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Cortical neurogenesis in adult rats after ischemic brain injury: most new neurons fail to mature

Neural Regeneration Research 2015年第2期10卷 277-285页

作者： Qing-quan Li guan-qun qiao Jun Ma Hong-wei Fan Ying-bin Li Department of Neurosurgery the Second Affiliated Hospital of Nanjing Medical University Department of Neurosurgery the First Hospital of Nanjing Medical University

The present study examines the hypothesis that endogenous neural progenitor cells isolated from the neocortex of ischemic brain can differentiate into neurons or glial cells and contribute to neural regeneration. We performed middle cerebral artery occlusion to establish a model of cerebral ischemia/reperfusion injury in adult rats. Immunohistochemical staining of the cortex 1, 3, 7, 14 or 28 days after injury revealed that neural progenitor cells double-positive for nestin and sox-2 appeared in the injured cortex 1 and 3 days post-injury, and were also positive for glial ifbrillary acidic protein. New neurons were labeled using bromodeoxyuridine and different stages of maturity were identiifed using doublecortin, microtubule-associated protein 2 and neuronal nuclei antigen immunohistochemistry. Immature new neurons coexpressing doublecortin and bromodeoxyuridine were observed in the cortex at 3 and 7 days post-injury, and semi-mature and mature new neurons double-positive for microtubule-associated protein 2 and bromode-oxyuridine were found at 14 days post-injury. A few mature new neurons coexpressing neuronal nuclei antigen and bromodeoxyuridine were observed in the injured cortex 28 days post-injury. Glial ifbrillary acidic protein/bromodeoxyuridine double-positive astrocytes were also found in the injured cortex. Our ifndings suggest that neural progenitor cells are present in the damaged cortex of adult rats with cerebral ischemic brain injury, and that they differentiate into astrocytes and immature neurons, but most neurons fail to reach the mature stage.

关键词： nerve regeneration middle cerebral artery occlusion brain injury neurons astrocytes oligodendrocytes neural progenitor cells proliferation differentiation neurogenesis neural regeneration

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基于区域信息化平台的以全科医生团队为基础的分级诊疗模式研究

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中国全科医学 2018年第16期21卷 1923-1926页

作者：臧国尧方力争陈丽英戴红蕾朱文华卢崇蓉陈建华李利晁冠群张佳乔巧华黄丽娟浙江大学医学院附属邵逸夫医院全科医学科浙江省杭州市310016

分级诊疗是我国新一轮医药卫生体制改革的重点,但目前我国的分级诊疗体系建设尚不完善,尚未健全规范有效的分级管理模式。浙江大学医学院附属邵逸夫医院于2014年建立并启动了健康云平台,并基于该平台开展以全科医生团队为基础的分级诊... 详细信息

分级诊疗是我国新一轮医药卫生体制改革的重点,但目前我国的分级诊疗体系建设尚不完善,尚未健全规范有效的分级管理模式。浙江大学医学院附属邵逸夫医院于2014年建立并启动了健康云平台,并基于该平台开展以全科医生团队为基础的分级诊疗。具体流程为:由基层医疗卫生机构全科医生为患者提供首诊,疑难问题征求患方意见后,通过医生端APP与综合医院全科医生联系,由综合医院全科医生给出进一步的治疗和检查建议,并为有需要的患者提供专科会诊/转诊服务。该模式使得各级医疗机构的全科医生合作更紧密,进一步建立了上下联动的分级诊疗模式,在一定程度上实现了各级医疗机构的诊疗服务同质化,有利于分级诊疗的持续推进。本文主要对该模式的工作流程及运行情况进行介绍,以期为我国各地区的分级诊疗信息化建设提供参考。

关键词：分级诊疗全科医生区域信息化平台

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Metabolic syndrome and gallstone disease

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World Journal of Gastroenterology 2012年第31期18卷 4215-4220页

作者： Li-Ying Chen qiao-Hua qiao Shan-Chun Zhang Yu-Hao Chen guan-qun Chao Li-Zheng Fang Department of Family Medicine Sir RunRun Shaw Hospital Zhejiang University Hangzhou 310016Zhejiang Province China Department of Epidemiology and Biosta-tistics School of Public Health Zhejiang University Hangzhou310058 Zhejiang Province China

