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Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：孙羽灵 YANG Yan QIAN Lin-nan guan dong-lang JIAN Tun-yu TANG Zong-xiang School of Medicine ·Holistic Integrative Medicine Nanjing University of Chinese Medicine

Backgrounds:Raw lacquer is an important chemical raw material needed in production and life,but the application and promotion of lacquer was limited by its high *** main component of lacquer is urushiol, and it also has strong sensitization as raw *** who are allergic to urushiol may develop a wart-like or wheal-like rash, with symptoms of burning, swelling,and ***, the mechanism of the intense itching induced by urushiol and the corresponding clinical treatment is still not *** hope to explore the mechanism and search therapeutic ***: 1) To explore the mechanism of urushiol-induced allergic pruritus related with mast cells.2) To explore how aloe-emodin can reduce urushiol-induced itching by inhibiting degranulation of mast cells.3) To search the pruritus substances and the signaling pathway released during the degranulation of mast ***:1) We extracted urushiol from fresh raw lacquer using suspension drop method.2)Scratching numbers of mice were used to evaluate the degree of pruritus induced by urushiol and reduceded by aloe-emodin in behavior tests.3) The difference in the number of mast cells and the number of degranulation of mast cells in skin sections was determined by hematoxylin-eosin staining and toluidine blue staining.4) qRT-PCR, Western Blot, ELISA and *** used to determine the pruritus substance which released by the degranulation of mast cells;5) We cultured DRG neurons from wildtype mice to find receptors and signaling pathways of pruritus substances using calcium imaging ***:1) 2% urushiol can cause acute scratching *** with the acetone control group, the scratching numbers was significantly increased during the first hour after 2% urushiol was applied to the neck of the mouse;Four hours later, the scratching numbers of the mouse decreased significantly compared with the first hour, but there was still a significant difference compared with the control g

关键词： urushiol mast cell degranulation aloe-emodin itch

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan Zhang Xiaomin Cheng Qinghua guan Jing dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Isolation and Purification of Pruritic Compounds from Yam(Dioscoreae Rhizoma)

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神经药理学报 2019年第4期 16-16页

作者： SUN Yu-ling YANG Yan QIAN Lin-nan guan dong-lang JIAN Tun-yu TANG Zong-xiang School of Medicine and Life Sciences Nanjing University of Chinese Medicine

Backgrounds:Chinese yam is a traditional Chinese medicine. It has many benefits for people,such as antidiarrhea,anti-inflammation,antidiabetic,hypocholesterolemia,antioxidation,antitumor,and immunomodulation. The mucus of the fresh yam could induce itch in the skin,however,the pruritus compound in yam is very unclear. Objective:1) To isolate and purify the pruritus compounds from fresh Chinese yam;2) To test the activity of the pruritus compound-allantoin;3) To study the cellular mechanism of allantoin-induced itching. Methods:We extracted allantoin crystal from fresh Chinese yam using suspension drop method. Multidimensional chromatographic separation methods including membrane filtration,ion exchange chromatography,C18 reverse phase chromatography,silica column and preparation liquid phase,mass spectrometry analysis were used to purify the active compounds. Scratch numbers of mice were used to evaluate the degree of pruritus induced by allantoin in behavior tests. We cultured DRG neurons from Pirt-GCaMP3 heterozygotes examined their responses to allantoin using calcium imaging techniques. We also examined the electrophysiological characteristics of the neurons induced by allantoin using whole cell recording. Results:We got the allantoin crystal by simple ethanol extraction. The content of allantoin extracted from yam( origin from Jiaozuo,Henan) is about 3.567 mg·g-1. Our results show that allantoin could induce more scratch numbers in mice than control group. Allantoin also directly activated DRG neurons to induce calcium influx and inward current. Conclusion:This is the first time to obtain allantoin crystal from fresh yam. Allantoin is widely found in many natural plants,but the effect of allantoin on DRG neurons and animal itching behavior was the first time. Our research shows that allantoin not only activated small DRG neurons,but also caused itch in mice. Allantoin could induce the itching behavior of mice,which not only help us understand the cause of yam t

关键词： allantoin calcium influx inward current dorsal horn ganglion itch

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山药中的致痒物质及致痒机制研究（英文）

生物化学与生物物理进展 2019年第10期46卷 1012-1019页

作者：杨雁孙羽灵刘培钱林楠关东朗简暾昱朱婵于光王长明朱静李德峰唐宗湘南京中医药大学医学与生命科学学院精神疾病与中医药防治重点实验室南京210023 南京中医药大学药学院南京210023 江苏省植物研究所南京210014 )中国科学院微生物研究所北京100101

