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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia hao Xu-Ya Chai Pei-Sai Li Yang liu Li-Xia liu Ying Xu Pan-Pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Molecular simulation study of the microstructures and properties of pyridinium ionic liquid[HPy][BF_(4)]mixed with acetonitrile

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原子与分子物理学报 2025年第4期42卷 27-32页

作者： XU Jian-Qiang MA Zhao-Peng CHENG Si liu Zhi-Cong ZHU guang-Lai Department of Physics School of Physics and Electronic InformationAnhui Normal UniversityWuhu 241002China

The microstructures and thermodynamic properties of mixed systems comprising pyridinium ionic liquid[HPy][BF_(4)]and acetonitrile at different mole fractions were studied using molecular dynamics simulation in this *** following properties were determined:density,self-diffusion coefficient,excess molar volume,and radial distribution *** results show that with an increase in the mole fraction of[HPy][BF_(4)],the self-diffusion coefficient ***,the excess molar volume initially decreases,reaches a minimum,and then *** rules of radial distribution functions(RDFs)of characteristic atoms are *** increasing the mole fraction of[HPy][BF_(4)],the first peak of the RDFs of HA1-F decreases,while that of CT6-CT6 rises at first and then *** indicates that the solvent molecules affect the polar and non-polar regions of[HPy][BF_(4)]differently.

关键词： Pyridinium ionic liquids Thermodynamic properties Molecular dynamics simulation Radial distribution functions

Lake sediment treatment with aluminum,iron,calcium and nitrate additives to reduce phosphorus release

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1367-1373页

作者： guang-rong liu Chun-song YE Jing-hao HE Qin QIAN Hua JIANG College of Power and MechanicalEngineering Wuhan University Wuhan 430072 China

Treatment of lake sediments with salts is a promising approach for preventing phosphorus release from sediments. Five 35-d treatments of undisturbed sediment cores in the East Lake, Wuhan, China were applied under anoxic conditions： nothing added （control）, Al2（SO4）3 added, FeCl3 added, CaCl2 added, and NaNO3 added. To identify changes in the P binding sites in the sediment caused by the treatments, different P binding forms were extracted from the sediment before and after the treatments. We found that the mean P release rates for anoxic treatments with Al2（SO4）3, FeCl3, CaCl2 and NaNO3 were -0.6, 0.03, 0.6 and 2.6 mg/（m^2·d）, respectively, while the P release rate with no additives was 7.3 mg/（m^2·d）. In suboxic conditions, the concentration of total phosphorus （TP ge 657 mg/kg） in sediment was much lower than that of untreated sediment （TPaverage 688 mg/kg） and treatments with salts （TP（Al2（SO4）3） 793 mg/kg, TP（FeCl3） 781 mg/kg, TP（NaNO3） 802 mg/kg, TP（CaCl2） 747 mg/kg）. We also found that adding CaCl2 prevented P release because of apatite formation and because PCa （Ca bound P） increased at the sediment surface. Addition of Fe^3＋ and NO3^- to the sediment increased the amounts of PFe. Mn （Redox-sensitive P, mostly Fe and Mn compounds）, since iron oxide has the ability to combine P. Addition of Al2（SO4）3 increased the fraction of PAl, Fe （P bound to metal oxides （Al, Fe）） and decreased the P and Fe in the water above the anoxic sediment, showing the greater ability orAl in binding P. The results showed that Al2（SO4）3, FeCl3, CaCl2 and NaNO3 all had an effect in controlling phosphorus release. The effect was related to the forms of phosphorus existing in the sediment before treatment and the forms resulting after adding the four reagents. The combination of Al^3＋ or Fe^3＋ with NO3^- promises to be a reasonable chemical treatment for increasing the P retention capacity of sediments in eutrophic lakes. If chemical treatment is combined with bioremediation, the aim o

关键词： Sediment Internal phosphorus Aluminum Iron Calcium Nitrate P fraction

Stabilize and Reinforce Hydrogen-Bonded Polymer Complex Elastic Fiber by Catechol Chemistry and Coordination

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Chinese Journal of Polymer Science 2023年第12期41卷 1846-1855,I0006页

