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Chinese Journal of Natural Medicines 2020年第8期18卷 628-632页

作者： ZOU Xiao-Peng QIN Chun-Jun HU Jing FU Jun-Jie tian guang-Zong MOSCOVITZ Oren SEEBERGER Peter H. YIN Jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Department of Biomolecular Systems Max Planck Institute of Colloids and InterfacesPotsdam 14476Germany Wuxi School of Medicine Jiangnan UniversityWuxi 214122China

D-Glycero-D-mannno-heptose 1β,7-bisphosphate(HBPβ)is an important intermediate for constructing the core structure of Gram-negative bacterial lipopolysaccharides and was reported as a pathogen-associated molecular pattern(PAMP)that regulates immune ***βwith 3-O-amyl amine linker and its monophosphate derivative D-glycero-D-mannno-heptose 7-phosphate(HP)with 1α-amyl amine linker have been synthesized as candidates for immunity study of HBPβ.The O3-amyl amine linker of heptose was installed by dibutyltin oxide-mediated regioselective alkylation under fine-tuned protecting *** stereoselective installation of 1β-phosphate ester was achieved by NIS-mediated phosphorylation at low *** strategy for installation of 3-O-amyl amine linker onto HBP derivative can be expanded to the syntheses of other conjugation-ready carbohydrates bearing anomeric phosphoester.

关键词： HBPβ-3-O-amyl amine HP-1α-O-amyl amine 3-O-Alkylation NIS-mediated phosphorylation

Orientational growth behavior and mechanism of delta(δ)phase precipitation in cold-rolled Inconel 718 alloy during heat treatment

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Journal of Iron and Steel Research International 2024年第1期31卷 264-274页

作者： Neng-yong Ye guang-liang Zhang tian-yue Huang Ming Cheng Shi-hong Zhang Lei Wang School of Materials Science&Engineering Taizhou UniversityTaizhou318000ZhejiangChina Institute of Metal Research Chinese Academy of SciencesShenyang110016LiaoningChina

Due to the important role ofδphase's quantity and morphology in the mechanical and fatigue properties of Inconel 718 alloy and its components,it is necessary to renew insights into the effect of cold deformation on theδphase precipitation,especially on the morphology ***,the nucleation and growth behavior ofδphase in cold-rolled Inconel 718 alloy during aging were *** results show that the precipitation rate and volume fraction ofδphase increase with increasing the cold rolling reduction from 10%to 50%.The volume fraction ofδphase reaches equilibrium after 5 h,remaining at 5.98%,6.52%,and 6.79%under different rolling reductions(10%,30%,and 50%),*** nucleation ofδphase mainly occurs on different sites(grain boundaries,new twin boundaries and old twin boundaries)under 10%rolling reduction,whileδphase mainly nucleates on the new grain boundaries of static recrystallization due to 50%rolling *** the growth ofδphase undergoes a process of alternate orientation growth from spherical(nucleation)→short rod(longitudinal orientation growth)→short rod(radial orientation growth)→dynamic *** 10%rolling reduction,δphase tends to grow into the matrix,while under 50%rolling reduction,the orientation grows faster and is easily affected by the grain boundary curvature.

关键词： Inconel 718 alloy Cold rolling δphase Orientation growth Morphology evolution

基于Wigner分布时频遮隔的信号分解算法

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电子学报 2008年第1期36卷 95-99,85页

作者：田光明陈光 电子科技大学自动化工程学院

综合特征值分解及Wigner分布时频遮隔提出了一种信号分解算法,并推广应用于其他交叉项抑制时频表示.对于由时频面上互不重叠分量合成的多分量信号,证明了信号分量可与各分量Wigner分布之和的逆Fourier变换的特征值分解相对应;通过阈值... 详细信息

综合特征值分解及Wigner分布时频遮隔提出了一种信号分解算法,并推广应用于其他交叉项抑制时频表示.对于由时频面上互不重叠分量合成的多分量信号,证明了信号分量可与各分量Wigner分布之和的逆Fourier变换的特征值分解相对应;通过阈值法可从抑制交叉项时频表示获得信号时频支撑区域,以此为模板遮隔Wigner分布可减少交叉项并保持自项聚集性,其逆Fourier变换的特征值分解就可实现多分量信号分解.仿真实例分析结果表明了该理论与算法的正确性和实用性.最后分析了算法性能并拓展了其实用范围.

