检索结果-南通市图书馆

Facial pain induces the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion

引用

Neuroscience Bulletin 2007年第2期23卷 92-100页

作者：裴磊林传友戴甲培殷光甫华中科技大学同济医学院神经生物学系武汉430030

Objective To investigate the involvement of transient receptor potential vanilloid receptor 1 （TRPV1） in the facial inflammatory pain in relation to thermal hyperalgesia and cold pain sensation. Methods Facial inflammatory pain model was developed by subcutaneous injection of turpentine oil （TO） into rat facial area. Head withdrawal thermal latency （HWTL） and head withdrawal cold latency （HWCL） were measured once a day for 21 d after TO treatment using thermal and cold measurement apparatus. The immunohistochemical staining, cell-size frequency analysis and the survey of average optical density （OD） value were used to observe the changes of TRPV1 expression in the neurons of the trigeminal ganglion （TG）, peripheral nerve fibers in the vibrissal pad, and central projection processes in the trigeminal sensory nuclei caudalis （Vc） on day 3, 5, 7, 14, and 21 after TO injection. Results HWTL and HWCL decreased significantly from day 1 to day 14 after TO injection with the lowest value on day 5 and day 3, respectively, and both recovered on day 21. The number of TRPV1-labeled neurons increased remarkably from day 1 to day 14 with a peak on day 7, and returned back to the normal level on day 21. In control rats, only small and medium-sized TG neurons were immunoreactive （IR） to TRPV1, and the TRPV1-IR terminals were abundant in both the vibrissal pad and the Vc. Within 2 weeks of inflammation, the expression of TRPV1 in small and medium-sized TG neurons increased obviously. Also the TRPV1 stained terminals and fibers appeared more frequent and denser in both the vibrissal pad skin and throughout laminae Ⅰ and the outer zone of laminae Ⅱ （Ⅱo） of Vc. Conclusion Facial inflammatory pain could induce hyperalgesia to noxious heat and cold stimuli, and result in increase of the numbers of TRPV1 positive TG neurons and the peripheral and central terminals of TG. These results suggest that the phenotypic changes of TRPV1 expression in small and medium-sized TG neurons and terminal

关键词： vanilloid receptors facial pain hyperalgesia trigeminal ganglion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of tanshinone on neuropathological changes induced by amyloid β-peptide(1-40)injection in rat hippocampus

引用

Acta Pharmacologica Sinica 2004年第7期25卷 15-22页

作者： Long-xuan LI2, Jia-pei DAI3, Li-qiang RU4, guang-fu yin4, Bin ZHAO Department of Neurology, Affiliated Hospital, guangdong Medical College, Zhanjiang 524001, China 3The Netherlands Institute for Brain Research, Amsterdam 1105AZ, the Netherlands 4Department of Neurobiology, TongjiMedical College of Huazhong Universityof Science and Technology, Wuhan 430030, China Department of Neurology Affiliated Hospital Guangdong Medical College Zhanjiang 524001 China. Longxuanlee30@ hotmail.co

AIM: To investigate the effect of tanshinone (Tan) on the neuropathological changes induced by amyloid β- peptide1-40(Aβ1-40) injection in hippocampus in rats. METHODS: Aβ1-4010 μg was injected bilaterally into the dorsal blade of the dentate gyrus in the hippocampus. The level of acetylcholinesterase (AChE) in hippocampus was evaluated by histochemistry. The expressions of neuronal nitric oxide synthase (nNOS) and inducible form of NOS (iNOS) were detected by immunohistochemistry and Western blot. Aβ1-40-injected rats were treated ig with Tan, the major active ingredient from Salvia miltiorrhiza of Chinese herb extract. RESULTS: The level of AChE positive fibers of each subfield in Aβ1-40-injected hippocampus decreased significantly compared with those of control (P< 0.01). The expression of nNOS was down-regulated whereas the iNOS was up-regulated. After treatment with Tan (50 mg/kg, ig), the changes mentioned above were significantly improved. Moreover, the correlation analysis revealed a significant negative correlation between the area percentage of AChE positive fibers and the number of iNOS positiveneural cellsin CA1,CA2 toCA3 (CA2-3),and dentategyrus (DG)subfields (P<0.01). CONCLUSION: Tan can protect the neuropathological changes induced by Aβ1-40 injection in hippocampus.

