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Deformation,structure and potential hazard of a landslide based on InSAR in Banbar county,Xizang(Tibet)

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China Geology 2024年第2期7卷 203-221页

作者： guan-hua zhao Heng-xing Lan Hui-yong Yin Lang-ping Li Alexander Strom Wei-feng Sun Chao-yang Tian College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Key Laboratory of Ecological Geology and Disaster Prevention Ministry of Natural ResourcesXi’an 710054China University of Chinese Academy of Sciences Beijing 100049China JSC“Hydroproject Institute” Moscow 125993Russia

The Tibetan Plateau is characterized by complex geological conditions and a relatively fragile ecological *** recent years,there has been continuous development and increased human activity in the Tibetan Plateau region,leading to a rising risk of *** landslide in Banbar County,Xizang(Tibet),have been perturbed by ongoing disturbances from human engineering activities,making it susceptible to instability and displaying distinct *** this study,small baseline subset synthetic aperture radar interferometry(SBAS-InSAR)technology is used to obtain the Line of Sight(LOS)deformation velocity field in the study area,and then the slope-orientation deformation field of the landslide is obtained according to the spatial geometric relationship between the satellite’s LOS direction and the ***,the landslide thickness is inverted by applying the mass conservation *** results show that the movement area of the landslide is about 6.57×10^(4)m^(2),and the landslide volume is about 1.45×10^(6)m^(3).The maximum estimated thickness and average thickness of the landslide are 39 m and 22 m,*** thickness estimation results align with the findings from on-site investigation,indicating the applicability of this method to large-scale earth *** deformation rate of the landslide exhibits a notable correlation with temperature variations,with rainfall playing a supportive role in the deformation process and displaying a certain *** activities exert the most substantial influence on the spatial heterogeneity of landslide deformation,leading to the direct impact of several prominent deformation areas due to human ***,utilizing the long short-term memory(LSTM)model to predict landslide displacement,and the forecast results demonstrate the effectiveness of the LSTM model in predicting landslides that are in a continuous development and movement *** landslide is still active,and based

关键词： Landslide InSAR Human activity Deformation Structure LSTM model Engineering construction Thickness Neural network Machine learning Prediction and prevention Tibetan Plateau Geological hazards survey engineering

Effect of air frying and baking on physicochemical properties and digestive properties of scallop (Patinopecten yessoensis) adductor muscle

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Food Bioscience 2023年第2期52卷 901-911页

作者： Zi-Ye Wang Zi-Xuan Wu guan-hua zhao De-Yang Li Yu-Xin Liu Lei Qin Peng-Fei Jiang Da-Yong Zhou School of Food Science and Technology Dalian Polytechnic UniversityDalian116034PR China National Engineering Research Center of Seafood Dalian116034PR China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic University116034PR China

In this study,the effects of dry heat treatments including air frying and baking on the physicochemical and digestive properties of proteins in scallop adductor muscle(SAM)were *** heat treatments,the proteins in SAM exhibited different degrees of oxidation,aggregation and *** both heat treatments,the increase of carbonyl and dityrosine contents and the decrease of free sulfhydryl groups and surface hydrophobicity of proteins in SAM were observed along with increasing heat ***,with increasing heat temperature,there was a progressive transition fromα-helix toβ-sheet in protein secondary ***,the protein solubility first increased and then decreased with increasing *** which,the solubility of 160℃-treated samples was the highest,which were 21.02%and 20.32%for air frying and *** protein digestive properties which reflected by the degree of hydrolysis(DH),soluble amino groups and soluble peptides showed a trend of increasing first and then decreasing with increasing *** gastrointestinal digestion,the DH,soluble amino groups and soluble peptides of 160℃-treated SAMs cooking by air frying were 69.96%,61.14%and 39.33%,respectively,which were significantly higher than all other samples including the fresh *** analysis showed that the protein digestive indexes were positively correlated with solubility,free sulfhydryl content and surface hydrophobicity,and negatively correlated with protein carbonyl content,dityrosine content and protein aggregation *** results provide evidence for knowing more about the effects of dry heat treatments on physicochemical and digestive properties of aquatic muscle food.

