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Tribological Behaviors of Electroless Nickel-Boron Coating on Titanium Alloy Surface

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 309-320页

作者： yao Jia Jianping lai Jiaxin Yu Huimin Qi Yafeng Zhang Hongtu He Key Laboratory of Testing Technology for Manufacturing Process in Ministry of Education State Key Laboratory of Environment-Friendly Energy MaterialsSouthwest University of Science and TechnologyMianyang 621010China

Titanium alloys are excellent structural materials in engineering fields,but their poor tribological properties limit their further *** plating is an effective method to enhance the tribological performance of alloys,but it is difficult to efficiently apply to titanium alloys,due to titanium alloy’s strong chemical *** this work,the electroless Nickel-Boron(Ni-B)coating was successfully deposited on the surface of titanium alloy(Ti-6AL-4V)via a new pre-treatment ***,linearly reciprocating sliding wear tests were performed to evaluate the tribological behaviors of titanium alloy and its electroless Ni-B *** was found that the Ni-B coatings can decrease the wear rate of the titanium alloy from 19.89×10^(−3)mm^(3)to 0.41×10^(−3)mm^(3),which attributes to the much higher hardness of Ni-B *** heat treatment,the hardness of Ni-B coating further increases corresponding to coating crystallization and hard phase ***,heat treatment does not improve the tribological performance of Ni-B coating,due to the fact that higher brittleness and more severe oxidative wear exacerbate the damage of heat-treated ***,the Ni-B coatings heat-treated both in air and nitrogen almost present the same tribological *** finding of this work on electroless coating would further extend the practical applications of titanium alloys in the engineering fields.

关键词： Electroless coating Titanium alloy Tribology Wear Heat treatment Nanoindentation

Coupling Analysis of Multiple Machine Learning Models for Human Activity Recognition

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Computers, Materials & Continua 2024年第6期79卷 3783-3803页

作者： Yi-Chun lai Shu-Yin Chiang yao-Chiang Kan Hsueh-Chun Lin Department of Public Health China Medical UniversityTaichung406040Taiwan Department of Information and Telecommunications Engineering Ming Chuan UniversityGui-ShanTaoyuan333Taiwan Department of Electrical Engineering Yuan Ze UniversityChung-Li32003Taiwan Department and Institute of Health Service Administrations China Medical UniversityTaichung406040Taiwan

Artificial intelligence(AI)technology has become integral in the realm of medicine and healthcare,particularly in human activity recognition(HAR)applications such as fitness and rehabilitation *** study introduces a robust coupling analysis framework that integrates four AI-enabled models,combining both machine learning(ML)and deep learning(DL)approaches to evaluate their effectiveness in *** analytical dataset comprises 561 features sourced from the UCI-HAR database,forming the foundation for training the ***,the MHEALTH database is employed to replicate the modeling process for comparative purposes,while inclusion of the WISDM database,renowned for its challenging features,supports the framework’s resilience and *** ML-based models employ the methodologies including adaptive neuro-fuzzy inference system(ANFIS),support vector machine(SVM),and random forest(RF),for data *** contrast,a DL-based model utilizes one-dimensional convolution neural network(1dCNN)to automate feature ***,the recursive feature elimination(RFE)algorithm,which drives an ML-based estimator to eliminate low-participation features,helps identify the optimal features for enhancing model *** best accuracies of the ANFIS,SVM,RF,and 1dCNN models with meticulous featuring process achieve around 90%,96%,91%,and 93%,*** analysis using the MHEALTH dataset showcases the 1dCNN model’s remarkable perfect accuracy(100%),while the RF,SVM,and ANFIS models equipped with selected features achieve accuracies of 99.8%,99.7%,and 96.5%,***,when applied to the WISDM dataset,the DL-based and ML-based models attain accuracies of 91.4%and 87.3%,respectively,aligning with prior research *** conclusion,the proposed framework yields HAR models with commendable performance metrics,exhibiting its suitability for integration into the healthcare services system through AI-driven applications.