关键词： tanshinone amyloid beta-protein acetylcholinesterase nitric oxide synthase hippocampus

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Research of Osteo-induced Rat Mesenchymal Stem Cells Seeding onβ-TCP/PLLA Porous Composite

引用

生物医学工程学杂志 2005年第S1期22卷 141-142页

作者： Qiao-Feng WU~1 Yan-Juan TANG~1 Huai-Qing CHEN~(1△) Jiang WU~1 guang-fu yin~21(Institute of Biomedical Engineering, West China Medical Center of Sichuan University, Chendu 610041,China)2(Institute of Material Science and Engineering, Sichuan University, Chendu 610065,China) Institute of Biomedical Engineering West China Medical Center of Sichuan University Chendu 610041 China Institute of Material Science and Engineering Sichuan University Chendu 610065 China

1 IntroductionPorous biodegradable synthetic materials such as β-tricalcium phosphate (β-TCP) and poly L-lactic acid(PLLA) are usually used in bone tissue ***, proper ratio, optimum pore size and porosity of the composites of β-TCP/PLLA are not very clear yet. In this study, we chose osteo-induced rat bone mesenchymal stem cells (rMSCs) as seeding cells, and cultured them on β-TCP/ PLLA scaffolds with different ratio, different pore size and different porosity. The aim is to investigate the optimum construction for supporting cell growth, proliferation and differentiation.

关键词： PLLA Cell MSCs TCP/PLLA Porous Composite Research of Osteo-induced Rat Mesenchymal Stem Cells Seeding on

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

引用

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA Haiyan HUANG yin YANG Hua WANG Xintian SHI Jianping LIU Lixia fu Yacheng QUAN Changyun LI Suyuan Cofoe Medical Technology Company Limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preparation and characterization of gadolinium hydroxide single-crystalline nanorods by a hydrothermal process

引用

Chinese Chemical Letters 2007年第4期18卷 491-494页

作者： Yi Dong yin guang Yan Hong Bai fu Xin School of Chemistry ＆ Materials Science Heilongjiang University Harbin 150080 China Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

The Gd（OH）3 nanorods with diameters of ca. 40--60 nm and lengths of more than 400-550 nm have been prepared by a novel hydrothermal technique. The structural features and chemical composition of the nanorods were investigated by X-ray diffraction （XILD）, transmission electron microscopy （TEM）, and field emission scanning electron microscope （FESEM）, selected area electron diffraction （SAED）, and high resolution transmission electron microscopy （HRTEM）. The possible mechanism for the formation of Gd（OH）3 nanorods was proposed.

关键词： Gd(OH)3 Nanorods Hydrothermal method Lanthanide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

[Solid-phase extraction coupled with high performance liquid chromatography-triple quadrupole mass spectrometry for simultaneous determination of seven coumarins in water samples from drinking water treatment plants]

引用

Se pu = Chinese journal of chromatography 2025年第1期43卷 78-86页

作者： Wen-Mei Jiao Jing-Ming Yang Ce Xu fu-Kang Gao Lu-Yao Shen Yu-Bo Yuan Zhi-Fen Guo guang Huang School of Life Sciences and Chemical Engineering Jiangsu Second Normal University Nanjing 211200 China. School of Stomatology Nanjing Medical University Nanjing 210029 China. School of Public Health Nanjing Medical University Nanjing 211166 China. Key Laboratory of Modern Toxicology Ministry of Education School of Public Health Nanjing Medical University Nanjing 211166 China.

