检索结果-南通市图书馆

Pufferfish gasdermin Ea is a significant player in the defense against bacterial pathogens

在线全文

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2024年第3期6卷 462-474页

作者： hang xu Kunpeng Qin Kangwei Hao Zihao yuan Li Sun CAS and Shandong Province Key Laboratory of Experimental Marine Biology Institute of OceanologyCAS Center for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China Laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China School of Marine Science University of Chinese Academy of SciencesQingdao 266400China

Gasdermins(GSDMs)are proteins cleaved by caspase(CASP)to trigger *** teleosts,pyroptosis is mediated by gasdermin E(GSDME).The Pufferfish,Takifugu rubripes,possesses two GSDME orthologs:named TrGSDMEa and *** is cleaved by CASP3/7 to liberate the N-terminal(NT)domain that can trigger pyroptosis in mammalian ***,the biological function of TrGSDMEa in pufferfish is unknown,and TrGSDMEb is poorly *** found that TrGSDMEb was cleaved by CASP1/3/6/7/8,but the resulting NT domain,despite its similarity to TrGSDMEa-NT domain in sequence and structure,failed to induce *** and TrGSDMEb exhibited similar expression patterns in pufferfish under normal physiological conditions but were up-and downregulated,respectively,in expression during Vibrio harveyi and Edwardsiella tarda *** infection induced the activation of TrGSDMEa and CASP3/7 in pufferfish cells,resulting in pyroptosis accompanied with IL-1βproduction and *** of TrGSDMEa-mediated pyroptosis via TrCASP3/7 reduced the death of pufferfish cells and augmented bacterial dissemination in fish ***-oriented mutagenesis identified 16 conserved residues in teleost GSDMEa that were required for the pore formation or auto-inhibition of *** study illustrates the role of GSDMEa-mediated pyroptosis in teleost defense against bacterial pathogens and provides new insights into the structure-based function of vertebrate GSDME.

关键词： GSDME Caspase Takifugu rubripes Bacterial infection Immune defense

Appraisal of an oligomerization behavior of unprotected carbohydrates induced by phosphorus reagent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2018年第2期61卷 243-250页

作者： hang yuan xu Yang Peng Chen Yan Liu Guo Tang Yufen Zhao Department of Chemical Biology College of Chemistry and Chemical Engineering Key Laboratory for Chemical Biology of Fujian ProvinceXiamen University Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education Department of Chemistry Tsinghua University

In this article, a novel oligomerization behavior of unprotected monosaccharides was discovered in a one-pot reaction induced by phosphorus reagent at room temperature. The inherent characteristics of the oligomerization reaction were dissected in detail by mass spectrometry based method combined with NMR technology. It was found that the main glycosidic bonding pattern is (1→6) linkage with 66% regioselectivity for each step. The ratio of α-(1→6) and β-(1→6) glycosidic bonds formed is around 1:1. The reactivity of 1-OH group from aldoses and the driving force from penta-coordinated phosphorus intermediates are the two critical factors for the oligomerization, according to the monitoring experiments by ESI-MS and NMR. Besides, the oligomerization reaction has good compatibility for various aldoses and could expand to O-glycosylated modification of peptides in vitro. The above results will provide a novel enlightenment to develop more convenient and higher-efficient methods for the synthesis of oligosaccharide library.

关键词： organic phosphorus activation oligosaccharide oligomerization one-pot unprotected synthesis

Integrated genomics provides insights into the evolution of the polyphosphate accumulation trait of ***

在线全文

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2024年第4期20卷 131-144页

作者： Xiaojing Xie xuhan deng Liping Chen Jing yuan hang Chen Chaohai wei Xianghui Liu Stefan Wuertz guanglei Qiu School of Environment and Energy South China University of TechnologyGuangzhou510006China Singapore Centre for Environmental Life Sciences Engineering Nanyang Technological UniversitySingapore637551Singapore School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore639798Singapore guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling Guangzhou510006China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou510006China

Candidatus Accumulibacter,a prominent polyphosphate-accumulating organism(PAO)in wastewater treatment,plays a crucial role in enhanced biological phosphorus removal(EBPR).The genetic underpinnings of its polyphosphate accumulation capabilities,however,remain largely ***,we conducted a comprehensive genomic analysis of ***-PAOs and their relatives within the Rhodocyclaceae family,identifying 124 core genes acquired via horizontal gene transfer(HGT)at its least common *** analysis of an enrichment culture of *** revealed active transcription of 44 of these genes during an EBPR cycle,notably including the polyphosphate kinase 2(PPK2)gene instead of the commonly recognized polyphosphate kinase 1(PPK1)***,the phosphate regulon(Pho)genes showed minimal transcriptions,pointing to a distinctive fact of Pho dysregulation,where PhoU,the phosphate signaling complex protein,was not regulating the high-affinity phosphate transport(Pst)system,resulting in continuous phosphate *** prevent phosphate toxicity,*** utilized the laterally acquired PPK2 to condense phosphate into polyphosphate,resulting in the polyphosphate-accumulating *** study provides novel insights into the evolutionary emergence of the polyphosphate-accumulating trait in ***,offering potential advancements in understanding the PAO phenotype in the EBPR process.

