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Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells

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Journal of Geriatric Cardiology 2023年第3期20卷 214-222页

作者： Bo JIANG Xuan li Mo WANG guang-xin li Peng-Wei REN Yu-Qi WANG Shi-Jie xin ling-Feng QIN Department of Vascular Surgery the First Hospital of China Medical UniversityKey Laboratory of PathogenesisPrevention and Therapeutics of Aortic AneurysmShenyangChina Department of Surgery Yale School of MedicineNew HavenCTUSA Department of Breast and Thyroid Surgery Peking University Shenzhen HospitalShenzhenChina Yale Stem Cell Center Yale School of MedicineNew HavenCTUSA Department of Biomedical Engineering Yale UniversityNew HavenCTUSA

BACKGROUND Trehalose is a naturally occurring disaccharide,which has been identified as an autophagy inducer and ex-hibits protective effect in cardiovascular diseases such as myocardial infraction and ***,the functional role of trehalose in abdominal aortic aneurysm(AAA)remains *** To study the effect of trehalose in AAA,trehalose(1 g/kg per day)were given for 14 continuous days in a mouse model of elastase-induced abdominal aortic *** day 14,ultrasound was performed to measure aortic diameter before the abdominal aortas were harvested and processed for further ***-Van Gieson staining and TUNEL staining were performed on paraffin sections to evaluate vascular histology and apoptosis,immunofluorescence staining and Western-blot were performed to evaluate expression of autophagy *** Echocardiography and in situ pictures demonstrated that trehalose attenuated infrarenal aorta ***-Van Gieson staining showed elastin degradation was improved in trehalose-treated *** with vehicle-treated mice,trehalose treatment restored smooth muscle cell contractile phenotype with increasedα-SMA,Calponin and Myh11 ***,trehalose also attenuated cell apoptosis and leukocytes ***,trehalose induced autophagy with decrease SQSTM1/p62 accumulation,increased lamp2 expression and LC3B *** Trehalose attenuated AAA progression with decreased inflammation and restored SMC contractile phenotype by inducing *** results demonstrated the therapeutic potential of trehalose in AAA.

关键词： abdominal aneurysm protective

Redistribution of Pb, Zn and Cu Fractions in Tailing Soils Treated with Different Extractants

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Pedosphere 2006年第3期16卷 312-318页

作者： liU Yun-Guo WANG Xian-Hai ZENG guang-Ming li xin ZHOU Chun-Hua FAN Ting li Yong-li YUAN xin-Zhong Department of Environmental Science and Engineering Hunan University Changsha 410082 （China） Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 （China） Graduate School of Chinese Academy of Sciences Beijing 100039 （China）

The efficiency of EDTA, HNO3 and CaCl2 as extractants to remove Pb, Zn and Cu from tailing soils without varying soil pH was investigated with distributions of Pb, Zn and Cu being determined before and after extraction using the sequential extraction procedure of the optimized European Community Bureau of Reference (BCR). Results indicated that EDTA and HNO3 were both effective extracting *** extractability of extractants for Pb and Zn was in the order EDTA > HNO3 > CaCl2, while for Cu it was HNO3 > EDTA > CaCl2. After EDTA extraction, the proportion of Pb, Zn and Cu in the four fractions varied greatly, which was related to the strong extraction and complexation ability. Before and after extraction with HNO3 and CaCl2, the percentages of Pb, Zn and Cu in the reducible, oxidizable and residual fractions changed little compared to the acid-extractable fraction. The lability of metal in the soil and the kinds of extractants were the factors controlling the effects of metal extraction.

