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NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase rl in response to oxidative DNA damage

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Protein & Cell 2018年第4期9卷 365-379页

作者： Junhong guan Shuyu Yu Xiaofeng zheng State Key Lab of Protein and Plant Gene Research School of Life Sciences Peking University Beijing 100871 China Department of Biochemistry and Molecular Biology School of Life Sciences Peking University Beijing 100871 China

NEDDylation has been shown to participate in the DNA damage pathway, but the substrates of neural precursor cell expressed developmentally downregulated 8 （NEDD8） and the roles of NEDDylation involved in the DNA damage response （DDR） are largely unknown. Translesion synthesis （TLS） is a damage-tolerance mechanism, in which RAD181RAD6-mediated monoubiq- uitinated proliferating cell nuclear antigen （PCNA） pro- motes recruitment of polymerase q （polq） to bypass lesions. Here we identify PCNA as a substrate of NEDD8, and show that E3 ligase RAD18-catalyzed PCNA NEDDylation antagonizes its ubiquitination. In addition, NEDP1 acts as the deNEDDylase of PCNA, and NEDP1 deletion enhances PCNA NEDDylation but reduces its ubiquitination. In response to H202 stimulation, NEDP1 disassociates from PCNA and RAD18-dependent PCNA NEDDylation increases markedly after its ubiquitination. impairment of NEDDylation by Ubc12 knockout enhances PCNA ubiquitination and promotes PCNA-polη interaction, while up-regulation of NEDDylation by NEDD8 overexpression or NEDP1 deletion reduces the excessive accumulation of ubiquitinated PCNA, thus inhibits PCNA-polη interaction and blocks polη foci formation. Moreover, Ubc12 knockout decreases cell sensitivity to H2O2-induced oxidative stress, but NEDP1 deletion aggravates this sensitivity. Collectively, our study elucidates the important role of NEDDylation in the DDR as a modulator of PCNA monoubiquitination and polη recruitment.

关键词： NEDDylation ubiquitination PCNA,oxidative stress DNA damage response

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Heteroscedasticity and/or Autocorrelation Checks in Longitudinal Nonlinear Models with Elliptical and AR(1) Errors

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Acta Mathematicae Applicatae Sinica 2012年第1期28卷 49-62页

作者： Chun-zheng CAO Jin-guan LIN College of Math&Physics Nanjing University of Information Science&TechnologyNanjing 210044China Department of Mathematics Southeast UniversityNanjing 210096China

The aim of this paper is to study the tests for variance heterogeneity and/or autocorrelation in nonlinear regression models with elliptical and AR（1） errors. The elliptical class includes several symmetric multivariate distributions such as normal, Student-S, power exponential, among others. Several diagnostic tests using score statistics and their adjustment are constructed. The asymptotic properties, including asymptotic chi-squave and approximate powers under local alternatives of the score statistics, are studied. The properties of test statistics are investigated through Monte Carlo simulations. A data set previously analyzed under normal errors is reanalyzed under elliptical models to illustrate our test methods.

关键词： autocorrelation elliptical distributions heteroscedasticity longitudinal data nonlinear model,score test

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Combination for Conflicting Interval-Valued Belief Structures with CSUI-DST Method

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Chinese Journal of Electronics 2022年第5期31卷 980-990页

作者： LI Shuangming guan Xin yi Xiao SUN Guidong Naval Aviation University Unit 92941 of PLA Unit 32801 of PLA

Since the basic probability of an intervalvalued belief structure(IBS) is assigned as interval number, its combination becomes difficult. Especially, when dealing with highly conflicting IBSs, most of the existing combination methods may cause counter-intuitive results,which can bring extra heavy computational burden due to nonlinear optimization model, and lose the good property of associativity and commutativity in Dempster-Shafer theory(DST). To address these problems, a novel conflicting IBSs combination method named CSUI(conflict,similarity, uncertainty, intuitionistic fuzzy sets)-DST method is proposed by introducing a similarity measurement to measure the degree of conflict among IBSs, and an uncertainty measurement to measure the degree of discord, non-specificity and fuzziness of IBSs. Considering these two measures at the same time, the weight of each IBS is determined according to the modified reliability degree. From the perspective of intuitionistic fuzzy sets, we propose the weighted average IBSs combination rule by the addition and number multiplication operators. The effectiveness and rationality of this combination method are validated with two numerical examples and its application in target recognition.

