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Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus

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The Innovation 2024年第1期5卷 98-108页

作者： Zongshan shen Shuhong Kuang Yong Zhang Jiayao Chen Shuting Wang Congfei Xu Yunjia Huang Min Zhang Shuheng Huang jun Wang ChuanJiang Zhao Zhengmei Lin Xuetao Shi Bin Cheng Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510060China National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Engineering of guangdong Province South China University of TechnologyGuangzhou 510006China School of Biomedical Science and Engineering South China University of TechnologyGuangzhou 510650China The First Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510080China

Cognitive decline has been linked to periodontitis through an undetermined pathophysiological *** study aimed to explore the mechanism underlying periodontitis-related cognitive decline and identify therapeutic strategies for this *** single-nucleus RNA sequencing we found that changes in astrocyte number,gene expression,and cell‒cell communication were associated with cognitive decline in mice with *** addition,activation of the NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome was observed to decrease the phagocytic capability of macrophages and reprogram macrophages to a more proinflammatory state in the gingiva,thus aggravating *** further investigate this finding,lipid-based nanoparticles carrying NLRP3 siRNA(NPsiNLRP3)were used to inhibit overactivation of the NLRP3 inflammasome in gingival macrophages,restoring the oral microbiome and reducing periodontal ***,gingival injection of NPsiNLRP3 reduced the number of Serpina3nhigh astrocytes in the hippocampus and prevented cognitive *** study provides a functional basis for the mechanism by which the destruction of periodontal tissues can worsen cognitive decline and identifies nanoparticle-mediated restoration of gingival macrophage function as a novel treatment for periodontitis-related cognitive decline.

关键词： NLRP3 periodontal number

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Viromes of Haemaphysalis longicornis reveal different viral abundance and diversity in free and engorged ticks

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Virologica Sinica 2024年第2期39卷 194-204页

作者： Jian Xiao Xuan Yao Xuhua Guan Jinfeng Xiong Yaohui Fang Jingyuan Zhang You Zhang Abulimiti Moming Zhengyuan Su Jiayin Jin Yingying Ge jun Wang Zhaojun Fan Shuang Tang Shu shen Fei Deng Key Laboratory of Virology and Biosafety and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Hubei Provincial Center for Disease Control and Prevention Wuhan430070China University of Chinese Academy of Sciences Beijing101408China Hubei Jiangxia Laboratory Wuhan430200China Xinjiang Key Laboratory of Vector-borne Infectious Diseases Urumqi830002China Current address:Department of Medical Laboratory The Second Affiliated HospitalHainan Medical UniversityHaikou57000China

Haemaphysalis longicornis ticks,commonly found in East Asia,can transmit various pathogenic viruses,includingthe severe fever with thrombocytopenia syndrome virus(SFTSV)that has caused febrile diseases among humansin Hubei ***,understanding of the viromes of *** was limited,and the prevalence ofviruses among *** ticks in Hubei was not well *** study investigates the viromes of bothengorged(fed)and free(unfed)*** ticks across three mountainous regions in Hubei Province from 2019to ***-sequencing analysis identified viral sequences that were related to 39 reference viruses belonging tounclassified viruses and seven RNA viral families,namely Chuviridae,Nairoviridae,Orthomyxoviridae,Parvoviridae,Phenuiviridae,Rhabdoviridae,and *** abundance and diversity in these ticks were analysed,andphylogenetic characteristics of the Henan tick virus(HNTV),Dabieshan tick virus(DBSTV),Okutama tick virus(OKTV),and Jingmen tick virus(JMTV)were elucidated based on their full genomic *** demonstrated that DBSTV was the most common virus found in individual *** ticks(12.59%),followed by HNTV(0.35%),whereas JMTV and OKTV were not *** results improve our understanding of *** tick viromes in central China and highlight the role of tick feeding status and geographyin shaping the viral *** findings of new viral strains and their potential impact on public health raisethe need to strengthen surveillance efforts for comprehensively assessing their spillover potentials.

