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基于CT影像组学术前预测淋巴结阴性胃癌淋巴血管侵犯

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中国医学影像学杂志 2024年第1期32卷 73-80页

作者：娄飞飞陈青青黄昊王芳何杰辛恩慧胡红杰浙江大学医学院附属邵逸夫医院放射科浙江杭州310000 湖州市南浔区人民医院放射科浙江湖州313000 上海联影智能医疗科技有限公司上海200030

目的探讨基于CT影像组学术前预测淋巴结阴性胃癌淋巴血管侵犯(LVI)的价值,并结合临床变量构建列线图。资料与方法回顾性分析浙江大学医学院附属邵逸夫医院2019年1月—2021年6月173例淋巴结阴性且病理证实为胃癌患者的临床及CT影像,其中... 详细信息

目的探讨基于CT影像组学术前预测淋巴结阴性胃癌淋巴血管侵犯(LVI)的价值,并结合临床变量构建列线图。资料与方法回顾性分析浙江大学医学院附属邵逸夫医院2019年1月—2021年6月173例淋巴结阴性且病理证实为胃癌患者的临床及CT影像,其中LVI阳性60例,LVI阴性113例,按7∶3随机分为训练组(n=121)和验证组(n=52)。基于训练组分别构建临床模型、影像组学模型、融合模型,并在验证组进行验证。临床资料和常规CT特征包括年龄、性别、肿瘤指标、肿瘤部位、肿瘤形态、强化幅度等,通过单因素及多因素分析筛选出临床显著变量并建立临床模型。用3D-Slicer软件勾画肿瘤感兴趣区并提取影像组学特征,用最小绝对值收缩和选择算子降维筛选特征,然后通过随机森林构建影像组学模型,并转化为随机森林评分。联合临床显著变量和随机森林评分构建融合模型并可视化为列线图。根据受试者工作特征曲线及曲线下面积(AUC)评估模型的预测效能,采用决策曲线分析评估临床实用性。结果影像组学模型优于临床模型,训练组和验证组中影像组学模型AUC分别为0.872(0.810~0.935)、0.827(0.707~0.947),临床模型AUC分别为0.767(0.682~0.852)、0.761(0.610~0.913)。列线图的预测效能得到进一步提高,AUC分别为0.898(0.842~0.953)、0.844(0.717~0.971)。决策曲线分析显示列线图的临床价值。结论本研究构建的影像组学模型可用于术前预测淋巴结阴性胃癌患者LVI状态,列线图可进一步提高预测效能。

关键词：胃肿瘤影像组学淋巴结阴性淋巴血管侵犯体层摄影术 X线计算机

Ultralong Organic Phosphorescence of Triazatruxene Derivatives for Dynamic Data Encryption and Anti-counterfeiting

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Chinese Journal of Chemistry 2023年第18期41卷 2261-2268页

作者： Baoshuai Liang Wei An jie Liu Yu Dong Shiyu Feng Weiguo huang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China FuzhouFujian 350002China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China

Comprehensive Summary,Organic luminogens with persistent room temperature phosphorescence(RTP)have drawn tremendous attentions due to their promising potentials in optoelectronic devices,information storage,biological imaging,and *** this work,six triazatruxene-based lumiogens with different peripheral substituents and configurations are synthesized and systematically *** results show that their fluorescence quantum yields in solid states range from 15.73%to 37.58%.Dispersing the luminogens as guest into the host(PPh_(3))could turn on the persistent RTP,where PPh_(3)acts as not only a rigid matrix to suppress the non-radiative transitions of the guest,but also provides energy transfer channels to the *** maximum phosphorescence efficiency and the longest lifetime could reach 29.35%and 0.99 s in co-crystal films of 6-TAT-CN/PPh_(3)and 5-TAT-H/PPh_(3),***,these host-guest co-crystalline films exhibit great potentials in advanced dynamic data encryption and *** work deepens the insight for low cost,halogen-free,and facile fabrication of all-organic persistent RTP materials.