关键词： interval-valued belief structure inference mechanisms interval number reliability degree fuzzy set theory uncertainty measurement DST CSUI uncertainty handling Dempster-Shafer theory similarity measurement weighted average IBSs combination rule reliability conflict similarity uncertainty intuitionistic fuzzy sets

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Boundary points, minimal L^(2) integrals and concavity property Ⅱ: Weakly pseudoconvex Kähler manifolds

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Science China Mathematics 2024年第7期67卷 1665-1718页

作者： Qi’an guan Zhitong Mi zheng Yuan School of Mathematical Sciences Peking UniversityBeijing100871China School of Mathematics and Statistics Beijing Jiaotong UniversityBeijing100044China Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100190China

In this paper, we consider minimal L^(2) integrals on the sublevel sets of plurisubharmonic functions on weakly pseudoconvex K?hler manifolds with Lebesgue measurable gain related to modules at boundary points of the sublevel sets, and establish a concavity property of the minimal L^(2) integrals. As applications, we present a necessary condition for the concavity degenerating to linearity, a concavity property related to modules at inner points of the sublevel sets, an optimal support function related to modules, a strong openness property of modules and a twisted version, and an effectiveness result of the strong openness property of modules.

关键词： minimal L^(2)integrals plurisubharmonic functions boundary points weakly pseudoconvex K?hler manifold

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Heterogeneous information network embedding with incomplete multi-view fusion

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Frontiers of Computer Science 2022年第5期16卷 221-223页

作者： Susu zheng Weiwei YUAN Donghai guan College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211100China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 211100China

1 Introduction and main contributions Multi-view based HIN embedding method embeds the multiple views of heterogeneous information networks(HIN)to the low-dimensional *** can preserve rich structural and semantic information by using HIN data of multiple views[1,2].In real networks,relations are partially observed due to privacy issues or other reasons,resulting in the incompleteness of single view[3,4].Existing methods usually ignore this problem,which lead to data sparse and it is difficult to extract the hidden semantic relationship of HIN.

关键词： network incomplete networks

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Special Conditional Similarity Reduction Solutions for Two Nonlinear Partial Differential Equations

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Communications in Theoretical Physics 2007年第2X期48卷 199-204页

作者： MA zheng-yi Department of Mathematics Zhejiang Lishui University Lishui 323000 China Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China

We present a method of special conditional similarity reduction solutions for nonlinear partial differential equations, As concrete examples of its application, we apply this method to the （2＋1）-dimensional modified Broer- Kaup equations and the variable coefficient KdV-mKdV equation, which have extensive physics backgrounds, and obtain abundant exact solutions derived from some reduction equations.

关键词： conditional similarity reduction (2+1)-dimensional modified Broer-Kaup equations

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A Better Candidate for Dark Matter is Cosmic Plasma

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Research in Astronomy and Astrophysics 2023年第10期23卷 277-280页

作者： yi-Jia zheng National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

In the ΛCDM cosmological model, based on observations of supernovae Ia, the cosmic dark energy density is assumed to be Ω_(Λ)~ 0.70 and the gravitational mass density is assumed to be Ω_(m)~ 0.30. Based on the assumption that the observed cosmic microwave background(CMB) is a thermal relic of the early hot universe, the cosmic plasma density should be small, i.e., Ω_(b)~ 0.05(otherwise the Sunyaev-Zeldovich effect of the cosmic plasma would ruin the observed CMB's perfect blackbody spectrum). To fill the gap between Ω_(m) and Ω_(b), non-baryonic dark matter Ω_(c)~ 0.25 is introduced into the ΛCDM model. If the CMB is the result of a partial thermal equilibrium between cosmic radiation and cosmic plasma, then the observed perfect blackbody spectrum of the CMB can coexist with cosmic plasma. In this case, it is not necessary to introduce non-baryonic cold dark matter into cosmological models. A better candidate for dark matter is the cosmic plasma.

