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两种不同多个混合纯音频率声治疗慢性主观性耳鸣的疗效分析

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中国处方药 2024年第7期22卷 183-185页

作者：何杨新关山越李卫红肇庆市第二人民医院耳鼻喉科广东肇庆526060

目的探讨两种不同多个混合纯音频率声在慢性主观性耳鸣患者中的治疗效果。方法选择2021年4月~2023年4月慢性主观性耳鸣患者100例为对象,用随机数字表法分为两组各50例。两组均采用常规方法治疗,在此基础上,对照组声治疗以耳鸣检测中测... 详细信息

目的探讨两种不同多个混合纯音频率声在慢性主观性耳鸣患者中的治疗效果。方法选择2021年4月~2023年4月慢性主观性耳鸣患者100例为对象,用随机数字表法分为两组各50例。两组均采用常规方法治疗,在此基础上,对照组声治疗以耳鸣检测中测得的耳鸣频率为中心频率,由7倍频程的不同频率纯音构成,观察组以耳鸣检测中测得的耳鸣频率为中心频率,由9个1/3频程的不同频率纯音构成,两组均完成3个月治疗,比较两组有效率、耳鸣残障量表(THI)、耳鸣严重程度评估量表(TEQ)、血清细胞黏附因子-1(sVCAM-1)及一氧化氮(NO)水平。结果治疗3个月后,观察组有效率为96.00%,高于对照组84.00%(P<0.05);治疗3个月后,观察组功能性、情感性、灾难性及TEQ评分,sVCAM-1及NO水平低于对照组(P<0.05)。结论由9个1/3频程的不同频率纯音构成的混合音频率声治疗慢性主观性耳鸣有效率较高,能改善患者耳鸣症状,有助于降低sVCAM-1及NO水平。

关键词：混合纯音频率声耳鸣残障量表耳鸣严重程度血清细胞黏附因子-1 一氧化氮

Prospects and Problems for Identification of Poisonous Plants in China using DNA Barcodes

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Biomedical and Environmental Sciences 2014年第10期27卷 794-806页

作者： XIE Lei WANG Ying Wei guan shan yue XIE Li Jing LONG Xin SUN Cheng Ye College of Nature Conservation Beijing Forestry University Institute of Botany the Chinese Academy of Sciences School of Agricultural Forestry and Environmental Sciences Forest Resources Clemson University National Institute of Occupational Health and Poison Control China Center for Disease Control and Prevention

Objective Poisonous plants are a deadly threat to public health in China. The traditional clinical diagnosis of the toxic plants is inefficient, fallible, and dependent upon experts. In this study, we tested the performance of DNA barcodes for identification of the most threatening poisonous plants in China. Methods Seventy-four accessions of 27 toxic plant species in 22 genera and 17 families were sampled and three DNA barcodes （motK, rbcL, and ITS） were amplified, sequenced and tested. Three methods, Blast, pairwise global alignment （PWG） distance, and Tree-Building were tested for discrimination power. Results The primer universality of all the three markers was high. Except in the case of ITS for Hemerocollis minor, the three barcodes were successfully generated from all the selected species. Among the three methods applied, Blast showed the lowest discrimination rate, whereas PWG Distance and Tree-Building methods were equally effective. The ITS barcode showed highest discrimination rates using the PWG Distance and Tree-Building methods. When the barcodes were combined, discrimination rates were increased for the Blast method.

关键词： Poisonous plants DNA barcoding metK rbcL iTS

A joint use of emergy evaluation, carbon footprint and economic analysis for sustainability assessment of grain system in China during 2000–2015

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Journal of Integrative Agriculture 2018年第12期17卷 2822-2835页

作者： WANG Xiao-long WANG Wei guan yue-shan XIAN Yuan-ran HUANG Zhi-xin FENG Hai-yi CHEN Yong College of Agriculture South China Agricultural University

