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A newly designed BIPV system with enhanced passive cooling and ventilation

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Building Simulation 2023年第11期16卷 2093-2107页

作者： Hadi Ahmadi Moghaddam Svetlana Tkachenko guan heng yeoh Victoria Timchenko School of Mechanical and Manufacturing Engineering University of New South WalesSydneyNSW2052Australia

Nowadays,the application of renewable energies such as solar energy in the building sector has increased notably considering the adverse impacts of climate change on human life;hence many studies have focused on the application of photovoltaic panels in *** the current study,a 3D computational fluid dynamics(CFD)model has been developed to evaluate the performance of a newly designed building-integrated photovoltaic(BIPV)*** the negative influence of overheating on the lifespan and performance of PV panels,their passive air cooling has been ***,the potential of rooftop-mounted solar panels in passive ventilation of buildings by generating natural convective currents has been *** developed CFD model takes into consideration the effects of radiation,conduction,and buoyancy-driven natural convective currents generated by solar PV panels which are heated due to the exposure to solar radiation heat *** results suggest that applying a high surface emissivity for the part of the roof beneath the PV panels intensifies the natural convective currents which in turn provides better cooling for PV panels with higher cooling effects at higher solar heat *** to a 34%increase in the convective mass flow rate and a 3 K decrease in the mean temperature of the panels were attained by modifying the emissivity of roof *** a 3 K decrease in the operating temperature of the PV panels can enhance their efficiency and lifespan by about 1.56%and 21%,*** on the operating conditions and system characteristics,the BIPV system yielded an air change rate(ACH)in the range of 3-13 which was considered to be highly prevalent in providing the required passive ventilation for a wide range of *** was also observed that the flow dynamics inside the building were affected by both the amount of solar heat load incident on the solar panels and the emissivity of the roof surface behind the panels.

关键词： air change rate BIPV natural convection passive cooling passive ventilation surface emissivity

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室内火灾数值模拟方法的探讨

燃烧科学与技术 2003年第2期9卷 100-103页

作者：陈大宏袁国杰 guan heng-yeoh 杨小亭方正武汉大学水利水电学院武汉430072 香港城市大学建筑学系澳大利亚原子能科学技术委员会原子能技术部

通过场模拟方法与Steckler的单室火灾实验资料比较,验证了作者开发的火灾场模拟模型Fire3D,同时讨论了不同燃烧模型和热辐射对计算结果的影响.定量比较显示,如果考虑燃烧和热辐射的模拟,则Fire3D能够提供与实验相吻合的速度和温度.CO含... 详细信息

通过场模拟方法与Steckler的单室火灾实验资料比较,验证了作者开发的火灾场模拟模型Fire3D,同时讨论了不同燃烧模型和热辐射对计算结果的影响.定量比较显示,如果考虑燃烧和热辐射的模拟,则Fire3D能够提供与实验相吻合的速度和温度.CO含量是建筑火灾预报中的重要指标,以Flamelet为基础的燃烧模型能计算出CO浓度.Flamelet模型和模拟热辐射的DOM方法联合运用会比较适合于建筑火灾的预报,值得进一步探讨.

关键词：建筑火灾燃烧模型场模拟火灾数值模拟 CFD

Development of an agent-based indoor evacuation model for local fire risks analysis

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Journal of Safety Science and Resilience 2023年第1期4卷 75-92页

作者： Rui Feng Cao Eric Wai Ming Lee Wei Xie Dong Li Gao Qian Chen Anthony Chun Yin Yuen guan heng yeoh Richard-Kwok-Kit Yuen Department of Architecture and Civil Engineering City University of Hong KongKowloon TongHong KongChina School of Mechanical and Manufacturing Engineering University of New South WalesSydneyNSW 2052Australia

Evidence suggests that in the event of a fire accident, a certain number of building occupants escape through smoke-filled environments. Consequently, evaluating the corresponding evacuation performance under such life-threatening conditions is important for advancing fire safety analyses. This study aimed to develop a fire-integrated evacuation model to consider the effects of spreading fire hazards (i.e., radiation, temperature, toxic gas, visibility) on evacuees in a room fire evacuation scenario. Furthermore, a novel quantitative approach was introduced to evaluate evacuees’ local fire risks and stress levels according to their egress paths. The escape characteristics at various stages of fire development were studied as well. The results demonstrate that evacuation performance varies considerably depending on the severity of evacuees’ confronted fire hazard conditions, which emphasizes the importance of minimizing the pre-evacuation time in fire evacuation emergencies.

