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Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido[2,3-b]pyrazin-3(4H)-one derivatives

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Chinese Chemical Letters 2011年第10期22卷 1223-1225页

作者： Guo Gang Zhang Ya Jing Liu Xiao guang ma hao Dong Ju Li Ping Gong Key Laboratory of Original New Drugs Design and Discovery of Ministry of Education School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

A series of novel 2-hydrazinylpyrido[2,3-b]pyrazin-3（4H）-one derivatives were synthesized and evaluated for their cytotoxic activities against A549,MDA-MB-231 and HT-29 cell lines in *** data indicated that compounds 5b,5c,10a and 10g possessed marked cytotoxicity,especially 10a（with IC_（50） values of 0.81,2.56 and 1.63μmol/L against A549,MDA-MB- 23 1 and HT29 cell lines,respectively）,which had emerged as a lead compound.

关键词： 2-Hydrazinylpyrido[2 3-b]pyrazin-3(4H)-ones Synthesis Cytotoxicity

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen hao Zhang Jiawei Xiao maoxiang Hou Huilong Liu Li ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang hao Wang Peng Xu Jing-Kai Wang Bo Chen hao Xu Deng Pan Yu-Yang ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

k_(eff)uncertainty quantification and analysis due to nuclear data during the full lifetime burnup calculation for a small-sized prismatic high temperature gas-cooled reactor

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Nuclear Science and Techniques 2021年第11期32卷 105-118页

作者： Rong-Rui Yang Yuan Yuan Chen hao Ji ma guang-hao Liu Fundamental Science on Nuclear Safety and Simulation Technology Laboratory College of Nuclear Science and TechnologyHarbin Engineering UniversityHarbin 150001China Department of Reactor Technology Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.LtdBeijing 100089China

To benefit from recent advances in modeling and computational algorithms,as well as the availability of new covariance data,sensitivity and uncertainty analyses are needed to quantify the impact of uncertain sources on the design parameters of small prismatic high-temperature gascooled reactors(HTGRs).In particular,the contribution of nuclear data to the k_(eff)uncertainty is an important part of the uncertainty analysis of small-sized HTGR physical *** this study,a small-sized HTGR designed by China Nuclear Power Engineering Co.,*** selected for k_(eff)uncertainty analysis during full lifetime burnup *** of the cold zero power(CZP)condition and full lifetime burnup process were constructed using the Reactor Monte Carlo Code RMC for neutron transport calculation,depletion calculation,and sensitivity and uncertainty *** the sensitivity analysis,the Contribution-Linked eigenvalue sensitivity/Uncertainty estimation via Track length importance Characterization(CLUTCH)method was applied to obtain sensitive information,and the "sandwich" method was used to quantify the k_(eff)*** also compared the k_(eff)uncertainties to other typical *** results show that ^(235)U is the largest contributor to k_(eff)uncertainty for both the CZP and depletion conditions,while the contribution of ^(239)Pu is not very significant because of the design of low discharge *** is worth noting that the radioactive capture reaction of ^(28)Si significantly contributes to the k_(eff)uncertainty owing to its specific fuel ***,the k_(eff)uncertainty during the full lifetime depletion process was relatively stable,only increasing by 1.12%owing to the low discharge burnup design of small-sized *** numerical results are beneficial for neutronics design and core parameters optimization in further uncertainty propagation and quantification study for small-sized HTGR.

关键词： Small-sized HTGR SU analysis Nuclear data Burnup

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基于语料库的朝鲜语命名实体结构特征研究

外语学刊 2025年第1期 9-18页

作者：黄政豪金光洙延边大学工学院延吉133002 延边大学外国语学院延吉133002

本文统计Klue⁃ner和Kochet⁃ner两个命名实体语料库中的新闻、评论和文化遗产文本数据包含的不同类别朝鲜语命名实体。根据统计结果分析朝鲜语命名实体的音节长度特征分布和格词尾结合率。分析结果表明,音节长度和格词尾的使用在命名实... 详细信息

本文统计Klue⁃ner和Kochet⁃ner两个命名实体语料库中的新闻、评论和文化遗产文本数据包含的不同类别朝鲜语命名实体。根据统计结果分析朝鲜语命名实体的音节长度特征分布和格词尾结合率。分析结果表明,音节长度和格词尾的使用在命名实体分类中具有一定的规律可循。本文的研究成果可用于命名实体分类工作,同时也可以为朝鲜语命名实体语料库构建提供分布结构建议。

关键词：朝鲜语格词尾命名实体识别特征提取名词分类

螺旋CT增强扫描在肾癌不同亚型诊断中的应用

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中国血液流变学杂志 2017年第3期27卷 335-338,347页