The rapid growth of grain yield in China accelerates a discussion on whether the grain system in China is sustainable. To answer the question, a comprehensive assessment from economic and environmental points is necessary. This study jointly used economic analysis(ECA), emergy evaluation(EME) and carbon footprint(CF) to analyze the environmental and economic sustainability of the grain production system in China based on the national statistical data during 2000–2015. Results showed that the costs of maize, wheat, rice and soybean had increased by 252-346% from 2000 to 2015, causing the lower profit of grain system in recent years. The situation resulted in a serious problem on economic sustainability of grain system in China. Meanwhile, the emergy sustainability index(ESI) of maize, wheat, rice and soybean systems were increasing during 2000–2015, and the CF on unit yield of the crops had been reduced by 10-30% in the study period. The results reflected the improved environmental sustainability of grain system in China during 2000–2015. Nevertheless, the emergy flow of industrial inputs for the crops were increased by 4-22% in the study period, and the CF from the inputs presented a growth rate of 16-23% as well during the same period. The results implied that the grain system in China was relying more on fossil-based inputs. Finally, according to the key points of cost, emergy and CF, we suggest that improving labor efficiency, advanced agricultural practices and optimizing cropping pattern will be effective ways to further improve the economic and environmental sustainability of grain system in China.

关键词： grain sustainability emergy profit carbon footprint time-series

The mononuclear phagocyte system in hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第45期28卷 6345-6355页

作者： Duan-Rui Qiao guan-yue shan Shuai Wang Jun-Ya Cheng Wei-Qun Yan Hai-Jun Li Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130021Jilin ProvinceChina Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Students Affairs China-Japan Union Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina Institute of Liver Diseases The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

The mononuclear phagocyte system(MPS)consists of monocytes,dendritic cells and macrophages,which play vital roles in innate immune defense against *** carcinoma(HCC)is a complex disease that is affected or initiated by many factors,including chronic hepatitis B virus infection,hepatitis C virus infection,metabolic disorders or alcohol *** function,tumor stage and the performance status of patients affect HCC clinical *** have shown that targeted treatment of tumor microenvironment disorders may improve the efficacy of HCC *** derived from the innate immune response can regulate T-cell differentiation,thereby shaping adaptive immunity,which is associated with the prognosis of ***,it is important to elucidate the function of the MPS in the progression of *** this review,we outline the impact of HCC on the *** illustrate how HCC reshapes MPS cell phenotype remodeling and the production of associated cytokines and characterize the function and impairment of the MPS in HCC.

关键词： Mononuclear phagocyte system Hepatocellular carcinoma Monocyte Dendritic cell Macrophage

Persistent greening against drying in northeast Asian semiarid grasslands:Asymmetrical responses of direct and legacy effects to intensified drought

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Advances in Climate Change Research 2024年第1期15卷 9-20页

作者： Yu-Tong MA Hai-shan CHEN Yao-Ming SONG Bo-Tao ZHOU shan-Lei SUN Xin-guan DU yue SUN Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Despite experiencing a decadal shift towards drought conditions at the end of the 2Oth century,semiarid grasslands in northeast Asia(NEA)exhibited an evident greening trend from 1982 to ***,the mechanism behind this phenomenon remains ***,we analysed the interdecadal changes in vegetation response to drought on the basis of the standardised precipitation evapotranspiration index(SPEI)and Global Inventory Modelling and Mapping Studies LAI4g datasets,with an emphasis on the differences between direct and legacy effects(as measured by resilience),to explore the mechanism of persistent grassland *** revealed that during the post-drought shift period(2000-2020),the sudden decrease in the water content of the intermediate soil layer triggered an intensified vegetation response to ***,although direct effects and resilience were amplified,they exhibited asymmetric *** was stronger than direct effects,and this difference increased with increasing drought(drought recovery)*** combined effects may account for persistent greening against intensified drying in the semiarid grasslands in *** the projected exacerbation of future droughts,this study holds notable importance for comprehending the long-term change dynamics of dryland ecosystems.

关键词： Semiarid grassland Drought decadal shift Direct effect Legacy effect(resilience) Northeast Asia

Reversal of complete atrioventricular block in dialysis patients following parathyroidectomy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1313-1319页

作者： shan-shan Xu Li-Hai Hao Yan-Meng guan Hemodialysis Center Weifang People’s HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic *** calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular *** case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular *** SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus *** developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular ***,she underwent parathyroidectomy(PTX)with ***,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was *** This case revealed that metastatic cardiac calcification can result in complete atrioventricular *** parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular *** is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.