关键词： BCR extraction fraction heavy metals redistribution

Greenways and Their Functions to Eco-Cities

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Ecological Economy 2005年第4期1卷 6-12页

作者： liu Yunguo Huang Zhe guang ming li xin Deparmnet of Environmental Science ＆ Engineering Hunan University Changsha 410082.PR.China

Greenways can be considered as linear open spaces along natural or artificial linear features such as rivers. shorelines, ridgelines, railroads, canals or roads. They are planned, designed, and managed to connect and protect ecological, scenic, recreational, historic, and cultural resources, The archetype of greenways could go back to the landscape axes and boulevards of Europe in the 18^th century and later tire parkways of USA in the late 19^th century . As a means of urban ecological planning, greenway planning is getting more and more important to sustainable development in urban areas and has become a worldwide activity or a movement. This paper reviews the evolution of greenways and identifies it into three distinct stages or “generations ”. introduces a general methodology of greenway planning, and expounds the functions of greenways to ecotitles. At the end. this paper emphasizes that it is significant to enhance the research and implementation of greenway planning in our country in the case that urbanization will be developing qulckly in the next decades.

关键词： greenways greenwayplanning eco-city greenway network

Surgical management of large and giant intracavernous and paraclinoid aneurysms

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Chinese Medical Journal 2008年第12期121卷 1061-1064页

作者： XU Bai-nan SUN Zheng-hui JIANG Jin-li WU Chen ZHOU Ding-biao YU xin-guang li Bao-min Department of Neurosurgery General Hospital of People's Liberation Army Beijing 100853 China

Background Due to their location, large and giant intracavernous and paraclinoid aneurysms remain a challenge for vascular neurosurgeons, We identified characteristics, surgical indications and treatment strategies of large and giant intracavernous and paraclinoid aneurysms in 36 patients.Methods The pterional approach was routinely used. The cervical internal carotid artery was exposed for proximal control of parent vessel and retrograde suction decompression. Paraclinoid aneurysms were directly clipped, intracavernous pseudoaneurysm was repaired and the intracavernous aneurysms were trapped with extracranial-intracranial bypass of saphenous vein graft. Intraoperative electroencephalogram （EEG） and somatosensory evoked potential （SSEP） monitoring were used to detect cerebral ischemia during the temporary occlusion of parent arteries. Microvascular Doppler ultrasonography was used to assess blood flow of the parent and branch vessels. Endoscopy was helpful particularly in dealing with internal carotid artery posterior wall aneurysms. Postoperative digital subtraction angiography （DSA） was performed in 33 of the 36 patients.Results Thirty-two paraclinoid aneurysms were directly clipped, 1 intracavernous pseudoaneurysm was repaired and the other 3 intracavernous aneurysms were trapped with revascularization. Except for two patients who died in the early postoperative stage, 34 patients＇ follow-up was 6-65 months （mean 10 months） and a Glasgow Outcome Scale score of 4 to 5 at discharge. At the 6-month follow-up examination, Rankin Outcome Scale scores were 0 to 2 in 32 patients. EEG and SSEP monitoring changed in six patients. Twelve clips were readjusted when insufficient blood flow in parent and branch vessels was detected. Three posterior wall aneurysms were clipped.Conclusions Intracavernous aneurysms not amenable to endovascular treatment should be treated surgically and surgical treatment is the first option for paraclinoid aneurysms. The temporary parent v

关键词： large and giant aneurysm intracavernous paraclinoid bypass surgical management clip

The Analysis of the Combined Territorial Machining and Contour line Machining Based on the CAXA Manufacturing Engineer 2004

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International Journal of Plant Engineering and Management 2012年第1期17卷 24-27页

作者： RUAN Xiao-guang CAO Han-xin li Fu-yang ZHANG Dang-fei College of Mechanical and Electronic Engineering Xi＇an University of Architecture and Technology Xi＇an 710055 P. R. China

This paper introduces the rough machining of territorial machining and contour line machining based on the CAXA manufacturing engineer 2004, and gives an analysis of the combined machining of territorial machining and contour line machining. Finally, it proves the superiority of the combined machining by the example of high speed machining of an aluminium alloy lamina part.