关键词： Room temperature phosphorescence Host-guest systems Energy transfer Data encryption Anti-counterfeiting Fluorophores

云南省“直过民族”中老年人抑郁症状的相关因素

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中国心理卫生杂志 2024年第8期38卷 666-673页

作者：王辛平陈杰杜兴梅邓春燕黄源邵维庆邓睿昆明医科大学公共卫生学院昆明650500

目的:了解云南“直过民族”中老年人的抑郁症状检出现状及相关因素。方法:采用分层整群抽样,通过9条目患者健康问卷(PHQ-9)对1035名“直过民族”中老年人的抑郁症状进行测量(总分≥5分判定为有抑郁症状),通过自编问卷调查社会人口学、... 详细信息

目的:了解云南“直过民族”中老年人的抑郁症状检出现状及相关因素。方法:采用分层整群抽样,通过9条目患者健康问卷(PHQ-9)对1035名“直过民族”中老年人的抑郁症状进行测量(总分≥5分判定为有抑郁症状),通过自编问卷调查社会人口学、社会人际网络、心理健康状况、身体健康状况和健康行为5维度的24个变量信息。结果:存在抑郁症状231人(22.32%)。Logistic回归分析显示,职业为工人(OR=8.73)或农民(OR=7.34)或其他(OR=7.13)、近1月内感到紧张或焦虑(OR=5.43)、患1种(OR=2.81)或多种慢性病(OR=2.14)、存在睡眠问题(OR=3.74)、衰弱(OR=1.69)、轻中度疼痛(OR=2.23、4.37)和久坐(OR=2.27)的中老年人抑郁症状发生风险较高;社会支持得分(OR=0.96)和生命意义感得分(OR=0.96)较高的中老年人,抑郁症状发生风险较低。结论:云南省“直过民族”中老年人抑郁症状检出率不低,且受多种因素影响。

关键词：直过民族中老年抑郁症状相关因素

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Journal of Mountain Science 2020年第10期17卷 2497-2511页

作者： WANG Xiao-qun huang Xin SHEN Man ZHOU Zhou WEI jie State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China College of Environment and Civil Engineering Chengdu University of TechnologyChengdu610059China Anhui Xinhua University Hefei230088China

The Diexi ancient dammed lake is in the upper reaches of the Minjiang *** terraces with lacustrine sediments occur at the *** terraces are the products of the graded outburst of the Diexi ancient dammed *** outburst of the ancient dammed lake would certainly have had an impact on the Chengdu Plain in the lower reaches of the Minjiang *** this paper,on-site sampling and laboratory analysis were used to analyze the sediments of the Diexi ancient dammed lake and the Jinsha site in Chengdu Plain,and the environmental indicators of each sediment layer were *** a comparative analysis of the environmental indicators in the sediments at the two locations,the following results were obtained:the palaeoclimatic and palaeoenvironmental characteristics at the two locations generally show consistent *** most important finding is that the types and content of the major pollen taxa at the two locations are *** Pinus content strongly proves that the soil layers at the Jinsha site was sourced from the upper reaches of the Minjiang *** that the demise of the ancient culture at the Jinsha site occurred close in time to the outburst of the ancient dammed lake,this similarity suggests that the cultural change at the Jinsha site may have been related to the outburst of the Diexi ancient dammed lake.

关键词： Minjiang River Diexi ancient dammed lake Jinsha site Palaeoclimate Palaeoenvironment

半夏炮制过程中毒性凝集素蛋白的基质辅助激光解吸电离飞行时间质谱分析

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质谱学报 2024年第2期45卷 226-236页

作者：黄益曼李春晖柏家辉陆颖洁李添董志颖苏越郭寅龙上海中医药大学交叉科学研究院上海201203 中国科学院上海有机化学研究所金属有机化学国家重点实验室上海200032 上海中医药大学中药学院上海201203

基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)受灵敏度和重复性的影响,对完整蛋白的定量分析存在困难。本研究采用纤维素纳米晶体(CNC)辅助MALDI-TOF MS,结合内标法定量分析半夏炮制过程中半夏凝集素(PTL),通过优化CNC辅助样本制备... 详细信息

