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Sexual,physical and overall adverse effects in patients treated with 5a-reductase inhibitors:a systematic review and meta-analysis

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Asian Journal of Andrology 2022年第4期24卷 390-397页

作者： Jun-Jie Zhang Xiao Shi Ting Wu Meng-Da Zhang Jin Tang guang-ming yin Zhi Long Le-Ye He Lin Qi Long Wang Department of Urology The Third Xiangya HospitalCentral South UniversityChangsha 410008China Department of Urology Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastroenterology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Cardiovascular Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410013China

Postfinasteride syndrome(PFS)is a term coined to characterize a constellation of reported undesirable sexual,physical,and neuropsychiatric side *** the present study,we conducted the meta-analysis to demonstrate whether the use of 5α-reductase inhibitors(5ARIs)increases the risk of PFS-like adverse effects.A search of studies published until May 10,2020,was performed using PubMed,EMBASE,and the Cochrane *** included randomized controlled trials with at least one comparison between male patients receiving 5ARIs versus placebo for the treatment of benign prostatic hyperplasia(BPH)or androgenetic alopecia(AGA),and identified 34 studies from 28 articles that met our eligibility *** the random-effects model,the overall use of 5ARIs exhibited a 1.87-fold risk of PFS-like adverse effects during the trial(95%confidence interval[CI]:1.64-2.14).Regarding specific types of adverse effects,the use of 5ARIs had a 1.89-fold risk of sexual adverse effects(95%CI:1.74-2.05)and was associated with an increased risk of physical adverse effects(relative risk[RR]:1.31,95%CI:0.80-2.15),albeit without statistical *** meta-analysis helped to better define the adverse effects caused by *** concluded that the overall use of 5ARIs significantly increased the risk of PFS-like adverse effects in men with AGA or BPH during *** awareness of and education on the PFS-like adverse effects are necessary for clinicians.

关键词： 5α-reductase inhibitors adverse effects androgenetic alopecia benign prostatic hyperplasia postfinasteride syndrome

A Potential Degree Sequence Problem of the Loebl-Komlós-Sós Conjecture

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Acta Mathematicae Applicatae Sinica 2024年

作者： guang-ming LI Jian-hua yin School of Mathematics and Statistics Hainan University

A non-increasing sequenceπ=(d1,..., dn) of nonnegative integers is said to be a graphic sequence if it is realizable by a simple graph G on n vertices. In this case, G is referred to as a realization ofπ. In terms of graphic sequences, the Loebl-Komlós-Sós conjecture states that for any integers k and n, if π=(d1,..., dn)is a graphic sequence with d「n/2」≥k, then every realization ofπcontains all trees with k edges as *** problem can be viewed as a forcible degree sequence problem. In this paper, we consider a potential degree sequence problem of the Loebl-Komlós-Sós conjecture, that is, we prove that for any integers k and n, ifπ=(d1,..., dn) is a graphic sequence with d「n/2」≥k, then there is a realization ofπcontaining all trees with k edges as subgraphs.

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Counterion-Mediated Hydrogen Bonding Making Strong Polyelectrolytes pH-Responsive:Current Understanding and Perspectives

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Chinese Journal of Polymer Science 2024年第9期42卷 1270-1277,I0005页

作者： Yue Huang guang-Tao Mei Zan Hua guang-ming Liu Hefei National Research Center for Physical Sciences at the Microscale Department of Chemical PhysicsKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei230026China The Key Laboratory of Functional Molecular Solids Ministry of Educationand Department of Materials ChemistrySchool of Chemistry and Materials ScienceAnhui Normal UniversityWuhu214002China

The counterion-mediated hydrogen bonding(CMHB)is related to the hydrogen bonding between bound counterions and polyelectrolyte chains in polyelectrolyte systems,where the counterions can both electrostatically bind to the charged groups of polyelectrolyte chains and act as hydrogen bond donors or acceptors to form hydrogen bonds with the hydrogen bond sites associated with polyelectrolyte chains simultaneously.A large number of literatures illustrate that strong polyelectrolytes(SPs)are insensitive to pH,which severely limmits the applications of SPs as smart ***,our studies have demonstrated that the CMHB makes SPs *** perspective discusses the mechanism of pH responsiveness of SPs and the pH-tunable properties of SPs,based on the pH-controlled CMHB *** future research directions on the pH responsiveness of SPs are also discussed *** is anticipated that the study of the pH responsiveness of SPs not only will provide a new understanding of the fundamental properties of SPs,but also will greatly expand the applications of SPs in the field of smart materials.

