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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： yi Wang Yuning Li Yakun Gu Wei Ma Yuying guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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船舶留置权法律制度的特殊性

中国海商法年刊 2009年第3期20卷 67-71页

作者：关正义孙光大连海事大学法学院辽宁大连116026 大连海事法院辽宁大连116001

对船舶留置权、以船舶为客体的留置权和一般留置权的法律定义进行比较,分析船舶留置权所担保的债权合同、被占有船舶的权属、受偿顺序以及实现方式等特殊内容,指出完全以一般留置权的法律规定适用于船舶留置权,无法公平有效地解决船舶... 详细信息

对船舶留置权、以船舶为客体的留置权和一般留置权的法律定义进行比较,分析船舶留置权所担保的债权合同、被占有船舶的权属、受偿顺序以及实现方式等特殊内容,指出完全以一般留置权的法律规定适用于船舶留置权,无法公平有效地解决船舶留置权在实践中遇到的各种问题,《中华人民共和国海商法》有必要另行规定船舶留置权法律制度,以维护相关各方的合法权益。

关键词：船舶留置权以船舶为客体的留置权一般留置权

论航次承租人海事赔偿责任限制权利问题——兼谈《中华人民共和国海商法》第204条的修改

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中国海商法研究 2021年第4期32卷 60-70页

作者：关正义严凌成大连海事大学法学院辽宁大连116026

《中华人民共和国海商法》第204条第2款并未明确说明航次承租人能否享有海事赔偿责任限制权利,导致当前学术界和实务界对此有很大争议。有必要从现代海事赔偿责任限制的权利基础、责任限制公约的立法背景、三类租船合同中的法律关系和... 详细信息

《中华人民共和国海商法》第204条第2款并未明确说明航次承租人能否享有海事赔偿责任限制权利,导致当前学术界和实务界对此有很大争议。有必要从现代海事赔偿责任限制的权利基础、责任限制公约的立法背景、三类租船合同中的法律关系和英美法的视角等不同层面,论证在将船舶转租给实际货主时赋予航次承租人海事赔偿责任限制权利具有正当性,且符合现代海事赔偿责任限制制度所要求的分摊海上风险和追求商法效率的价值取向。同时,建议对《中华人民共和国海商法》第204条作出适当修改。

关键词：海事赔偿责任限制航次承租人《中华人民共和国海商法》修改

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju zheng yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao zhengwei Wang Zhizhong guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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CLC油污民事责任公约适用的若干法律问题

沈阳师范大学学报（社会科学版） 2007年第6期31卷 102-106页

作者：关正义林鹏鸠大连海事大学辽宁大连116001 大连恒信律师事务所辽宁大连116001

CLC油污民事责任公约的适用范围能否扩大到国内案件,"谁漏油,谁赔偿"的原则在实践中是否存在其局限性,CLC公约与国内法适用上带来的不同法律后果如何以制订专门的油污损害民事责任法律制度加以解决,是研究海上油污损害民事责任需要认真... 详细信息

CLC油污民事责任公约的适用范围能否扩大到国内案件,"谁漏油,谁赔偿"的原则在实践中是否存在其局限性,CLC公约与国内法适用上带来的不同法律后果如何以制订专门的油污损害民事责任法律制度加以解决,是研究海上油污损害民事责任需要认真思考的问题。

关键词： CLC公约油污损害民事赔偿责任责任主体

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无船承运人相关法律问题研究

中国海商法年刊 2006年第1期18卷 101-115页

作者：关正义陈敬根大连海事法院大连海事大学法学院辽宁大连116026 大连海事大学法学院

在分析了无船承运人基本特征的基础上,就无船承运人的识别、无船承运人海事赔偿责任的限制、无船承运人的货物留置权、无船承运人履约能力保证等问题进行了探讨。

关键词：无船承运人识别海事赔偿责任限制货物留置权

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli Si Naijia Xue yi Liu Ran zheng ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo zheng Yu-Tao zheng yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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同方期刊数据库

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船舶抵押权登记若干法律问题研究

中国海商法年刊 2011年第2期22卷 68-72页

作者：关正义刘安宁大连海事大学法学院辽宁大连116026 大连海事法院辽宁大连116001 辽宁师范大学法学院辽宁大连116029

船舶抵押权登记在中国具有"相对的公信力",未经登记不能对抗的"第三人"包括已另行设立且登记的船舶抵押权人以及依法律行为取得船舶所有权的所有权人,船舶抵押权登记日期依申请日确定比较合理,不应允许对抵押金额及抵押期限予以登记,应... 详细信息

船舶抵押权登记在中国具有"相对的公信力",未经登记不能对抗的"第三人"包括已另行设立且登记的船舶抵押权人以及依法律行为取得船舶所有权的所有权人,船舶抵押权登记日期依申请日确定比较合理,不应允许对抵押金额及抵押期限予以登记,应建立船舶抵押权登记请求权制度和登记错误的补救机制。

关键词：船舶抵押权登记登记请求权