关键词： Heat treatment Solubility Protein oxidation Aggregation Degradation In vitro digestion

The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1495-1503页

作者： Wei-Ming Yan Tao Chen Xiao-Cheng Wang Lin-Song Qi guan-hua zhao Guo-Qing Yang Yi-Fei Ma Ye Tao Lei Zhang Zuo-Ming Zhang Department of Clinical Medicine Faculty of Aerospace MedicineKey Laboratory of Aerospace Medicine of the National Education Ministrythe Fourth Military Medical University Department of Health Service Faculty of Aerospacethe Fourth Military Medical University Department of Aviation Physical Examination and Ophthalmology Air Force General Hospital Department of Ophthalmology General Hospital of Chinese PLAOphthalmology &Visual Science Key Lab of PLA

AIM：To investigate the effects of hydrogen-rich saline（HRS）on microglia activation and Sirtuin type 1（Sirt1）in rats with N-methyl-N-nitrosourea（MNU）-induced retinitis pigmentosa（RP）.METHODS：Rats were divided into norm（N）group,model（M）group and HRS（H）*** in M and H groups were given saline and HRS respectively prior to and after administration of *** one day（d1）and d3 afterwards,electroretinogram and histological examination were performed to confirm the effects of HRS on retinal function and structure of MNU-induced *** staining of anti-ionized calcium-binding adapter molecule 1（Iba1）,a maker of microglia cells,was performed,with quantitative real-time polymerase chain reaction（qRT-PCR）for its m RNA ***,Sirt1 m RNA and protein expression in the retinas were detected by Western blot and ***：HRS preserved the retinal function and mitigated the reduction of photoreceptor degeneration in MNU-treated *** presence of microglia cells was somewhat more obvious in H group than that in M group at *** suppressed the further activation of microglia cells,with the number of microglia cells less than that of M group at *** of qRT-PCR of Iba1 were consistent with those of immunofluorescence staining,with the m RNA expression of Iba1 in H group more intensive than that of M group at d1（P〈0.05）,while less than that of M group at d3（P〈0.05）.Furthermore,the Sirt1 m RNA and protein expression decreased after MNU administration,while HRS mitigated the MNU-induced downregulation of ***：HRS can effectively keep microglia activation induced by MNU to an appropriate extent,while upregulate Sirt1 in MNU-induced RP.

关键词： hydrogen hydrogen-rich saline electroretinogram microglia Sirtl retinitis pigmentosa

一例Emanuel综合征胎儿的遗传学诊断及追溯

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中华医学遗传学杂志 2017年第5期34卷 709-713页

作者：赵艳辉庞泓高铭冯小静关云萍赵华佟丹滑君曹霞何绍嵩李岭沈阳市妇婴医院遗传室 110010 沈阳市妇婴医院产科门诊 110010 沈阳市妇婴医院影像科 110010 西南交通大学2016级成都611756 四川大学生命科学学院遗传医学研究所成都610041

目的对1例孕30怕周B超提示为Dandy-Walker畸形的胎儿进行遗传学检查，追溯其发病原因，并为其父母在再次妊娠时提供产前诊断。方法应用常规G显带法分析患儿及其父母的染色体核型，之后用下一代测序和荧光原位杂交对患儿及其母亲进行分... 详细信息

目的对1例孕30怕周B超提示为Dandy-Walker畸形的胎儿进行遗传学检查，追溯其发病原因，并为其父母在再次妊娠时提供产前诊断。方法应用常规G显带法分析患儿及其父母的染色体核型，之后用下一代测序和荧光原位杂交对患儿及其母亲进行分析。再次妊娠时应用上述方法对胎儿进行产前诊断。结果G显带染色体分析显示胎儿的核型为47，XX，＋mar，其父亲核型正常，母亲核型为46，XX，t（11；22）（q23；q11）。胎儿脐带血DNA下一代测序的结果提示其11号及22号染色体上存在重复区段，荧光原位杂交结果证实胎儿所携带的标记染色体为＋der（22）t（11；22）（q23；q11），确诊为Emanuel综合征。再次妊娠时产前诊断提示胎儿携带与母亲相同的平衡易位。经咨询后孕妇选择继续妊娠，并生育一正常儿。结论成功诊断1例Emanud综合征胎儿，其标记染色体来源于母亲所携带的46，XX，t（11；22）（q23；q11）平衡易位。对于产前发现的Dandy-Walker畸形进行染色体检查非常重要，必要时可结合高分辨率的检测手段以明确其病因。

关键词： Dandy-Walker畸形 Emanuel综合征标记染色体下一代测序产前诊断荧光原位杂交

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li hua Zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

Multipotent mesenchymal stromal cells are fully permissive for human cytomegalovirus infection

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Virologica Sinica 2016年第3期31卷 219-228页