Chlorinated coumarins, which are as cytotoxic as highly toxic halobenzoquinones toward CHO-K1 cells, have recently been identified as disinfection byproducts in drinking water disinfection processes. Therefore, detecting coumarins in water samples collected at various stages from drinking water treatment plants helps assess the formation of chlorinated coumarins in drinking water. Hence, a simple, rapid, accurate, and sensitive method for quantifying coumarins in water samples is required. In this study, a method was developed based on solid-phase extraction coupled with high performance liquid chromatography-triple-quadrupole mass spectrometry for analyzing seven coumarins in water samples from drinking water treatment plants, including 6,7-dihydroxycoumarin, 7-hydroxycoumarin, 6-hydroxy-4-methylcoumarin, 8-chloro-7-hydroxycoumarin, coumarin, 7-chloro-6-hydroxy-4-methylcoumarin, and 3,8-dichloro-7-hydroxycoumarin. Sample pretreatment involved solid-phase extraction using HLB columns, followed by elution with water and methanol, each containing 0.25% formic acid. The extracted solution was separated via gradient elution using a Phenomenex Luna C18 column (100 mm×2.0 mm, 3 mm) with 0.1% formic acid aqueous solution and methanol as the mobile phases, with analytes detected by triple-quadrupole mass spectrometry equipped with electrospray ionization source in multiple reaction monitoring mode. The matrix effect, precision, and accuracy of the developed method were investigated using raw and treated water as matrices. Matrix effects of 0.84-1.12 were recorded for the detection of 6,7-dihydroxycoumarin, 7-hydroxycoumarin, 6-hydroxy-4-methylcoumarin, and coumarin in raw water, while values of 0.67-0.70 were recorded for 8-chloro-7-hydroxycoumarin, 7-chloro-6-hydroxy-4-methylcoumarin, and 3,8-dichloro-7-hydroxycoumarin in finished water. The three chlorinated coumarins exhibited matrix effects above 0.80 after the finished water matrix had been diluted four times. These re

关键词： coumarins disinfection byproducts drinking water high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) solid-phase extraction (SPE)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enterochromaffin Cell:Friend or Foe for Human Health?

引用

Neuroscience Bulletin 2023年第11期39卷 1732-1734页

作者： Yang Yu Yong-Chang Li fu-Chao Zhang guang-yin Xu Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversitySuzhou 215123China

Enterochromaffin(EC)cells are a type of enteroendocrine cells that reside in the epithelial lining of the gastrointestinal *** function as sensory transducers of stimuli present in the intestinal lumen,as afferent nerves do not protrude into the lumen,but have been shown to act as a friend or a foe depending on various *** has been well-described that EC cells play their role by releasing 5-HT to activate neighboring afferent nerves in a paracrine fashion,while emerging evidence suggests the existence of synaptic-like connections between enteroendocrine cells and adjacent afferent nerves based on in vitro co-culture and in vivo viral tracing studies.

关键词： nerves releasing Human

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

早期静脉溶栓联合机械取栓治疗急性缺血性脑卒中的效果及预后研究

引用

临床误诊误治 2019年第7期32卷 34-39页

作者：杨占辉尹学敬王树平杨彦林王鹏付广印韩东亮衡水市哈励逊国际和平医院介入治疗科河北衡水053000 衡水市哈励逊国际和平医院产科河北衡水053000

目的观察早期静脉溶栓联合机械取栓对急性缺血性脑卒中患者的临床效果及对预后的影响。方法将2014年1月—2016年12月本院收治的200例急性缺血性脑卒中患者采取随机数字表法等分为观察组和对照组。对照组在发病4.5h内给予静脉溶栓,8h内... 详细信息