关键词： Secondary hyperparathyroidism Ectopic calcification Atrioventricular block Reversal Case report

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

IQGAP3 promotes the progression of glioma as an immune and prognostic marker

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Oncology Research 2024年第4期32卷 659-678页

作者： XIAOFENG GAO JUANJUAN GE XUZHENG GAO NA MEI YANTING SU SHIGANG shan WENBIN QIAN JIANGHENG guan ZHENWANG ZHANG LONG WANG Hubei Provincial Key Laboratory of Diabetic Cardiovascular Diseases Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China School of Basic Medical Sciences Xianning Medical CollegeHubei University of Science and TechnologyHubei University of Science and TechnologyXianning437100China School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China Department of Neurosurgery The General Hospital of Chinese PLA Central Theater CommandWuhan430070China

Background:IQGAP3 plays a crucial role in regulating cell proliferation,division,and cytoskeletal *** expression of IQGAP3 has been linked to various tumors,but its function in glioma is not well ***:Various methods,including genetic differential analysis,single-cell analysis,ROC curve analysis,Cox regression,Kaplan-Meier analysis,and enrichment analysis,were employed to analyze the expression patterns,diagnostic potential,prognostic implications,and biological processes involving IQGAP3 in normal and tumor *** impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using ***,the cBioPortal database was used to analyze copy number variations and mutation sites of *** validation was also performed to assess the effects of IQGAP3 on glioma cells and explore underlying ***:High IQGAP3 expression in gliomas is associated with an unfavorable prognosis,particularly in wild-type IDH and 1p/19q non-codeleted *** analysis revealed that IQGAP3 is involved in regulating the cell cycle,PI3K/AKT signaling,p53 signaling,and PLK1-related ***,IQGAP3 expression may be closely related to the immunosuppressive microenvironment of ***-K88742110 and LY-303511 are potential drugs for targeting IQGAP3 in anti-glioma *** vitro experiments showed that downregulation of IQGAP3 inhibits the proliferation and migration of glioma cells,with the PLK1/PI3K/AKT pathway potentially playing a crucial role in IQGAP3-mediated glioma ***:IQGAP3 shows promise as a valuable biomarker for diagnosis,prognosis,and immunotherapeutic strategies in gliomas.

关键词： IQGAP3 Tumor immune infiltration Prognosis Glioma Biomarker

Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors

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World Journal of Gastroenterology 2024年第11期30卷 1533-1544页

作者： Li-Min Yang Hong-Juan Wang shan-Lin Li guan-Hua Gan Wen-Wen Deng Yong-Sheng Chang Lian-Feng Zhang Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterology Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in *** To evaluate the efficacy of radiofrequency ablation in combination with sorafenib for improving liver function and its impact on the prognosis of patients with this *** Data from 100 patients with liver cancer complicated with portal hypertension from May 2014 to March 2019 were analyzed and divided into a study group(n=50)and a control group(n=50)according to the treatment *** research group received radiofrequency ablation(RFA)in combination with sorafenib,and the control group only received *** short-term efficacy of both the research and control groups was *** function and portal hypertension were compared before and after ***-fetoprotein(AFP),glypican-3(GPC-3),and AFP-L3 levels were compared between the two groups prior to and after *** occurrence of adverse reactions in both groups was *** 3-year survival rate was compared between the two *** data were compared between the survival and non-surviving *** identify the independent risk factors for poor prognosis in patients with liver cancer complicated by portal hypertension,multivariate logistic regression analysis was *** When comparing the two groups,the research group's total effective rate(82.00%)was significantly greater than that of the control group(56.00%;P<0.05).Following treatment,alanine aminotransferase and aspartate aminotransferase levels increased,and portal vein pressure decreased in both *** degree of improvement for every index was substantially greater in the research group than in the control group(P<0.05).Following treatment,the AFP,GPC-3,and AFP-L3 levels in both groups decreased,with the research group having significantly lower levels than the control group(P<0.05).The incidence of diarrhea,rash,nausea and vomiting,and fatigue in the research group was significantly great

关键词： Radiofrequency ablation Sorafenib Liver cancer Portal hypertension Efficacy Prognosis analysis