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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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Productive functional evolution of rural settlements:analysis of livelihood strategy and land use transition in eastern China

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Journal of Mountain Science 2017年第12期14卷 2540-2554页

作者： ZHANG Bai-lin JIANG guang-hui CAI Wei-min SUN Pi-ling ZHANG Feng-rong School of Management Tianjin Polytechnic University School of Resources Science and Technology Beijing Normal University School of Resource and Environmental Sciences China Agricultural University

In China, rural settlements are usually multifunctional complex of natural societies and they also play important productive function. This study explored the spatiotemporal evolution of the productive function of three rural settlements, i.e.,Hetaoyuan, Dawengshan, and Gaoqiao, in the Yimeng Mountain in Shandong province of eastern *** lived in this three types of rural settlements were all involved in agricultural production(i.e., grain threshing, drying and storage), which had remained dominant in Hetaoyuan. Dawengshan became an industrial-oriented settlement, while Gaoqiao became a commercial-oriented settlement. This evolution was reflected in the livelihood strategy changes of rural households and the transition of rural settlements changes. The choice of livelihood strategy was affected by the livelihood assets and policies, which resulted in the spatiotemporal evolution of the productive function of rural settlements. This study can provide references for the implementation and adjustment of rural residential land consolidation policies and the improvement of production and the quality of rural life in future.

关键词： Rural settlements Productive function Spatiotemporal evolution Livelihood strategy Land use transition Eastern China

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Microstructure and Properties of Ti and Ti+Nb Ultra-Low-Carbon Bake Hardened Steels

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Journal of Iron and Steel Research International 2009年第6期16卷 33-40页

作者： CHEN Ji-ping KANG Yong-lin HAO Ying-min LIU guang-ming XIONG Ai-ming School of Materials Science and Engineering University of Science and Technology Beijing State Key Laboratory for Advanced Metals and Materials Beijing 100083 China Shougang Research Institute of Technology Beijing 100041 China

Hot rolling, cold rolling and continuous annealing processes of Ti bearing and Ti＋ Nb stabilized ultra-low-carbon bake hardened steels were experimentally studied. The microstructure and texture evolution, as well as the morphology, size and distribution of second phase precipitates during hot rolling, cold rolling and continuous annealing were also analyzed. The results showed that the size of NbC precipitates in Ti＋Nb stabilized ultra-low-carbon bake hardened steel was smaller than that of TiC precipitates in Ti bearing ultra-low-carbon bake hardened steel, which made the average grain size of Ti＋ Nb stabilized ultra-low-carbon bake hardened steel finer than that of Ti bearing ultra-low-carbon bake hardened steel; for the yield strength, the former was higher than the latter; but for the r value which reflects the deep-drawing performance, the former was lower than the latter.

关键词： ultra-low-carbon bake hardened steel texture microstructure mechanical property

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New Families of Exact Solutions for （2＋1）-Dimensional Broer-Kaup System

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Communications in Theoretical Physics 2005年第2期43卷 251-256页

作者： ZHAOHong BAICheng-lin HANJi-guang DepartmentofCommunicationEngineering，LiaochengUniversity，Liaocheng252059，China

Using a further modified extended tanh-function method, rich new families of the exact solutions for the (2+ 1)-dimensional Broer-Kaup (BK) system, comprising the non-traveling wave and coefficient functions' soliton-... 详细信息

关键词： further modified extended tanh-function method (2+1)-dimensional Broer-Kaup(BK) system soliton-like solutions periodic form solution

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Effects of telbivudine and entecavir for HBeAg-positive chronic hepatitis B: A meta-analysis

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World Journal of Gastroenterology 2012年第43期18卷 6290-6301页

作者： Qi-min Su Xiao-guang Ye Department of Infectious Diseases the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina

AIM:To compare the effects of telbivudine (LDT) and entecavir (ETV) in treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B by meta-analysis. METHODS:We conducted a literature search using PubMed, MEDlinE, EMBASE, the China National Knowledge Infrastructure, the VIP database, the Wanfang database and the Cochrane Controlled Trial Register for all relevant articles published before April 1, 2012. Randomized controlled trials (RCTs) comparing LDT with ETV for treatment of HBeAg-positive chronic hepatitis B were included. The data was analyzed with Review Manager Software 5.0. We used relative risk (RR) as an effect measure, and reported its 95% CI. Meta-analysis was performed using either a fixedeffect or random-effect model, based on the absence or presence of significant heterogeneity. Two reviewers assessed the risk of bias and extracted data indepen- dently and in duplicate. The analysis was executed using the main outcome parameters including hepatitis B virus (HBV) DNA undetectability, alanine aminotransferase (ALT) normalization, HBeAg loss, HBeAg seroconversion, drug-resistance, and adverse reactions. Meta-analysis of the included trials and subgroup analyses were conducted to examine the association between pre-specified characteristics with the therapeutic effects of the two agents. RESULTS:Thirteen eligible trials (3925 patients in total) were included and evaluated for methodological quality and heterogeneity. In various treatment durations of 4 wk, 8 wk, 12 wk, 24 wk, 36 wk, 48 wk, 52 wk, 60 wk and 72 wk, the rates of HBV DNA undetectability and ALT normalization in the two groups were similar, without statistical significance. At 4 wk and 8 wk of the treatment, no statistical differences were found in the rate of HBeAg loss between the two groups, while the rate in the LDT group was higher than in the ETV group at 12 wk, 24 wk, 48 wk and 52 wk, respectively (RR 2.28, 95% CI 1.16, 7.03, P = 0.02; RR 1.45, 95% CI 1.16, 1.82, P = 0.001; R

关键词： Telbivudine Entecavir Hepatitis B e antigen-positive chronic hepatitis B Randomized controlled trials Meta-analysis