山药是一种传统中药,对人体有许多益处,如抗腹泻、抗炎、抗糖尿病、低胆固醇血症、抗氧化、抗肿瘤和免疫调节.山药黏液接触皮肤,常引起严重瘙痒.而山药中存在的致痒物质成分尚不清楚.我们采用乙醇提取、膜过滤、离子交换色谱、悬浮液滴... 详细信息

山药是一种传统中药,对人体有许多益处,如抗腹泻、抗炎、抗糖尿病、低胆固醇血症、抗氧化、抗肿瘤和免疫调节.山药黏液接触皮肤,常引起严重瘙痒.而山药中存在的致痒物质成分尚不清楚.我们采用乙醇提取、膜过滤、离子交换色谱、悬浮液滴法从新鲜山药中提取尿囊素晶体.从河南焦作山药中提取的尿囊素含量约为3.567 mg/g.活性实验结果表明,尿囊素引起的小鼠抓挠反应次数显著地高于对照组.尿囊素直接激活背根神经节神经元,诱导钙流入,还可以诱导神经元内向电流产生.我们首次在细胞水平证明尿囊素能够激活神经细胞,诱导痒觉信号传导.

关键词：山药尿囊素钙离子内流背根神经节

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SEOE: an option graph based semantically embedding method for prenatal depression detection

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Frontiers of Computer Science 2024年第6期18卷 186911-186911页

作者： HAN Xiaosong CAO Mengchen XU dong FENG Xiaoyue LIANG Yanchun lang Xiaoduo guan Renchu College of Computer Science and Technology Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Department of Electrical Engineering and Computer Science and Christopher S. Bond Life Sciences Center University of Missour Department of Computer Science and Technology Zhuhai Laboratory of Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Zhuhai College of Science and Technology Jilin Provincial Institute of Population Science and Technology

Prenatal depression, which can affect pregnant women’s physical and psychological health and cause postpartum depression, is increasing dramatically. Therefore, it is essential to detect prenatal depression early and conduct an attribution analysis. Many studies have used questionnaires to screen for prenatal depression, but the existing methods lack attributability. To diagnose the early signs of prenatal depression and identify the key factors that may lead to prenatal depression from questionnaires, we present the semantically enhanced option embedding (SEOE) model to represent questionnaire options. It can quantitatively determine the relationship and patterns between options and depression. SEOE first quantifies options and resorts them, gathering options with little difference, since Word2Vec is highly dependent on context. The resort task is transformed into an optimization problem involving the traveling salesman problem. Moreover, all questionnaire samples are used to train the options’ vector using Word2Vec. Finally, an LSTM and GRU fused model incorporating the cycle learning rate is constructed to detect whether a pregnant woman is suffering from depression. To verify the model, we compare it with other deep learning and traditional machine learning methods. The experiment results show that our proposed model can accurately identify pregnant women with depression and reach an F1 score of 0.8. The most relevant factors of depression found by SEOE are also verified in the literature. In addition, our model is of low computational complexity and strong generalization, which can be widely applied to other questionnaire analyses of psychiatric disorders.

关键词： questionnaire analyses text classification graph representation learning traveling salesman problem prenatal depression

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Typing Evolving Ambients

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Journal of Shanghai University(English Edition) 2001年第Z1期5卷 26-30页

作者： guan Xu-dong Department of Computer Science & Engineering Shanghai Jiao Tong University Shanghai 200030 People's Republic of China

This paper presents a type system that deals with the type evolution problem of the ambient calculus . It breaks the law that the open capability must introduce to the opening process the exact type information of the opened ambient. It can also serve as a general type architecture supporting type evolution. A typical usage of the type system is illustrated in the immobile server example.

关键词： Theory of computation Type system Ambient calculus

Nonconforming Finite Element Methods for the Constrained Optimal Control Problems Governed by Nonsmooth Elliptic Equations

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 471-481页

作者： Hong-bo guan dong-yang SHI College of Mathematics and Information Sciences Zhengzhou University of Light IndustryZhengzhou 450002China School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China

In this paper,nonconforming finite element methods(FEMs)are proposed for the constrained optimal control problems(OCPs)governed by the nonsmooth elliptic equations,in which the popular EQr1 ot element is employed to approximate the state and adjoint state,and the piecewise constant element is used to approximate the ***,the convergence and superconvergence properties for the nonsmooth elliptic equation are obtained by introducing an auxiliary ***,the goal-oriented error estimates are obtained for the objective function through establishing the negative norm error ***,the methods are extended to some other well-known nonconforming elements.

关键词： nonconforming finite element supercloseness and superconvergence optimal control problems nonsmooth elliptic equations goal-oriented error estimate

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