关键词： Fire emergency Indoor evacuation modeling Local fire risks Evacuation dynamics

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计算流体力学

General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis

作者： (澳)Jiyuan Tu (澳)guan heng yeoh (美)Chaoqun Liu

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Science China Chemistry 2024年第8期67卷 2637-2646页

作者： Meng He Yankai Yang heng Zhang Zhipeng guan Zhi-Bing Dong Hong Yi Aiwen Lei School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China College of Chemistry and Molecular Sciences and Institute for Advanced Studies(IAS) Wuhan UniversityWuhan 430072China

CF_(2)H-containing molecules play pivotal roles in diverse fields from medicinal chemistry to materials science. However, the application of existing CF_(2)H reagents as a source of CF_(2)H radical is limited by their reactivity and preparation. Herein, we develop a simple and general visible-light-catalyzed radical difluoromethylation reaction of alkenes, dienes, and heteroaromatics using commercially available, easy-to-handle, and low-cost difluoroacetic anhydride as the CF_(2)H reagent. This scalable protocol enables the convenient synthesis of a range of CF_(2)H-containing compounds under mild conditions, exhibiting a broad substrate scope and functional group tolerance. Potential applications are further demonstrated by gram-scale synthesis, sunlight experiments, derivatization experiments as well as the synthesis of bioactive molecules.

关键词： radical difluoromethylation alkenes/dienes/heteroaromatics difluoroacetic anhydride photoredox

ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway

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Current Medical Science 2024年第2期44卷 406-418页

作者： Cheng-cheng ZHU heng-liang SUN Teng-fei LONG Yuan-yuan LYU Jiang-li LIU guan-tai NI Anhui Medical University Hefei 230032China Department of Obstetrics and Gynecology The First Affiliated Hospital of Wannan Medical CollegeWuhu 241001China

Objective:Uterine corpus endometrial carcinoma(UCEC),a kind of gynecologic malignancy,poses a significant risk to women’s *** precise mechanism underlying the development of UCEC remains *** finger protein 554(ZNF554),a member of the Krüppel-associated box domain zinc finger protein superfamily,was reported to be dysregulated in various illnesses,including malignant *** study aimed to examine the involvement of ZNF554 in the development of ***:The expression of ZNF554 in UCEC tissues and cell lines were examined by qRT-PCR and Western blot *** with stably overexpressed or knocked-down ZNF554 were established through lentivirus ***-8,wound healing,and Transwell invasion assays were employed to assess cell proliferation,migration,and *** iodide(PI)staining combined with fluorescence-activated cell sorting(FACS)flow cytometer was utilized to detect cell cycle ***-PCR and Western blotting were conducted to examine relative mRNA and protein *** immunoprecipitation assay and luciferase reporter assay were used to explore the regulatory role of ZNF554 in RNA binding motif 5(RBM5).Results:The expression of ZNF554 was found to be reduced in both UCEC samples and cell *** expression of ZNF554 was associated with higher tumor stage,decreased overall survival,and reduced disease-free survival in ***554 overexpression suppressed cell proliferation,migration,and invasion,while also inducing cell cycle *** contrast,a decrease in ZNF554 expression resulted in the opposite ***,ZNF554 transcriptionally regulated RBM5,leading to the deactivation of the Wingless(WNT)/β-catenin signaling ***,the findings from rescue studies demonstrated that the inhibition of RBM5 negated the impact of ZNF554 overexpression onβ-catenin and p-glycogen synthase kinase-3β(p-GSK-3β).Similarly,the deliberate activation of RBM5 reduced the increase inβ-catenin and

关键词： zinc finger protein 554 endometrial carcinoma RNA binding motif 5 Wingless/β-catenin signaling pathway

Photocatalytic dicarboxylation of strained C-C bonds with CO_(2) via consecutive visible-light-induced electron transfer

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Chinese Chemical Letters 2024年第6期35卷 268-273页

作者： Yi Liu Zhe-Hao Wang guan-Hua Xue Lin Chen Li-Hua Yuan Yi-Wen Li Da-Gang Yu Jian-heng Ye Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Dicarboxylic acids have a wide range of applications in the polymer industry to construct valuable *** has recently emerged as an efficient and sustainable strategy to generate dicarboxylic ***,photocatalytic dicarboxylation with CO_(2) is mainly limited to unsaturated bonds,and the dicarboxylation of C-C single bonds still remains a ***,we report a photocatalytic dicarboxylation of C-C single bonds in strained rings with CO_(2) units via consecutive photo-induced electron transfer(ConPET).It is also the first photocatalytic reductive ring-opening reaction of ***,this transition-metal-free protocol exhibits good functional group tolerance,broad substrate scope,facile scalability,and easy product ***,diacids can easily be derivatized to mainchain liquid crystalline polyesters.