关键词： Ticks Virome Haemaphysalis longicornis Phylogenetic analysis Viral abundance and diversity

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Regeneration of photovoltaic industry silicon waste toward high-performance lithium-ion battery anode

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Rare Metals 2024年第10期43卷 4948-4960页

作者： Kai Wang Xiao-Bin Zhong Yue-Xian Song Yao-Hui Zhang Yan-Gang Zhang Xiao-Gang You Pu-guang Ji Kurbanov Mirtemir Shodievich Umedjon Khalilov Gong-Kai Wang Xin Zhang Xing-Liang Yao Feng Li jun-Fei Liang Hua Wang School of Energy and Power Engineering North University of China Zhongyuan Critical Metals Laboratory Zhengzhou University Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Material Science and EngineeringHebei University of Technology Arifov Institute of Ion-Plasma and Laser Technologies Academy of Sciences of the Republic of Uzbekistan New Uzbekistan University Arifov Institute of Ion-Plasma and Laser Technologies Academy of Sciences of Uzbekistan University of Antwerp School of Chemistry Beihang University

The diamond-wire sawing silicon waste（DWSSW） from the photovoltaic industry has been widely considered as a low-cost raw material for lithium-ion battery silicon-based electrode,but the effect mechanism of impurities presents in DWSSW on lithium storage performance is still not well understood;meanwhile,it is urgent to develop a strategy for changing DWSSW particles into high-performance electrode *** this work,the occurrence state of impurities presents in DWSSW was carefully analyzed using in situ Ar ion etching technology Then,the novel Si@C@SiOx@PAl-NDC composite was designed through in situ encapsulation *** obtained Si@C@SiOx@PAl-NDC electrode shows a high first capacity of 2343.4 mAh·g-1with an initial Coulombic efficiency （ICE） of 84.4%under current density of 1.0 A·g-1,and can deliver an impressive capacity of 984.9 mAh·g-1after 200 *** numerical simulation modeling calculations,the increase in proportion of Si4+/Si0and Si3+/Si0valence states in SiOxlayer leads to a decrease in von Mises stress,which ultimately improves the cycling structural ***,the porous 2D-3D aluminum/nitrogen （Al/N） co-doped carbon layer and nanowires on SiOxlayer can provide abundant active sites for lithium storage due to its developed hierarchical pores structure,which facilitates ion transport What is more,the performance of Si@C@SiOx@PAl-NDC//LiFePO4full cell shows its great potential in practical application.

关键词： Aluminum/nitrogen co-doped In situ encapsulation Lithium-ion batteries Porous carbon nanowires Sawing silicon waste

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Spontaneous intra-abdominal hematomas in a hepatocellular carcinoma patient treated with lenvatinib:a case report

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Oncology and Translational Medicine 2024年第2期10卷 99-102页

作者： Hong Ma jun-Feng Li An-Rong Wang Yong Tan guang-Jin Yuan Department of Oncology the People's Hospital of Dianjiang ChongqingChina Department of Interventional Therapy the People's Hospital of Dianjiang ChongqingChina

A 44-year-old patient was admitted with tumor rupture in the left hepatic lateral lobe,and he underwent emergent exploratory laparotomy and proceeded for hepatic left lateral lobectomy on September 19,*** final diagnosis of hepatocellular carcinoma was confirmed by histopathological examination of the surgical ***,the patient received hepatic arterial infusion chemotherapy with FOLFOX(oxaliplatin,fluorouracil,and leucovorin)for 5 ***,recurrence of the hepatocellular carcinoma was diagnosed in the abdominal *** patient was then treated with *** less than 1 month of the treatment with lenvatinib,the patient was admitted to the emergency room on june 2,2022,because of acute intra-abdominal bleeding(hematomas).Percutaneous intra-abdominal angiography found that the bleeding vessels were the right gastroepiploic artery and left gastric *** patient was stabilized after arterial embolization using gelatin *** diagnosis and management of spontaneous intra-abdominal hematomas are discussed.

关键词： Arterial embolization Hematomas Hepatocellular carcinoma Lenvatinib

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Host plant traits play a crucial role in shaping the composition of epiphytic microbiota in the arid desert,Northwest China

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Journal of Arid Land 2024年第5期16卷 699-724页

作者： ZHANG jun ZHANG Yuanming ZHANG Qi State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Biodiversity Conservation and Application in Arid Lands Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China Xinjiang Field Scientific Observation Research Station of Tianshan Wild Fruit Forest Ecosystem Yili Botanical GardenXinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China College of Life Sciences Shihezi UniversityShihezi 832003China

