accuracy to 94.85%.To investigate the performance degradation of the proposed neural network in some classes,an ECG cardiologist was enlisted to review questionable ECGs;this process provides a promising direction for network performance ***,the proposed computerized ECG interpretation approach has practical significance because it could help professional physicians analyze patients’heart conditions based on real-time 12-lead ECG or grade their disease severity in advance.

关键词： computerized ECG interpretation large-scale 12-lead clinical ECG database lightweight neural network

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Research progress of carbon-based particle electrodes in three-dimensional electrode reactors for wastewater treatment

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新型炭材料(中英文) 2024年

作者： LU Hua-yu LIU Wei-feng qin Lei LIU Xu-guang Institute of New Carbon Materials College of Materials Science and Engineering Taiyuan University of Technology Key Laboratory of Interface Science and Engineering in Advanced Materials (Taiyuan University of Technology) Ministry of Education Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering

Three-dimensional(3D) electrode technology is a competitive water treatment technology owing to its high catalytic efficiency, low energy consumption, and promising development. The introduction of a third electrode on the basis of a 2D electrode system forms a 3D electrode system, and the introduced third electrode is also known as the particle electrode. Particle electrodes in3D electrode system are generally in the form of particles or crumbs that be filled in between the cathode and anode. The core of the3D electrode system is the particle electrode, so the selection of particle electrode materials is the focus of the research of 3D electrode technology. Carbon-based materials are widely used as particle electrodes in 3D electrode technology because of their advantages of large specific surface area, good adsorption performance, high chemical stability, and low price. In this review, the research progress of carbon-based materials as particle electrodes for degrading organic pollutants in recent years is collected, the principle of3D electrode technology is introduced, along with the classification of particle electrodes and the current research status of carbonbased particle electrodes, and the challenges and future development of carbon-based particle electrodes in wastewater treatment are summarized.

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Efficient conversion of aromatic and phenylpropanoid alcohols to acids by the cascade biocatalysis of alcohol and aldehyde dehydrogenases

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Synthetic and Systems Biotechnology 2024年第2期9卷 187-195页

作者： Zetian Qiu Xiaohui Liu Jie Yu Yushuo zhao guang-Rong zhao Shengying Li Kun Liu Lei Du Li Ma State Key Laboratory of Microbial Technology Shandong UniversityQingdaoShandong266237China Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350China School of Health Management Hengxing UniversityQingdaoShandong266100China

Benzyl and phenylpropanoid acids are widely used in organic synthesis of fine chemicals,such as pharmaceuticals and ***,biocatalysis of these acids has received less attention than chemical *** of the main challenges for biological production is the limited availability of alcohol dehydrogenases and aldehyde *** microorganisms are potential sources of these *** this study,129 alcohol dehydrogenases and 42 aldehyde dehydrogenases from Corynebacterium glutamicum,Pseudomonas aeruginosa,and Bacillus subtilis were identified and explored with various benzyl and phenylpropanoid alcohol and aldehyde substrates,among which four alcohol dehydrogenases and four aldehyde dehydrogenases with broad substrate specificity and high catalytic activity were ***,a cascade whole-cell catalytic system including ADH-90,ALDH-40,and the NAD(P)H oxidase LreNox was established,which showed high efficiency in converting cinnamyl alcohol and p-methylbenzyl alcohol into the respective carboxylic ***,this biocatalytic system can be easily scaled up to gram-level production,facilitating preparation purposes.

关键词： Benzyl acids Phenylpropanoid acids Alcohol dehydrogenases Aldehyde dehydrogenases Whole-cell catalysis

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Porous Ti_(3)C_(2)T_(x) MXene nanosheets sandwiched between polyimide fiber mats for electromagnetic interference shielding

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Nano Research 2024年第3期17卷 2070-2078页

作者： Wenhao Liang Juntao Wu Shan Zhang Pei-Yan zhao Yi Cong Yongqiang Guo guang-Sheng Wang Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

With the rapid development of wireless communication technology and electronic devices,the issue of electromagnetic interference(EMI)is becoming increasingly *** a new and flexible electromagnetic interference shielding material has become a challenging ***,a sandwich-structured EMI shielding composite film was prepared using electrospinning and vacuum filtration *** this process,a porous MXene was synthesized through a reaction with cobalt acetate and served as the intermediate layer in the composite film to shield electromagnetic *** electrospun polyimide(PI)fibers were used as the top and bottom layers of the composite film,which can protect the porous MXene from *** lightweight and flexible composite film integrates electromagnetic interference shielding and thermal insulation capabilities,showing excellent comprehensive *** composite film achieves an EMI shielding effectiveness of 48.8 dB in X-band(8.2–12.4 GHz),and absolute shielding effectiveness of the composite film reached a satisfying 4142.43(dB·cm^(2))/*** to the design of a multi-layer porous structure,the density of the composite film is 0.65 g/***,the thermal conductivity of the film is 0.042 W/(m·K)due to the clamping of electrospun PI fibers,showing excellent thermal insulation ***,the composite film exhibits excellent high and low-temperature *** summary,this work provides a feasible strategy for preparing a lightweight polymer-based EMI shielding film.