关键词： Candidatus Accumulibacter Comparative genomics Horizontal gene transfer(HGT) PhoU Polyphosphate kinase 2(PPK2)

FeNi doped porous carbon as an efficient catalyst for oxygen evolution reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2021年第2期15卷 279-287页

作者： Jun-wei Zhang hang Zhang Tie-Zhen Ren Zhong-Yong yuan Teresa JBandosz Hebei Provincial Key Laboratory of Green Chemical Technology&High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) School of Materials Science and EngineeringNankai UniversityTianjin 300350China Department of Chemistry and Biochemistry The City College of New YorkNew YorkNY 10031USA

Polymer-derived porous carbon was used as a support of iron and nickel species with an objective to obtain an efficient oxygen reduction reaction(OER)*** surface features were extensively characterized using X-ray diffraction,X-ray photoelectron spectroscopy and high-resolution transmission electron *** FeNi-modified carbon the overpotential for OER was very low(280 mV)and comparable to that on noble metal catalyst IrO_(2).The electrochemical properties have been investigated to reveal the difference between the binary alloy-and single metal-doped *** work demonstrates a significant step for the development of low-cost,environmentally-friendly and highly-efficient OER catalysts.

关键词： OER polystyrene salt porous carbon FeNi alloy p/n junction

Computer simulation of super-magnetoelastic behavior near critical region of magnetic materials based on phase-field method

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2023年第8期42卷 2477-2488页

作者： Zhao Zhang Cheng-Chao Hu An-hang Zhou Yu-Xin xu yuan-yuan Wu Hai-Hua Huang Hou-Bing Huang Jun-Jie Ni wei Li wei-Feng Rao School of Materials Science and Engineering Liaocheng UniversityLiaocheng 252059China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China School of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Shandong Institute of Mechanical Design and Research Jinan 250031China

Since the discovery of ferromagnetic morphotropic phase boundary(MPB)in 2010,the connotation and extension of MPB have been becoming more and more *** the last dozen years,much experimental work has been done to design magnetostrictive materials based on the MPB ***,due to the difficulty in direct experimental observations and the complexity of theoretical treatments,the insight into the microstructure property relationships and underlying mechanisms near the ferromagnetic MPB has not been fully ***,we have reviewed our recent computer simulation work about the super-magnetoelastic behavior near the critical region of several typical ***-field modeling and simulation are employed to explore the domain configuration and engineering in single crystals as well as the grain size effect in ***,a general nano-embryonic mechanism for superelasticity is also ***,some future perspectives and challenges are presented to stimulate a deeper consideration of the research paradigm between multiscale modeling and material development.

关键词： Super-magnetoelastic behavior Phase-field simulation Morphotropic phase boundary(MPB)

Saturated-core fault current limiters for AC power systems:Towards reliable,economical and better performance application

在线全文

学校读者我要写书评

暂无评论

High Voltage 2020年第4期5卷 416-424页

作者： Jiaxin yuan Pengcheng Gan Zhaoyang Zhang hang Zhou Liangliang wei KazuhiroMuramatsu School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072People's Republic of China School of Electrical Engineering and Automation Shenzhen Institute of Wuhan UniversityShenzhen518057People's Republic of China Department of Electrical Engineering Graduate School of EngineeringKyoto UniversityKyoto 606-8501Japan Department of Electrical and Electronic Engineering Saga UniversitySaga 840–8512Japan

With the continuous expansion of power grid capacity,the problem of short-circuit current exceeding the standard is becoming increasingly *** current limiter is a promising solution and is gradually becoming a research *** this study,fault current limiters are classified into four *** saturated-core fault current limiters are emphatically introduced,including its working principle and comparison with the other three *** core fault current limiters are divided into four branches according to the ways leading the core saturated.A comprehensive review of the research activities and emerging technologies of saturated-core fault current limiters for AC power systems is presented in this *** working principle and typical structure of DC-biased-,permanent-magnet-,superconducting-and hybrid-type saturated-core fault current limiters are *** advantages and disadvantages of four types of saturated core fault current limiters are compared in detail from the aspects of current-limiting performance,iron core size and DC magnetomotive *** grid application examples of some types of devices are presented,as well as new progress in the techniques,are covered and discussed in *** may find the content of this study helpful as a detailed literature review or as practical technical guidance.

