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Influence of self-similar stresses on scenario earthquake construction:An example along the Tanlu Fault

Science China Earth Sciences 2024年第5期67卷 1687-1697页

作者： Feng HU Huajian YAO Houyun yu Zeyu LU Jieyi HOU Song luo Zhigang SHAO Xiaofei CHEN School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Mengcheng Geophysical National Field Scientific Observatory Hefei 230026China Department of Earth and Space Science Southern University of Science and TechnologyShenzhen 518055China Institute of Earthquake Prediction China Earthquake AdministrationBeijing 100036China

As a famous deep and large fault in eastern China,the Tanlu Fault passes through Anhui,Jiangsu,and Shandong and into northeastern *** is important to improve the understanding of seismic hazard assessments in areas near *** start a scenario earthquake simulation in the M7.5 earthquake potential area of the Xinyi-Sihong segment of the Tanlu *** fault rupture length and width are constrained according to the scaling law of large intraplate earthquakes,the background normal stress is depth dependent,and the initial shear stresses are determined using trial and error by matching the earthquake *** the 120 km rupture length of the M7.5 earthquake,we compare the horizontal uniform stress model and self-similar stress perturbation *** findings reveal that the seismic source time function of the horizontal uniform stress model is similar to that of the Haskell model and that of the self-similar stress perturbation model is more similar to that of a real earthquake *** compare the dynamic rupture simulation and ground motion results under four different stress conditions and find that the shorter the characteristic length of the self-similar function is,the rougher the initial *** the M7.5earthquake with an epicenter in the vicinity of Suqian,the Xinyi-Tancheng segment,which is located in the IX-intensity zone north of the epicenter,vibrates more strongly on the northern side than on the southern side due to the influence of the lowvelocity zone and the peak slip *** response spectra analysis at stations in the study area is useful for improving the earthquake resistance capability.

关键词： Scenario earthquakes Self-similar stress Tanlu Fault Dynamic rupture Ground motion

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Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM_(2.5)-aggravated COPD airway remodeling by enhancing myofibroblast differentiation

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Science China(Life Sciences) 2024年第5期67卷 970-985页

作者： Huaqi Guo luo Fei Hengyi yu Yan Li Yan Feng Shaowei Wu Yan Wang The Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200011China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200020China Department of Occupational and Environmental Health Sciences School of Public HealthXi’an Jiao Tong University Health Science CenterXi’an 710049China

Emphysema,myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution,especially fine particulate matter(PM_(2.5)),leading to chronic obstructive pulmonary disease(COPD).Specifically,bronchial epithelium-fibroblast communication participates in airway remodeling,which results in *** increasing number of studies are now being conducted on the role of exosome-mediated cell-cell communication in disease ***,we investigated whether exosomes generated from bronchial epithelial cells could deliver information to normal stromal fibroblasts and provoke cellular responses,resulting in airway obstruction in *** studied the mechanism of exosome-mediated intercellular communication between human bronchial epithelial(HBE) cells and primary lung fibroblasts(pLFs).We found that PM_(2.5)-induced HBE-derived exosomes promoted myofibroblast differentiation in ***,the exosomal lncRNA expression profiles derived from PM_(2.5)-treated HBE cells and nontreated HBE cells were investigated using an Agilent Human LncRNA *** coculture assays and direct exosome treatment,we found that HBE cell-derived exosomal HOTAIRM1 facilitated the myofibroblast differentiation of ***,we discovered that exosomal HOTAIRM1 enhanced p LF proliferation to secrete excessive collagen secretion,leading to airway obstruction by stimulating the TGF-β/SMAD3 signaling ***,PM_(2.5)reduced FEV1/FVC and FEV1 and increased the level of serum exosomal HOTAIRM1 in healthy people;moreover,serum exosomal HOTAIRM1 was associated with PM_(2.5)-related reductions in FEV1/FVC and *** findings show that PM_(2.5)triggers alterations in exosome components and clarify that one of the paracrine mediators of myofibroblast differentiation is bronchial epithelial cell-derived HOTAIRM1,which has the potential to be an effective prevention and therapeutic target for PM_(2.5)-induced COPD.