关键词： cosmology:theory (cosmology:)dark matter gravitational lensing:weak X-rays:galaxies:clusters

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Effect of Cosmic Plasma on the Observation of Supernovae Ia

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Research in Astronomy and Astrophysics 2024年第2期24卷 46-49页

作者： yi-Jia zheng National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

In observational cosmology,a supernova la is used as a standard candle in order to extend the Hubble diagram to a higher redshift *** found that the observed brightness of high redshift supernovae la is dimmer than *** dimming effect is considered observational evidence for the existence of dark energy in the *** should be noted that this conclusion is based on an assumption that the mass density of the cosmic plasma is very ***,the dimming effect caused by the Compton scattering of free electrons in cosmic plasma can be neglected.X-ray observations suggest that the mass density of the cosmic plasma may be very *** theory,the observed dimming effect of high redshift supernovae Ia may be caused by the Compton scattering of free electrons in the cosmic *** this paper it will be shown that this idea is ***,there is no need to introduce the confusing concept of dark energy into cosmology.

关键词： Cosmology-cosmology observations-cosmology theory-(cosmology:)dark energy-(cosmology:)listance scale-X-rays diffuse background-plasmas-opacity

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Endogenous/exogenous dual stimulation“ROS engineering”amplification combined with autophagy-augmented for efficient ferroptosis therapy

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Nano Research 2025年第1期18卷 597-606页

作者： Pengye Du Pengpeng Lei Yuan Liang Ran An yi Wei Shuyu Liu Jianhao zheng Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry Tsinghua UniversityBeijing 100084China

“Reactive oxygen species(ROS)engineering”is one of the most promising anti-tumor treatments developed in recent *** explosion of ROS will cause oxidative stress,thereby inducing tumor cell ***,ROS accumulation in tumor cells is eliminated by endogenous cellular self-regulation *** this work,a kind of endogenous/exogenous dual stimulation nanoagent noted as UMZC is *** reaction occurs between NH_(2)-MIL-88B(Fe)contained in UMZC and the overexpression of endogenous H_(2)O_(2)to generate ROS,amplified by endogenous H_(2)S of colon tumor *** addition,NH_(2)-MIL-88B(Fe)also functions to deplete glutathione(GSH)for stopping it from consuming *** nanoparticles at the core of UMZC convert near-infrared into visible light,which excites zinc phthalocyanine to initiate the photochemical reaction that generates more ROS,thus alleviating the lack of tissue penetration depth for visible *** agonist chitosan oligosaccharides induce enhancement of cellular autophagy for disrupting cellular metabolic stress and the resistance to oxidative stress of tumor cells,allowing“ROS engineering”to fully exert anti-tumor *** of ROS generation,GSH depletion,and induced cellular autophagy caused by nanoagents have promoting effects on the occurrence of ***,the nanoagents show the ability to effectively treat colon tumors.

关键词： reactive oxygen species(ROS)engineering upconversion nanoparticles cellular autophagy ferroptosis tumor therapy

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Diabetes mellitus is a risk factor of acute kidney injury in liver transplantation patients

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 215-221页

作者： Yu-Jia Wang Jian-Hua Li yi guan Qiong-Hong Xie Chuan-Ming Hao zheng-Xin Wang Division of Nephrology Huashan HospitalFudan UniversityShanghai 200040China Division of General Surgery Huashan HospitalFudan UniversityShanghai 200040China

Background: Diabetes mellitus has become an increasing global health burden with rapid growing prevalence. Patients with diabetes have higher susceptibility to acute kidney injury(AKI). Liver transplantation(LT) predisposes the kidney to injury. However, the association between diabetes and AKI in LT patients remains unclear. Methods: We conducted a retrospective cohort study examining risk factors for AKI in patients undergone orthotopic LT. Potential risk factors including baseline estimated glomerular filtration rate(e GFR), the model for end-stage liver disease(MELD) score, diabetes, hypertension and intraoperative blood loss were screened. The primary endpoint was AKI occurrence. Multivariate logistic regression was used to analyze the association between potential risk factors and AKI. Results: A total of 291 patients undergone orthotopic LT were included in the present study. Among them, 102 patients(35.05%) developed AKI within 5 days after LT. Diabetes was identified as an independent risk factor for AKI. Patients who developed AKI had worse graft function recovery and higher mortality within 14 days after LT compared to those who did not develop AKI. AKI patients with diabetes had a significant decline of e GFR within the first postoperative year, compared with patients who did not develop AKI and who developed AKI but without diabetes. Conclusions: Diabetes is an independent risk factor for AKI after orthotopic LT. AKI is associated with delayed graft function recovery and higher mortality in short-term postoperative period. Diabetic patients who developed AKI after LT experience a faster decline of e GFR within the first year after surgery.

关键词： Acute kidney injury Liver transplantation Diabetes Renal function

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