关键词： Human activity recognition artificial intelligence support vector machine random forest adaptive neuro-fuzzy inference system convolution neural network recursive feature elimination

T-tube bridging fistula jejunal anastomosis for treatment of pancreatic lumbar dorsal fistula after necrotizing pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 428-430页

作者： Su-lai Liu Guo-guang Li Wei Cheng Chuang Peng Ying-Hui Song Department of Hepatobiliary Surgery Hunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal UniversityChangsha 410000China

Infectious pancreatic necrosis causes external pancreatic fistula in some ***,external pancreatic fistula requires fistula-gastric and/or intestinal anastomosis,and digestive endoscopic interventional treatment[1–3].It is especially difficult to treat external pancreatic fistulas with small fistulas where the external fistula is located in the lower *** common treatment is to remove the body and tail of the pancreas and the *** operation is very traumatic.A new pancreatic fistula may still occur at the pancreatic *** above operations may lead to unnecessary resection of the spleen,colon injury and other *** order to solve this problem,we innovatively used T-tube bridging fistula jejunal anastomosis plus continuous negative pressure suction to treat three cases of external pancreatic fistulas in the lower back,and all of them achieved good results.

关键词： fistula anastomosis spleen

Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

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Marine Life Science & Technology 2024年第3期6卷 502-514页

作者： Jian-Yu Liu yao-yao Jiang Peng-Jie Li Bo yao Yi-Jing Song Ji-Xiu Gao Gulab Said Yang Gao Jun-Yu lai Chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan Laoshan Laboratory Qingdao 266237China Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common malignancies that threaten human life,bladder cancer occurs frequently with a high mortality rate in the world,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especially in the area of *** A(BFA)is a natural Arf-GEFs inhibitor,but due to the low aqueous solubility,strong toxicity,and poor bioavailability,it is urgent to conduct structural optimization ***,a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell *** was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines T24 and J82(IC50=0.079 and 0.081μmol/L)with high selectivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a T24 nude mice xenograft model(TGI=52.63%)and prolonged the survival time(ILS=68.16%)in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic T *** mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.

关键词： Bladder cancer Marine natural products Brefeldin A EGFR/PI3K/AKT EGFR/ERK T-cell infiltration

A meso–molecular muscle based on copillar[5]arenes

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Chinese Chemical Letters 2024年第3期35卷 308-311页

作者： Yu yao Peiling Zhang Dan Zhou Zhinan lai Shijun Li Feihe Huang Zibin Zhang College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material TechnologyHangzhou Normal UniversityHangzhou 311121China Department of Chemistry Stoddart Institute of Molecular ScienceZhejiang UniversityHangzhou 310027China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

A meso–molecular muscle was prepared by capping the[c2]daisy chain based on a mono-functionalized copillar[5]arene with an imidazolium group in its *** its crystal structure,we observed that it was a cyclic dimer composed of two mirror image subcomponents,a pR-and a pS-copillar[5]*** conformations were fixed by the doubly interlocked mechanical *** comparison of the^1H NMR and COSY spectra,we found that the length of this meso–molecular muscle could be controlled not only by the solvents,but also by the counter anions.

关键词： Pillararenes Molecular muscles [c2]daisy chains Planar chirality

d-d Orbital coupling induced by crystal-phase engineering assists acetonitrile electroreduction to ethylamine

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Journal of Energy Chemistry 2024年第2期89卷 216-225,I0006页

作者： Honggang Huang yao Chen Hui Fu Cun Chen Hanjun Li Zhe Zhang Feili lai Shuxing Bai Nan Zhang Tianxi Liu Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122JiangsuChina Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071ShandongChina