作者： Ze-Xin liu De-Zhong liu Cai-Hong Zhang Wei-Jie Wang hao Huang Shu-guang Yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-Dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Hydrogen-bonded polymer complex fiber of poly(ethylene oxide)(PEO)and poly(acrylic acid)(PAA)shows rubber elasticity in ambient environment,but the fiber has relatively low strength and weak *** apply the catechol chemistry and metal coordination to stabilize and strengthen the PEO/PAA *** is grafted with dopamine(Dopa),and then combines with PEO to prepare ***-Dopa in the fiber is crosslinked through oxidation induced dismutation and the metal ions are introduced through *** cross-linking and coordination greatly improve the stability of the fiber against the erosion of alkaline *** four different metal coordination fibers,PEO/PAA-Dopa/Cu fiber keeps the excellent extensibility(~1000%)and presents much higher initial modulus(~7 MPa),ultimate strength(~20 MPa),and toughness(~60 MJ/m^(3))than its precursor PEO/PAA *** addition,PEO/PAA-Dopa/Cu fiber shows quick recovery and large energy dissipation ratio compared with the PEO/PAA *** distinct mechanical properties enhancement of the hydrogen-bonded complex fiber is attributed to the synergy of hydrogen bonds,coordination and covalent bond cross-linking.

关键词： Elastic fiber Hydrogen-bonded complexation Catechol chemistry Coordination Elastomer

Numerical study of fluid resonance of a two-dimensional heaving-free moonpool in a wide range of incident waves

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Journal of Hydrodynamics 2022年第4期34卷 647-664页

作者： Peng-lin Jing guang-hua He Zheng-xiao Luan Chao-gang liu hao Yang School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China School of Ocean Engineering Harbin Institute of TechnologyWeihaiWeihai 264209China Shandong Institute of Shipbuilding Technology Weihai 264209China

The fluid resonance of a moonpool freely heaving in a beam sea is studied by an in-house constrained interpolation profile(CIP)***,the moonpool behaves as in the piston mode with a narrow *** numerical studies are carried out for a wide range of the incident waves,and a new secondary resonant region is identified in the low frequency region of the incident waves,besides the ordinary main resonant *** results demonstrate that the horizontal wave forces are significant in the secondary resonant region,although the resonant wave elevations are less remarkable than those of the main resonant *** is concluded that the fluid resonance of the low frequency is excited mainly by the heave motion of the *** studies of the moonpool draft and the gap width of the moonpool based on the fluid resonance are also performed.

关键词： Gap resonance low-frequency incident wave heave motion constrained interpolation profile(CIP)

Effects of rare earth elements on inclusions, microstructure and impact toughness of spring steel

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Journal of Iron and Steel Research International 2024年第4期31卷 933-944页

作者： Chun-lei hao Chao-yun Yang Peng liu Yi-kun Luan Bao-guang Sang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Mechanical Engineering and Automation Dalian Polytechnic UniversityDalian 116034LiaoningChina

Spring steel is an indispensable basic part manufacturing material in mechanical equipment,which is widely used in transportation tools such as automobiles,railways,construction machinery and other *** effects of rare earth(RE)on inclusions,microstructure,carbides and impact toughness of 50CrV spring steel were studied by means of optical microscope,scanning electron microscope,transmission electron microscope and impact *** results show that the addition of rare earth can modify the main MnS and Al_(2)O_(3) inclusions in steel to form spherical or near-spherical rare earth inclusions,and the size of inclusions is significantly *** the quenched structure,the size of martensite slab becomes smaller and the structure is *** tempering,the carbide changes from sheet to ellipse,which makes it easier for spring steel to form stress concentration cracks under *** becomes finer and more dispersed,which leads to better pinning of grain boundaries and smaller grain *** impact toughness of 50CrV-RE spring steel increased from 21 to 41 J by 95%due to the improvement of inclusions,microstructure and carbides by rare *** is possible to improve the strength and toughness of spring steel for the improvement of railway running speed and the development of vehicle lightweight in China.

