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Aβ-Aggregation-Generated Blue Autofluorescence Illuminates Senile Plaques as well as Complex Blood and Vascular Pathologies in Alzheimer’s Disease

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Neuroscience Bulletin 2024年第8期40卷 1115-1126页

作者： Hualin Fu Jilong Li Chunlei Zhang Peng Du Guo Gao Qiqi Ge xinping guan Daxiang Cui Institute of Nano Biomedicine and Engineering School of Sensing Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine Shanghai Jiao Tong UniversityShanghai 200240China Department of Colorectal Surgery School of MedicineXinhua HospitalShanghai Jiao Tong UniversityShanghai 200092China Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China The Key Laboratory of System Control and Information Processing Ministry of EducationShanghai 200240China

Senile plaque blue autofluorescence was discovered around 40 years ago,however,its impact on Alzheimer’s disease(AD)pathology has not been fully *** analyzed senile plaques with immunohistochemistry and fluorescence imaging on AD brain sections and also Aβ aggregation in *** DAPI or Hoechst staining,the nuclear blue fluorescence could only be correctly assigned after subtracting the blue plaque *** flower-like structures wrapping dense-core blue fluorescence formed by cathepsin D staining could not be considered central-nucleated neurons with defective lysosomes since there was no nuclear staining in the plaque core when the blue autofluorescence was *** Aβ self-oligomers and Aβ/hemoglobin heterocomplexes generated blue *** Aβ amyloid blue autofluorescence not only labels senile plaques but also illustrates red cell aggregation,hemolysis,cerebral amyloid angiopathy,vascular plaques,vascular adhesions,and *** summary,we conclude that Aβ-aggregation-generated blue autofluorescence is an excellent multi-amyloidosis marker in Alzheimer’s disease.

关键词： Senile plaque Blue autofluorescence Aβ Amyloid aggregation Hemoglobin Cathepsin D.Microaneurysm Alzheimer's disease

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Dynamic Coverage with Wireless Sensor and Actor Networks in Underwater Environment

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IEEE/CAA Journal of Automatica Sinica 2015年第3期2卷 274-281页

作者： Xiaoyuan Luo Liu Feng Jing Yan xinping guan the Institute of Electrical Engineering Yanshan University the Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of China

This paper studies the problem of dynamic coverage with wireless sensor and actor networks (WSANs) in underwater environment. Different from most existing works, the WSANs consist of two kinds of nodes, i.e., sensor nodes (SNs) which cannot move autonomously and actor nodes (ANs) which can move autonomously according to the performance requirement. The problem of how to coordinate two kinds of nodes to facilitate dynamic coverage in underwater environment is challenging due to their heterogeneous capabilities. To reduce redundancy of communication links and improve connectivity between ANs and SNs in underwater WSANs, a min-weighted rigid graph based topology optimization scheme is first developed, such that the underwater communication energy consumption can be saved. With the optimized topology, a dynamic coverage strategy is proposed to improve the coverage among SNs and ANs for underwater WSAN where underwater fluid motions are considered. Furthermore, it is proved that the network coverage area is connected by using the min-weighted rigid graph. Finally, simulation results are presented to show the effectiveness of the main results. © 2014 Chinese Association of Automation.

关键词： Energy utilization Graphic methods Sensor nodes Topology

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Network system capacity:Towards integrating sensing,communication and control

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National Science Open 2024年第1期3卷 147-149页

作者： xinping guan Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China Shanghai Engineering Research Center of Intelligent Control and Management Shanghai 200240China

Network systems refer to a new generation of systems with integrated information perception,transmission and utilization capabilities through communication networks,which are adopted to achieve desirable objectives under physical and information related uncertainties and/or adversary *** the information-rich era[1,2],one of the fundamental issues is to exploit the limit of feedback control on dissipating such uncertainties in the scenarios of networked sensing and communication[3].

关键词： communication integrating system

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Fuzzy-based Tracking Controller Design for Autonomous Underwater Vehicle 36

Fuzzy-based Tracking Controller Design for Autonomous Underw...