关键词： Counterion binding Hydrogen bond Polyelectrolyte brush Polyelectrolyte complexation

Swelling of Spherical Polyelectrolyte Gels

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Chinese Journal of Polymer Science 2024年第9期42卷 1386-1392,I0009页

作者： ming-Yu Duan Jia-Dong Chen Yi-ming Liu Zhao-Feng Peng guang Chen Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijing 100871China

Polyelectrolyte(PE)gels,distinguished by their unique stimuli-responsive swelling behavior,serve as the basis of broad applications,such as artificial muscles and drug *** this work,we present a theoretical model to analyze the electrostatics and its contribution to the swelling behavior of PE gels in salt *** minimizing the free energy of PE gels,we obtain two distinct scaling regimes for the swelling ratio at equilibrium with respect to the salt *** compare our predictions for the swelling ratio with experimental measurements,which show excellent *** addition,we employ a finite element method to assess the applicability range of our theoretical model and *** anticipate that our model will also provide valuable insights into drug adsorption and release,deformation of red blood cells,4D printing and soft robotics,where the underlying mechanism of swelling remains enigmatic.

关键词： Gels Polyelectrolytes Swelling Stimuli-responsive Electrostatic interaction Cell model

Surface diffraction beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 47-57页

作者： Yue-Liang Gu Xu Zheng Xing-Min Zhang Bin Zhao guang-Zhi yin Da-ming Zhu Yuan-He Sun Xing-Yu Gao Xiao-Long Li Shanghai Advanced Research Institute Chinese Academy of Sciences239 Zhangheng RoadPudong DistrictShanghai201204China

BL02U2 of the Shanghai Synchrotron Radiation Facility is a surface diffraction beamline with a photon flux of 5.5×10^(12) photons/s at 10 keV and a beam size of 160µm×80µm at the sample *** is dedicated to studying surfaces(solid-vacuum,solid-gas)and interfaces(solid-solid,solid-liquid,and liquid-liquid)in nanoscience,condensed matter,and soft matter systems using various surface scattering techniques over an energy range of 4.8-28 keV with transmission and reflection ***,BL02U2 has a high energy resolution,high angular resolution,and low beam divergence,which can provide excellent properties for X-ray diffraction experiments,such as grazing incident X-ray diffraction,X-ray reflectivity,crystal truncation rods,and liquid X-ray *** of in situ environments can also be provided for the samples *** paper describes the setup of the new beamline and its applications in various fields.

关键词： Surface and interface Beamline Surface diffraction Microstructure

Thermal effect of holmium laser lithotripsy under ureteroscopy

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Chinese Medical Journal 2019年第16期132卷 2004-2007页

作者： Xin-Kun Wang Zhi-Qiang Jiang Jing Tan guang-ming yin Kai Huang Department of Urology Third Xiangya HospitalCentral South UniversityChangshaHunan 410013China

To the Editor: Ureteral calculus is a common urological disease. In recent years, one of the main treatment methods is ureteroscopy with holmium laser lithotripsy. However, with the extensive application of holmium laser lithotripsy, the increasing incidence of postoperative ureteral stricture or even occlusion has attracted the attention of clinicians to its etiology. The issue of the intraoperative holmium laser thermal effect has also gradually gained attention. The holmium laser is a long-wavelength pulsed laser, which crushes calculi by an optomechanical/photoacoustic mechanism as well as a photothermal mechanism, and it is mainly based on the photothermal mechanism.[1] Currently, multiple in vitro studies worldwide have confirmed that the holmium laser did increase the water temperature in the working area. However, these studies only simulated the lithotripsy process of the holmium laser in vitro, which did not completely reflect the thermal effect of the holmium laser during an actual operation. Accordingly, this study monitored the temperature changes of the lavage fluid in the operative field during the actual holmium laser lithotripsy process under an ureteroscope, with the aim of providing more information for the etiology study of ureteral stricture after ureteroscopy with holmium laser lithotripsy.

关键词： Thermal effect holmium laser lithotripsy ureteroscopy

Review of Fiber-Optic Localized Surface Plasmon Resonance Sensors:Geometries,Fabrication Technologies,and Bio-Applications

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Photonic Sensors 2024年第2期14卷 31-56页

作者： Mengdi LU Chen WANG Ruizhi FAN ming LIN Jianye guang Wei PENG Affiliated Cancer Hospital Dalian University of TechnologyShenyang 110042China School of Physics Dalian University of TechnologyDalian 116024China