基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)受灵敏度和重复性的影响,对完整蛋白的定量分析存在困难。本研究采用纤维素纳米晶体(CNC)辅助MALDI-TOF MS,结合内标法定量分析半夏炮制过程中半夏凝集素(PTL),通过优化CNC辅助样本制备的时长和比例,以麦胚凝集素(TVL)为内标,直接分析不同炮制程度半夏各炮制品及其浸泡上清液中PTL含量。结果表明,CNC辅助MALDI样本制备有效提升了MALDI-TOF MS定量分析的线性和重复性。随着炮制时间的延长,姜半夏、清半夏和法半夏炮制品的PTL含量逐渐下降,浸泡上清液中PTL含量逐渐上升。其中,由于pH值的改变,法半夏炮制品浸泡上清液中PTL含量呈先上升后下降的趋势。此外,将该方法应用于不同饮片生产企业的多批次半夏炮制品饮片中,均未检出PTL。该方法操作简便,可有效分析半夏炮制过程中PTL含量的变化,为研究半夏炮制过程对PTL的影响提供了参考。

关键词：半夏炮制方法半夏凝集素(PTL) 纤维素纳米晶体(CNC) 基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)

mRNA-based modalities for infectious disease management

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Nano Research 2023年第1期16卷 672-691页

作者： Mengjie Zhang Abid Hussain Haiyin Yang Jinchao Zhang Xing-jie Liang Yuanyu huang School of Life Science Advanced Research Institute of Multidisciplinary ScienceSchool of Medical Technology(Institute of Engineering Medicine)Key Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China School of Materials and the Environment Beijing Institute of TechnologyZhuhai 519085China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education College of Chemistry and Environmental ScienceHebei UniversityBaoding 071002China Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of ChinaBeijing 100190China

The novel coronavirus disease 2019(COVID-19)is still rampant all over the world,causing incalculable losses to the *** pharmaceutical organizations around the globe are focusing on vaccine research and drug development to prevent further damage caused by the *** messenger RNA(mRNA)technology has got ample of attention after the success of the two very effective mRNA vaccines during the recent pandemic of *** vaccine has been promoted to the core stage of pharmaceutical industry,and the rapid development of mRNA technology has exceeded *** COVID-19,the mRNA vaccine has been tested for various infectious diseases and undergoing clinical *** to the ability of constant mutation,the viral infections demand abrupt responses and immediate production,and therefore mRNA-based technology offers best answers to sudden *** need for mRNA-based vaccine became more obvious due to the recent emergence of new Omicron *** this review,we summarized the unique properties of mRNA-based vaccines for infectious diseases,delivery technologies,discussed current challenges,and highlighted the prospects of this promising technology in the *** also discussed various clinical studies as well preclinical studies conducted on mRNA therapeutics for diverse infectious diseases.

关键词： messenger RNA(mRNA)vaccine lipid-nanoparticle infectious disease drug delivery coronavirus disease 2019(COVID-19) virus

Assessing recent recurrence after hepatectomy for hepatitis Brelated hepatocellular carcinoma by a predictive model based on sarcopenia

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World Journal of Gastroenterology 2024年第12期30卷 1727-1738页

作者： Hong Peng Si-Yi Lei Wei Fan Yu Dai Yi Zhang Gen Chen Ting-Ting Xiong Tian-Zhao Liu Yue huang Xiao-Feng Wang Jin-Hui Xu Xin-Hua Luo Department of Infectious Diseases Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Department of Hepatobiliary Surgery Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

BACKGROUND Sarcopenia may be associated with hepatocellular carcinoma(HCC)following *** traditional single clinical variables are still insufficient to predict *** still lack effective prediction models for recent recurrence(time to recurrence5 cm(HR=2.222,95%CI:1.285-3.842,P<0.05),and hepatitis B virus DNA level≥2000 IU/mL(HR=2.1,95%CI:1.407-3.135,P<0.05)were independent risk factors associated with postoperative recurrence of *** on the sarcopenia to assess the RFS model of hepatectomy with hepatitis B-related liver cancer disease(SAMD)was established combined with other the above risk *** area under the curve of the SAMD model was 0.782(95%CI:0.705-0.858)in the training cohort(sensitivity 81%,specificity 63%)and 0.773(95%CI:0.707-0.838)in the validation ***,a SAMD score≥110 was better to distinguish the high-risk group of postoperative recurrence of *** Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-rel

关键词： Alpha-fetoprotein Hepatitis B virus Hepatectomy Hepatocellular carcinoma Nomogram Predictive models Recurrence Recurrence-free survival Risk factors Sarcopenia