关键词： saturated Saturated performance

Mapping the landscape of gastric signet ring cell carcinoma:Overcoming hurdles and charting new paths for advancement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第2期16卷 94-109页

作者： Shu-yuan Wang Jing-hang Wang Run-Kai Chen Zhen yuan Hao Cui Bo wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from ***,there still persist some controversies regarding the associated research *** To summarize the current obstacles and potential future directions for research on *** To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this ***,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection *** analysis results were visually *** This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and *** popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC.

关键词： Gastric cancer Signet ring cell carcinoma Bibliometric analysis CiteSpace VOSviewer

Shape of slab solidification end under non-uniform cooling and its influence on the central segregation with mechanical soft reduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2021年第11期28卷 1788-1798页

作者： Jie Li Yan-hui Sun hang-hang An Pei-yuan Ni Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Metallurgy Northeastern UniversityShenyang 110819China Hesteel Group Technology Research Institute Shijiazhuang 050000China

In order to study the effect of continuous casting process parameters on the shape of slab solidification end under non-uniform cooling,a solidification model of a continuous-cast slab with non-uniform cooling condition was established with ProCAST *** model was verified by the results of nail shooting tests and the infrared temperature measurement *** characteristic parameters were defined to evaluate the uniformity of the shape of slab solidification *** results showed that the nonuniformity at the beginning and end of solidification,the solidification end length,and the solidification unevenness increased with the rise of casting *** each 10°C increase of superheat,the solidification unevenness increased by about ***,the effect of superheat on the solidification end length can be *** secondary cooling strength showed minimal effect on the nonuniformity at the beginning and end of *** the increase in secondary cooling intensity,the solidification end length decreased,but the solidification unevenness *** addition,the central segregation of the slab produced with and without the mechanical soft reduction(MSR)process was *** transverse flow of molten steel with low solid fraction influenced the central segregation morphology under MSR.

关键词： continuous casting heat transfer model nail shooting shape of solidification end central segregation

Pharmacokinetics and bioequivalence of ranitidine and bismuth derived from two compound preparations

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第17期12卷 2742-2748页

作者： Quan Zhou Zou-Rong Ruan Hong yuan Bo Jiang Dong-hang xu Department of Clinical Pharmacology the 2^th Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To evaluate the bioequivalence of ranitidine and bismuth derived from two compound preparations. METHODS： The bioavailability was measured in 20 healthy male Chinese volunteers following a single oral dose （equivalent to 200 mg of ranitidine and 220 mg of bismuth） of the test or reference products in the fasting state. Then blood samples were collected for 24 h. Plasma concentrations of ranitidine and bismuth were analyzed by high-performance liquid chromatography and inductively coupled plasma-mass spectrometry （ICPMS）, respectively. The non-compartmental method was used for pharmacokinetic analysis. Log-transformed Cmax, AUC（0-t） and AUC（0-∞） were tested for bioequivalence using ANOVA and Schuirmann two-one sided t-test. Tmax was analyzed by Wilcoxon＇s test. RESULTS： Various pharmacokinetic parameters of ranitidine derived from the two compound preparations, including Cmax, AUC（0-t）, AUC（0-∞）, Tmax and T1/2, were nearly consistent with previous observations. These parameters derived from test and reference drug were as follows： Cmax（0.67 ± 0.21 vs 0.68 ± 0.22 mg/L）, AUC（0-t）（3.1 ± 0.6 vs 3.0 ± 0.7 mg/L per hour）, AUC（0-∞）（3.3 ± 0.6 vs 3.2 ± 0.8 mg/L per hour）, Tmax （2.3 ± 0.9 VS 2.1 ± 0.9 h） and T1/2 （2.8 ± 0.3 vs 3.1 ± 0.4 h）. In addition, double-peak absorption profiles of ranitidine were found in some Chinese volunteers. For bismuth, those parameters derived from test and reference drug were as follows： Cmax （11.80 ± 7.36 vs 11.40 ± 6.55 μg/L）, AUC（0-t）（46.65 ± 16.97 vs 47.03 ± 21.49 μg/L per hour）, Tmax （0.50 ± 0.20 vs 0.50 ± 0.20 h） and T1/2 （10.2 ± 2.3 vs 13.0 ± 6.9 h）. Ninety percent of confidence intervals for the test/reference ratio of Cmax, AUC（0-t） and AUC（0-∞） derived from both ranitidine and bismuth were found within the bioequivalence acceptable range of 80%-125%. No significant difference was found in Tmax derived from both ranitidine and bismuth. CONCLUSION： The two compound preparations are bioequivalent and may be prescribed intercha

关键词： Ranitidine Bismuth Compound preparation Bioequivalence Pharmacokinetics Healthy volunteers High-performanace liquid chromatography Inductively coupled plasma-mass spectrometry