The d-d orbital coupling induced by crystal-phase engineering can effectively adjust the electronic structure of electrocatalysts,thus showing significant catalytic performance,while it has been rarely explored in electrochemical acetonitrile reduction reaction(ARR)to ***,we successfully realize the structural transformation of Pd Cu metallic aerogels(MAs)from face-centered cubic(FCC)to body-centered cubic(BCC)through annealing ***,the BCC Pd Cu MAs exhibit excellent ARR performance with high ethylamine selectivity of 90.91%,Faradaic efficiency of 88.60%,yield rate of 316.0 mmol h^(-1)g^(-1)_(Pd+Cu)and long-term stability for consecutive electrolysis within 20 h at-0.55 V *** hydrogen electrode,outperforming than those of FCC Pd Cu *** the membrane electrode assembly system,BCC Pd Cu MAs also demonstrate excellent ethylamine yield rate of 389.5 mmol h^(-1)g^(-1)_(Pd+Cu).Density functional theory calculation reveals that the d-d orbital coupling in BCC Pd Cu MAs results in an evident correlation effect for the interaction of Pd and Cu sites,which boosts up the Cu sites electronic activities to enhance ARR *** work opens a new route to develop efficient ARR electrocatalysts from the perspective of crystalline structure transformation.

关键词： d-d Orbital coupling Crystal-phase engineering Metallic aerogels Acetonitrile electroreduction reaction Ethylamine

Power Flow Analytical Solutions and Multi-dimensional Voltage Stability Boundaries Based on Multivariate Quotient-difference Method

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1168-1178页

作者： Chengxi Liu Qiupin lai School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Hubei Engineering and Technology Research Center for AC/DC Intelligent Distribution Network Wuhan 430072China IEEE

This paper proposes a novel Multivariate Quotient-Difference(MQD)method to obtain the approximate analytical solution for AC power flow ***,in the online environment,the power flow solutions covering different operating conditions can be directly obtained by plugging values into multiple symbolic variables,such that the power injections and consumptions of selected buses or areas can be independently *** method first derives a power flow solution through a Multivariate Power Series(MPS).Next,the MQD method is applied to transform the obtained MPS to a Multivariate Pad´e Approximants(MPA)to expand the Radius of Convergence(ROC),so that the accuracy of the derived analytical solution can be significantly *** addition,the hypersurface of the voltage stability boundary can be identified by an analytical formula obtained from the coefficients of *** direct method for power flow solutions and voltage stability boundaries is fast for many online applications,since such analytical solutions can be derived offline and evaluated online by only plugging values into the symbolic variables according to the actual operating *** proposed method is validated in detail on New England 39-bus and IEEE 118-bus systems with independent load variations in multi-regions.

关键词： Analytical power flow solution multivariate power series multivariate Padéapproximants multivariate quotient-difference multi-dimensional voltage stability boundary

Cell atlas of CCl_(4)-induced progressive liver fibrosis reveals stage-specific responses

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Zoological Research 2023年第3期44卷 451-466页

作者： Peng-Cheng Guo Jing Zuo Ke-Ke Huang guang-yao lai Xiao Zhang Juan An Jin-Xiu Li Li Li Liang Wu Yi-Ting Lin Dong-Ye Wang Jiang-Shan Xu Shi-Jie Hao Yang Wang Rong-Hai Li Wen Ma Yu-Mo Song Chang Liu Chuan-Yu Liu Zhen Dai Yan Xu Amar Deep Sharma Michael Ott Qing Ou-Yang Feng Huo Rong Fan Yong-Yin Li Jin-Lin Hou Giacomo Volpe Long-Qi Liu Miguel A.Esteban Yi-Wei lai State Key Laboratory for Zoonotic Diseases Key Laboratory for Zoonosis Research of Ministry of EducationInstitute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchunJilin 130062China BGI-Hangzhou HangzhouZhejiang 310012China BGI-Shenzhen ShenzhenGuangdong 518083China Key Laboratory of Biological Targeting Diagnosis Therapy and Rehabilitation of Guangdong Higher Education InstitutesFifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510799China Laboratory of Integrative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouGuangdong 510530China Joint School of Life Sciences Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical UniversityGuangzhouGuangdong 510530China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhouGuangdong 510530China Biotherapy Centre Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Department of Hepatobiliary Surgery and Liver Transplant Center General Hospital of Southern Theater CommandGuangzhouGuangdong 510010China Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangdong Provincial Key Laboratory of Viral Hepatitis ResearchGuangzhouGuangdong 510515China Hematology and Cell Therapy Unit IRCCS-Istituto Tumori‘Giovanni Paolo II’Bari 70124Italy Institute of Experimental Hematology Hannover Medical SchoolHannover 30625Germany

Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis,a major cause of morbidity and mortality ***,there are currently no effective anti-fibrotic therapies available,especially for latestage patients,which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cellspecific responses in different fibrosis *** reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes,we generated a single-nucleus transcriptomic atlas encompassing 49919nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride(CCl_(4))-induced progressive liver *** analysis distinguished the sequential responses to injury of hepatocytes,hepatic stellate cells and endothelial ***,we reconstructed the cell-cell interactions and gene regulatory networks implicated in these *** integrative analyses uncovered previously overlooked aspects of hepatocyte proliferation exhaustion and disrupted pericentral metabolic functions,dysfunction for clearance by apoptosis of activated hepatic stellate cells,accumulation of pro-fibrotic signals,and the switch from an anti-angiogenic to a pro-angiogenic program during CCl_(4)-induced progressive liver *** dataset thus constitutes a useful resource for understanding the molecular basis of progressive liver fibrosis using a relevant animal model.

关键词： Liver fibrosis Toxicity Single-cell and single-nucleus RNA-sequencing Hepatocytes Hepatic stellate cells Angiogenesis Cell-cell interactions Gene regulatory networks

Genome-Wide Identification of Tomato (Solanum lycopersicum L.) CKX Gene Family and Expression Analysis in the Callus Tissue under Zeatin Treatment

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1143-1158页

作者： Zhengfeng lai Dongmei Lian Shaoping Zhang Yudong Ju Bizhen Lin Yunfa yao Songhai Wu Jianji Hong Zhou Li Subtropical Agriculture Research Institute Fujian Academy of Agricultural SciencesZhangzhou363005China

The cytokinin oxidase/dehydrogenase(CKX)enzyme is essential for controlling theﬂuctuating levels of endogen-ous cytokinin(CK)and has a signiﬁcant impact on different aspects of plant growth and ***-less,there is limited knowledge about CKX genes in tomato(Solanum lycopersicum L.).Here we performed genome-wide identiﬁcation and analysis of nine SlCKX family members in tomatoes using bioinformatics *** results revealed that nine SlCKX genes were unevenly distributed onﬁve chromosomes(Chr.1,Chr.4,Chr.8,Chr.10,and Chr.12).The amino acid length,isoelectric points,and molecular weight of the nine SlCKX proteins ranged from 453 to 553,5.77 to 8.59,and 51.661 to 62.494 kD,*** localization analysis indi-cated that SlCKX2 proteins were located in both the vacuole and cytoplasmic matrix;SlCKX3 and SlCKX5 pro-teins were located in the vacuole;and SlCKX1,4,6,7,8,and 9 proteins were located in the cytoplasmic ***,we observed differences in the gene structures and phylogenetic relationships of SlCKX proteins among different ***1-9 were positioned on two out of the three branches of the CKX phylogenetic tree in the multispecies phylogenetic tree construction,revealing their strong conservation within phylogenetic *** patterns of expression of CKX genes were noticed in callus cultures exposed to varying con-centrations of exogenous ZT,suggesting their roles in speciﬁc developmental and physiological functions in the regeneration *** results may facilitate subsequent functional analysis of SlCKX genes and provide valu-able insights for establishing an efﬁcient regeneration system for tomatoes.

关键词： Tomato SlCKX gene family phylogenetic relationships trans-zeatin expression pattern