Localized surface plasmon resonance(LSPR)biosensors,which enable nanoscale confinement and manipulation of light,offer the enhanced sensitivity and electromagnetic energy *** integration of LSPR with the fiber-optic technology has led to the development of compact and versatile sensors for miniaturization and remote *** comprehensive review explores various sensor configurations,fiber types,and geometric shapes,highlighting their benefits in terms of sensitivity,integration,and performance *** techniques such as focused non-chemical bonding strategies and self-assembly of nanoparticles are discussed,providing control over nanostructure morphology and enhancing sensor ***-applications of fiber-optic LSPR(FOLSPR)sensors are detailed,specifically in biomolecular interactions and analysis of proteins,pathogens and cells,nucleic acids(DNA and RNA),and other small molecules(organic compounds and heavy metal ions).Surface modification and detection schemes are emphasized for their potential for label-free and real-time *** challenges and prospects of FOLSPR sensors are addressed,including the developments in sensitivity,fabrication techniques,and measurement *** with emerging technologies such as nanomaterials is highlighted as a promising direction for future ***,this review provides insights into the advancements and potential applications of FOLSPR sensors,paving the way for sensitive and versatile optical biosensing platforms in various fields.

关键词： Fiber-optic localized surface plasmon resonance biosensor nanoparticles geometric configuration fabrication technology

Focal mechanics and disaster characteristics of the 2024 M 7.6 Noto Peninsula Earthquake,Japan

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1378-1387页

作者： guang-qi CHEN Yan-qiang WU ming-yao XIA Zhi-yuan LI School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300131China Graduate School of Engineering Kyushu UniversityFukuoka 819-0395Japan The First Monitoring and Application Center China Earthquake AdministrationTianjin 300180China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China

On January 1,2024,a devastating M 7.6 earthquake struck the Noto Peninsula,Ishikawa Prefecture,Japan,resulting in significant casualties and property *** information from the first six days after the earthquake,this article analyzes the seismic source characteristics,disaster situation,and emergency response of this *** results show:1)The earthquake rupture was of the thrust type,with aftershock distribution showing a north-east-oriented belt-like feature of 150 km.2)Global Navigation Satellite System(GNSS)and Interferometric synthetic aperture radar(InSAR),observations detected significant westward to north-westward co-seismic displacement near the epicenter,with the maximum horizontal displacement reaching 1.2 m and the vertical uplift displacement reaching 4 m.A two-segment fault inversion model fits the observational data well.3)Near the epicenter,large Peak Ground Velocity(PGV)and Peak Ground Acceleration(PGA)were observed,with the maxima reaching 145 cm/s and 2681 gal,respectively,and the intensity reached the highest level 7 on the Japanese(Japan Meteorological Agency,JMA)intensity standard,which is higher than level 10 of the United States Geological Survey(USGS)Modified Mercalli Intensity(MMI)standard.4)The observation of the very rare multiple strong pulse-like ground motion(PLGM)waveform poses a topic worthy of research in the field of earthquake engineering.5)As of January 7,the earthquake had left 128 deaths and 560 injuries in Ishikawa Prefecture,with 1305 buildings completely or partially destroyed,and had triggered a chain of disasters including tsunamis,fires,slope failures,and road ***,this paper summarizes the emergency rescue,information dissemination,and other disaster response and management measures taken in response to this *** work provides a reference case for carrying out effective responses,and offers lessons for handling similar events in the future.

关键词： Noto Peninsula Earthquake earthquake rupture mechanism earthquake disaster emergency response pulse-like ground motion

Stress corrosion cracking behavior of buried oil and gas pipeline steel under the coexistence of magnetic field and sulfate-reducing bacteria

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Petroleum Science 2024年第2期21卷 1320-1332页

作者： Jian-Yu He Fei Xie Dan Wang guang-Xin Liu ming Wu Yue Qin College of Petroleum Engineering Liaoning Petrochemical UniversityFushun113001LiaoningChina Key Laboratory of Oil and Gas Storage and Transportation Technology in Liaoning Province Fushun113001LiaoningChina State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China PipeChina West East Gas Pipeline Company Shanghai200120China

Magnetic field and microorganisms are important factors influencing the stress corrosion cracking(SCC)of buried oil and gas pipelines. Once SCC occurs in buried pipelines, it will cause serious hazards to the soil environment. The SCC behavior of X80 pipeline steel under the magnetic field and sulfate-reducing bacteria(SRB) environment was investigated by immersion tests, electrochemical tests, and slow strain rate tensile(SSRT) tests. The results showed that the corrosion and SCC sensitivity of X80 steel decreased with increasing the magnetic field strength in the sterile environment. The SCC sensitivity was higher in the biotic environment inoculated with SRB, but it also decreased with increasing magnetic field strength, which was due to the magnetic field reduces microbial activity and promotes the formation of dense film layer. This work provided theoretical guidance on the prevention of SCC in pipeline steel under magnetic field and SRB coexistence.

关键词： Magnetic field Sulfate-reducing bacteria Film layer Stress corrosion cracking Oil and gas pipelines