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Correlation Study on Sweetness of Amino Acid with Different Configurations and Quantum Chemical Parameters

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Chinese Journal of Structural Chemistry 2006年第5期25卷 589-593页

作者： LIJun-ling GU Jun QIU guang-min College of Chemistry and Chemical Engineering China Universitry of Petroleum Dongying Shandong 257061 China College of Petroleum Engineering China University of Petroleum Dongying Shandong 257061 China

Quantum chemical parameters of 10 amino acids with D- and L-configurations were firstly calculated with semi-empirical AM1 method. Furthermore, the relationship between molecular structures of D-, L-amino acids and their sweetness were observed. The results show that upon different configurations of amino acids, the sweetness is relative with their formation heat, dipole moment, energy gap of frontier orbital and other parameters. The formation heats of the same amino acids possessing D- and L-configurations are different except glycine. The algebraic value of D-amino acid is generally larger than that of corresponding L-configuration with only one except of tyrosine. The dipole moment of D-amino acid is generally larger than that of corresponding L-amino acid except tyrosine and lysine. The lowest unoccupied orbital energy （ELUMO） of D-amino acid is higher than that of corresponding L-configuration except phenylalanine. △E of D-amino acid is larger than that of L-amino acid except histidine, phenylalanine and lysine. The larger gap will have advantage for its matching with frontier orbital energy of human protein acceptor, which strengthens the interaction between D-amino acid and sweet taste acceptor. Besides, the changing rules of these parameters are generally identical.

关键词： amino acid sweetness AMI semi-empirical method quantum chemical parameter

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Recovery of the Solitons Using a Lattice Boltzmann Model

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Chinese Physics Letters 1999年第2期16卷 109-110页

作者： YAN guang-wu SONG min Laboratory for Nonlinear Mechanics of Continuous Media Institute of MechanicsChinese Academy of SciencesBeijing 100080 Department of Mathematics Jilin UniversityChangchun 130023 Division of Foundation Jilin Province Architect CollegeChangchun 130053

We formulate a lattice Boltzmann model which simulates Korteweg-de Vries equation by using a method of higher moments of lattice Boltzmann *** a series of lattice Boltzmann equations in different time scales and the conservation law in time scale t0,we obtain equilibrium distribution *** numerical examples show that the method can be used to simulate soliton.

关键词： equation. function. lattice

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Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

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Military Medical Research 2024年第1期11卷 98-114页

作者： guang-Long Ma Wei-Feng lin Faculty of Medicine Centre for Cancer ImmunologyUniversity of SouthamptonSouthampton SO166YDUK Department of Molecular Chemistry and Materials Science Weizmann Institute of Science76100 RehovotIsrael Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the *** the same time,success drives more attention from scientists to improve ***,only a small portion of patients are responsive to this therapy,and it comes with a unique spectrum of side effects termed immunerelated adverse events(irAEs).The use of nanotechnology could improve ICBs’delivery to the tumor,assist them in penetrating deeper into tumor tissues and alleviate their *** nanomedicine has been investigated and used for decades,and is well-recognized as the most successful nano-drug delivery *** successful combination of ICB with liposomal nanomedicine could help improve the efficacy of ICB *** this review,we highlighted recent studies using liposomal nanomedicine(including new emerging exosomes and their inspired nanovesicles)in associating ICB therapy.

关键词： Liposome Exosome Immune checkpoint blockade(ICB)

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NUMERICAL SIMULATION OF LAminAR SQUARE IMPINGING JET FLOWS

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Journal of Hydrodynamics 2005年第3期17卷 269-274页

作者： CHENQing-guang XUZhong WUYu-lin ZHANGYong-jian DepartmentofThermalEngineering TsinghuaUniversityBeijing100084China DepartmentofFluidEngineering Xi＇anJiaotongUniversityXi＇an710049China DepartmentofMechanicalandElectronicEngineering ShandongUniversityofScienceandTechnologyQingdao266510China

A theoretical study has been undertaken to determine the flow characteristics associated with a three-dimensional laminar impinging jet issuing from a square pipe nozzle. Interesting flow structures around the jet are detected. The numerical result reveals the existence of four streamwise velocity off-center peaks near the impingement plate, which is different from the rectangular jet impingement. The mechanism of the formation of the off-center velocity peaks and the parameters affecting the flow-field characteristics are discussed by comparison of the computed results with different nozzle-to-plate spacings and Reynolds numbers.

关键词： three-dimensional simulation laminar square impinging jet off-center velocity peaks

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Two-Type Information Fusion Based IP-to-AS Mapping Table Refining

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Journal of Computer Science & Technology 2017年第3期32卷 571-584页

作者： Qing Jiang Hang-Yu Hu guang-min Hu School of Communication and Information Engineering University of Electronic Science and Technology of China Chengdu 611731 China

The Internet topology at the autonomous system （AS） level is of great importance, and traceroute has been known to be a potential tool to obtain a complete AS topology. The original IP-to-AS mapping table maps the IP addresses in traceroute paths to their origin ASes, which may cause false AS links. The existing methods refine the original mapping table based on traceroute-BGP path pairs or alias resolution data. However, the information extracted from either of them is inaccurate and incomplete. In this paper, we present a two-type information fusion based method to refine the original mapping table. We extract four kinds of information from path pair and alias resolution data. Based on these information, we build a candidate AS set for each router. Then we choose the AS that is consistent with the existing information to be the owner AS of each router and map all of the IP addresses on the router to it. We validate the result with the ground truth from PeeringDB and Looking Glass severs. Compared with the existing methods, our method produces a more accurate mapping table. In addition, we discuss the coverage of our method and show that our method is convergent and more robust against the reduction of information or the increase of incorrect information.

关键词： network topology Internet routers BGP traceroute

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