关键词： PM2.5 exosomal lncRNAs HOTAIRM1 chronic obstructive pulmonary disease

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Morphological Classification of Infrared Galaxies Based on WISE

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Research in Astronomy and Astrophysics 2024年第4期24卷 222-236页

作者： Zhi-Ren Pan Bo Qiu Cui-Xiang Liu A-Li luo Xia Jiang Xiao-yu Guo School of Electronic and Information Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

This study introduces a novel convolutional neural network,the WISE Galaxy Classification Network(WGC),for classifying spiral and elliptical galaxies using Wide-field Infrared Survey Explorer(WISE)*** attains an accuracy of 89.03%,surpassing the combined use of K-means or SVM with the Color-Color method in more accurately identifying galaxy *** enhanced variant,WGC_mag,integrates magnitude parameters with image features,further boosting the accuracy to 89.89%.The research also delves into the criteria for galaxy classification,discovering that WGC primarily categorizes dust-rich images as elliptical galaxies,corresponding to their lower star formation rates,and classifies less dusty images as spiral *** paper explores the consistency and complementarity of WISE infrared images with SDSS optical images in galaxy morphology *** SDSS Galaxy Classification Network(SGC),trained on SDSS images,achieved an accuracy of 94.64%.The accuracy reached 99.30% when predictions from SGC and WGC were *** the complementarity of features in WISE and SDSS images,a novel variant of a classifier,namely the Multi-band Galaxy Morphology Integrated Classifier,has been *** classifier elevates the overall prediction accuracy to 95.39%.Lastly,the versatility of WGC was validated in other data *** the HyperLEDA data set,the distinction between elliptical galaxies and Sc,Scd and Sd spiral galaxies was most pronounced,achieving an accuracy of 90%,surpassing the classification results of the Galaxy Zoo 2 labeled WISE data *** research not only demonstrates the effectiveness of WISE images in galaxy morphology classification but also represents an attempt to integrate multi-band astronomical data to enhance understanding of galaxy structures and evolution.

关键词： methods:data analysis infrared:galaxies galaxies:spiral galaxies:elliptical and lenticular cD

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Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1693-1710页

作者： Xiong Chen Jinfu Qian Shiqi Liang Jianchang Qian Wu luo yujuan Shi Hong Zhu Xiang Hu Gaojun Wu Xiaokun Li guang Liang Department of Endocrinology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China Department of Wound Repair the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Department of Cardiology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China School of Pharmaceutical Sciences Hangzhou Medical CollegeHangzhou 311399China

Protein tyrosine kinases (RTKs) modulate a wide range of pathophysiological events in several non-malignant disorders, including diabetic complications. To find new targets driving the development of diabetic cardiomyopathy (DCM), we profiled an RTKs phosphorylation array in diabetic mouse hearts and identified increased phosphorylated fibroblast growth factor receptor 1 (p-FGFR1) levels in cardiomyocytes, indicating that FGFR1 may contribute to the pathogenesis of DCM. Using primary cardiomyocytes and H9C2 cell lines, we discovered that high-concentration glucose (HG) transactivates FGFR1 kinase domain through toll-like receptor 4 (TLR4) and c-Src, independent of FGF ligands. Knocking down the levels of either TLR4 or c-Src prevents HG-activated FGFR1 in cardiomyocytes. RNA-sequencing analysis indicates that the elevated FGFR1 activity induces pro-inflammatory responses via MAPKs–NFκB signaling pathway in HG-challenged cardiomyocytes, which further results in fibrosis and hypertrophy. We then generated cardiomyocyte-specific FGFR1 knockout mice and showed that a lack of FGFR1 in cardiomyocytes prevents diabetes-induced cardiac inflammation and preserves cardiac function in mice. Pharmacological inhibition of FGFR1 by a selective inhibitor, AZD4547, also prevents cardiac inflammation, fibrosis, and dysfunction in both type 1 and type 2 diabetic mice. These studies have identified FGFR1 as a new player in driving DCM and support further testing of FGFR1 inhibitors for possible cardioprotective benefits.