作者： guan-hua Qiao Fei zhao Shuang Cheng Min-hua Luo State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of Sciences

Congenital human cytomegalovirus(HCMV) infection is a leading infectious cause of birth *** studies have reported birth defects with multiple organ maldevelopment in congenital HCMV-infected neonates. Multipotent mesenchymal stromal cells(MSCs) are a group of stem/progenitor cells that are multi-potent and can self-renew, and they play a vital role in multiorgan formation. Whether MSCs are susceptible to HCMV infection is unclear. In this study, MSCs were isolated from Wharton's jelly of the human umbilical cord and identified by their plastic adherence, surface marker pattern, and differentiation capacity. Then, the MSCs were infected with the HCMV Towne strain, and infection status was assessed via determination of viral entry,replication initiation, viral protein expression, and infectious virion release using western blotting,immunofluorescence assays, and plaque forming assays. The results indicate that the isolated MSCs were fully permissive for HCMV infection and provide a preliminary basis for understanding the pathogenesis of HCMV infection in non-nervous system diseases, including multi-organ malformation during fetal development.

关键词： human cytomegalovirus(HCMV) multipotent mesenchymal stromal cells(MSCs) susceptibility umbilical cord Wharton's jelly

准分子激光角膜原位磨镶术后远期视觉质量的观察

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国际眼科杂志 2017年第4期17卷 719-723页

作者：赵冠华张磊丁一峰严伟明陈涛吴飞张作明第四军医大学航空航天医学系中国陕西省西安市710032 第四军医大学学员一旅五营十七连中国陕西省西安市710032

目的:研究接受准分子激光角膜原位磨镶术(Laser in situ keratomileusis,LASIK)患者的视觉质量在术后数年内是否稳定,应用视觉质量分析系统(Optical Quality Analysis System,OQASⅡ)对LASIK术后远期视觉质量进行评价。方法:从第四军医... 详细信息

目的:研究接受准分子激光角膜原位磨镶术(Laser in situ keratomileusis,LASIK)患者的视觉质量在术后数年内是否稳定,应用视觉质量分析系统(Optical Quality Analysis System,OQASⅡ)对LASIK术后远期视觉质量进行评价。方法:从第四军医大学学员中招募志愿者作为受试者,从中选择曾行LASIK手术者35例70眼作为观察组,未行LASIK手术者70例140眼作为对照组,应用OQASⅡ比较近期观察组(LASIK术后2~4a)和远期观察组(LASIK术后5~11a)的视觉质量,通过设立近期对照组(≤22岁)和远期对照组(≥23岁)探讨年龄、用眼习惯等混杂因素对视觉质量的影响,并分别与近期观察组和远期观察组相比较。观察指标为客观散射指数(OSI)、MTF截止空间频率(MTF cutoff)、斯特列尔比值(SR)、100%对比敏感度的OQAS分值(OV100%)、20%对比敏感度的OQAS分值(OV20%)和9%对比敏感度的OQAS分值(OV9%)。结果:在术后数年内,观察组的OSI显著高于对照组,而MTF cutoff、SR以及OV100%、OV20%和OV9%显著低于对照组(P0.05)。结论:LASIK是矫正近视的常用手术方法,随术后时间延长,因手术一定程度降低的视觉质量有恢复的趋势,但在数年内不能完全恢复,基本保持稳定的状态。OQAS能够对LASIK术后的视觉质量进行定性和定量分析,有助于近视矫正术后视觉质量的分析和手术方案的改进。

关键词：准分子激光角膜原位磨镶术视觉质量近视调制传递函数

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu zhao Juan-Han Yu Yi-hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

Protein lysine crotonylation in cellular processions and disease associations

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Genes & Diseases 2024年第5期11卷 219-235页

作者： Hongling zhao Yang Han Pingkun Zhou hua guan Shanshan Gao Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation MedicineBeijing 100850China

Protein lysine crotonylation(Kcr)is one conserved form of posttranslational modifications of proteins,which plays an important role in a series of cellular physiological and pathological *** e-amino groups are the primary sites of such modification,resulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these *** levels of Kcr modifications have been identified on both histone and non-histone *** present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discussion of the mechanisms whereby Kcr modification governs a range of biological *** addition,given the importance of protein Kcr modification in disease onset and progression,the potential viability of Kcr regulators as therapeutic targets is elucidated.

关键词： Cell biology Disease Lysine crotonylation Posttranslational modification Therapeutic target