关键词： Wigner分布时频遮隔特征值分解信号分解

Calculation of the Physical and Microdosimetric Parameters of Electron and Alpha-Particle Radiation Using Monte Carlo Simulations

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Chinese Physics Letters 2014年第3期31卷 181-183页

作者： GENG Jin-Peng CAO tian-guang LI Duo-Fang AN Hai-Long HAN Ying-Rong LI Jin HU Jin-Shan LI Nan-Nan ZHAN Yong Institute of Biophysics School of Sciences Hebei University of Technology Tianjin 300401

Various ionizing radiations, such as electrons and alpha particles, transfer their energy to media by produced secondary electrons and induce double- or single-strand break of DNA, which result in variable effects. To understand how the ionizing radiations interact with DNA and break it, several models have been developed, most of them consider the water as a vapor state. Actually, the ionizing particles interact with DNA which is solved in liquid water. To compare the difference of vapor and liquid water models, we calculate the stopping power, continuous slowing down approximation （CSDA） range and S value of electrons and alpha particles at cellular scale in liquid and vapor by Monte Carlo simulations, respectively. Our data show that the stopping power and CSDA range are different in liquid and vapor water in a special energy range. For many S values, the liquid model is better than the vapor model when the energy of the electrons is higher than 100 keV and the vapor model is higher than the liquid model for the 1 MeV alpha particles.

关键词： MICRODOSIMETRY RESEARCH ELECTRONS -- Research RADIATION NUCLEAR cluster model MONTE Carlo method

Effects of Alcohol Addition on the Deposition of Diamond Thick Films by dc Plasma Chemical Vapor Deposition Method

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Chinese Physics Letters 1998年第3期15卷 228-229页

作者： BAI Yi-zhen JIANG Zhi-gang WANG Chun-lei JIN Zeng-sun LÜXian-yi ZOU guang-tian National Laboratory of Superhard Materials Jilin UniversityChangchun 130023

Diamond films have been deposited by dc plasma chemical vapor deposition *** addition of alcohol in the resource gas largely increases the deposition *** effects of alcohol addition on deposition rate and film quality... 详细信息

关键词： Diamond alcohol film

Assessment of bearing performance degradation via extension and EEMD combined approach

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Journal of Central South University 2017年第5期24卷 1155-1163页

作者： LIU Yu-mei ZHAO Cong-cong XIONG Ming-ye ZHAO Ying-hui QIAO Ning-guo tian guang-dong Transportation College Jilin UniversityChangchun 130022China College of Engineering and Technology Jilin Agricultural UniversityChangchun 130118China University of Illinois at Urbana-Champaign IllinoisChampaign-Urbana 61801USA Engineering Department Changchun Visteon Faway Automotive Electronics Co.Ltd.Changchun 130011China

As a key component in rotating machinery, the operating reliability of bearing influences the performance and service life of the equipment directly. In order to describe bearing performance degradation(BPD) process effectively, an assessment approach combining extension and ensemble empirical mode decomposition(EEMD) was proposed. First, the extension was utilized to construct the matter-element of bearing operating state, and the energy moment of intrinsic mode functions(IMFs) was used as characteristic parameter of the matter-element. Then, to determine classical domains of characteristic parameters, the mathematical statistics method was adopted. Finally, the BPD was analyzed qualitatively and quantitatively according to the comprehensive correlation degree of bearing current operating state related to its healthy state. The analytic results of bearing test-rig show that the proposed method indicates the incipient fault approximately occurring in the 81 st hour, and the method also quantitatively presents the degree of BPD. By contrast, the BPD assessment based on time-domain features extraction method could not achieve the above two results effectively.

关键词： bearing performance degradation assessment extension ensemble empirical mode decomposition mathematical statistics

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产业补贴模式下的制造企业低碳生产行为选择

计算机集成制造系统 2018年第3期24卷 772-780页

作者：浦徐进田广江南大学商学院江苏无锡214122

为研究政府低碳产业补贴对处于不同市场地位的制造商低碳生产决策的影响,考察由领导型制造企业和追随型制造企业组成的双寡头市场,构建了双方的Stackelberg博弈模型。研究发现:补贴政策对不同企业低碳生产行为的激励效果不同,当补贴力... 详细信息

为研究政府低碳产业补贴对处于不同市场地位的制造商低碳生产决策的影响,考察由领导型制造企业和追随型制造企业组成的双寡头市场,构建了双方的Stackelberg博弈模型。研究发现:补贴政策对不同企业低碳生产行为的激励效果不同,当补贴力度达到某一阈值后,领导型企业率先选择低碳生产,随着补贴力度的进一步提高,追随型企业也将选择低碳生产;当企业面临较高的低碳产品生产成本和较低的消费者低碳偏好时,政府应该给予低碳企业较高的补贴;实现社会福利最大化的低碳补贴政策与消费者低碳偏好负相关,而与低碳产品减排标准、低碳产品环境效益、政府对环境的重视程度等因素正相关。