关键词： Diabetic cardiomyopathy Protein tyrosine kinases FGFR1 Cardiomyocytes Inflammatory responses Toll-like receptor4 c-Src NFkB

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Detection of a mud volcano in the Weitan Banks area of the northern South China Sea

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Journal of Oceanology and Limnology 2024年第5期42卷 1450-1469页

作者： Wei luo Pin YAN Yanlin WANG Junhui yu Qionghua WAN Zhenbo ZHANG Tao XUE Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering guangdong Laboratory(guangzhou) Guangzhou 511458China CNOOC International Energy Services(Beijing)Co. Ltd.Beijing 100028China University of Chinese Academy of Sciences Beijing 100049China Oilfield Engineering Research Institute of Geophysics CNOOC Energy Technology and ServicesZhanjiang 524057China

Situated between the petroliferous Cenozoic Zhujiang(Pearl)River Mouth Basin and the mud volcano-rich Mesozoic Dongsha Basin in the middle sector of the northern South China Sea,the Weitan Banks area has been previously mapped as a basement high that is composed of Mesozoic magmatic *** this study,we present several favorable indicators for petroleum geology that were detected from geophysical profiling and benthic sampling in the area.A conspicuous hill was discovered,named“Zhongwei Hill”,~80 m high above the~340 m deep seafloor and~1 km broad,in a depression with more than 7 km thick sedimentary *** Zhongwei Hill was seismically imaged with a mushroom-shaped structure and containing a cake-like crown,fluid flow pipes,and an~10 km broad anticline at ***,the hill represents a source-plumbing-eruption *** gas zones linked to deep fracture were found at or near the *** correlation indicates that the deep strata comprise the Jurassic and Paleogene strata,the major hosts of hydrocarbon source *** addition to the hill,there are number of mounds from which three bottom water samples were collected and the samples are rich in dissolved methane with concentrations high up to~900 nmol/L,much higher than the background level(0.5–2 nmol/L).The benthic samples are rich in coarse sediment clastics,authigenic carbonate nodules,and deep-water habitats likely feeding on methanotrophic *** these observations and the context,we propose that the Zhongwei Hill represents a mud volcano,likely thermally driven,that seeps methane from Jurassic and Paleogene source layers,thus poses a favorable clue for significant hydrocarbon generation capacity in transitional zone of the Zhujiang River Mouth Basin and the Dongsha Basin.

关键词： South China Sea Zhongwei Hill deep-level anticline mud volcano Mesozoic source layer hydrocarbon generation

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Comparison and Verification of Coherent Doppler Wind Lidar and Radiosonde Data in the Beijing Urban Area

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Advances in Atmospheric Sciences 2024年第11期41卷 2203-2214页

作者： Zexu luo Xiaoquan SONG Jiaping YIN Zhichao BU yubao CHEN Yongtao yu Zhenlu ZHANG College of Marine Technology Faculty of Information Science and EngineeringOcean University of ChinaQingdao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQingdao 266237China Qingdao Leice Transient Technology Co.LTD Qingdao 266100China CMA Meteorological Observation Centre Beijing 100081China Beijing Municipal Meteorological Observation Center Beijing 102600China Qingdao Meteorological Comprehensive Support Center Qingdao 266003China

As a new type of wind field detection equipment, coherent Doppler wind lidar(CDWL) still needs more relevant observation experiments to compare and verify whether it can achieve the accuracy and precision of traditional observation equipment in urban areas. In this experiment, a self-developed CDWL provided four months of observations in the southern Beijing area. After the data acquisition time and height match, the wind profile data obtained based on a Doppler beam swinging(DBS) five-beam inversion algorithm were compared with radiosonde data released from the same location. The standard deviation(SD) of wind speed is 0.8 m s^(–1), and the coefficient of determination R~2 is 0.95. The SD of the wind direction is 17.7° with an R~2 of 0.96. Below the height of the roughness sublayer(about 400 m), the error in wind speed and wind direction is significantly greater than the error above the height of the boundary layer(about 1500 m). For the case of wind speeds less than 4 m s^(–1), the error of wind direction is more significant and is affected by the distribution of surrounding buildings. Averaging at different height levels using suitable time windows can effectively reduce the effects of turbulence and thus reduce the error caused by the different measurement methods of the two devices.