Phyllosphere microorganisms are a crucial component of environmental microorganisms,highly influenced by host characteristics,and play a significant role in plant health and ***,the impact of host characteristics on shaping phyllosphere microbial communities of plants with different life forms remains *** high-throughput sequencing technology,this study analyzed the diversity and community composition of phyllosphere epiphytic microorganisms(e.g.,bacteria and fungi)of various plant life forms in the hinterland of the Gurbantunggut Desert,Northwest *** annotation of prokaryotic taxa(FAPROTAX)and fungi function guild(FUNGuild)were employed to assess the ecological functions of microorganisms and to investigate the role of stochastic and deterministic processes in shaping phyllosphere microbial *** showed a diverse array of phyllosphere epiphytic microorganisms in the desert plants,with Proteobacteria,Cyanobacteria,and Actinobacteriota dominating bacterial community,while Ascomycota and Basidiomycota were prevalent in fungal *** across different plant life forms highlighted distinct microbial communities,indicating strong filtering effects by plant *** prediction identified intracellular parasites(accounting for 27.44%of bacterial community abundance),chemoheterotrophy(10.12%),and phototrophy(17.41%)as the main functions of epiphytic bacteria on leaves of different life form *** prediction indicated that phyllosphere epiphytic fungi primarily served as Saprotrophs(81.77%),Pathotrophs(17.41%),and Symbiotrophs(0.82%).Co-occurrence network analysis demonstrated a predominance of positive correlations among different microbial ***-Crick dissimilarity index analysis revealed that deterministic processes predominantly influenced phyllosphere bacterial and fungal community *** partitioning analysis and random forest modeling suggested that pla

关键词： phyllosphere epiphytic bacteria phyllosphere epiphytic fungi community structure community diversity functional diversity plant life form plant functional traits

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Exploring reservoir computing:Implementation via double stochastic nanowire networks

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Chinese Physics B 2024年第3期33卷 572-582页

作者：唐健峰夏磊李广隶付军段书凯王丽丹 College of Artificial Intelligence Southwest UniversityChongqing 400715China Brain-inspired Computing & Intelligent Control of Chongqing Key Laboratory Chongqing 400715China National & Local Joint Engineering Laboratory of Intelligent Transmission and Control Technology Chongqing 400715China Chongqing Brain Science Collaborative Innovation Center Chongqing 400715China Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationSouthwest UniversityChongqing 400715China State Key Laboratory of Intelligent Vehicle Safety Technology Chongqing 400715China

Neuromorphic computing,inspired by the human brain,uses memristor devices for complex *** studies show that self-organizing random nanowires can implement neuromorphic information processing,enabling data *** paper presents a model based on these nanowire networks,with an improved conductance variation *** suggest using these networks for temporal information processing via a reservoir computing scheme and propose an efficient data encoding method using voltage *** nanowire network layer generates dynamic behaviors for pulse voltages,allowing time series prediction *** experiment uses a double stochastic nanowire network architecture for processing multiple input signals,outperforming traditional reservoir computing in terms of fewer nodes,enriched dynamics and improved prediction *** results confirm the high accuracy of this architecture on multiple real-time series datasets,making neuromorphic nanowire networks promising for physical implementation of reservoir computing.

关键词： double-layer stochastic(DS)nanowire network architecture neuromorphic computation nanowire network reservoir computing time series prediction

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Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1199-1208页

作者： Xinyi Yang Xu Zheng Yuqi Zhu Xiaying Zhao jun Liu Jiangna Xun Songhua Yuan jun Chen Hanyu Pan Jinlong Yang Jing Wang Zhimin Liang Xiaoting shen Yue Liang Qinru Lin Huitong Liang Min Li Fei Peng Daru Lu Jianqing Xu Hongzhou Lu Shibo Jiang Ping Zhao Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesYiwu Research InstituteFudan UniversityShanghaiChina Department of Microbiology Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Changzheng Hospital Naval Medical UniversityShanghaiChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesFudan UniversityShanghaiChina Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People’s Hospital of ShenzhenShenzhenGuangdongChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes multi-organ damage,which includes hepatic dysfunction,as observed in over 50%of COVID-19 *** I converting enzyme(peptidyl-dipeptidase A)2(ACE2)is the primary receptor for SARS-CoV-2 entry into host cells,and studies have shown the presence of intracellular virus particles in human hepatocytes that express ACE2,but at extremely low ***,we asked if hepatocytes might express receptors other than ACE2 capable of promoting the entry of SARS-CoV-2 into *** address this question,we performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1(ASGR1)promoted SARS-CoV-2 pseudovirus infection of HeLa *** Huh-7 cells,simultaneous knockout of ACE2 and ASGR1 prevented SARS-CoV-2 pseudovirus *** the immortalized THLE-2 hepatocyte cell line and primary hepatic parenchymal cells,both of which barely expressed ACE2,SARSCoV-2 pseudovirus could successfully establish an ***,after treatment with ASGR1 antibody or siRNA targeting ASGR1,the infection rate significantly dropped,suggesting that SARS-CoV-2 pseudovirus infects hepatic parenchymal cells mainly through an ASGR1-dependent *** confirmed that ASGR1 could interact with Spike protein,which depends on receptor binding domain(RBD)and N-terminal domain(NTD).Finally,we also used Immunohistochemistry and electron microscopy to verify that SARS-CoV-2 could infect primary hepatic parenchymal *** inhibiting ASGR1 in primary hepatic parenchymal cells by siRNA,the infection efficiency of the live virus decreased ***,these findings indicate that ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of hepatic parenchymal cells.