关键词： Rare earth-Spring steel Inclusion Microstructure Impact toughness

Circular Polarization of Fast Radio Bursts in the Curvature Radiation Scenario

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Research in Astronomy and Astrophysics 2022年第7期22卷 206-213页

作者： hao Tong Hong-guang Wang School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China

The curvature radiation is applied to the explanation of the circular polarization of fast radio bursts(FRBs).Significant circular polarization is reported in both apparently non-repeating and repeating *** radiation can produce significant circular polarization at the wing of the radiation *** the curvature radiation scenario,in order to see significant circular polarization in FRBs,(1) more energetic bursts,(2) bursts with electrons having higher Lorentz factor,and(3) a slowly rotating neutron star at the center are *** rotational period of the central neutron star may explain why some FRBs have high circular polarization,while others do *** possible difference in refractive index for the parallel and perpendicular components of electric field,the position angle may change rapidly over the narrow pulse window of the radiation *** position angle swing in FRBs may also be explained by this non-geometric origin,besides that of the rotating vector model.

关键词： stars:magnetars (stars:)pulsars:general polarization

Research progress of catalysts for direct coal liquefaction

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Journal of Energy Chemistry 2025年第1期 481-497页

作者： Wei Song Penggao liu Xinyue Chen Ting Wang Chunrong He Rui hao Kaiyu liu State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of Chemistry Xinjiang University College of Chemistry and Chemical Engineering Henan Polytechnic University Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical Engineering Central South University

Coal direct liquefaction technology is a crucial contemporary coal chemical technology for efficient and clean use of coal resources. The development of direct coal liquefaction technology and the promotion of alternative energy sources are important measures to guarantee energy security and economic security. However, several challenges need to be addressed, including low conversion rate, inadequate oil yield, significant coking, demanding reaction conditions, and high energy consumption. Extensive research has been conducted on these issues, but further exploration is required in certain aspects such as pyrolysis of macromolecules during the liquefaction process, hydrogen activation, catalysts' performance and stability, solvent hydrogenation, as well as interactions between free radicals to understand their mechanisms better. This paper presents a comprehensive analysis of the design strategy for efficient catalysts in coal liquefaction, encompassing the mechanism of coal liquefaction, catalyst construction,and enhancement of catalytic conversion efficiency. It serves as a comprehensive guide for further research endeavors. Firstly, it systematically summarizes the conversion mechanism of direct coal liquefaction, provides detailed descriptions of various catalyst design strategies, and especially outlines the catalytic mechanism. Furthermore, it addresses the challenges and prospects associated with constructing efficient catalysts for direct coal liquefaction based on an understanding of their action mechanisms.

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N~δ-保护鸟氨酸的微波合成(英文)

农业科学与技术：英文版 2010年第Z1期 205-208页

作者：张玲凌心安琳薛运生郑友广贾根光史豪刘毅徐州医学院药学院

[目的]用微波法合成Nδ-保护鸟氨酸。[方法]以L-鸟氨酸盐酸盐为原料,与碱式碳酸铜反应得到L-鸟氨酸铜络合物,在δ-氨基上分别引入苄氧羰基、叔丁氧羰基、芴甲氧羰基、乙酰基和邻苯二甲酰基,得到了Nδ-保护鸟氨酸铜络合物,微波辐射下用ED... 详细信息

[目的]用微波法合成Nδ-保护鸟氨酸。[方法]以L-鸟氨酸盐酸盐为原料,与碱式碳酸铜反应得到L-鸟氨酸铜络合物,在δ-氨基上分别引入苄氧羰基、叔丁氧羰基、芴甲氧羰基、乙酰基和邻苯二甲酰基,得到了Nδ-保护鸟氨酸铜络合物,微波辐射下用EDTA-2Na脱去铜离子,得到Nδ-苄氧羰基鸟氨酸、Nδ-叔丁氧羰基鸟氨酸、Nδ-芴甲氧羰基鸟氨酸、Nδ-乙酰基鸟氨酸和Nδ-邻苯二甲酰基鸟氨酸5个Nδ-保护鸟氨酸。探讨了微波辐射功率、时间及投料比例对脱铜反应的影响。[结果]脱铜反应的最佳反应条件为:n(Nδ-保护鸟氨酸铜络合物)∶n(EDTA)=1∶1.1～1∶1.2,微波辐射功率为250～300W,反应时间为4～6min,收率分别为93.2%、86.2%、88.7%、86.3%和86.4%(以Nδ-保护鸟氨酸铜络合物计)。产物结构经元素分析和1HNMR确证。[结论]该合成工艺对环境友好、简便、高效,产物收率与纯度均较高。

关键词： N-保护鸟基酸脱铜 EDTA莫2Na 微波合成