关键词： coherent Doppler wind lidar radiosonde wind measurement urban boundary layer

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Enhanced Cooling Efficiency of Urban Trees on Hotter Summer Days in 70 Cities of China

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Advances in Atmospheric Sciences 2024年第11期41卷 2259-2275页

作者： Limei YANG Jun GE Yipeng CAO yu LIU Xing luo Shiyao WANG Weidong GUO School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Joint International Research Laboratory of Atmospheric and Earth System Sciences Nanjing UniversityNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China

Increasing the urban tree cover percentage(TCP) is widely recognized as an efficient way to mitigate the urban heat island effect. The cooling efficiency of urban trees can be either enhanced or attenuated on hotter days, depending on the physiological response of urban trees to rising ambient temperature. However, the response of urban trees' cooling efficiency to rising urban temperature remains poorly quantified for China's cities. In this study, we quantify the response of urban trees' cooling efficiency to rising urban temperature at noontime [~1330 LT(local time), LT=UTC+8] in 17summers(June, July, and August) from 2003–19 in 70 economically developed cities of China based on satellite observations. The results show that urban trees have stronger cooling efficiency with increasing temperature, suggesting additional cooling benefits provided by urban trees on hotter days. The enhanced cooling efficiency values of urban trees range from 0.002 to 0.055℃ %-1 per 1℃ increase in temperature across the selected cities, with larger values for the lowTCP-level cities. The response is also regulated by background temperature and precipitation, as the additional cooling benefit tends to be larger in warmer and wetter cities at the same TCP level. The positive response of urban trees' cooling efficiency to rising urban temperature is explained mainly by the stronger evapotranspiration of urban trees on hotter *** results have important implications for alleviating urban heat risk by utilizing urban trees, particularly considering that extreme hot days are becoming more frequent in cities under global warming.

关键词： urban trees cooling efficiency China's cities evapotranspiration summer hot days

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A dual-mode integration framework and application to agile feedback design of launch vehicles

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International Journal of Mechanical System Dynamics 2024年第2期4卷 226-239页

作者： Wenfeng Zhang Xiaoshuang Cai Zhendong Liu Shan luo Rendong yu Shanghai Institute of Aerospace System Engineering ShanghaiChina

In recent decades,the design of complex systems like launch vehicles in the aerospace industry has presented engineers with challenges that go beyond system *** such as time-to-market pressures and intricate industrial processes have underscored the increasing significance of agile design *** design is derived from the simplification of the design process and enhancing cross-domain data transmission and *** methods based on model-based system engineering have improved iteration times in system architecture design,challenges persist in cross-domain data *** to the diversity of complex system models and data,a single-mode integration method is difficult to realize the data link construction of all tools *** address this challenge,this paper proposes a dualmode data integration framework with expansibility,universality,and cost-efficiency which leverages the benefits of Remote Procedure Call and Intermediate Exchange Module,addressing the challenge of constructing cross-domain data links under single-mode *** this study,two critical requirements of the first-and second-stage separation systems,namely,weight and minimum separation gap,are selected for data feedback.A Modelica-based multiphysics simulation model is developed in MWorks;visualization and computation of the minimum gap are carried out in *** bridge the gap between domain-specific tools,Matlab and Functional Mock-up Unit modules are introduced as middleware,facilitating data feedback *** entire simulation process is orchestrated using activity diagrams in the MagicDraw *** study delves into the influence of critical design parameters,such as the initial angular velocity of separation and the thrust of the retro rocket,on the minimum separation *** provides an analysis of minimum separation gap variations under uncertain operating conditions and examines design ***,the paper highlights the signifi

关键词： data feedback dual-mode data integration FMU launch vehicle MBSE Modelica

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The MtRGF6 Peptide Differentially Regulates Root Development and Symbiotic Nodulation of Medicago truncatula and Lotus japonicus

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1237-1248页

作者： Junhui Yan Yawen Wang Qiong Li yu Zhou Xu Wang Li luo School of Life Sciences Shanghai Key Laboratory of Bio-Energy CropsShanghai UniversityShanghai200444China College of Life Science State Key Laboratory of Tea Plant Biology and UtilizationAnhui Agricultural UniversityHefei230036China