关键词： ACE2 infection glycoprotein

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Advances in the studies of the supported ruthenium catalysts for CO_(2)methanation

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Chinese Journal of Catalysis 2024年第8期63卷 1-15页

作者： Chenyang shen Menghui Liu Song He Haibo Zhao Chang-jun Liu Collaborative Innovation Center of Chemical Science&Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Key Laboratory of Mesoscopic Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023JiangsuChina State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan430074HubeiChina

CO_(2)methanation has a potential in the large-scale utilization of carbon *** has also been considered to be useful for the renewable energy *** commercial pipeline for natural gas transportation can be directly applied for the methane product of CO_(2)*** supported ruthenium(Ru)catalyst has been confirmed to be active and stable for CO_(2)methanation with its high ability in the dissociation of hydrogen and the strong binding of carbon ***_(2)methanation over the supported Ru catalyst is structure *** size of the Ru catalyst and the support have significant effects on the activity and the mechanism.A significant challenge re-mained is the structural controllable preparation of the supported Ru catalyst toward a sufficiently high low-temperature *** this review,the recent progresses in the investigations of the supported Ru catalysts for CO_(2)methanation are *** challenges and the future devel-opments are also discussed.

关键词： Ruthenium Carbon dioxide Methanation Hydrogenation Catalyst and metal-support interaction

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A quantum-enhanced magnetometer using a single high-spin nucleus in silicon

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Chinese Physics B 2024年第9期33卷 110-115页

作者： Tao Xin Ke Zhang jun Li shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Physikalisch-Technische Bundesanstalt Bundesallee 10038116 BraunschweigGermany Institute of Quantum Precision Measurement State Key Laboratory of Radio Frequency Heterogeneous IntegrationShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China

Quantum enhanced metrology has the potential to go beyond the standard quantum limit and eventually to the ultimate Heisenberg *** particular,quantum probes prepared in nonclassical coherent states have recently been recognized as a useful resource for ***,there has been considerable interest in constructing magnetic quantum sensors that combine high resolution and high ***,we explore a nanoscale magnetometer with quantum-enhanced sensitivity,based on 123Sb(I=7/2)nuclear spin doped in silicon,that takes advantage of techniques of spin-squeezing and coherent *** the optimal squeezed initial state,the magnetic field sensitivity may be expected to approach 6 aT·Hz^(−1/2)·cm^(−3/2) and 603 nT·Hz^(−1/2) at the single-spin *** magnetic sensor may provide a novel sensitive and high-resolution route to microscopic mapping of magnetic fields as well as other applications.

关键词： quantum magnetometer silicon quantum qubit nuclear electrical resonance

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High precision current mirror circuit based on two-dimensional material transistors

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Science China(Information Sciences) 2024年第8期67卷 353-354页

作者： Shiping GAO Chen PAN Pincheng SU Xing-Jian YANGDONG Wentao YU Zhoujie ZENG Yu shen Jingwen SHI Yanwei CUI Pengfei WANG Yuekun YANG Cong WANG Bing CHENG Shi-jun LIANG Feng MIAO Institute of Interdisciplinary Physical Sciences School of Physics Nanjing University of Science and Technology Institute of Brain-Inspired Intelligence National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced Microstructures

The emerging two-dimensional field-effect transistor(2DFET) is considered an important candidate device for driving future integrated circuit technology toward higher performance, lower power consumption, and more functionalities [1,2]. Among the integrated circuits, analog circuits play a crucial role as they are responsible for sampling, amplifying, and transmitting signals.

关键词： Timing circuits

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