关键词： CAXA territorial machining contour line machining

The Experimental Study on Constructing the Tissue Engineered Myocardium-like Tissue in vitro with Bone Mesenchymal Stem Cells

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Chinese Journal of Biomedical Engineering(English Edition) 2010年第1期19卷 8-15页

作者： xinG Wan-hong MA Jie GUO guang-wei li xin-hua XI Hu-yu Department of Cardiothoracic Surgery the Second Hospital of Shanxi Medical University Taiyuan 030001 China

Objective:Unlike other tissues,myocardium has not substitute whick can be used to repair damaged cardiac *** paper proposes engineering 3-D myocardium-like tissue constructs in vitro with bone mesenchymal stem cells(BMSCs) of infant and poly-lactic-co-glycolic acid(PLGA)in ***:Bone marrow was obtained from the sternal marrow cavum outflow of infant with congenital heart disease (CHD)undergoing cardiac *** were obtained by density gradient *** cells in passages two were induced in DMED with 10 umol/L 5- Azacytidine(5-Aza)for 24 *** the induced BMSCS were cultured nearly into filled,the cells were planted in the scaffold of PLGA in 5.5×106 cells/*** cell- scaffold complex has been cultured in the shake cultivation for 1 week,then the complex has been planted in the dorse of the nude *** the experiment had been finished,the histology,immunology,real time PCR and so on were ***: The BMSCs of infant with congenital heart disease have the properties of the stable growth and the rapid *** immunohistochemistry showed that tissue engineered myocardium constructed in vitro expressed some cardiac related proteins such asα-actin,Cx-43,Desmine,cTNI and so *** transparent myofilaments,gap junctions and intercalated disk-like structure formation could be observed in the 3D tissue-like constructs by transmission electron microscope(TEM).The engineered myocardium-like tissue had the auto-myocardial property as assessed by real time- PCR and so ***:The engineered myocardial tissue-like constructs could be built with infant BMSCs and PLGA in *** results may provide the first step on the long road toward engineering myocardial material for repairing the defect or augmenting the tract in CHD,such as ventricular septal defect,tetralogy of Fallot and so on.

关键词： tissue engineering bone mesenchymal stem cells 5-Azacytidine myocardium in vitro

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin li xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

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基于按需和贪婪转发的移动自组网路由协议

工程科学学报 2017年第5期39卷 778-785页

作者：黄金科樊晓光向新李帅空军工程大学航空航天工程学院西安710038

移动自组网的动态拓扑特性给路由协议的设计带来了一定的挑战,尤其是在高动态的网络环境中.本文针对该问题,提出了一种新的基于按需和贪婪转发的路由协议,该协议是在RGR模式的基础上提出以下三点改进,即:(1)通过受限的洪泛机制降低网络... 详细信息

移动自组网的动态拓扑特性给路由协议的设计带来了一定的挑战,尤其是在高动态的网络环境中.本文针对该问题,提出了一种新的基于按需和贪婪转发的路由协议,该协议是在RGR模式的基础上提出以下三点改进,即:(1)通过受限的洪泛机制降低网络在路由发现阶段的控制开销;(2)通过移动预测机制,在被动寻路阶段监视被动路径的状态和在GGF阶段帮助节点选取适当的邻居作为下一跳节点;(3)通过路径请求延迟机制以减少不必要的资源浪费.仿真结果表明:改进的RGR协议与现有的RGR、AODV、Modified-RGR和Optimized-RGR相比,不仅具有较高的数据包接收成功率,而且平均路由开销和端到端时延也相对较低.

关键词：移动自组织网路由协议受限洪泛移动预测路由请求延迟性能分析

Wafer‑Scale Vertical 1D GaN Nanorods/2D MoS_(2)/PEDOT:PSS for Piezophototronic Effect‑Enhanced Self‑Powered Flexible Photodetectors

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Nano-Micro Letters 2025年第3期17卷 102-116页

作者： xin Tang Hongsheng Jiang Zhengliang lin Xuan Wang Wenliang Wang Guoqiang li State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Department of Electronic Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

van der Waals(vdW)heterostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of the most appealing systems in next-generation flexible ***,hand-stacked vdW-type photodetectors are not compatible with large-areaarray fabrication and show unimpressive performance in self-powered ***,vertical 1D GaN nanorods arrays(NRAs)/2D MoS_(2)/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays *** as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W^(−1)and a high detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II ***,the strain-tunable photodetection performances of device have been ***,the device at−0.78%strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,which are superior to the state-of-the-art self-powered flexible *** work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection,which performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals heterostructure Piezophototronic effect Self-powered photodetection Flexible sensors