AIM： To investigate the association between metabolic syndrome （NetS） and the development of gallstone disease （GSD）. METHODS： A cross-sectional study was conducted in 7570 subjects （4978 men aged 45.0：1：8.8 years, and 2592 women aged 45.3：1：9.5 years） enrolled from the physical check-up center of the hospital. The subjects included 918 patients with gallstones （653 men and 265 women） and 6652 healthy controls （4325 men and 2327 women） without gallstones. Body mass index （BII）, waist circumference, blood pressure, fasting plasma glucose （FPG） and serum lipids and lipoproteins levels were measured. Colorimetric method was used to measure cholesterol, high-density lipoprotein cho- lesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C）. Dextrose oxidizing enzyme method was used to measure FPG. Subjects were asked to complete a questionnaire that enquired about the information on demographic data, age, gender, histories of diabetes mellitus, hypertension, and chronic liver disease and so on. Metabolic syndrome was diagnosed according to the Adult Treatment Panel HI （ATP ]3） criteria. Gall- stones were defined by the presence of strong intralu- minal echoes that were gravity-dependent or attenu- ated ultrasound transmission. RESULTS： Among the 7570 subjects, the prevalence of the gallstone disease was 12.1% （13.1% in men and 10.2% in women）. BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose and serum triglyceride （TG） in cases group were higher than in controls, while serum high-density lipid was lower than in controls. There were significant differences in the waist circumference, blood pressure, FPG and TG between cases and controls. In an age- adjusted logistic regression model, metabolic syndrome was associated with gallstone disease. The age-adjust- ed odds ratio of MetS for GSD in men was 1.29 [95% confidence interval （CI）, 1.09-1.52; P = 0.0030], and 1.68 （95% CI, 1.26-2.25; P = 0.0004） in women; the overa

关键词： Gallstone disease Obesity Hypertension Dyslipidemia Metabolic syndrome

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Analytically Derived Wind Wave Growth Relations

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China Ocean Engineering 2002年第3期17卷 359-368页

作者： guan Changlong(管长龙) SUN qun(孙群) Physical Oceanography Laboratory and Institute of Physical Oceanography Ocean University of Qingdao Qingdao 266003 China Physical Oceanography Laboratory and Institute of Physical Oceanography Ocean University of Qingdao Qingdao 266003 China

By the use of the 3/2 power law presented by Toba combined with the significant wave energy balance equation for wind wave, wind wave growth at a limited fetch is analytically investigated. The new wind wave growth relations (WWGRs) are analytically derived with sheltering coefficient and wind drag coefficient as parameters. The geometrical average of observational values of sheltering coefficient and the arithmetic average of observational values of wind drag coefficient are applied to determine the new WWGRs. Comparisons with existing empirical WWGRs are made.

关键词： wind wave wind wave growth relation 3/2 power law

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Flexible High Energy Density Sodium Dual-ion Battery with Long Cycle life

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Energy & Environmental Materials 2022年第4期5卷 1285-1293页

作者： Yongpeng Li qun guan Jianli Cheng Bin Wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Institute of Fundamental and Frontiers Sciences Yangtze Delta Region Institute(Huzhou)University of Electronic Sciences and Technology of ChinaChengdu 611731China

Flexible fiber-shaped sodium dual-ion batteries(FSDIBS)as a proof of concept are fabricated by using the hierarchical ReS_(2) nanosheets anchored on the carbon nanotube(ReS_(2)@CNT)fiber as anode and graphite on the CNT as *** to large interlayer spacing and weak layer coupling force of the ReS_(2) nanosheets and the anion accommodation of the graphite combined with good flexibility of the CNT fiber,the FSDIBS demonstrate outstanding electrochemical performances with high working voltage and high specific volumetric energy density,durable cycling life,and good *** FSDIBS show a specific discharge capacity of 97.8 mAh cm^(−3) at a current density of 630 mA cm^(−3) and high specific energy density of 25.12 mWh cm^(−3)(based on the whole volume of the two electrodes)and superb stability with a capacity retention of 91.8%even after bending for 2100 ***,a series of ex situ/in situ characterizations are verified that the reversible shuttles of the Na^(+) cations and PF_(6)^(-) anions between the anode and cathode are simultaneously occurred during the charge/discharge process.

关键词： dual-ion batteries fiber-shaped flexibility ReS_(2) sodium ions

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Application of Fe(Ⅵ)in abating contaminants in water:State of art and knowledge gaps

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 7-27页

作者： Shuchang Wang Binbin Shao Junlian qiao Xiaohong guan State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092China International Joint Research Center for Sustainable Urban Water System Tongji UniversityShanghai200092China

