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SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

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Research 2024年第3期2023卷 369-389页

作者： Xiujuan Du Yuhua Yan Juehua Yu Tailin Zhu Chu-Chung Huang lingli Zhang Xingyue Shan Ren li Yuan Dai Hui LV Xiao-Yong Zhang Jianfeng Feng wei-guang li Qiang Luo Fei li Developmental and Behavioral Pediatric Department Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children's Environmental HealthXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Developmental and Behavioral Pediatric Department Shanghai Xinhua Children's HospitalShanghai 200092China National Clinical Research Center for Aging and Medicine at Huashan Hospital Institute of Science and Technology for Brain-lnspired IntelligenceMinistry of Education-Key Laboratory of Computational Neuroscience and Brain-lnspired IntelligenceFudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenom InstituteFudan UniversityShanghai 200032China Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) School of Life SciencesEast China Normal UniversityShanghai 200062China Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Center for Experimental Studies and Research The First Affliated Hospital of Kunming Medical UniversityKunming 650032China Shanghai Research Center for Brain Science and Brain-lnspired Intelligence Shanghai201210China Institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China.

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study, we performed a genome-wide association study using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity risk and fluid intelligence. Our results revealed novel common genetic loci (SH2B1, TUFM, ATP2A1, and FOXO3) underlying the association between fluid intelligence and body metabolism. Surprisingly, we demonstrated that SH2B1 variation influenced fluid intelligence independently of its effects on metabolism but partially mediated its association with bilateral hippocampal volume. Consistently, selective genetic ablation of Sh2b1 in the mouse hippocampus, particularly in inhibitory neurons, but not in excitatory neurons, significantly impaired working memory, short-term novel object recognition memory, and behavioral flexibility, but not spatial learning and memory, mirroring the human intellectual performance. Single-cell genetic profiling of Sh2B1-regulated molecular pathways revealed that Sh2b1 deletion resulted in aberrantly enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study thus provides unprecedented insight into the role of SH2B1 in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

关键词： metabolism impaired reversed

A convergent mean shift algorithm to select targets for LAMOST

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Research in Astronomy and Astrophysics 2009年第7期9卷 803-811页

作者： guang-wei li Gang Zhao National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

This paper firstly finds that the Mean Shift Algorithm used by the Observation Control System （OCS） Research Group of the University of Science and Technology of China in Survey Strategy System 2.10 （SSS2.10） to select targets for the Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） is not convergent in theory. By carefully studying the mathematical formulation of the Mean Shift Algorithm, we find that it tries to find a point where some objective function achieves its maximum value; the Mean Shift Vector can be regarded as the ascension direction for the objective function. If we regard the objective function as the numerical description for the imaging quality of all targets covered by the focal panel, then the Mean Shift Algorithm can find the place where the imaging quality is the best. So, the problem of selecting targets is equal to the problem of finding the place where the imaging quality is the best. In addition, we also give some effective heuristics to improve computational speed and propose an effective method to assign point sources to the respective fibers. As a result, our program runs fast, and it costs only several seconds to generate an observation.

关键词： methods: data analysis - methods: statistical

Emerging approaches to probing ion channel structure and function

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Neuroscience Bulletin 2012年第4期28卷 351-374页

作者： wei-guang li Tian-Le Xu Neuroscience Division Department of Biochemistry and Molecular Cell BiologyInstitute of Medical SciencesShanghaiJiao Tong University School of MedicineShanghai 200025China

Ion channels,as membrane proteins,are the sensors of the *** act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable *** of their importance in cellular communication,ion channels have been intensively studied at the structural and functional ***,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation（or sensitization）,inactivation（or desensitization）,and various forms of *** emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity.

关键词： ion channel structure and function mutagenesis covalent modification voltage-clamp fluorometry computational chemistry

Pyrolysis Characteristics and Kinetics of the Preparation Process of Sludge-Based Activated Carbon by ZnCl_2 Activation Method

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Journal of Harbin Institute of Technology(New Series) 2013年第6期20卷 29-36页

作者： Xin li guang-Zhi Wang wei-guang li Ping Wang School of Municipal and Environmental Engineering Harbin Institute of Technology State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology

To obtain the pyrolysis characteristics and kinetics of preparation process of sludge-based activated carbon by ZnCl2 activation method （*** pyrolysis process of the sludge with ZnCl2 activation）,the characteristic of mass loss and gas products generated during pyrolysis of the sludge with ZnCl2 activation were analyzed by thermogravimetric analysis coupled with Fourier Transform Infrared Spectroscopy （TG-FTIR）.The kinetic parameters were calculated by the Coats-Redfem method and the mechanism models were *** role of ZnCl2 in the pyrolysis process of the sludge with ZnCl2 activation was also illustrated through the comparison of the pyrolysis characteristics and kinetics of the sludge with and without ZnCl2 *** results showed that the pyrolysis process of the sludge with ZnCl2 activation can be divided into four stages including the dehydration of sludge and initial depolymerization of a small portion of organics matters,the decomposition of large molecular organic matters into small molecular intermediates,the further degradation of intermediates and volatilization of ZnCl2,and the decomposition of inorganic minerals and undecomposed organic ***2,CO,CH4,H2O,some aldehydes and carboxylic acids are the major pyrolysis gaseous *** activation energies and pre-exponential factors are in the range of 28.84-206.42 kJ/mol and 9885.16-8.08× 1011 min-1,*** the pyrolysis of sludge,ZnC12 not only can function as a dehydration agent and inhibit the formation of tar,but also can peptize the organic matters in the sludge,making them easier to be decomposed.