关键词： porous MXene polyimide electromagnetic interference shielding thermal insulation

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Super-high bed sintering for iron ores:behaviors,causes and solutions of horizontal segregation on strand

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Journal of Iron and Steel Research International 2024年第7期31卷 1590-1596页

作者： Liang-ping Xu Hui-bo Liu Zhong-lin Dong Qiang Zhong Yu-chao zhao guang-hui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Horizontal segregation has been a constraint to the development and application of super-high bed *** eliminate the horizontal segregation of super-high bed sintering,several typical sintering machines were sampled and analyzed,and theoretical calculation was made to compare the bed depth and their differences in different areas within the mixture ***,solutions were proposed and applied to a 265 m^(2) sintering *** results showed that the horizontal seg-regation of the 265 m^(2) sintering machine was dominated by particles larger than 8 mm with horizontal segregation degree of 0.48,while 360 and 550 m^(2) sintering machines were affected by 5-8 mm and 1-3 mm particles with horizontal segregation degree of 0.27 and 0.31,*** analysis indicated the different segregation distribution results from the matching of the bed depth of each area within the mixture ***,the horizontal segregation degree not larger than 0.06 was achieved by optimizing the time parameters and the division of three zones on the 265 m^(2) sintering machine.

关键词： Super-high bed sintering Horizontal segregation Feeder Particle distribution Agglomeration

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Sparse antenna array design methodologies:A review

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Journal of Electronic Science and Technology 2024年第3期22卷 1-15页

作者： Pan Wu Yan-Hui Liu Zhi-qin zhao qing-Huo Liu School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Eastern Institute of Technology Ningbo315200China

Designing a sparse array with reduced transmit/receive modules(TRMs)is vital for some applications where the antenna system’s size,weight,allowed operating space,and cost are *** arrays exhibit distinct architectures,roughly classified into three categories:Thinned arrays,nonuniformly spaced arrays,and clustered *** numerous advanced synthesis methods have been presented for the three types of sparse arrays in recent years,a comprehensive review of the latest development in sparse array synthesis is *** work aims to fill this gap by thoroughly summarizing these *** study includes synthesis examples to facilitate a comparative analysis of different techniques in terms of both accuracy and ***,this review is intended to assist researchers and engineers in related fields,offering a clear understanding of the development and distinctions among sparse array synthesis techniques.

关键词： Clustered array Nonuniformly spaced array Sparse antenna array Synthesis method Thinned array

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Corrosion behavior of Al_(2)O_(3)-C bricks in MnO-containing mold slag

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Journal of Iron and Steel Research International 2024年第6期31卷 1486-1492页

作者： Yi-jiang zhao guang-qiang Li Yang Wu Cheng Yuan Ze Meng Xiao-xuan Deng Yu Liu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Research Institute of Technology Shougang Group Co.Ltd.Beijing 100043China

In order to explore the corrosion mechanism of Al_(2)O_(3)-C refractories in the mold flux bearing MnO,the immersion test of Al_(2)O_(3)-C refractories in CaO-SiO2-CaF2-MnO slag with different MnO contents was carried out at 1550℃.The results show that Mn particles were observed in the slag after experiment,due to the reduction of MnO by graphite in *** amounts of graphite were observed at the interface between refractories and slag,indicating that the oxidation of graphite is limited by the poor contact between graphite and molten ***,the oxidation of graphite is not the main cause of damage to refractories.A small quantity of CaO·2Al_(2)O_(3)(CA_(2))and CaO·6Al_(2)O_(3)(CA_(6))adjacent to Al_(2)O_(3) grain was detected at the slag/reaction layer ***_(2) and CA_(6) possess relatively high melting points,which is beneficial to hindering the further penetration of ***,the dissolution of Al_(2)O_(3) into slag is still the main cause for refractories *** increase in the MnO content of mold slag decreases the viscosity and then results in the severe corrosion of Al_(2)O_(3)-C bricks.

关键词： Al_(2)O_(3)-C refractory MnO-containing slag Graphite Corrosion

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