作者：陈蒙郝光宇马新星胡春洪苏州大学附属第一医院放射科江苏苏州215006

目的探讨不同亚型肾癌的CT特征,评估CT增强扫描在其诊断中的应用价值.方法回顾性分析112例经手术及术后病理证实肾癌患者的CT资料,其中透明细胞癌86例,乳头状肾细胞癌13例,嫌色细胞癌13例,观察其影像学特征及三期增强CT值,并与病理结... 详细信息

目的探讨不同亚型肾癌的CT特征,评估CT增强扫描在其诊断中的应用价值.方法回顾性分析112例经手术及术后病理证实肾癌患者的CT资料,其中透明细胞癌86例,乳头状肾细胞癌13例,嫌色细胞癌13例,观察其影像学特征及三期增强CT值,并与病理结果进行对照分析.结果三种肾癌的平扫CT值差异无统计学意义.三期增强中,透明细胞癌均比乳头状肾细胞癌和嫌色细胞癌强化明显,差异有统计学意义（P〈0.01）,以皮质期最为显著.乳头状肾细胞癌和嫌色细胞癌的各期强化值差异无统计学意义.透明细胞癌出现不均匀强化的概率（87.2％）明显高于乳头状肾细胞癌（46.2％）和嫌色细胞癌（53.8％）,差异有统计学意义（P〈0.05）.透明细胞癌发生坏死或囊变的概率高于乳头状肾细胞癌和嫌色细胞癌.嫌色细胞癌出现钙化的概率高于透明细胞癌和乳头状肾细胞癌.结论肾癌不同亚型之间的CT表现及增强扫描存在差异,CT三期增强扫描能为肾癌的诊断和鉴别诊断提供重要指导价值.

关键词：肾癌亚型螺旋CT 增强扫描

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu hao Gao Qingqing Wang Pengfei Lv Sam S.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 ma h g-1,0.26 ma h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

An Overview of Stretchable Supercapacitors Based on Carbon Nanotube and Graphene

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Chinese Journal of Polymer Science 2020年第5期38卷 491-505,I0006页

作者： Wen-Le ma Zhi-hao Cai Yi Zhang Zi-Yuan Wang Lun Xia Su-Ping ma guang-hao Li Yi Huang National Institute for Advanced materials Tianjin Key Laboratory of Metal and Molecule Based Material ChemistryKey Laboratory of Functional Polymer MaterialsCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)School of Materials Science and EngineeringNankai UniversityTianjin 300350China Beijing Institute of Aeronautical materials Beijing 100095China

The wearable demand of modern electronic devices makes flexible and stretchable energy storage device urgently *** and flexible supercapacitors(SCs)are energy storage devices that provide ultrahigh power density while having long-term durability,high security,and electrochemical *** different SCs electrode materials,CNTs and graphene-based materials exhibit great potential in terms of stretchable SCs due to its ultrahigh electrical conductivity,large specific surface area and good mechanical *** this review,the state-of-the-art process and achievements in the field of stretchable SCs enabled by CNTs and graphene are presented,which include the novel design strategy,mechanical and electrochemical *** final section highlights current challenges and future perspectives on research in this thriving field.

关键词： Stretchable Supercapacitors Carbon materials Graphene CNTs

Molecular simulation study of the microstructures and properties of pyridinium ionic liquid[HPy][BF_(4)]mixed with acetonitrile

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原子与分子物理学报 2025年第4期42卷 27-32页

作者： XU Jian-Qiang ma Zhao-Peng CHENG Si LIU Zhi-Cong ZHU guang-Lai Department of Physics School of Physics and Electronic InformationAnhui Normal UniversityWuhu 241002China

The microstructures and thermodynamic properties of mixed systems comprising pyridinium ionic liquid[HPy][BF_(4)]and acetonitrile at different mole fractions were studied using molecular dynamics simulation in this *** following properties were determined:density,self-diffusion coefficient,excess molar volume,and radial distribution *** results show that with an increase in the mole fraction of[HPy][BF_(4)],the self-diffusion coefficient ***,the excess molar volume initially decreases,reaches a minimum,and then *** rules of radial distribution functions(RDFs)of characteristic atoms are *** increasing the mole fraction of[HPy][BF_(4)],the first peak of the RDFs of HA1-F decreases,while that of CT6-CT6 rises at first and then *** indicates that the solvent molecules affect the polar and non-polar regions of[HPy][BF_(4)]differently.

关键词： Pyridinium ionic liquids Thermodynamic properties Molecular dynamics simulation Radial distribution functions