关键词： sludge ZnCl2 activation pyrolysisCLC number:X705 Document code:AArticle ID:1005-9113(2013)06-0029-08

Radar target recognition based on micro-Doppler effect

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Optoelectronics Letters 2008年第6期4卷 456-459页

作者： DONG wei-guang li Yan-jun College of Astronautics Northwestern Polytechnical University Xi ＇an 710072 China

Mechanical vibration of target structures will modulate the phase function of radar backscattering,and will induce the frequency modulation of returned signals from the target. It generates a side bands of the target body Doppler frequency shift,which is helpful for target recognition. Based on this,a micro-Doppler atomic storehouse is built for the target recognition,and four kinds of common classifiers are used separately to perform the classified recognition. The simulation experimental results show that this method has high recognition rate above 90%.

关键词：雷达目标显微多普勒效应信息处理后向散射

Molecular and functional characterization of three odorant-binding proteins from the wheat blossom midge,Sitodiplosis mosellana

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Insect Science 2020年第4期27卷 721-734页

作者： wei-Ning Cheng Yu-Dong Zhang wei liu guang-wei li Keyan Zhu-Salzman Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYang lingShaanxiChina Shaanxi Key Laboratory of Chinese Jujube Van'an UniversityVan'anShaanxiChina Department of Entomology Texas A&M UniversityCollege StationTXUSA

Sitodiplosis mosellana,a periodic but devastating wheat pest,relies on wheat spike volatiles as a cue in sclecing hosts for *** odorant-binding proteins(OBPs)are thought to play essential roles in filtering,binding and transporting hydropho-bic odorant molecules to specific *** date,the molecular mechanisms underlying *** olfaction are poorly ***,three *** antenna-specific OBP genes,SmosOBPII,16 and 21,were cloned and bacterially *** properties of the recombinant proteins to 28 volatiles emitted from wheat spikes were in-vestigated using fluorescence competitive binding *** analysis suggested that these SmosOBPs belong to the Classic OBP ***-binding analysis showed that all three SmosOBPs preferentially bound alcohol,ester and ketone com-pounds,and SmosOBP11 and 16 also selectively bound terpenoid *** par-ticular,the three SmosOBPs had high binding affinities(Kilicited strong electroantennogram(EAG)response fromfemale *** addition,SmosOBP11 displayed significantly higher binding(Kilicited significant EAG response,suggesting that SmosOBP11 plays a ma-jor role in recognition and transportation of these *** findings have provided important insight into the molecular mechanism by which *** specifically rec-ognizes plant volatiles for host selection,and have facilitated identification of effective volatile attractants that are potentially useful for pest monitoring and trapping.

关键词： binding assay electroantennogram response host selection odorant-binding protein Sitodiplosis mosellana wheat spike violates

Segregating memories: targeting microenvironment of neuronal ensembles

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Signal Transduction and Targeted Therapy 2022年第11期7卷 3995-3997页

作者： Ying liu Miao Xu wei-guang li Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan University200032ShanghaiChina

A recent study by Shen et *** that a delayed augmentation in the neuronal expression of C–C chemokine receptor type 5(CCR5)—a well-known immune molecule in the peripheral inflammatory microenvironment—after the acquisition of a contextual memory determines the duration of the temporal window for linking with another memory,effectively elucidating mechanisms that shape the memory linking timescales.

关键词： linking ensemble dating

Effects of PAHs on Biotransformation Enzymatic Activities in Fish

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Chemical Research in Chinese Universities 2011年第3期27卷 413-416页

作者： LU guang-hua CHEN wei li Ying ZHU Zhi Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes Ministry of Education College of Environment Hohai University Nanjing 210098 P. R. China

Biotransformation and detoxification responses to the exposure to five polycyclic aromatic hydrocarbons were investigated in crucian（Carassius auratus）. Juvenile crucian were treated with a single intraperitoneal injection of each compound at dosages of 0.1, 1.0, 2.0, 5.0 and 8.0（or 10.0） mg/kg and sacrificed 15 d later to determine 7-ethoxyresorufin-O-deethylase（EROD） and glutathione S-transferases（GST） activities in gill S9 fractions. EROD activity is significantly increased by benzo（b）fluoranthene and indeno（1,2,3-cd）pyrene at all the doses. High dosages of PAHs induced GST activity and the inducing ability of them increased in the following order： fluorene fluorantheneindeno（1,2,3-cd）pyrenebenzo（g,h,i）perylenebenzo（b）fluoranthene. In all the cases, dose dependence appeared to exist. The gill EROD and GST in Carassius auratus are useful biomarkers to estimate sub-acute toxicity of both polycyclic aromatic hydrocarbons（PAHs） and PAHs-like compounds.

关键词： Polycyclic aromatic hydrocarbon Gill 7-Ethoxyresorufin-O-deethylase activity Glutathione S-transferases activity

Predict the evolution of mechanical property of Al-li alloys in a marine environment

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Defence Technology（防务技术） 2024年第1期31卷 557-566页

作者： wei li lin Xiang guang Wu Hongli Si Jinyan Chen Yiming Jin Yan Su Jianquan Tao Chunyang Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100036China Chongqing Innovation Center Beijing Institute of TechnologyChongqing400044China First Research Institute of the Ministry of Public Security for PR China Beijing100036China Southwest Technology and Engineering Research Institute Chongqing400039China

The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and *** study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-li alloys in the marine *** obtained the mechanical properties of Al-li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure *** obtained the strain evolution by digital image correlation(DIC).The strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-Term Memory(LSTM)neural ***,the output data of LSTM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-li *** main conclusions are as follows:*** variation law of mechanical properties of2297-T8 in the Marine atmosphere is *** the increase in outdoor exposure test time,the tensile elastic model of 2297-T8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.*** prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.*** study shows that a CNN/LSTM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure *** results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.

关键词： Marine environment Al-li alloy Machine learning Corrosion