The past two decades have witnessed the rapid development and wide application of Fe(Ⅵ)in the field of water de-contamination because of its environmentally benign ***(Ⅵ)has been mainly applied as a highly efficient oxidant/disinfectant for the selective elimination of *** in situ generated iron(III)(hydr)oxides with the function of adsorption/coagulation can further increase the removal of contaminants by Fe(Ⅵ)in some *** of the limitations of Fe(Ⅵ)per se,various modified methods have been developed to improve the performance of Fe(Ⅵ)oxidation *** on the published literature,this paper summarized the current views on the intrinsic properties of Fe(Ⅵ)with the emphasis on the self-decay mechanism of Fe(Ⅵ).The applications of Fe(Ⅵ)as a sole oxidant for decomposing organic contaminants rich in electron-donating moieties,as a bi-functional reagent(both oxidant and coagulant)for eliminating some special contaminants,and as a disinfectant for inactivating microorganisms were systematically ***,the difficulties in synthesizing and preserving Fe(Ⅵ),which limits the large-scale application of Fe(Ⅵ),and the potential formation of toxic byproducts during Fe(Ⅵ)application were *** paper also systematically reviewed the important nodes in developing methods to improve the performance of Fe(Ⅵ)as oxidant or disinfectant in the past two decades,and proposed the future research needs for the development of Fe(Ⅵ)technologies.

关键词： Ferrate Oxidation Disinfection Coagulation Enhancement

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Effectiveness of acupuncture to treat irritable bowel syndrome: A meta-analysis

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World Journal of Gastroenterology 2014年第7期20卷 1871-1877页

作者： guan-qun Chao Shuo Zhang Department of Family Medicine Sir Run Run Shaw HospitalZhejiang University Department of Gastroenterology the First Affiliated Hospital of Zhejiang Chinese Medical University

AIM: To evaluate the efficacy of acupuncture for treatment of irritable bowel syndrome (IBS) through meta-analysis of randomized controlled trials.

关键词： Irritable bowel syndrome Functional gastrointestinal disorder Acupuncture Meta-analysis

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The mononuclear phagocyte system in hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第45期28卷 6345-6355页

作者： Duan-Rui qiao guan-Yue Shan Shuai Wang Jun-Ya Cheng Wei-qun Yan Hai-Jun Li Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130021Jilin ProvinceChina Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Students Affairs China-Japan Union Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina Institute of Liver Diseases The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

The mononuclear phagocyte system(MPS)consists of monocytes,dendritic cells and macrophages,which play vital roles in innate immune defense against *** carcinoma(HCC)is a complex disease that is affected or initiated by many factors,including chronic hepatitis B virus infection,hepatitis C virus infection,metabolic disorders or alcohol *** function,tumor stage and the performance status of patients affect HCC clinical *** have shown that targeted treatment of tumor microenvironment disorders may improve the efficacy of HCC *** derived from the innate immune response can regulate T-cell differentiation,thereby shaping adaptive immunity,which is associated with the prognosis of ***,it is important to elucidate the function of the MPS in the progression of *** this review,we outline the impact of HCC on the *** illustrate how HCC reshapes MPS cell phenotype remodeling and the production of associated cytokines and characterize the function and impairment of the MPS in HCC.

关键词： Mononuclear phagocyte system Hepatocellular carcinoma Monocyte Dendritic cell Macrophage

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Generating femtosecond coherent X-ray pulses in a diffractionlimited storage ring with the echo-enabled harmonic generation scheme

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Nuclear Science and Techniques 2018年第10期29卷 191-199页

作者： Wei-Hang Liu guan-qun Zhou Yi Jiao Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 10004China University of Chinese Academy of Sciences Beijing 100049China

To study ultrafast processes at the sub-picosecond level, novel methods based on coherent harmonic generation technologies have been proposed to generate ultrashort radiation pulses in existing ring-based light sources. Using the High Energy Photon Source as an example, we numerically test the feasibility of implementing one coherent harmonic generation technology, i.e.,the echo-enabled harmonic generation(EEHG) scheme, in a diffraction-limited storage ring(DLSR). Two different EEHG element layouts are considered, and the effect of the EEHG process on the electron beam quality is also analyzed. Studies suggest that soft X-ray pulses, with pulse lengths of a few femtoseconds and peak powers of up to1 MW, can be generated by using the EEHG scheme, while causing little perturbation to the regular operation of a DLSR.

关键词： Echo-enabled harmonic generation Diffraction-limited storage ring High-energy photon source Femtosecond X-ray pulses

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Breast Fibromatosis after Hydrophilic Polyacrylamide Gel Injection for Breast Augmentation: a Case Report and Review of the Literature

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Chinese Medical Sciences Journal 2011年第2期26卷 126-128页

作者： Xiao Long qun qiao Division of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijng 100730 China

BREAST fibromatosis is a rare kind of lesion. The average incidence is about 2-4 per million every year} So far there have been about 100 cases reported altogether.2 In this report, we describe a case of breast fibromatosis developed after hydrophilic polyacrylamide gel （HPG） injection for breast augmentation. By reviewing the literature, the possible pathogenesis of this case and the proper treatment strategy are investigated.

关键词： breast tumor fibromatosis hydrophilic polyacrylamide gel breast augmentation

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