关键词： Consecutive photo-induced electron transfer Visible-light catalysis Dicarboxylation Carbon dioxide Cyclopropanes

Deformation,structure and potential hazard of a landslide based on InSAR in Banbar county,Xizang(Tibet)

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China Geology 2024年第2期7卷 203-221页

作者： guan-hua Zhao heng-xing Lan Hui-yong Yin Lang-ping Li Alexander Strom Wei-feng Sun Chao-yang Tian College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Key Laboratory of Ecological Geology and Disaster Prevention Ministry of Natural ResourcesXi’an 710054China University of Chinese Academy of Sciences Beijing 100049China JSC“Hydroproject Institute” Moscow 125993Russia

The Tibetan Plateau is characterized by complex geological conditions and a relatively fragile ecological *** recent years,there has been continuous development and increased human activity in the Tibetan Plateau region,leading to a rising risk of *** landslide in Banbar County,Xizang(Tibet),have been perturbed by ongoing disturbances from human engineering activities,making it susceptible to instability and displaying distinct *** this study,small baseline subset synthetic aperture radar interferometry(SBAS-InSAR)technology is used to obtain the Line of Sight(LOS)deformation velocity field in the study area,and then the slope-orientation deformation field of the landslide is obtained according to the spatial geometric relationship between the satellite’s LOS direction and the ***,the landslide thickness is inverted by applying the mass conservation *** results show that the movement area of the landslide is about 6.57×10^(4)m^(2),and the landslide volume is about 1.45×10^(6)m^(3).The maximum estimated thickness and average thickness of the landslide are 39 m and 22 m,*** thickness estimation results align with the findings from on-site investigation,indicating the applicability of this method to large-scale earth *** deformation rate of the landslide exhibits a notable correlation with temperature variations,with rainfall playing a supportive role in the deformation process and displaying a certain *** activities exert the most substantial influence on the spatial heterogeneity of landslide deformation,leading to the direct impact of several prominent deformation areas due to human ***,utilizing the long short-term memory(LSTM)model to predict landslide displacement,and the forecast results demonstrate the effectiveness of the LSTM model in predicting landslides that are in a continuous development and movement *** landslide is still active,and based

关键词： Landslide InSAR Human activity Deformation Structure LSTM model Engineering construction Thickness Neural network Machine learning Prediction and prevention Tibetan Plateau Geological hazards survey engineering

Aloin ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Jingqian Su Jianbin Xiao Siyuan Chen heng Zhao Xiaoni Zhang Zhihua Feng Kunsen Chen Biyun guan Wenzhi Chen Youqiang Chen Duo Chen Qi Chen Fujian Key Laboratory of Innate Immune Biology， Biomedical Research Center of South China， College of Life Science， Fujian Normal University The Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Products of the State Oceanic Administration， Fujian Key Laboratory of Special Marine Bioresource Sustainable Utilization， Southern Institute of Oceanography， College of Life Science， Fujian Normal University

Most Aloe species are used as new food or functional food ingredient. Even though widely known for its health benefits， the anti-inflammatory effects and underlying mechanisms of Aloin (Alo)， an anthraquinone compound isolated from plant species of the genus Aloe， remain unidentified. Here， we investigated the protective effects of Alo against cecal ligation and puncture (CLP)-induced sepsis and microflora in mice. Alo significantly improved CLP-induced sepsis and the survival rate of septic mice， downregulated the expression of proinflammatory factors， and decreased the infiltration of inflammatory cells in tissues. Alo upregulated the proportion of peritoneal macrophages， reduced the number of peritoneal bacteria， decreased the content of short-chain fatty acids and bile acids in the abdominal cavity， and suppressed TLR-2/4/NF-κB/NLRP3/Caspase-1/3/8 signaling. Furthermore， Alo altered the composition of the microbiome and promoted the growth of Lactobacillus， which showed a stronger anti-inflammatory effect. Whole-genome analysis identified the genes Saa3， Il10， Fpr1， and Eif4a1 associated with the protective effects of Alo in mice with CLP-induced sepsis. Overall， our results provide novel insights into the therapeutic potential and mechanism of action of Alo in the treatment of sepsis.

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