目的观察早期静脉溶栓联合机械取栓对急性缺血性脑卒中患者的临床效果及对预后的影响。方法将2014年1月—2016年12月本院收治的200例急性缺血性脑卒中患者采取随机数字表法等分为观察组和对照组。对照组在发病4.5h内给予静脉溶栓,8h内给予动脉溶栓治疗;观察组在发病3.0~4.5h内行静脉溶栓,8h内行机械取栓术治疗。①治疗后3周根据美国国立卫生研究院卒中量表(national Institute of Health stroke scale,NIHSS)评分评估两组临床疗效;②比较两组治疗前及治疗后24h、3d、3周NIHSS评分;③治疗后3周比较两组血管开通及取栓后血管狭窄侧支代偿率;④治疗后即刻及治疗后3周观察两组血管灌注改良脑梗死溶栓血流分级(modified thrombolysis in cerebral infarction,mTICI);⑤治疗后3周观察两组再出血率、再闭塞率、病死率。结果①治疗3个月后观察组临床总有效率为93.00%高于对照组的74.00%(P<0.05)。②治疗后24h、3d、3周两组NIHSS评分较治疗前均降低,且随着治疗时间的延长NIHSS评分逐渐降低(P<0.05);观察组术后24h、3d、3周NIHSS评分低于对照组相同时间(P<0.05或P<0.01)。③治疗3周后,观察组血管开通率、取栓后血管狭窄侧支代偿率均高于对照组(P<0.05)。④两组治疗后3周mTICI分级≥2b级比例均较术后即刻升高,且治疗后即刻、治疗后3周观察组mTICI分级≥2b级比例高于对照组,差异均有统计学意义(P<0.05或P<0.01)。⑤治疗后3周,观察组再出血率、再闭塞率、病死率均低于对照组(P<0.05)。结论早期静脉溶栓联合机械取栓治疗急性缺血性脑卒中可以提高临床效果,促进患者神经功能恢复,降低致残率及致死率,促进患者早日康复;并提示严格掌握手术适应证、选择合理手术时间、充分术前评估对治疗效果的重要性。

关键词：脑卒中,缺血性静脉溶栓机械溶栓治疗结果预后

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

非厄米PT对称多通道光波导体系的调控及动力学

引用

原子与分子物理学报 2025年第1期42卷 108-117页

作者：孙武叶伏秋张光成吉首大学物理与机电工程学院吉首416000

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换... 详细信息

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换为重整化参数后的等效未调制系统后,发现可以通过额外引入单频周期调制的光波导去调控体系的PT对称性,并且讨论了周期调制的非厄米三通道波导体系的能谱特性.最后通过解析和数值的方法给出了光在非厄米三通道光学波导中的动力学演化.

关键词： PT对称非厄米三通道波导

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Polymer-based smart fibers and textiles for wearable electronics

引用

Science China Technological Sciences 2025年第1期 85-120页

作者： Sanming HU Li WANG Zaixian YUAN Kun CHEN Wei PENG Hai yin Zhijun SHI guang YANG School of Biomedical Engineering and Imaging Xianning Medical CollegeHubei University of Science and Technology College of Life Science and Technology Huazhong University of Science and Technology Wuhan Branch of the National Science Library Chinese Academy of Sciences

Smart fibers and textiles have attracted considerable interest for application in wearable devices because of their advantages of being human-friendly, lightweight, flexible, and comfortable. In addition, they are considered to have potential applications in health monitoring, energy management, and human-machine interaction systems. Polymers and polymer fibers,with excellent mechanical strength, wrinkle resistance, and heat resistance, are widely used to fabricate smart fibers and textiles. Herein, a comprehensive overview of polymer-based fibers and textiles is provided. First, we review the design principles of various polymer-based smart textiles, including textile-based sensors, energy capture and storage textiles, and computation and display textiles. Next, materials used for preparing polymer-based smart fibers, such as metals, carbon-based materials, and natural and synthetic polymers, particularly conductive polymers, are summarized. In addition, this review summarizes key technologies used for preparing smart fibers and the conventional structures of smart textiles. furthermore, the applications of smart textiles in personal health monitoring, thermal management, energy capture and storage, and computation and displays are discussed. Finally, the current challenges, limitations, and future trends of smart fibers and textiles are discussed.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：