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第36届中国控制会议

作者： Hongjun Ban Xian Yang Xiaoyuan Luo Jing Yan xinping guan Institute of Electrical Engineering Yanshan University Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of China Institute of Information Science and Engineering Yanshan University

ISBN: (纸本)9781538629185

Autonomous Underwater Vehicle（AUV） is referred as a promising device to extend human intelligences to harsh underwater *** applications of AUV demand accurate trajectory tracking,however the nonlinear and model inaccuracy constraints on AUV make it challenging to achieve tracking *** this paper,we are concerned with the trajectory tracking problem for *** AUV is assumed to be auto navigated in surge,sway,heave and *** first give the 4-DOF mathematical model of ***,the tracking control problem is formulated into T-S fuzzy *** on this,T-S fuzzy-based position and head controllers,which depend on the relative state errors between the AUV and reference,are designed for AUV to achieve the trajectory tracking ***,simulation results are presented to show the effectiveness of the proposed tracking controllers,wherein the influence of chattering problem can be reduced by compared with SMC-based controller.

关键词： Autonomous underwater vehicle(AUV) tracking target fuzzy underwater

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Distributed Target Tracking using Consensus-based Bayesian Filtering by Underwater Acoustic Sensor Networks 36

Distributed Target Tracking using Consensus-based Bayesian F...

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第36届中国控制会议

作者： Jing Yan Bin Pu Xuyang Tian Xiaoyuan Luo Xinbin Li xinping guan Institute of Electrical Engineering Yanshan University Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of China

ISBN: (纸本)9781538629185

Underwater target tracking,which aims to achieve accurate position of underwater target,has been one of the key issues in the underwater ***,due to the unique underwater environment such as extraneous interference and weak communication,how to realize the accurate tracking of underwater target becomes a challenging *** this paper,we are concerned with the problem of underwater target *** Bayesian based rule is proposed to judge the existence of target for single sensor *** order to realize the tracking for the underwater target,a consensus-based Bayesian tracking method is proposed,which possesses better accuracy and spends less time in *** addition,the consensus of the consensus-based Bayesian algorithm is ***,simulation results are performed to show the effectiveness of the proposed algorithm in this paper.

关键词： Underwater target tracking acoustic sensor networks consensus

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Novel cyber-physical collaborative detection and localization method against dynamic load altering attacks in smart energy grids

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Global Energy Interconnection 2024年第3期7卷 362-376页

作者： Xinyu Wang Xiangjie Wang Xiaoyuan Luo xinping guan Shuzheng Wang School of Electrical Engineering Yanshan UniversityQinhuangdao066004P.R.China School of Electrical Engineering Jiangsu Collaborative Innovation Center for Smart Distribution NetworkNanjing636600P.R.China School of Electronic and Electrical Engineering Shanghai Jiaotong UniversityShanghai200240P.R.China

Owing to the integration of energy digitization and artificial intelligence technology,smart energy grids can realize the stable,efficient and clean operation of power ***,the emergence of cyber-physical attacks,such as dynamic load-altering attacks(DLAAs)has introduced great challenges to the security of smart energy ***,this study developed a novel cyber-physical collaborative security framework for DLAAs in smart energy *** proposed framework integrates attack prediction in the cyber layer with the detection and localization of attacks in the physical ***,a data-driven method was proposed to predict the DLAA sequence in the cyber *** designing a double radial basis function network,the influence of disturbances on attack prediction can be *** on the prediction results,an unknown input observer-based detection and localization method was further developed for the physical *** addition,an adaptive threshold was designed to replace the traditional precomputed threshold and improve the detection performance of the ***,through the collaborative work of the cyber-physics layer,injected DLAAs were effectively detected and *** with existing methodologies,the simulation results on IEEE 14-bus and 118-bus power systems verified the superiority of the proposed cyber-physical collaborative detection and localization against DLAAs.

关键词： Smart energy grids Cyber-physical system Dynamic load altering attacks Attack prediction Detection and localization

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中国共产党百年社会政策的实践与经验

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中国社会科学 2022年第2期 103-122,206页

作者：关信平南开大学社会建设与管理研究院天津300350

中国共产党在百年发展中,秉持以人民为中心,为中国人民谋幸福,为中华民族谋复兴的初心,在各个时期都致力于主张、制定和实施社会政策,以实现其保障和改善民生并推动革命、建设、改革的目标。中国共产党百年的社会政策发展始终坚持为了... 详细信息