Rhizobia induces nitrogen-ﬁxing nodules in legumes used in agricultural production,providing a direct source of combined nitrogen to leguminous *** peptides,such as CLAVATA3/EMBRYO SURROUNDING REGION peptides(CLE),are known to regulate the formation and development of nitrogen-ﬁxing nodules in *** meristem growth factor(RGF)peptides from Medicago truncatula not only regulate root develop-ment but also modulate nodulation symbiosis with Sinorhizobium ***,the impact of RGF peptides from one leguminous species on the others remains *** this study,we investigate the effects of the RGF family peptide MtRGF6p from *** on nodulation symbiosis and root development in Lotus *** MtRGF6 gene is predominantly expressed in the root nodules of *** and shows low identity with RGF homologous genes from *** gene promoter is active in the primordia of root nodules and lat-eral roots,as well as in young nodules and roots,and the meristem,infection,and nitrogen-ﬁxing regions of the mature *** synthesized MtRGF6p promoted primary root growth in *** but sup-pressed the growth of *** primary *** peptide negatively affected the initiation of nodule primor-dia,the formation of infection threads,and nodulation in both legumes,with a low dosage showing effects on *** compared to *** results suggest that the MtRGF6 peptide from *** may serve as an inter-species signal affecting the root organ development of ***.

关键词： Peptide RGF legume symbiotic nodulation lateral root

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Next-generation probiotic candidates targeting intestinal health in weaned piglets: Both live and heat-killed Akkermansia muciniphila prevent pathological changes induced by enterotoxigenic Escherichia coli in the gut

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Animal Nutrition 2024年第02期17卷 110-122页

作者： Cong Lan Hua Li yuqing Shen Yang Liu Aimin Wu Jun He Jingyi Cai Gang Tian Xiangbing Mao Zhiqing Huang Bing yu Ping Zheng Jie yu Junqiu luo Hui Yan yuheng luo Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of ChinaKey Laboratory of Animal Disease-Resistant Nutrition of Sichuan ProvinceEngineering Research Center of Animal Disease-Resistance Nutrition Biotechnology of Ministry of Education of ChinaAnimal Nutrition InstituteSichuan Agricultural University

The use of next-generation probiotics （NGP） in pigs for combating diseases has been subject to limited *** we explored the potential of a well-known NGP candidate Akkermansia muciniphila targeting pig gut *** the first screening experiment,we found that the abundance of *** peaked at 14 d old but decreased at weaning （21 d old;P<0.05）,suggesting the weaning period may be an effective window for *** *** that,48 crossbred weaned pigs at 28 d old were randomly assigned to five groups:control （CON）,high/low live *** （HA/LA）,and high/low heatkilled *** （HIA/LIA）.From 1 to 28 d old,the CON group received gastric infusion of anaerobic sterile saline every other day;the HA and LA groups were gavaged every other day with 1×1010CFU/5 m L and 5×10～8CFU/5 mL live ***,respectively;and the HIA and LIA groups were gavaged every other day with 1×1010CFU/5 mL and 5×10～8CFU/5 mL heat-killed ***,*** d 29,pigs in the CON group were randomly and equally divided into two groups,one of which was named the enterotoxigenic Escherichia coli （ETEC） group,and all groups except CON received a 5-d ETEC *** supplementation of *** numerically reduced the diarrhea rate of weaned pigs compared to the pigs that only received the ETEC challenge （P=0.57）,but the LIA group had a higher diarrhea rate than the CON group （P<0.05）.Consistent with this,the supplementation of *** improved the small intestinal morphology and structure,proportion of CD4+T lymphocytes in the blood,as well as the expression of genes related to intestinal barrier and antioxidant indices of pigs with ETEC challenge,especially for the LA group （P<0.05）.Meanwhile,*** supplementation reduced the expression of ETEC virulence factor genes in the ileum and colon of pigs challenged by ETEC （P<0.05）.Therefore,*** may protect the intestinal health of weaned piglets from damage caused by

关键词： Akkermansia muciniphila Weaned piglet Enterotoxigenic Escherichia coli challenge Intestinal health

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