选区激光熔化成形TiC/TC4复合材料的工艺参数与组织演变研究

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中国激光 2024年第16期51卷 155-167页

作者：黄宏康罗霞戴玉宏何鑫刘允中黄本生范舟西南石油大学新能源与材料学院四川成都610500 华南理工大学国家金属材料近净成形工程技术研究中心广东广州510640 成都新杉宇航科技有限公司四川成都610500

钛基复合材料具有高弹性模量、高比强度、高耐磨性和优异的高温耐久性等特点,在航空航天领域有良好的应用前景。采用低能球磨制备了纳米TiC颗粒与TC4的复合粉体,然后使用选区激光熔化(SLM)制备了TiC/TC4钛基复合材料,分析了不同体能量密... 详细信息

钛基复合材料具有高弹性模量、高比强度、高耐磨性和优异的高温耐久性等特点,在航空航天领域有良好的应用前景。采用低能球磨制备了纳米TiC颗粒与TC4的复合粉体,然后使用选区激光熔化(SLM)制备了TiC/TC4钛基复合材料,分析了不同体能量密度(29~97 J/mm^(3))对复合材料成形质量、显微组织、显微硬度的影响,并总结了组织演变机理和TiC演变过程。结果表明,成形该复合材料的最佳体能量密度为50~70 J/mm^(3),在该范围内试样的最高相对密度可达99.7%,显微硬度为385~392 HV。横截面上,显微组织的晶粒呈特殊的双尺寸分布,即由初生β等轴晶和沿其外围生长的不规则共晶区组成;纵截面上,显微组织呈鱼鳞状形貌分布且熔池内存在大量流纹状组织。复合材料中存在未溶TiC(主要分布于初生β晶界附近)、共晶TiC(主要呈链状网络分布于共晶β晶界)以及沉淀析出TiC(主要呈颗粒状分布于晶粒内)。随着体能量密度的增加,链状共晶TiC向棒状转变,晶内TiC尺寸长大。共晶TiC与β-Ti没有取向关系,共晶TiC、沉淀析出TiC与α'-Ti均存在明显取向关系,即{11-20}α'-Ti//{110}TiC。

关键词：激光技术钛基复合材料选区激光熔化显微组织演变 TiC演变

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial

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Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tieming Xie Xing Zhang Xiaoxuan Wang Jing huang Yiqiang Tang Zhigang Liu Guoping Shen Chaoming Li Fangxiao Lu Lei Wang Fagui Jiang Caixing Sun Yuanyuan Chen Ming Chen Department of Radiation Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Radiation Oncology Yuebei People’s Hospital Affiliated to the Medical College of Shantou UniversityShaoguan 512026China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 311403China Department of Radiation Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Chinese Academy of SciencesHangzhou 310022China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.LtdNanjing 210000China Department of Radiation Oncology The Affiliated Huai’an First People’s Hospital of Nanjing Medical UniversityHuai’an 223399China Department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang UniversityNanchang 330029China Department of Radiotherapy Dongguan Institute of Clinical Cancer ResearchDongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523059China The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 519000China Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Oncology Maoming People’s HospitalMaoming 525000China Department of Radiation Oncology Kecheng District People’s HospitalQuzhou 324003China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou 510060China United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University&Chinese Academy of Sciences Ion Medical Technology Co. LtdGuangzhou 510060China

Objective:Glioblastomas are highly vascularized malignant *** determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed ***:This multicenter,single-arm trial(NCT04119674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November *** underwent treatment with the standard STUPP regimen[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2)of body surface area/d,7 d/w from the first to the last day of radiotherapy),followed by 6 cycles of adjuvant TMZ(150-200 mg/m^(2)×5 d during each 28-d cycle)plus anlotinib(8 mg/d on d 1-14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/*** primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned *** median PFS was 10.9 months(95%CI,9.9-18.7 months)and the 12-month PFS rate was 48.5%.The median OS was 17.4 months(95%CI,14.5-21.1 months)and the 12-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=19)],hypoalbuminemia[46%(n=15)],and hypercholesterolemia[46%(n=15)]during concurrent chemoradiotherapy and leukopenia[73%(n=24)],hypertriglyceridemia[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant *** patients discontinued treatment due to ***1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter ***:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable ***1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.

关键词： Glioblastoma anti-angiogenesis multi-kinase inhibitor anlotinib temozolomide progression-free survival