中国共产党在百年发展中,秉持以人民为中心,为中国人民谋幸福,为中华民族谋复兴的初心,在各个时期都致力于主张、制定和实施社会政策,以实现其保障和改善民生并推动革命、建设、改革的目标。中国共产党百年的社会政策发展始终坚持为了中国人民的根本利益,将革命理想与经济社会现实相结合,重视社会公平与经济效率的结合,注重社会政策的体系完整性和结构合理性,不断优化民生保障的责任主体。在新的历史时期,面对新的挑战,社会政策未来发展中应认真总结传承百年社会政策发展的经验,始终坚持以人民为中心的发展理念,积极回应我国高质量发展和共同富裕道路的要求,提高对人口、经济和社会发展中各种新问题、新风险的应对能力,更加高效能地发挥作用,并进一步加强社会政策理论研究、学科建设和国际传播与交流。

关键词：中国共产党百年历史社会政策

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重大突发事件中困难群体兜底保障体系建设思路

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中共中央党校（国家行政学院）学报 2020年第3期24卷 22-28页

作者：关信平南开大学社会建设与管理研究院天津津南300350

困难群体在重大突发事件中具有高风险性和脆弱性,需要政府和社会对困难群体提供兜底保障。重大突发事件困难群体兜底保障具有专门的内容和行动特点,应进一步加强社会救助制度的兜底保障功能,加强重大突发事件困难群体兜底保障政策体系... 详细信息

困难群体在重大突发事件中具有高风险性和脆弱性,需要政府和社会对困难群体提供兜底保障。重大突发事件困难群体兜底保障具有专门的内容和行动特点,应进一步加强社会救助制度的兜底保障功能,加强重大突发事件困难群体兜底保障政策体系建设和预案建设。

关键词：重大突发事件困难群体兜底保障社会救助

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论我国社会保障制度一体化建设的意义及相关政策

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东岳论丛 2011年第5期32卷 5-12页

作者：关信平南开大学社会工作与社会政策系天津300071

社会保障制度一体化问题是当代各国社会保障制度建设和发展遇到的一个带有普遍性的问题。过去长期以来我国社会保障制度一直存在着严重的城乡二元结构,改革开放以来,我国的社会保障制度又在一定程度上出现了碎片化的倾向,这些对我国未... 详细信息

社会保障制度一体化问题是当代各国社会保障制度建设和发展遇到的一个带有普遍性的问题。过去长期以来我国社会保障制度一直存在着严重的城乡二元结构,改革开放以来,我国的社会保障制度又在一定程度上出现了碎片化的倾向,这些对我国未来社会保障的体系建构和发展都是不利的。随着"十一五"期间我国社会保障体系的较快发展,尤其是农村社会保障的长足发展和覆盖城乡社会保障体系的发展,碎片化和二元结构问题已经是制约我国社会保障进一步发展的因素。因此,加强社会保障制度一体化建设的问题应该提到重要议事日程。为此,本文结合我国实际,对社会保障制度一体化的含义、表现和意义进行理论探讨,对社会保障制度一体化的现状及问题进行分析,并在此基础上提出促进我国社会保障一体化建设的政策建议。

关键词：社会保障一体化碎片化

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全面建成小康社会条件下我国普惠性民生建设的方向与重点

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经济社会体制比较 2020年第5期 8-15页

作者：关信平南开大学社会建设与管理研究院

在全面建成小康社会的条件下,我国民生建设面临新的目标和要求。党中央提出了加强普惠性民生建设的要求,而如何全面理解和落实这一要求是摆在我国学术界和各级政府面前的一个重要任务。文章结合国际经验和我国实际,从理论上分析了普惠... 详细信息

在全面建成小康社会的条件下,我国民生建设面临新的目标和要求。党中央提出了加强普惠性民生建设的要求,而如何全面理解和落实这一要求是摆在我国学术界和各级政府面前的一个重要任务。文章结合国际经验和我国实际,从理论上分析了普惠性民生建设的含义和内容,以及当前我国加强普惠性民生建设的意义、目标、原则和具体任务。文章认为,在全面建成小康社会的条件下,我国加强普惠性民生建设对完善民生保障体系具有重要的意义。在过去近20年里我国普惠性民生建设已经取得显著成就,但目前还存在一些短板,应该进一步加强。在此基础上,文章提出了当前我国普惠性民生建设的重点领域,以及全面建成小康社会条件下我国普惠性民生建设的目标、原则与要求。

关键词：民生建设普惠性社会政策全面建成小康社会

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