关键词：低碳生产补贴政策双寡头市场博弈模型

Chemical synthesis of a synthetically useful L-galactosaminuronic acid building block

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Chinese Journal of Natural Medicines 2022年第5期20卷 387-392页

作者： QIN Chun-Jun HOU Hong-Li DING Mei-Ru QI Yi-Kuan tian guang-Zong ZOU Xiao-Peng FU Jun-Jie HU Jing YIN Jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Wuxi School of Medicine Jiangnan UniversityWuxi 214122China

Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has been a promising approach to prepare well-defined oligosaccharides, facilitating the structure-activity relationship exploration and biomedical applications of bacterial glycans. L-Galactosaminuronic acid is a rare sugar that has been only found in cell surface glycans of gram-negative bacteria. Here, an orthogonally protected L-galactosaminuronic acid building block was designed and chemically synthesized. A synthetic strategy based on glycal addition and TEMPO/BAIB-mediated C6 oxidation served well for the transformation of commercial L-galactose to the corresponding L-galactosaminuronic acid. Notably, the C6 oxidation of the allyl glycoside was more efficient than that of the selenoglycoside. In addition, a balance between the formation of allyl glycoside and the recovery of selenoglycoside was essential to improve efficiency of the NIS/TfOH-catalyzed allylation. This synthetically useful L-galactosaminuronic acid building block will provide a basis for the syntheses of complex bacterial glycans.

关键词： L-galactosaminuronic acid Chemical synthesis Orthogonal protection Glycal addition C6 oxidation

Wurtzite Boron Nitride Crystal Growth in the Region of Cubic Boron Nitride Crystal Synthesizing

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Chinese Physics Letters 1998年第1期15卷 70-71页

作者： ZHANG Tie-chen YU San LI Dong-mei GUO Wei-li GAO Chun-xiao ZOU guang-tian National Key Laboratory for Superhard Materials Jilin UniversityChangchun 130023

Micro-grains of wurtzite boron nitride(wBN)crystal have been observed in the region of 5.0-7.0 GPa pressure and 1800-2000 K temperature where cubic boron nitride has been synthesized in the presence of a *** wBN grain size is about *** presence of these micro-grains indicates that the pressure for wBN growth could be lower than that found in the previous work.

关键词： catalyst boron Crystal

In vivo administration of Fms-like tyrosine kinase-3 ligand effectively stimulates lung dendritic cell expansion in mice

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Chinese Medical Journal 2012年第14期125卷 2562-2567页

作者： WANG Hong-wei LU Jiang-yang WANG Lin tian guang Department of Pathology First Affiliated Hospital of GeneralHospital of People's Liberation Army Beijing 100048 China Department of Stomatology General Hospital of People'sLiberation Army Beijing 100853 China

Background Dendritic ceils （DCs） are the most important professional antigen presenting cells that play a key role in initiating adaptive immune responses. The depletion and dysfunction of DCs contribute to the development of immunodeficiency or immunoparalysis in some lung diseases. In the present study, we investigated the effects of Fms-like tyrosine kinase-3 ligand （FIt3L） administration in vivo on lung DCs expansion to provide an experimental basis of FIt3L used as a potential therapeutic agent for the related lung disorders. Methods Balb/c mice were randomly divided into FIt3L group （n=10） and control group （n=10）. Each mouse in the FIt3L group received subcutaneous administration of FIt3L at a dose of 10 pg once daily for nine consecutive days. Lung histology was observed, and CD11c and CD205 were immunologically labeled in lung tissue sections. Low-density lung cells were separated by density gradient centrifugation, and then subsets and MHC-II/I-Ad expression of DCs were analyzed by flow cytometry. Results In the FIt3L group the number and density of DC-like cells were markedly increased compared with the control group, mainly distributed in the alveolar septa. Immunological labeling in situ found that there were significantly higher numbers of CD11c＋ and CD205＋ DCs in lung mesenchymal tissue （P 〈0.05）, where they formed a denser reticular formation. Flow cytometry analysis demonstrated that the proportions of myeloid CD11c＋CD11b＋ DCs and plasmacytoid CD11c＋CD45R/B220＋ DCs in the low-density lung cells in the FIt3L group were significantly higher compared with the control group; showing 3.17- and 3.3-fold increase respectively （P 〈0.05）. The proportion of CD11c＋ DCs expressing MHC-II/I-Ad＋ was significantly increased, with a 2.7-fold increase as compared with the control group （P 〈0.05）. Conclusions FIt3L administration in vivo induces lung DCs expansion, favoring myeloid and plasmacytoid DC subsets, which are phenotypically more mature. FIt3L may be useful

关键词： Fins-like tyrosine kinase-3 ligand lung, dendritic cell, MHC-II CD205